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Items: 36


Dimerization of a ubiquitin variant leads to high affinity interactions with a ubiquitin interacting motif.

Manczyk N, Veggiani G, Gish GD, Yates BP, Ernst A, Sidhu SS, Sicheri F.

Protein Sci. 2019 May;28(5):848-856. doi: 10.1002/pro.3593. Epub 2019 Mar 12.


Direct Phosphorylation of SRC Homology 3 Domains by Tyrosine Kinase Receptors Disassembles Ligand-Induced Signaling Networks.

Dionne U, Chartier FJM, López de Los Santos Y, Lavoie N, Bernard DN, Banerjee SL, Otis F, Jacquet K, Tremblay MG, Jain M, Bourassa S, Gish GD, Gagné JP, Poirier GG, Laprise P, Voyer N, Landry CR, Doucet N, Bisson N.

Mol Cell. 2018 Jun 21;70(6):995-1007.e11. doi: 10.1016/j.molcel.2018.05.013. Epub 2018 Jun 18.


Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function.

Zeqiraj E, Tian L, Piggott CA, Pillon MC, Duffy NM, Ceccarelli DF, Keszei AF, Lorenzen K, Kurinov I, Orlicky S, Gish GD, Heck AJ, Guarné A, Greenberg RA, Sicheri F.

Mol Cell. 2015 Sep 17;59(6):970-83. doi: 10.1016/j.molcel.2015.07.028. Epub 2015 Sep 3.


Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T-cell costimulatory receptor.

Tian R, Wang H, Gish GD, Petsalaki E, Pasculescu A, Shi Y, Mollenauer M, Bagshaw RD, Yosef N, Hunter T, Gingras AC, Weiss A, Pawson T.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1594-603. doi: 10.1073/pnas.1503286112. Epub 2015 Mar 17.


Directed network wiring identifies a key protein interaction in embryonic stem cell differentiation.

Yasui N, Findlay GM, Gish GD, Hsiung MS, Huang J, Tucholska M, Taylor L, Smith L, Boldridge WC, Koide A, Pawson T, Koide S.

Mol Cell. 2014 Jun 19;54(6):1034-41. doi: 10.1016/j.molcel.2014.05.002. Epub 2014 Jun 5.


Identification of a novel protein interaction motif in the regulatory subunit of casein kinase 2.

Cao JY, Shire K, Landry C, Gish GD, Pawson T, Frappier L.

Mol Cell Biol. 2014 Jan;34(2):246-58. doi: 10.1128/MCB.00968-13. Epub 2013 Nov 11.


Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate.

Findlay GM, Smith MJ, Lanner F, Hsiung MS, Gish GD, Petsalaki E, Cockburn K, Kaneko T, Huang H, Bagshaw RD, Ketela T, Tucholska M, Taylor L, Bowtell DD, Moffat J, Ikura M, Li SS, Sidhu SS, Rossant J, Pawson T.

Cell. 2013 Feb 28;152(5):1008-20. doi: 10.1016/j.cell.2013.01.056.


Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock.

Xu C, Jin J, Bian C, Lam R, Tian R, Weist R, You L, Nie J, Bochkarev A, Tempel W, Tan CS, Wasney GA, Vedadi M, Gish GD, Arrowsmith CH, Pawson T, Yang XJ, Min J.

Sci Signal. 2012 May 29;5(226):ra39. doi: 10.1126/scisignal.2002979.


Targeting the SH2-kinase interface in Bcr-Abl inhibits leukemogenesis.

Grebien F, Hantschel O, Wojcik J, Kaupe I, Kovacic B, Wyrzucki AM, Gish GD, Cerny-Reiterer S, Koide A, Beug H, Pawson T, Valent P, Koide S, Superti-Furga G.

Cell. 2011 Oct 14;147(2):306-19. doi: 10.1016/j.cell.2011.08.046.


Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation.

Filippakopoulos P, Kofler M, Hantschel O, Gish GD, Grebien F, Salah E, Neudecker P, Kay LE, Turk BE, Superti-Furga G, Pawson T, Knapp S.

Cell. 2008 Sep 5;134(5):793-803. doi: 10.1016/j.cell.2008.07.047.


SH2 domains, interaction modules and cellular wiring.

Pawson T, Gish GD, Nash P.

Trends Cell Biol. 2001 Dec;11(12):504-11. Review.


Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cells.

Gruenheid S, DeVinney R, Bladt F, Goosney D, Gelkop S, Gish GD, Pawson T, Finlay BB.

Nat Cell Biol. 2001 Sep;3(9):856-9.


Structural basis for specificity switching of the Src SH2 domain.

Kimber MS, Nachman J, Cunningham AM, Gish GD, Pawson T, Pai EF.

Mol Cell. 2000 Jun;5(6):1043-9.


The shc adaptor protein forms interdependent phosphotyrosine-mediated protein complexes in mast cells stimulated with interleukin 3.

Velazquez L, Gish GD, van Der Geer P, Taylor L, Shulman J, Pawson T.

Blood. 2000 Jul 1;96(1):132-8.


The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif.

Lin D, Gish GD, Songyang Z, Pawson T.

J Biol Chem. 1999 Feb 5;274(6):3726-33.


The B-cell transmembrane protein CD72 binds to and is an in vivo substrate of the protein tyrosine phosphatase SHP-1.

Wu Y, Nadler MJ, Brennan LA, Gish GD, Timms JF, Fusaki N, Jongstra-Bilen J, Tada N, Pawson T, Wither J, Neel BG, Hozumi N.

Curr Biol. 1998 Sep 10;8(18):1009-17.


The discoidin domain receptor tyrosine kinases are activated by collagen.

Vogel W, Gish GD, Alves F, Pawson T.

Mol Cell. 1997 Dec;1(1):13-23.


SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1.

Anafi M, Kiefer F, Gish GD, Mbamalu G, Iscove NN, Pawson T.

J Biol Chem. 1997 Oct 31;272(44):27804-11.


Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells.

Holland SJ, Gale NW, Gish GD, Roth RA, Songyang Z, Cantley LC, Henkemeyer M, Yancopoulos GD, Pawson T.

EMBO J. 1997 Jul 1;16(13):3877-88.


RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc, and the SH2 domain of Grb2.

Lorenzo MJ, Gish GD, Houghton C, Stonehouse TJ, Pawson T, Ponder BA, Smith DP.

Oncogene. 1997 Feb 20;14(7):763-71.


Characterization of the phosphotyrosine-binding domain of the Drosophila Shc protein.

Li SC, Lai KM, Gish GD, Parris WE, van der Geer P, Forman-Kay J, Pawson T.

J Biol Chem. 1996 Dec 13;271(50):31855-62.


The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2.

Chook YM, Gish GD, Kay CM, Pai EF, Pawson T.

J Biol Chem. 1996 Nov 29;271(48):30472-8. Erratum in: J Biol Chem 1997 Feb 7;272(6):3870.


SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors.

Colwill K, Feng LL, Yeakley JM, Gish GD, Cáceres JF, Pawson T, Fu XD.

J Biol Chem. 1996 Oct 4;271(40):24569-75.


A potential SH3 domain-binding site in the Crk SH2 domain.

Anafi M, Rosen MK, Gish GD, Kay LE, Pawson T.

J Biol Chem. 1996 Aug 30;271(35):21365-74.


Identification of residues that control specific binding of the Shc phosphotyrosine-binding domain to phosphotyrosine sites.

van der Geer P, Wiley S, Gish GD, Lai VK, Stephens R, White MF, Kaplan D, Pawson T.

Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):963-8.


A Drosophila shc gene product is implicated in signaling by the DER receptor tyrosine kinase.

Lai KM, Olivier JP, Gish GD, Henkemeyer M, McGlade J, Pawson T.

Mol Cell Biol. 1995 Sep;15(9):4810-8.


Biochemical and genetic analysis of the Drk SH2/SH3 adaptor protein of Drosophila.

Raabe T, Olivier JP, Dickson B, Liu X, Gish GD, Pawson T, Hafen E.

EMBO J. 1995 Jun 1;14(11):2509-18.


A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides.

van der Geer P, Wiley S, Lai VK, Olivier JP, Gish GD, Stephens R, Kaplan D, Shoelson S, Pawson T.

Curr Biol. 1995 Apr 1;5(4):404-12.


Direct demonstration of an intramolecular SH2-phosphotyrosine interaction in the Crk protein.

Rosen MK, Yamazaki T, Gish GD, Kay CM, Pawson T, Kay LE.

Nature. 1995 Mar 30;374(6521):477-9.


SH2 domain specificity and activity modified by a single residue.

Marengere LE, Songyang Z, Gish GD, Schaller MD, Parsons JT, Stern MJ, Cantley LC, Pawson T.

Nature. 1994 Jun 9;369(6480):502-5.


Interactions of the SH2 domain of lymphocyte-specific tyrosine protein kinase p56lck with phosphotyrosine-containing proteins.

Peri KG, Gervais FG, Weil R, Davidson D, Gish GD, Veillette A.

Oncogene. 1993 Oct;8(10):2765-72.


SH2 and SH3 domains: from structure to function.

Pawson T, Gish GD.

Cell. 1992 Oct 30;71(3):359-62. Review. No abstract available.


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