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Items: 33

1.

Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs.

Jeffreys LN, Poddar H, Golovanova M, Levy CW, Girvan HM, McLean KJ, Voice MW, Leys D, Munro AW.

Sci Rep. 2019 Feb 7;9(1):1577. doi: 10.1038/s41598-018-37330-y.

2.

Characterization of Cytochrome P450 Enzymes and Their Applications in Synthetic Biology.

Jeffreys LN, Girvan HM, McLean KJ, Munro AW.

Methods Enzymol. 2018;608:189-261. doi: 10.1016/bs.mie.2018.06.013. Epub 2018 Aug 20.

PMID:
30173763
3.

Structural and catalytic properties of the peroxygenase P450 enzyme CYP152K6 from Bacillus methanolicus.

Girvan HM, Poddar H, McLean KJ, Nelson DR, Hollywood KA, Levy CW, Leys D, Munro AW.

J Inorg Biochem. 2018 Nov;188:18-28. doi: 10.1016/j.jinorgbio.2018.08.002. Epub 2018 Aug 3.

4.

Expression, Purification, and Biochemical Characterization of the Flavocytochrome P450 CYP505A30 from Myceliophthora thermophila.

Baker GJ, Girvan HM, Matthews S, McLean KJ, Golovanova M, Waltham TN, Rigby SEJ, Nelson DR, Blankley RT, Munro AW.

ACS Omega. 2017 Aug 31;2(8):4705-4724. doi: 10.1021/acsomega.7b00450. Epub 2017 Aug 18.

5.

Catalytic Determinants of Alkene Production by the Cytochrome P450 Peroxygenase OleTJE.

Matthews S, Belcher JD, Tee KL, Girvan HM, McLean KJ, Rigby SE, Levy CW, Leys D, Parker DA, Blankley RT, Munro AW.

J Biol Chem. 2017 Mar 24;292(12):5128-5143. doi: 10.1074/jbc.M116.762336. Epub 2017 Jan 4.

6.

Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1.

Chenge JT, Duyet LV, Swami S, McLean KJ, Kavanagh ME, Coyne AG, Rigby SE, Cheesman MR, Girvan HM, Levy CW, Rupp B, von Kries JP, Abell C, Leys D, Munro AW.

J Biol Chem. 2017 Jan 27;292(4):1310-1329. doi: 10.1074/jbc.M116.748822. Epub 2016 Dec 8.

7.

Analysis of Heme Iron Coordination in DGCR8: The Heme-Binding Component of the Microprocessor Complex.

Girvan HM, Bradley JM, Cheesman MR, Kincaid JR, Liu Y, Czarnecki K, Fisher K, Leys D, Rigby SE, Munro AW.

Biochemistry. 2016 Sep 13;55(36):5073-83. doi: 10.1021/acs.biochem.6b00204. Epub 2016 Sep 1.

PMID:
27546061
8.

Applications of microbial cytochrome P450 enzymes in biotechnology and synthetic biology.

Girvan HM, Munro AW.

Curr Opin Chem Biol. 2016 Apr;31:136-45. doi: 10.1016/j.cbpa.2016.02.018. Epub 2016 Mar 22. Review.

9.

Heme sensor proteins.

Girvan HM, Munro AW.

J Biol Chem. 2013 May 10;288(19):13194-203. doi: 10.1074/jbc.R112.422642. Epub 2013 Mar 28. Review.

10.

What makes a P450 tick?

Munro AW, Girvan HM, Mason AE, Dunford AJ, McLean KJ.

Trends Biochem Sci. 2013 Mar;38(3):140-50. doi: 10.1016/j.tibs.2012.11.006. Epub 2013 Jan 26. Review.

PMID:
23356956
11.

The crystal structure of the FAD/NADPH-binding domain of flavocytochrome P450 BM3.

Joyce MG, Ekanem IS, Roitel O, Dunford AJ, Neeli R, Girvan HM, Baker GJ, Curtis RA, Munro AW, Leys D.

FEBS J. 2012 May;279(9):1694-706. doi: 10.1111/j.1742-4658.2012.08544.x. Epub 2012 Mar 16.

12.

Analysis of the oxidation of short chain alkynes by flavocytochrome P450 BM3.

Waltham TN, Girvan HM, Butler CF, Rigby SR, Dunford AJ, Holt RA, Munro AW.

Metallomics. 2011 Apr;3(4):369-78. doi: 10.1039/c1mt00004g. Epub 2011 Mar 23.

PMID:
21431175
13.

Flavocytochrome P450 BM3 mutant W1046A is a NADH-dependent fatty acid hydroxylase: implications for the mechanism of electron transfer in the P450 BM3 dimer.

Girvan HM, Dunford AJ, Neeli R, Ekanem IS, Waltham TN, Joyce MG, Leys D, Curtis RA, Williams P, Fisher K, Voice MW, Munro AW.

Arch Biochem Biophys. 2011 Mar 1;507(1):75-85. doi: 10.1016/j.abb.2010.09.014. Epub 2010 Sep 22.

PMID:
20868649
14.

Glutamate-haem ester bond formation is disfavoured in flavocytochrome P450 BM3: characterization of glutamate substitution mutants at the haem site of P450 BM3.

Girvan HM, Levy CW, Williams P, Fisher K, Cheesman MR, Rigby SE, Leys D, Munro AW.

Biochem J. 2010 Apr 14;427(3):455-66. doi: 10.1042/BJ20091603.

PMID:
20180779
15.

Probing the molecular determinants of coenzyme selectivity in the P450 BM3 FAD/NADPH domain.

Dunford AJ, Girvan HM, Scrutton NS, Munro AW.

Biochim Biophys Acta. 2009 Aug;1794(8):1181-9. doi: 10.1016/j.bbapap.2009.03.014. Epub 2009 Apr 1.

PMID:
19344791
16.

Novel haem co-ordination variants of flavocytochrome P450BM3.

Girvan HM, Toogood HS, Littleford RE, Seward HE, Smith WE, Ekanem IS, Leys D, Cheesman MR, Munro AW.

Biochem J. 2009 Jan 1;417(1):65-76. doi: 10.1042/BJ20081133.

PMID:
18721129
17.

Cytochrome P450/redox partner fusion enzymes: biotechnological and toxicological prospects.

McLean KJ, Girvan HM, Munro AW.

Expert Opin Drug Metab Toxicol. 2007 Dec;3(6):847-63. Review.

PMID:
18028029
18.

Analysis of the interactions of cytochrome b5 with flavocytochrome P450 BM3 and its domains.

Noble MA, Girvan HM, Smith SJ, Smith WE, Murataliev M, Guzov VM, Feyereisen R, Munro AW.

Drug Metab Rev. 2007;39(2-3):599-617.

PMID:
17786641
19.

Conformational dynamics of the cytochrome P450 BM3/N-palmitoylglycine complex: the proposed "proximal-distal" transition probed by temperature-jump spectroscopy.

Brenner S, Hay S, Girvan HM, Munro AW, Scrutton NS.

J Phys Chem B. 2007 Jul 12;111(27):7879-86. Epub 2007 Jun 16.

PMID:
17571881
20.

Variations on a (t)heme--novel mechanisms, redox partners and catalytic functions in the cytochrome P450 superfamily.

Munro AW, Girvan HM, McLean KJ.

Nat Prod Rep. 2007 Jun;24(3):585-609. Epub 2007 May 4. Review. No abstract available.

PMID:
17534532
21.

Laser photoexcitation of NAD(P)H induces reduction of P450 BM3 heme domain on the microsecond time scale.

Girvan HM, Heyes DJ, Scrutton NS, Munro AW.

J Am Chem Soc. 2007 May 23;129(20):6647-53. Epub 2007 Apr 28.

PMID:
17465554
22.
23.

CYP121, CYP51 and associated redox systems in Mycobacterium tuberculosis: towards deconvoluting enzymology of P450 systems in a human pathogen.

McLean KJ, Dunford AJ, Sabri M, Neeli R, Girvan HM, Balding PR, Leys D, Seward HE, Marshall KR, Munro AW.

Biochem Soc Trans. 2006 Dec;34(Pt 6):1178-82. Review.

PMID:
17073780
24.

Flavocytochrome P450 BM3 and the origin of CYP102 fusion species.

Girvan HM, Waltham TN, Neeli R, Collins HF, McLean KJ, Scrutton NS, Leys D, Munro AW.

Biochem Soc Trans. 2006 Dec;34(Pt 6):1173-7. Review.

PMID:
17073779
25.

Cytochrome P450--redox partner fusion enzymes.

Munro AW, Girvan HM, McLean KJ.

Biochim Biophys Acta. 2007 Mar;1770(3):345-59. Epub 2006 Aug 30. Review.

PMID:
17023115
26.

Biophysical characterization of the sterol demethylase P450 from Mycobacterium tuberculosis, its cognate ferredoxin, and their interactions.

McLean KJ, Warman AJ, Seward HE, Marshall KR, Girvan HM, Cheesman MR, Waterman MR, Munro AW.

Biochemistry. 2006 Jul 11;45(27):8427-43.

PMID:
16819841
27.

Cytochrome P450s: creating novel ligand sets.

Seward HE, Girvan HM, Munro AW.

Dalton Trans. 2005 Nov 7;(21):3419-26. Epub 2005 Sep 26. Review.

PMID:
16234920
28.

The dimeric form of flavocytochrome P450 BM3 is catalytically functional as a fatty acid hydroxylase.

Neeli R, Girvan HM, Lawrence A, Warren MJ, Leys D, Scrutton NS, Munro AW.

FEBS Lett. 2005 Oct 24;579(25):5582-8. Epub 2005 Sep 28.

29.

Flavocytochrome P450 BM3: an update on structure and mechanism of a biotechnologically important enzyme.

Warman AJ, Roitel O, Neeli R, Girvan HM, Seward HE, Murray SA, McLean KJ, Joyce MG, Toogood H, Holt RA, Leys D, Scrutton NS, Munro AW.

Biochem Soc Trans. 2005 Aug;33(Pt 4):747-53. Review.

PMID:
16042591
30.

Interaction of nitric oxide with cytochrome P450 BM3.

Quaroni LG, Seward HE, McLean KJ, Girvan HM, Ost TW, Noble MA, Kelly SM, Price NC, Cheesman MR, Smith WE, Munro AW.

Biochemistry. 2004 Dec 28;43(51):16416-31.

PMID:
15610036
31.

Flavocytochrome P450 BM3 mutant A264E undergoes substrate-dependent formation of a novel heme iron ligand set.

Girvan HM, Marshall KR, Lawson RJ, Leys D, Joyce MG, Clarkson J, Smith WE, Cheesman MR, Munro AW.

J Biol Chem. 2004 May 28;279(22):23274-86. Epub 2004 Mar 12.

32.

A single mutation in cytochrome P450 BM3 induces the conformational rearrangement seen upon substrate binding in the wild-type enzyme.

Joyce MG, Girvan HM, Munro AW, Leys D.

J Biol Chem. 2004 May 28;279(22):23287-93. Epub 2004 Mar 12.

33.

Formation of transient oxygen complexes of cytochrome p450 BM3 and nitric oxide synthase under high pressure.

Marchal S, Girvan HM, Gorren AC, Mayer B, Munro AW, Balny C, Lange R.

Biophys J. 2003 Nov;85(5):3303-9.

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