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Items: 23

1.

Tsc3 regulates SPT amino acid choice in Saccharomyces cerevisiae by promoting alanine in the sphingolipid pathway.

Ren J, Saied EM, Zhong A, Snider J, Ruiz C, Arenz C, Obeid LM, Girnun GD, Hannun YA.

J Lipid Res. 2018 Nov;59(11):2126-2139. doi: 10.1194/jlr.M088195. Epub 2018 Aug 28.

PMID:
30154231
2.

De novo lipogenesis represents a therapeutic target in mutant Kras non-small cell lung cancer.

Singh A, Ruiz C, Bhalla K, Haley JA, Li QK, Acquaah-Mensah G, Montal E, Sudini KR, Skoulidis F, Wistuba II, Papadimitrakopoulou V, Heymach JV, Boros LG, Gabrielson E, Carretero J, Wong KK, Haley JD, Biswal S, Girnun GD.

FASEB J. 2018 Jun 15:fj201800204. doi: 10.1096/fj.201800204. [Epub ahead of print]

PMID:
29906244
3.

Heme degradation enzyme biliverdin IXβ reductase is required for stem cell glutamine metabolism.

Li Z, Nesbitt NM, Malone LE, Gnatenko DV, Wu S, Wang D, Zhu W, Girnun GD, Bahou WF.

Biochem J. 2018 Mar 29;475(6):1211-1223. doi: 10.1042/BCJ20180016.

PMID:
29500232
4.

PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth.

Montal ED, Dewi R, Bhalla K, Ou L, Hwang BJ, Ropell AE, Gordon C, Liu WJ, DeBerardinis RJ, Sudderth J, Twaddel W, Boros LG, Shroyer KR, Duraisamy S, Drapkin R, Powers RS, Rohde JM, Boxer MB, Wong KK, Girnun GD.

Mol Cell. 2015 Nov 19;60(4):571-83. doi: 10.1016/j.molcel.2015.09.025. Epub 2015 Oct 17.

5.

The RUNX2 Transcription Factor Negatively Regulates SIRT6 Expression to Alter Glucose Metabolism in Breast Cancer Cells.

Choe M, Brusgard JL, Chumsri S, Bhandary L, Zhao XF, Lu S, Goloubeva OG, Polster BM, Fiskum GM, Girnun GD, Kim MS, Passaniti A.

J Cell Biochem. 2015 Oct;116(10):2210-26. doi: 10.1002/jcb.25171.

6.

Cyclin D1 represses gluconeogenesis via inhibition of the transcriptional coactivator PGC1α.

Bhalla K, Liu WJ, Thompson K, Anders L, Devarakonda S, Dewi R, Buckley S, Hwang BJ, Polster B, Dorsey SG, Sun Y, Sicinski P, Girnun GD.

Diabetes. 2014 Oct;63(10):3266-78. doi: 10.2337/db13-1283. Epub 2014 Jun 19.

7.

Rapid detection of an ABT-737-sensitive primed for death state in cells using microplate-based respirometry.

Clerc P, Carey GB, Mehrabian Z, Wei M, Hwang H, Girnun GD, Chen H, Martin SS, Polster BM.

PLoS One. 2012;7(8):e42487. doi: 10.1371/journal.pone.0042487. Epub 2012 Aug 3.

8.

Metformin prevents liver tumorigenesis by inhibiting pathways driving hepatic lipogenesis.

Bhalla K, Hwang BJ, Dewi RE, Twaddel W, Goloubeva OG, Wong KK, Saxena NK, Biswal S, Girnun GD.

Cancer Prev Res (Phila). 2012 Apr;5(4):544-52. doi: 10.1158/1940-6207.CAPR-11-0228. Epub 2012 Mar 31.

9.

The diverse role of the PPARγ coactivator 1 family of transcriptional coactivators in cancer.

Girnun GD.

Semin Cell Dev Biol. 2012 Jun;23(4):381-8. doi: 10.1016/j.semcdb.2012.01.007. Epub 2012 Jan 21. Review.

10.

N-Acetylfarnesylcysteine is a novel class of peroxisome proliferator-activated receptor γ ligand with partial and full agonist activity in vitro and in vivo.

Bhalla K, Hwang BJ, Choi JH, Dewi R, Ou L, Mclenithan J, Twaddel W, Pozharski E, Stock J, Girnun GD.

J Biol Chem. 2011 Dec 2;286(48):41626-35. doi: 10.1074/jbc.M111.257915. Epub 2011 Oct 6.

11.

PGC1α promotes tumor growth by inducing gene expression programs supporting lipogenesis.

Bhalla K, Hwang BJ, Dewi RE, Ou L, Twaddel W, Fang HB, Vafai SB, Vazquez F, Puigserver P, Boros L, Girnun GD.

Cancer Res. 2011 Nov 1;71(21):6888-98. doi: 10.1158/0008-5472.CAN-11-1011. Epub 2011 Sep 13.

12.

Liposomal doxorubicin increases radiofrequency ablation-induced tumor destruction by increasing cellular oxidative and nitrative stress and accelerating apoptotic pathways.

Solazzo SA, Ahmed M, Schor-Bardach R, Yang W, Girnun GD, Rahmanuddin S, Levchenko T, Signoretti S, Spitz DR, Torchilin V, Goldberg SN.

Radiology. 2010 Apr;255(1):62-74. doi: 10.1148/radiol.09091196. Epub 2010 Feb 16.

13.

Meeting report: Sixth Annual AACR International Conference on Frontiers in Cancer Prevention Research.

Girnun GD, Howe LR, Manne S, Mao JT, Reid ME, Szabo E.

Cancer Prev Res (Phila). 2008 Jul;1(2):146-9. doi: 10.1158/1940-6207.CAPR-08-0023.

14.

Regression of drug-resistant lung cancer by the combination of rosiglitazone and carboplatin.

Girnun GD, Chen L, Silvaggi J, Drapkin R, Chirieac LR, Padera RF, Upadhyay R, Vafai SB, Weissleder R, Mahmood U, Naseri E, Buckley S, Li D, Force J, McNamara K, Demetri G, Spiegelman BM, Wong KK.

Clin Cancer Res. 2008 Oct 15;14(20):6478-86. doi: 10.1158/1078-0432.CCR-08-1128.

15.

Synergy between PPARgamma ligands and platinum-based drugs in cancer.

Girnun GD, Naseri E, Vafai SB, Qu L, Szwaya JD, Bronson R, Alberta JA, Spiegelman BM.

Cancer Cell. 2007 May;11(5):395-406.

16.

Hic-5 regulates an epithelial program mediated by PPARgamma.

Drori S, Girnun GD, Tou L, Szwaya JD, Mueller E, Xia K, Shivdasani RA, Spiegelman BM.

Genes Dev. 2005 Feb 1;19(3):362-75. Erratum in: Genes Dev. 2005 Apr 1;19(7):875. Kia, Xia [corrected to Xia, Kai].

17.

Percutaneous tumor ablation: reduced tumor growth with combined radio-frequency ablation and liposomal doxorubicin in a rat breast tumor model.

D'Ippolito G, Ahmed M, Girnun GD, Stuart KE, Kruskal JB, Halpern EF, Goldberg SN.

Radiology. 2003 Jul;228(1):112-8. Epub 2003 Jun 13.

PMID:
12808127
18.

PPARgamma ligands: taking Ppart in chemoprevention.

Girnun GD, Spiegelman BM.

Gastroenterology. 2003 Feb;124(2):564-7. Review. No abstract available.

PMID:
12557160
19.

Identification of a functional peroxisome proliferator-activated receptor response element in the rat catalase promoter.

Girnun GD, Domann FE, Moore SA, Robbins ME.

Mol Endocrinol. 2002 Dec;16(12):2793-801.

PMID:
12456800
20.

APC-dependent suppression of colon carcinogenesis by PPARgamma.

Girnun GD, Smith WM, Drori S, Sarraf P, Mueller E, Eng C, Nambiar P, Rosenberg DW, Bronson RT, Edelmann W, Kucherlapati R, Gonzalez FJ, Spiegelman BM.

Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13771-6. Epub 2002 Oct 7.

21.

Radio-frequency ablation increases intratumoral liposomal doxorubicin accumulation in a rat breast tumor model.

Monsky WL, Kruskal JB, Lukyanov AN, Girnun GD, Ahmed M, Gazelle GS, Huertas JC, Stuart KE, Torchilin VP, Goldberg SN.

Radiology. 2002 Sep;224(3):823-9.

PMID:
12202721
22.

Role of antioxidant enzyme expression in the selective cytotoxic response of glioma cells to gamma-linolenic acid supplementation.

Preuss M, Girnun GD, Darby CJ, Khoo N, Spector AA, Robbins ME.

Free Radic Biol Med. 2000 Apr 1;28(7):1143-56.

PMID:
10832077
23.

Eicosapentaenoic acid alters manganese superoxide dismutase immunoreactive protein levels in normal but not malignant central nervous system derived cells.

Girnun GD, Oberley LW, Moore SA, Robbins ME.

Adv Exp Med Biol. 1999;469:647-53. No abstract available.

PMID:
10667394

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