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Greatwall promotes cell transformation by hyperactivating AKT in human malignancies.
Vera J, Lartigue L, Vigneron S, Gadea G, Gire V, Del Rio M, Soubeyran I, Chibon F, Lorca T, Castro A.
Elife. 2015 Nov 27;4. pii: e10115. doi: 10.7554/eLife.10115.
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The p53 isoform Δ133p53β promotes cancer stem cell potential.
Arsic N, Gadea G, Lagerqvist EL, Busson M, Cahuzac N, Brock C, Hollande F, Gire V, Pannequin J, Roux P.
Stem Cell Reports. 2015 Apr 14;4(4):531-40. doi: 10.1016/j.stemcr.2015.02.001. Epub 2015 Mar 5.
Senescence from G2 arrest, revisited.
Gire V, Dulic V.
Cell Cycle. 2015;14(3):297-304. doi: 10.1080/15384101.2014.1000134. Review.
Eroded human telomeres are more prone to remain uncapped and to trigger a G2 checkpoint response.
Jullien L, Mestre M, Roux P, Gire V.
Nucleic Acids Res. 2013 Jan;41(2):900-11. doi: 10.1093/nar/gks1121. Epub 2012 Nov 27.
Gain of oncogenic function of p53 mutants regulates E-cadherin expression uncoupled from cell invasion in colon cancer cells.
Roger L, Jullien L, Gire V, Roux P.
J Cell Sci. 2010 Apr 15;123(Pt 8):1295-305. doi: 10.1242/jcs.061002. Epub 2010 Mar 23.
[Senescence: a telomeric limit to immortality or a cellular response to physiologic stresses?].
Gire V.
Med Sci (Paris). 2005 May;21(5):491-7. Review. French.
TNFalpha induces sequential activation of Cdc42- and p38/p53-dependent pathways that antagonistically regulate filopodia formation.
Gadea G, Roger L, Anguille C, de Toledo M, Gire V, Roux P.
J Cell Sci. 2004 Dec 15;117(Pt 26):6355-64. Epub 2004 Nov 23.
Dysfunctional telomeres at senescence signal cell cycle arrest via Chk2.
Cell Cycle. 2004 Oct;3(10):1217-20. Epub 2004 Oct 13.
DNA damage checkpoint kinase Chk2 triggers replicative senescence.
Gire V, Roux P, Wynford-Thomas D, Brondello JM, Dulic V.
EMBO J. 2004 Jul 7;23(13):2554-63. Epub 2004 Jun 10.
p21-Mediated nuclear retention of cyclin B1-Cdk1 in response to genotoxic stress.
Charrier-Savournin FB, Château MT, Gire V, Sedivy J, Piette J, Dulic V.
Mol Biol Cell. 2004 Sep;15(9):3965-76. Epub 2004 Jun 4.
Permanent cell cycle exit in G2 phase after DNA damage in normal human fibroblasts.
Baus F, Gire V, Fisher D, Piette J, Dulić V.
EMBO J. 2003 Aug 1;22(15):3992-4002.
PI-3-kinase is an essential anti-apoptotic effector in the proliferative response of primary human epithelial cells to mutant RAS.
Gire V, Marshall C, Wynford-Thomas D.
Oncogene. 2000 May 4;19(19):2269-76.
RAS oncogene activation induces proliferation in normal human thyroid epithelial cells without loss of differentiation.
Gire V, Wynford-Thomas D.
Oncogene. 2000 Feb 10;19(6):737-44.
Activation of mitogen-activated protein kinase is necessary but not sufficient for proliferation of human thyroid epithelial cells induced by mutant Ras.
Gire V, Marshall CJ, Wynford-Thomas D.
Oncogene. 1999 Aug 26;18(34):4819-32.
Contrasting effects of activating mutations of GalphaS and the thyrotropin receptor on proliferation and differentiation of thyroid follicular cells.
Ludgate M, Gire V, Crisp M, Ajjan R, Weetman A, Ivan M, Wynford-Thomas D.
Oncogene. 1999 Aug 26;18(34):4798-807.
Multiple connexin expression in peripheral nerve, Schwann cells, and Schwannoma cells.
Mambetisaeva ET, Gire V, Evans WH.
J Neurosci Res. 1999 Jul 15;57(2):166-75.
Control of replicative life span in human cells: barriers to clonal expansion intermediate between M1 senescence and M2 crisis.
Bond JA, Haughton MF, Rowson JM, Smith PJ, Gire V, Wynford-Thomas D, Wyllie FS.
Mol Cell Biol. 1999 Apr;19(4):3103-14.
[Origin and progression of thyroid epithelial tumors: molecular and cellular mechanisms].
Arch Anat Cytol Pathol. 1998;46(1-2):11-8. Review. French.
Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies.
Mol Cell Biol. 1998 Mar;18(3):1611-21.
An amphotropic retroviral vector expressing a mutant gsp oncogene: effects on human thyroid cells in vitro.
Ivan M, Ludgate M, Gire V, Bond JA, Wynford-Thomas D.
J Clin Endocrinol Metab. 1997 Aug;82(8):2702-9.
Tolerance of high levels of wild-type p53 in transformed epithelial cells dependent on auto-regulation by mdm-2.
Blaydes JP, Gire V, Rowson JM, Wynford-Thomas D.
Oncogene. 1997 Apr 17;14(15):1859-68.
Calcium is transported into the lumen of pig thyroid follicles by fluid phase basolateral to apical transcytosis.
Fonlupt P, Audebet C, Gire V, Bernier-Valentin F, Rousset B.
J Cell Physiol. 1997 Apr;171(1):43-51.
Involvement of a membrane-bound form of glutamate dehydrogenase in the association of lysosomes to microtubules.
Rajas F, Gire V, Rousset B.
J Biol Chem. 1996 Nov 22;271(47):29882-90.
Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence.
Bond J, Haughton M, Blaydes J, Gire V, Wynford-Thomas D, Wyllie F.
Oncogene. 1996 Nov 21;13(10):2097-104.
Endocytosis of albumin and thyroglobulin at the basolateral membrane of thyrocytes organized in follicles.
Gire V, Kostrouch Z, Bernier-Valentin F, Rabilloud R, Munari-Silem Y, Rousset B.
Endocrinology. 1996 Feb;137(2):522-32.
Multinucleated cells can continuously generate mononucleated cells in the absence of mitosis: a study of cells of the avian osteoclast lineage.
Solari F, Domenget C, Gire V, Woods C, Lazarides E, Rousset B, Jurdic P.
J Cell Sci. 1995 Oct;108 ( Pt 10):3233-41.
Protein endocytosis by a kidney tubule suspension: metabolic requirements.
Simonnet H, Gauthier C, Gire V, Baverel G.
Biochim Biophys Acta. 1994 Jan 19;1189(2):152-62.
Dynamic analysis of drug action on in vitro reconstituted thyroid follicle by microinjection of tracer molecules and videomicroscopy.
Rousset B, Munari-Silem Y, Gire V, Fonlupt P.
Cell Biol Toxicol. 1992 Jul-Sep;8(3):1-7.
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