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Items: 1 to 50 of 161

1.

Evaluation of Operational Models of Agonism and Allosterism at Receptors with Multiple Orthosteric Binding Sites.

Gregory KJ, Giraldo J, Diao J, Christopoulos A, Leach K.

Mol Pharmacol. 2020 Jan;97(1):35-45. doi: 10.1124/mol.119.118091. Epub 2019 Nov 8.

PMID:
31704718
2.

Transplantation of PEGylated islets enhances therapeutic efficacy in a diabetic nonhuman primate model.

Stabler CL, Giraldo JA, Berman DM, Gattás-Asfura KM, Willman MA, Rabassa A, Geary J, Diaz W, Kenyon NS, Kenyon NS.

Am J Transplant. 2019 Oct 9. doi: 10.1111/ajt.15643. [Epub ahead of print]

PMID:
31597005
3.

Nanoparticle-Mediated Genetic Engineering of Plants.

Wang JW, Grandio EG, Newkirk GM, Demirer GS, Butrus S, Giraldo JP, Landry MP.

Mol Plant. 2019 Aug 5;12(8):1037-1040. doi: 10.1016/j.molp.2019.06.010. Epub 2019 Jul 5. No abstract available.

PMID:
31283997
4.

Artificial Intelligence: A Novel Approach for Drug Discovery.

Díaz Ó, Dalton JAR, Giraldo J.

Trends Pharmacol Sci. 2019 Aug;40(8):550-551. doi: 10.1016/j.tips.2019.06.005. Epub 2019 Jul 3.

PMID:
31279568
5.

Nanobiotechnology approaches for engineering smart plant sensors.

Giraldo JP, Wu H, Newkirk GM, Kruss S.

Nat Nanotechnol. 2019 Jun;14(6):541-553. doi: 10.1038/s41565-019-0470-6. Epub 2019 Jun 5. Review.

PMID:
31168083
6.

Revealing the Mechanism of Agonist-Mediated Cannabinoid Receptor 1 (CB1) Activation and Phospholipid-Mediated Allosteric Modulation.

Díaz Ó, Dalton JAR, Giraldo J.

J Med Chem. 2019 Jun 13;62(11):5638-5654. doi: 10.1021/acs.jmedchem.9b00612. Epub 2019 May 29.

PMID:
31095906
7.

Distinct Dopamine D₂ Receptor Antagonists Differentially Impact D₂ Receptor Oligomerization.

Wouters E, Marín AR, Dalton JAR, Giraldo J, Stove C.

Int J Mol Sci. 2019 Apr 4;20(7). pii: E1686. doi: 10.3390/ijms20071686.

8.

Molecular and descriptive epidemiology of intestinal protozoan parasites of children and their pets in Cauca, Colombia: a cross-sectional study.

Villamizar X, Higuera A, Herrera G, Vasquez-A LR, Buitron L, Muñoz LM, Gonzalez-C FE, Lopez MC, Giraldo JC, Ramírez JD.

BMC Infect Dis. 2019 Feb 26;19(1):190. doi: 10.1186/s12879-019-3810-0.

9.

Can Adding Constitutive Receptor Activity Redefine Biased Signaling Quantification?

Zhou B, Hall DA, Giraldo J.

Trends Pharmacol Sci. 2019 Mar;40(3):156-160. doi: 10.1016/j.tips.2019.01.002. Epub 2019 Feb 1. Review.

PMID:
30718029
10.

Frequency of anesthetic overdose with mean alveolar concentration-guided anesthesia at high altitude.

Giraldo JC, Acosta C, Giraldo-Grueso M.

Med Gas Res. 2019 Jan 9;8(4):150-153. doi: 10.4103/2045-9912.248265. eCollection 2018 Oct-Dec.

11.

Successful Management of Massive Air Embolism During Cardiopulmonary Bypass Using Multimodal Neuroprotection Strategies.

Quintero OL, Giraldo JC, Sandoval NF.

Semin Cardiothorac Vasc Anesth. 2019 Sep;23(3):324-332. doi: 10.1177/1089253218819782. Epub 2018 Dec 27.

PMID:
30589392
12.

Cerium Oxide Nanoparticles Decrease Drought-Induced Oxidative Damage in Sorghum Leading to Higher Photosynthesis and Grain Yield.

Djanaguiraman M, Nair R, Giraldo JP, Prasad PVV.

ACS Omega. 2018 Oct 31;3(10):14406-14416. doi: 10.1021/acsomega.8b01894.

13.

Polymethacrylamide and Carbon Composites that Grow, Strengthen, and Self-Repair using Ambient Carbon Dioxide Fixation.

Kwak SY, Giraldo JP, Lew TTS, Wong MH, Liu P, Yang YJ, Koman VB, McGee MK, Olsen BD, Strano MS.

Adv Mater. 2018 Nov;30(46):e1804037. doi: 10.1002/adma.201804037. Epub 2018 Oct 9.

PMID:
30368934
14.

Catalytic Scavenging of Plant Reactive Oxygen Species In Vivo by Anionic Cerium Oxide Nanoparticles.

Newkirk GM, Wu H, Santana I, Giraldo JP.

J Vis Exp. 2018 Aug 26;(138). doi: 10.3791/58373.

PMID:
30199043
15.

Synthesis toward Bivalent Ligands for the Dopamine D2 and Metabotropic Glutamate 5 Receptors.

Qian M, Wouters E, Dalton JAR, Risseeuw MDP, Crans RAJ, Stove C, Giraldo J, Van Craenenbroeck K, Van Calenbergh S.

J Med Chem. 2018 Sep 27;61(18):8212-8225. doi: 10.1021/acs.jmedchem.8b00671. Epub 2018 Sep 18.

PMID:
30180563
16.

Alice in Wonderland syndrome: a novel neurological presentation of Zika virus infection.

Paniz-Mondolfi AE, Giraldo J, Rodríguez-Morales AJ, Pacheco O, Lombó-Lucero GY, Plaza JD, Adami-Teppa FJ, Carrillo A, Hernandez-Pereira CE, Blohm GM.

J Neurovirol. 2018 Oct;24(5):660-663. doi: 10.1007/s13365-018-0645-1. Epub 2018 Aug 13.

PMID:
30105501
17.

Standoff Optical Glucose Sensing in Photosynthetic Organisms by a Quantum Dot Fluorescent Probe.

Li J, Wu H, Santana I, Fahlgren M, Giraldo JP.

ACS Appl Mater Interfaces. 2018 Aug 29;10(34):28279-28289. doi: 10.1021/acsami.8b07179. Epub 2018 Aug 14.

PMID:
30058800
18.

Using machine learning tools for protein database biocuration assistance.

König C, Shaim I, Vellido A, Romero E, Alquézar R, Giraldo J.

Sci Rep. 2018 Jul 5;8(1):10148. doi: 10.1038/s41598-018-28330-z.

19.

An operational model for GPCR homodimers and its application in the analysis of biased signaling.

Zhou B, Giraldo J.

Drug Discov Today. 2018 Sep;23(9):1591-1595. doi: 10.1016/j.drudis.2018.04.004. Epub 2018 Apr 9. Review.

PMID:
29649573
20.

Representation Learning for Class C G Protein-Coupled Receptors Classification.

Cruz-Barbosa R, Ramos-Pérez EG, Giraldo J.

Molecules. 2018 Mar 19;23(3). pii: E690. doi: 10.3390/molecules23030690.

21.

Structural insights into positive and negative allosteric regulation of a G protein-coupled receptor through protein-lipid interactions.

Bruzzese A, Gil C, Dalton JAR, Giraldo J.

Sci Rep. 2018 Mar 13;8(1):4456. doi: 10.1038/s41598-018-22735-6.

22.

A method for the quantification of biased signalling at constitutively active receptors.

Hall DA, Giraldo J.

Br J Pharmacol. 2018 Jun;175(11):2046-2062. doi: 10.1111/bph.14190. Epub 2018 Apr 25.

23.

Systematic Analysis of Primary Sequence Domain Segments for the Discrimination Between Class C GPCR Subtypes.

König C, Alquézar R, Vellido A, Giraldo J.

Interdiscip Sci. 2018 Mar;10(1):43-52. doi: 10.1007/s12539-018-0286-3. Epub 2018 Feb 19.

PMID:
29460086
24.

Relationship between the Polymeric Ionization Degree and Powder and Surface Properties in Materials Derived from Poly(maleic anhydride-alt-octadecene).

Salamanca CH, Yarce CJ, Zapata CA, Giraldo JA.

Molecules. 2018 Feb 2;23(2). pii: E320. doi: 10.3390/molecules23020320.

25.

Correction: Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator.

Font J, López-Cano M, Notartomaso S, Scarselli P, Di Prieto P, Bresolí-Obach R, Battaglia G, Malhaire F, Rovira X, Catena J, Giraldo J, Pin JP, Fernández-Dueñas V, Goudet C, Nonell S, Nicoletti F, Llebaria A, Ciruela F.

Elife. 2018 Jan 8;7. pii: e34752. doi: 10.7554/eLife.34752. No abstract available.

26.

A Survey of Physics-Based Attack Detection in Cyber-Physical Systems.

Giraldo J, Urbina D, Cardenas A, Valente J, Faisal M, Ruths J, Tippenhauer NO, Sandberg H, Candell R.

ACM Comput Surv. 2018;51. doi: 10.1145/3203245.

27.

In Vivo Delivery of Nanoparticles into Plant Leaves.

Wu H, Santana I, Dansie J, Giraldo JP.

Curr Protoc Chem Biol. 2017 Dec 14;9(4):269-284. doi: 10.1002/cpch.29.

PMID:
29241293
28.

Text mining and expert curation to develop a database on psychiatric diseases and their genes.

Gutiérrez-Sacristán A, Bravo À, Portero-Tresserra M, Valverde O, Armario A, Blanco-Gandía MC, Farré A, Fernández-Ibarrondo L, Fonseca F, Giraldo J, Leis A, Mané A, Mayer MA, Montagud-Romero S, Nadal R, Ortiz J, Pavon FJ, Perez EJ, Rodríguez-Arias M, Serrano A, Torrens M, Warnault V, Sanz F, Furlong LI.

Database (Oxford). 2017 Jan 1;2017. doi: 10.1093/database/bax043.

29.

A Nanobionic Light-Emitting Plant.

Kwak SY, Giraldo JP, Wong MH, Koman VB, Lew TTS, Ell J, Weidman MC, Sinclair RM, Landry MP, Tisdale WA, Strano MS.

Nano Lett. 2017 Dec 13;17(12):7951-7961. doi: 10.1021/acs.nanolett.7b04369. Epub 2017 Dec 1.

30.

Ocular flutter following Zika virus infection.

Karam E, Giraldo J, Rodriguez F, Hernandez-Pereira CE, Rodriguez-Morales AJ, Blohm GM, Paniz-Mondolfi AE.

J Neurovirol. 2017 Dec;23(6):932-934. doi: 10.1007/s13365-017-0585-1. Epub 2017 Nov 16.

PMID:
29147884
31.

A Complementary Scale of Biased Agonism for Agonists with Differing Maximal Responses.

Burgueño J, Pujol M, Monroy X, Roche D, Varela MJ, Merlos M, Giraldo J.

Sci Rep. 2017 Nov 13;7(1):15389. doi: 10.1038/s41598-017-15258-z.

32.

Persistent drought monitoring using a microfluidic-printed electro-mechanical sensor of stomata in planta.

Koman VB, Lew TTS, Wong MH, Kwak SY, Giraldo JP, Strano MS.

Lab Chip. 2017 Nov 21;17(23):4015-4024. doi: 10.1039/c7lc00930e.

PMID:
29116279
33.

Iso-Kikuchi Syndrome: Report of 3 Pediatric Cases.

Tirelli LL, Luna PC, Cano R, Giraldo JP, Larralde M.

Actas Dermosifiliogr. 2018 Jun;109(5):e33-e36. doi: 10.1016/j.ad.2017.06.014. Epub 2017 Nov 1. English, Spanish.

PMID:
29102318
34.

Anionic Cerium Oxide Nanoparticles Protect Plant Photosynthesis from Abiotic Stress by Scavenging Reactive Oxygen Species.

Wu H, Tito N, Giraldo JP.

ACS Nano. 2017 Nov 28;11(11):11283-11297. doi: 10.1021/acsnano.7b05723. Epub 2017 Nov 10.

PMID:
29099581
35.

Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer.

Liu J, Zhang Z, Moreno-Delgado D, Dalton JA, Rovira X, Trapero A, Goudet C, Llebaria A, Giraldo J, Yuan Q, Rondard P, Huang S, Liu J, Pin JP.

Elife. 2017 Aug 10;6. pii: e26985. doi: 10.7554/eLife.26985.

36.

Enhanced Mortality to Metastatic Bladder Cancer Cell Line MB49 in Vasoactive Intestinal Peptide Gene Knockout Mice.

Mirsaidi N, Burns MP, McClain SA, Forsyth E, Li J, Dukes B, Lin D, Nahvi R, Giraldo J, Patton M, Wang P, Lin K, Miller E, Ratliff T, Hamidi S, Crist S, Takemaru KI, Szema A.

Front Endocrinol (Lausanne). 2017 Aug 7;8:162. doi: 10.3389/fendo.2017.00162. eCollection 2017.

37.

Quantifying the allosteric interactions within a G-protein-coupled receptor heterodimer.

Zhou B, Giraldo J.

Drug Discov Today. 2018 Jan;23(1):7-11. doi: 10.1016/j.drudis.2017.07.009. Epub 2017 Jul 27.

PMID:
28756203
38.

Analysis of positive and negative allosteric modulation in metabotropic glutamate receptors 4 and 5 with a dual ligand.

Dalton JAR, Pin JP, Giraldo J.

Sci Rep. 2017 Jul 10;7(1):4944. doi: 10.1038/s41598-017-05095-5.

39.

Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells.

Moreno Delgado D, Møller TC, Ster J, Giraldo J, Maurel D, Rovira X, Scholler P, Zwier JM, Perroy J, Durroux T, Trinquet E, Prezeau L, Rondard P, Pin JP.

Elife. 2017 Jun 29;6. pii: e25233. doi: 10.7554/eLife.25233.

40.

Angiotensin II type 1/adenosine A 2A receptor oligomers: a novel target for tardive dyskinesia.

Oliveira PA, Dalton JAR, López-Cano M, Ricarte A, Morató X, Matheus FC, Cunha AS, Müller CE, Takahashi RN, Fernández-Dueñas V, Giraldo J, Prediger RD, Ciruela F.

Sci Rep. 2017 May 12;7(1):1857. doi: 10.1038/s41598-017-02037-z.

41.

Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator.

Font J, López-Cano M, Notartomaso S, Scarselli P, Di Pietro P, Bresolí-Obach R, Battaglia G, Malhaire F, Rovira X, Catena J, Giraldo J, Pin JP, Fernández-Dueñas V, Goudet C, Nonell S, Nicoletti F, Llebaria A, Ciruela F.

Elife. 2017 Apr 11;6. pii: e23545. doi: 10.7554/eLife.23545. Erratum in: Elife. 2018 Jan 08;7:.

42.

Blastocystis subtyping and its association with intestinal parasites in children from different geographical regions of Colombia.

Ramírez JD, Flórez C, Olivera M, Bernal MC, Giraldo JC.

PLoS One. 2017 Feb 21;12(2):e0172586. doi: 10.1371/journal.pone.0172586. eCollection 2017.

43.

Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals.

Gómez-Santacana X, Pittolo S, Rovira X, Lopez M, Zussy C, Dalton JA, Faucherre A, Jopling C, Pin JP, Ciruela F, Goudet C, Giraldo J, Gorostiza P, Llebaria A.

ACS Cent Sci. 2017 Jan 25;3(1):81-91. doi: 10.1021/acscentsci.6b00353. Epub 2016 Dec 19.

44.

Positional isomers of bispyridine benzene derivatives induce efficacy changes on mGlu5 negative allosteric modulation.

Gómez-Santacana X, Dalton JAR, Rovira X, Pin JP, Goudet C, Gorostiza P, Giraldo J, Llebaria A.

Eur J Med Chem. 2017 Feb 15;127:567-576. doi: 10.1016/j.ejmech.2017.01.013. Epub 2017 Jan 12.

PMID:
28109949
45.

Dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4.

Zussy C, Gómez-Santacana X, Rovira X, De Bundel D, Ferrazzo S, Bosch D, Asede D, Malhaire F, Acher F, Giraldo J, Valjent E, Ehrlich I, Ferraguti F, Pin JP, Llebaria A, Goudet C.

Mol Psychiatry. 2018 Mar;23(3):509-520. doi: 10.1038/mp.2016.223. Epub 2016 Dec 20.

PMID:
27994221
46.

The impact of cell surface PEGylation and short-course immunotherapy on islet graft survival in an allogeneic murine model.

Giraldo JA, Molano RD, Rengifo HR, Fotino C, Gattás-Asfura KM, Pileggi A, Stabler CL.

Acta Biomater. 2017 Feb;49:272-283. doi: 10.1016/j.actbio.2016.11.060. Epub 2016 Nov 30.

47.

Nitroaromatic detection and infrared communication from wild-type plants using plant nanobionics.

Wong MH, Giraldo JP, Kwak SY, Koman VB, Sinclair R, Lew TT, Bisker G, Liu P, Strano MS.

Nat Mater. 2017 Feb;16(2):264-272. doi: 10.1038/nmat4771. Epub 2016 Oct 31.

PMID:
27798623
48.

Persistence of Breakage in Specific Chromosome Bands 6 Years after Acute Exposure to Oil.

Francés A, Hildur K, Barberà JA, Rodríguez-Trigo G, Zock JP, Giraldo J, Monyarch G, Rodriguez-Rodriguez E, de Castro Reis F, Souto A, Gómez FP, Pozo-Rodríguez F, Templado C, Fuster C.

PLoS One. 2016 Aug 1;11(8):e0159404. doi: 10.1371/journal.pone.0159404. eCollection 2016.

49.

OptoGluNAM4.1, a Photoswitchable Allosteric Antagonist for Real-Time Control of mGlu4 Receptor Activity.

Rovira X, Trapero A, Pittolo S, Zussy C, Faucherre A, Jopling C, Giraldo J, Pin JP, Gorostiza P, Goudet C, Llebaria A.

Cell Chem Biol. 2016 Aug 18;23(8):929-34. doi: 10.1016/j.chembiol.2016.06.013. Epub 2016 Jul 28.

50.

Have many estimates of efficacy and affinity been misled? Revisiting the operational model of agonism.

Roche D, van der Graaf PH, Giraldo J.

Drug Discov Today. 2016 Nov;21(11):1735-1739. doi: 10.1016/j.drudis.2016.06.019. Epub 2016 Jun 24.

PMID:
27349169

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