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Items: 1 to 50 of 174

1.

The Fine Tuning of Drp1-Dependent Mitochondrial Remodeling and Autophagy Controls Neuronal Differentiation.

Vantaggiato C, Castelli M, Giovarelli M, Orso G, Bassi MT, Clementi E, De Palma C.

Front Cell Neurosci. 2019 Apr 4;13:120. doi: 10.3389/fncel.2019.00120. eCollection 2019.

2.

The Suv420h histone methyltransferases regulate PPAR-γ and energy expenditure in response to environmental stimuli.

Pedrotti S, Caccia R, Neguembor MV, Garcia-Manteiga JM, Ferri G, de Palma C, Canu T, Giovarelli M, Marra P, Fiocchi A, Molineris I, Raso M, Sanvito F, Doglioni C, Esposito A, Clementi E, Gabellini D.

Sci Adv. 2019 Apr 17;5(4):eaav1472. doi: 10.1126/sciadv.aav1472. eCollection 2019 Apr.

3.

Dysfunctional autophagy induced by the pro-apoptotic natural compound climacostol in tumour cells.

Zecchini S, Proietti Serafini F, Catalani E, Giovarelli M, Coazzoli M, Di Renzo I, De Palma C, Perrotta C, Clementi E, Buonanno F, Ortenzi C, Marcantoni E, Taddei AR, Picchietti S, Fausto AM, Cervia D.

Cell Death Dis. 2018 Dec 19;10(1):10. doi: 10.1038/s41419-018-1254-x.

4.

Phage-Based Anti-HER2 Vaccination Can Circumvent Immune Tolerance against Breast Cancer.

Bartolacci C, Andreani C, Curcio C, Occhipinti S, Massaccesi L, Giovarelli M, Galeazzi R, Iezzi M, Tilio M, Gambini V, Wang J, Marchini C, Amici A.

Cancer Immunol Res. 2018 Dec;6(12):1486-1498. doi: 10.1158/2326-6066.CIR-18-0179. Epub 2018 Oct 16. Erratum in: Cancer Immunol Res. 2019 Mar;7(3):526.

PMID:
30327365
5.

Autophagy controls neonatal myogenesis by regulating the GH-IGF1 system through a NFE2L2- and DDIT3-mediated mechanism.

Zecchini S, Giovarelli M, Perrotta C, Morisi F, Touvier T, Di Renzo I, Moscheni C, Bassi MT, Cervia D, Sandri M, Clementi E, De Palma C.

Autophagy. 2019 Jan;15(1):58-77. doi: 10.1080/15548627.2018.1507439. Epub 2018 Sep 10.

PMID:
30081710
6.

Nitric Oxide Generated by Tumor-Associated Macrophages Is Responsible for Cancer Resistance to Cisplatin and Correlated With Syntaxin 4 and Acid Sphingomyelinase Inhibition.

Perrotta C, Cervia D, Di Renzo I, Moscheni C, Bassi MT, Campana L, Martelli C, Catalani E, Giovarelli M, Zecchini S, Coazzoli M, Capobianco A, Ottobrini L, Lucignani G, Rosa P, Rovere-Querini P, De Palma C, Clementi E.

Front Immunol. 2018 May 29;9:1186. doi: 10.3389/fimmu.2018.01186. eCollection 2018.

7.

Regulation of Human Macrophage M1-M2 Polarization Balance by Hypoxia and the Triggering Receptor Expressed on Myeloid Cells-1.

Raggi F, Pelassa S, Pierobon D, Penco F, Gattorno M, Novelli F, Eva A, Varesio L, Giovarelli M, Bosco MC.

Front Immunol. 2017 Sep 7;8:1097. doi: 10.3389/fimmu.2017.01097. eCollection 2017.

8.

Enhanced cytotoxic effect of camptothecin nanosponges in anaplastic thyroid cancer cells in vitro and in vivo on orthotopic xenograft tumors.

Gigliotti CL, Ferrara B, Occhipinti S, Boggio E, Barrera G, Pizzimenti S, Giovarelli M, Fantozzi R, Chiocchetti A, Argenziano M, Clemente N, Trotta F, Marchiò C, Annaratone L, Boldorini R, Dianzani U, Cavalli R, Dianzani C.

Drug Deliv. 2017 Nov;24(1):670-680. doi: 10.1080/10717544.2017.1303856.

9.

Reversal of Defective Mitochondrial Biogenesis in Limb-Girdle Muscular Dystrophy 2D by Independent Modulation of Histone and PGC-1α Acetylation.

Pambianco S, Giovarelli M, Perrotta C, Zecchini S, Cervia D, Di Renzo I, Moscheni C, Ripolone M, Violano R, Moggio M, Bassi MT, Puri PL, Latella L, Clementi E, De Palma C.

Cell Rep. 2016 Dec 13;17(11):3010-3023. doi: 10.1016/j.celrep.2016.11.044.

10.

Anti-α-enolase antibody limits the invasion of myeloid-derived suppressor cells and attenuates their restraining effector T cell response.

Cappello P, Tonoli E, Curto R, Giordano D, Giovarelli M, Novelli F.

Oncoimmunology. 2015 Dec 21;5(5):e1112940. doi: 10.1080/2162402X.2015.1112940. eCollection 2016 May.

11.

miRNA-Mediated KHSRP Silencing Rewires Distinct Post-transcriptional Programs during TGF-β-Induced Epithelial-to-Mesenchymal Transition.

Puppo M, Bucci G, Rossi M, Giovarelli M, Bordo D, Moshiri A, Gorlero F, Gherzi R, Briata P.

Cell Rep. 2016 Jul 26;16(4):967-978. doi: 10.1016/j.celrep.2016.06.055. Epub 2016 Jul 7.

12.

In Vitro and In Vivo Therapeutic Evaluation of Camptothecin-Encapsulated β-Cyclodextrin Nanosponges in Prostate Cancer.

Gigliotti CL, Minelli R, Cavalli R, Occhipinti S, Barrera G, Pizzimenti S, Cappellano G, Boggio E, Conti L, Fantozzi R, Giovarelli M, Trotta F, Dianzani U, Dianzani C.

J Biomed Nanotechnol. 2016 Jan;12(1):114-27.

PMID:
27301177
13.

Essential role for acid sphingomyelinase-inhibited autophagy in melanoma response to cisplatin.

Cervia D, Assi E, De Palma C, Giovarelli M, Bizzozero L, Pambianco S, Di Renzo I, Zecchini S, Moscheni C, Vantaggiato C, Procacci P, Clementi E, Perrotta C.

Oncotarget. 2016 May 3;7(18):24995-5009. doi: 10.18632/oncotarget.8735.

14.

Regulation of Langerhans cell functions in a hypoxic environment.

Pierobon D, Raggi F, Cambieri I, Pelassa S, Occhipinti S, Cappello P, Novelli F, Musso T, Eva A, Castagnoli C, Varesio L, Giovarelli M, Bosco MC.

J Mol Med (Berl). 2016 Aug;94(8):943-55. doi: 10.1007/s00109-016-1400-9. Epub 2016 Mar 10.

15.

Human mesenchymal stem cells and derived extracellular vesicles induce regulatory dendritic cells in type 1 diabetic patients.

Favaro E, Carpanetto A, Caorsi C, Giovarelli M, Angelini C, Cavallo-Perin P, Tetta C, Camussi G, Zanone MM.

Diabetologia. 2016 Feb;59(2):325-33. doi: 10.1007/s00125-015-3808-0. Epub 2015 Nov 23.

PMID:
26592240
16.

H19 long noncoding RNA controls the mRNA decay promoting function of KSRP.

Giovarelli M, Bucci G, Ramos A, Bordo D, Wilusz CJ, Chen CY, Puppo M, Briata P, Gherzi R.

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):E5023-8. doi: 10.1073/pnas.1415098111. Epub 2014 Nov 10.

17.

Class II transactivator-induced MHC class II expression in pancreatic cancer cells leads to tumor rejection and a specific antitumor memory response.

Ekkirala CR, Cappello P, Accolla RS, Giovarelli M, Romero I, Garrido C, Garcia-Lora AM, Novelli F.

Pancreas. 2014 Oct;43(7):1066-72. doi: 10.1097/MPA.0000000000000160.

18.

Destabilization of nucleophosmin mRNA by the HuR/KSRP complex is required for muscle fibre formation.

Cammas A, Sanchez BJ, Lian XJ, Dormoy-Raclet V, van der Giessen K, López de Silanes I, Ma J, Wilusz C, Richardson J, Gorospe M, Millevoi S, Giovarelli M, Gherzi R, Di Marco S, Gallouzi IE.

Nat Commun. 2014 Jun 27;5:4190. doi: 10.1038/ncomms5190.

19.

Human mesenchymal stem cell-derived microvesicles modulate T cell response to islet antigen glutamic acid decarboxylase in patients with type 1 diabetes.

Favaro E, Carpanetto A, Lamorte S, Fusco A, Caorsi C, Deregibus MC, Bruno S, Amoroso A, Giovarelli M, Porta M, Perin PC, Tetta C, Camussi G, Zanone MM.

Diabetologia. 2014 Aug;57(8):1664-73. doi: 10.1007/s00125-014-3262-4. Epub 2014 May 17.

20.

KSRP and MicroRNA 145 are negative regulators of lipolysis in white adipose tissue.

Lin YY, Chou CF, Giovarelli M, Briata P, Gherzi R, Chen CY.

Mol Cell Biol. 2014 Jun;34(12):2339-49. doi: 10.1128/MCB.00042-14. Epub 2014 Apr 14.

21.

B7h triggering inhibits the migration of tumor cell lines.

Dianzani C, Minelli R, Gigliotti CL, Occhipinti S, Giovarelli M, Conti L, Boggio E, Shivakumar Y, Baldanzi G, Malacarne V, Orilieri E, Cappellano G, Fantozzi R, Sblattero D, Yagi J, Rojo JM, Chiocchetti A, Dianzani U.

J Immunol. 2014 May 15;192(10):4921-31. doi: 10.4049/jimmunol.1300587. Epub 2014 Apr 11.

22.

KSRP ablation enhances brown fat gene program in white adipose tissue through reduced miR-150 expression.

Chou CF, Lin YY, Wang HK, Zhu X, Giovarelli M, Briata P, Gherzi R, Garvey WT, Chen CY.

Diabetes. 2014 Sep;63(9):2949-61. doi: 10.2337/db13-1901. Epub 2014 Apr 10.

23.

Chimeric rat/human HER2 efficiently circumvents HER2 tolerance in cancer patients.

Occhipinti S, Sponton L, Rolla S, Caorsi C, Novarino A, Donadio M, Bustreo S, Satolli MA, Pecchioni C, Marchini C, Amici A, Cavallo F, Cappello P, Pierobon D, Novelli F, Giovarelli M.

Clin Cancer Res. 2014 Jun 1;20(11):2910-21. doi: 10.1158/1078-0432.CCR-13-2663. Epub 2014 Mar 25.

24.

Autoantibodies to Ezrin are an early sign of pancreatic cancer in humans and in genetically engineered mouse models.

Capello M, Cappello P, Linty FC, Chiarle R, Sperduti I, Novarino A, Salacone P, Mandili G, Naccarati A, Sacerdote C, Beghelli S, Bersani S, Barbi S, Bassi C, Scarpa A, Nisticò P, Giovarelli M, Vineis P, Milella M, Novelli F.

J Hematol Oncol. 2013 Sep 6;6:67. doi: 10.1186/1756-8722-6-67.

25.

Solid lipid nanoparticles of cholesteryl butyrate inhibit the proliferation of cancer cells in vitro and in vivo models.

Minelli R, Occhipinti S, Gigliotti CL, Barrera G, Gasco P, Conti L, Chiocchetti A, Zara GP, Fantozzi R, Giovarelli M, Dianzani U, Dianzani C.

Br J Pharmacol. 2013 Sep;170(2):233-44. doi: 10.1111/bph.12255.

26.

Pro-inflammatory profile of preeclamptic placental mesenchymal stromal cells: new insights into the etiopathogenesis of preeclampsia.

Rolfo A, Giuffrida D, Nuzzo AM, Pierobon D, Cardaropoli S, Piccoli E, Giovarelli M, Todros T.

PLoS One. 2013;8(3):e59403. doi: 10.1371/journal.pone.0059403. Epub 2013 Mar 19.

27.

KSRP silencing favors neural differentiation of P19 teratocarcinoma cells.

Giovarelli M, Bucci G, Pasero M, Gherzi R, Briata P.

Biochim Biophys Acta. 2013 May;1829(5):469-79. doi: 10.1016/j.bbagrm.2013.02.008. Epub 2013 Feb 24.

PMID:
23462617
28.

Chronic hypoxia reprograms human immature dendritic cells by inducing a proinflammatory phenotype and TREM-1 expression.

Pierobon D, Bosco MC, Blengio F, Raggi F, Eva A, Filippi M, Musso T, Novelli F, Cappello P, Varesio L, Giovarelli M.

Eur J Immunol. 2013 Apr;43(4):949-66. doi: 10.1002/eji.201242709. Epub 2013 Mar 6.

29.

Vaccination with ENO1 DNA prolongs survival of genetically engineered mice with pancreatic cancer.

Cappello P, Rolla S, Chiarle R, Principe M, Cavallo F, Perconti G, Feo S, Giovarelli M, Novelli F.

Gastroenterology. 2013 May;144(5):1098-106. doi: 10.1053/j.gastro.2013.01.020. Epub 2013 Jan 16.

30.

Triggering of B7h by the ICOS modulates maturation and migration of monocyte-derived dendritic cells.

Occhipinti S, Dianzani C, Chiocchetti A, Boggio E, Clemente N, Gigliotti CL, Soluri MF, Minelli R, Fantozzi R, Yagi J, Rojo JM, Sblattero D, Giovarelli M, Dianzani U.

J Immunol. 2013 Feb 1;190(3):1125-34. doi: 10.4049/jimmunol.1201816. Epub 2012 Dec 28.

31.

Bone morphogenetic protein/SMAD signaling orients cell fate decision by impairing KSRP-dependent microRNA maturation.

Pasero M, Giovarelli M, Bucci G, Gherzi R, Briata P.

Cell Rep. 2012 Nov 29;2(5):1159-68. doi: 10.1016/j.celrep.2012.10.020. Epub 2012 Nov 21.

32.

The hypoxic environment reprograms the cytokine/chemokine expression profile of human mature dendritic cells.

Blengio F, Raggi F, Pierobon D, Cappello P, Eva A, Giovarelli M, Varesio L, Bosco MC.

Immunobiology. 2013 Jan;218(1):76-89. doi: 10.1016/j.imbio.2012.02.002. Epub 2012 Feb 10.

PMID:
22465745
33.

PI3K/AKT signaling determines a dynamic switch between distinct KSRP functions favoring skeletal myogenesis.

Briata P, Lin WJ, Giovarelli M, Pasero M, Chou CF, Trabucchi M, Rosenfeld MG, Chen CY, Gherzi R.

Cell Death Differ. 2012 Mar;19(3):478-87. doi: 10.1038/cdd.2011.117. Epub 2011 Sep 2.

34.

KSRP, many functions for a single protein.

Briata P, Chen CY, Giovarelli M, Pasero M, Trabucchi M, Ramos A, Gherzi R.

Front Biosci (Landmark Ed). 2011 Jan 1;16:1787-96. Review.

PMID:
21196264
35.

Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo.

Bosco MC, Pierobon D, Blengio F, Raggi F, Vanni C, Gattorno M, Eva A, Novelli F, Cappello P, Giovarelli M, Varesio L.

Blood. 2011 Mar 3;117(9):2625-39. doi: 10.1182/blood-2010-06-292136. Epub 2010 Dec 10.

36.

Expression of IFNγR2 mutated in a dileucine internalization motif reinstates IFNγ signaling and apoptosis in human T lymphocytes.

Boselli D, Ragimbeau J, Orlando L, Cappello P, Capello M, Ambrogio C, Chiarle R, Marsili G, Battistini A, Giovarelli M, Pellegrini S, Novelli F.

Immunol Lett. 2010 Nov 30;134(1):17-25. doi: 10.1016/j.imlet.2010.08.005. Epub 2010 Aug 13.

PMID:
20709103
37.

The proapoptotic activity of the Interferon-inducible gene IFI16 provides new insights into its etiopathogenetic role in autoimmunity.

Gugliesi F, De Andrea M, Mondini M, Cappello P, Giovarelli M, Shoenfeld Y, Meroni P, Gariglio M, Landolfo S.

J Autoimmun. 2010 Sep;35(2):114-23. doi: 10.1016/j.jaut.2010.04.001. Epub 2010 May 21.

38.

The interferon-inducible gene IFI16 secretome of endothelial cells drives the early steps of the inflammatory response.

Baggetta R, De Andrea M, Gariano GR, Mondini M, Rittà M, Caposio P, Cappello P, Giovarelli M, Gariglio M, Landolfo S.

Eur J Immunol. 2010 Aug;40(8):2182-9. doi: 10.1002/eji.200939995.

39.

Human mesenchymal stem cells modulate cellular immune response to islet antigen glutamic acid decarboxylase in type 1 diabetes.

Zanone MM, Favaro E, Miceli I, Grassi G, Camussi E, Caorsi C, Amoroso A, Giovarelli M, Perin PC, Camussi G.

J Clin Endocrinol Metab. 2010 Aug;95(8):3788-97. doi: 10.1210/jc.2009-2350. Epub 2010 May 13.

PMID:
20466784
40.

Circulating autoantibodies to phosphorylated α-enolase are a hallmark of pancreatic cancer.

Tomaino B, Cappello P, Capello M, Fredolini C, Sperduti I, Migliorini P, Salacone P, Novarino A, Giacobino A, Ciuffreda L, Alessio M, Nisticò P, Scarpa A, Pederzoli P, Zhou W, Petricoin Iii EF, Liotta LA, Giovarelli M, Milella M, Novelli F.

J Proteome Res. 2011 Jan 7;10(1):105-12. doi: 10.1021/pr100213b. Epub 2010 Jun 10.

41.

Survival and migration of human dendritic cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway.

Scutera S, Fraone T, Musso T, Cappello P, Rossi S, Pierobon D, Orinska Z, Paus R, Bulfone-Paus S, Giovarelli M.

J Immunol. 2009 Sep 1;183(5):3004-13. doi: 10.4049/jimmunol.0804384. Epub 2009 Aug 5.

42.

IL-6, but not IFN-gamma, triggers apoptosis and inhibits in vivo growth of human malignant T cells on STAT3 silencing.

Regis G, Icardi L, Conti L, Chiarle R, Piva R, Giovarelli M, Poli V, Novelli F.

Leukemia. 2009 Nov;23(11):2102-8. doi: 10.1038/leu.2009.139. Epub 2009 Jul 23.

PMID:
19626047
43.

An integrated humoral and cellular response is elicited in pancreatic cancer by alpha-enolase, a novel pancreatic ductal adenocarcinoma-associated antigen.

Cappello P, Tomaino B, Chiarle R, Ceruti P, Novarino A, Castagnoli C, Migliorini P, Perconti G, Giallongo A, Milella M, Monsurrò V, Barbi S, Scarpa A, Nisticò P, Giovarelli M, Novelli F.

Int J Cancer. 2009 Aug 1;125(3):639-48. doi: 10.1002/ijc.24355.

44.

CCL16 enhances the CD8+ and CD4+ T cell reactivity to human HER-2 elicited by dendritic cells loaded with rat ortholog HER-2.

Caorsi C, Cappello P, Ceruti P, Amici A, Marchini C, Novelli F, Forni G, Giovarelli M.

Int J Immunopathol Pharmacol. 2008 Oct-Dec;21(4):867-77.

PMID:
19144272
45.

Monocytes and dendritic cells in a hypoxic environment: Spotlights on chemotaxis and migration.

Bosco MC, Puppo M, Blengio F, Fraone T, Cappello P, Giovarelli M, Varesio L.

Immunobiology. 2008;213(9-10):733-49. doi: 10.1016/j.imbio.2008.07.031. Epub 2008 Sep 21. Review.

PMID:
18926289
46.

Activin A induces Langerhans cell differentiation in vitro and in human skin explants.

Musso T, Scutera S, Vermi W, Daniele R, Fornaro M, Castagnoli C, Alotto D, Ravanini M, Cambieri I, Salogni L, Elia AR, Giovarelli M, Facchetti F, Girolomoni G, Sozzani S.

PLoS One. 2008 Sep 24;3(9):e3271. doi: 10.1371/journal.pone.0003271.

47.

Human dendritic cells differentiated in hypoxia down-modulate antigen uptake and change their chemokine expression profile.

Elia AR, Cappello P, Puppo M, Fraone T, Vanni C, Eva A, Musso T, Novelli F, Varesio L, Giovarelli M.

J Leukoc Biol. 2008 Dec;84(6):1472-82. doi: 10.1189/jlb.0208082. Epub 2008 Aug 25.

PMID:
18725395
48.

Lack of plasma protein hemopexin dampens mercury-induced autoimmune response in mice.

Fagoonee S, Caorsi C, Giovarelli M, Stoltenberg M, Silengo L, Altruda F, Camussi G, Tolosano E, Bussolati B.

J Immunol. 2008 Aug 1;181(3):1937-47.

49.

Lactoferrin, a major defense protein of innate immunity, is a novel maturation factor for human dendritic cells.

Spadaro M, Caorsi C, Ceruti P, Varadhachary A, Forni G, Pericle F, Giovarelli M.

FASEB J. 2008 Aug;22(8):2747-57. doi: 10.1096/fj.07-098038. Epub 2008 Mar 25.

PMID:
18364398
50.

Transcriptome of hypoxic immature dendritic cells: modulation of chemokine/receptor expression.

Ricciardi A, Elia AR, Cappello P, Puppo M, Vanni C, Fardin P, Eva A, Munroe D, Wu X, Giovarelli M, Varesio L.

Mol Cancer Res. 2008 Feb;6(2):175-85. doi: 10.1158/1541-7786.MCR-07-0391.

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