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Structural Prediction of the Dimeric Form of the Mammalian Translocator Membrane Protein TSPO: A Key Target for Brain Diagnostics.

Zeng J, Guareschi R, Damre M, Cao R, Kless A, Neumaier B, Bauer A, Giorgetti A, Carloni P, Rossetti G.

Int J Mol Sci. 2018 Aug 31;19(9). pii: E2588. doi: 10.3390/ijms19092588.


Spatial Inhomogeneity of Cardiac Norepinephrine Transport Protein and Meta-[123I]Iodobenzylguanidine Uptake in Swine Myocardial Tissue.

Kusmic C, Giorgetti A, Barsanti C, Burchielli S, Petroni D, Kusch A, Genovesi D, Menichetti L, Marzullo P.

Mol Imaging Biol. 2018 Sep 5. doi: 10.1007/s11307-018-1269-9. [Epub ahead of print]


Cardiac amyloidosis: The starched heart.

Giorgetti A, Genovesi D, Emdin M.

J Nucl Cardiol. 2018 Aug 17. doi: 10.1007/s12350-018-1399-0. [Epub ahead of print] No abstract available.


Direct Parametric Maps Estimation from Dynamic PET Data: An Iterated Conditional Modes Approach.

Scipioni M, Giorgetti A, Della Latta D, Fucci S, Positano V, Landini L, Santarelli MF.

J Healthc Eng. 2018 Jul 8;2018:5942873. doi: 10.1155/2018/5942873. eCollection 2018.


Allosteric sodium binding cavity in GPR3: a novel player in modulation of Aβ production.

Capaldi S, Suku E, Antolini M, Di Giacobbe M, Giorgetti A, Buffelli M.

Sci Rep. 2018 Jul 23;8(1):11102. doi: 10.1038/s41598-018-29475-7.


Hoof Quality of Anglo-Arabian and Haflinger Horses.

Tocci R, Sargentini C, Martini A, Andrenelli L, Pezzati A, Benvenuti D, Giorgetti A.

J Vet Res. 2017 Sep 19;61(3):367-373. doi: 10.1515/jvetres-2017-0049. eCollection 2017 Sep.


Accelerated PET kinetic maps estimation by analytic fitting method.

Scipioni M, Giorgetti A, Della Latta D, Fucci S, Positano V, Landini L, Santarelli MF.

Comput Biol Med. 2018 Aug 1;99:221-235. doi: 10.1016/j.compbiomed.2018.06.015. Epub 2018 Jun 20.


MIRATE: MIps RATional dEsign Science Gateway.

Busato M, Distefano R, Bates F, Karim K, Bossi AM, López Vilariño JM, Piletsky S, Bombieri N, Giorgetti A.

J Integr Bioinform. 2018 Jun 13. pii: /j/jib.ahead-of-print/jib-2017-0075/jib-2017-0075.xml. doi: 10.1515/jib-2017-0075. [Epub ahead of print]


Orthosteric and benzodiazepine cavities of the α1β2γ2 GABAA receptor: insights from experimentally validated in silico methods.

Amundarain MJ, Viso JF, Zamarreño F, Giorgetti A, Costabel M.

J Biomol Struct Dyn. 2018 May 4:1-19. doi: 10.1080/07391102.2018.1462733. [Epub ahead of print]


Predicting ligand binding poses for low-resolution membrane protein models: Perspectives from multiscale simulations.

Schneider J, Korshunova K, Musiani F, Alfonso-Prieto M, Giorgetti A, Carloni P.

Biochem Biophys Res Commun. 2018 Mar 29;498(2):366-374. doi: 10.1016/j.bbrc.2018.01.160. Epub 2018 Feb 2.


Effects of GHB on psychomotor and driving performance.

Centola C, Giorgetti A, Zaami S, Giorgetti R.

Curr Drug Metab. 2018 Jan 23. doi: 10.2174/1389200219666180124113802. [Epub ahead of print]


Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine.

Ariani P, Vandelle E, Wong D, Giorgetti A, Porceddu A, Camiolo S, Polverari A.

J Vis Exp. 2017 Dec 22;(130). doi: 10.3791/56626.


Preemptive and Postoperative Medication Protocols for Root Coverage Combined with Connective Tissue Graft.

Giorgetti APO, Matos R, Casarin RCV, Pimentel SP, Cirano FR, Ribeiro FV.

Braz Dent J. 2018 Jan-Feb;29(1):23-29. doi: 10.1590/0103-6440201801452.


Open Boundary Simulations of Proteins and Their Hydration Shells by Hamiltonian Adaptive Resolution Scheme.

Tarenzi T, Calandrini V, Potestio R, Giorgetti A, Carloni P.

J Chem Theory Comput. 2017 Nov 14;13(11):5647-5657. doi: 10.1021/acs.jctc.7b00508. Epub 2017 Oct 27.


Agonist Binding to Chemosensory Receptors: A Systematic Bioinformatics Analysis.

Fierro F, Suku E, Alfonso-Prieto M, Giorgetti A, Cichon S, Carloni P.

Front Mol Biosci. 2017 Sep 6;4:63. doi: 10.3389/fmolb.2017.00063. eCollection 2017.


All muscarinic acetylcholine receptors (M1-M5) are expressed in murine brain microvascular endothelium.

Radu BM, Osculati AMM, Suku E, Banciu A, Tsenov G, Merigo F, Di Chio M, Banciu DD, Tognoli C, Kacer P, Giorgetti A, Radu M, Bertini G, Fabene PF.

Sci Rep. 2017 Jul 11;7(1):5083. doi: 10.1038/s41598-017-05384-z.


Fentanyl novel derivative-related deaths.

Giorgetti A, Centola C, Giorgetti R.

Hum Psychopharmacol. 2017 May;32(3). doi: 10.1002/hup.2605. Epub 2017 Jun 21. Review.


Accuracy of 99mTc-Hydroxymethylene diphosphonate scintigraphy for diagnosis of transthyretin cardiac amyloidosis.

Cappelli F, Gallini C, Di Mario C, Costanzo EN, Vaggelli L, Tutino F, Ciaccio A, Bartolini S, Angelotti P, Frusconi S, Farsetti S, Vergaro G, Giorgetti A, Marzullo P, Genovesi D, Emdin M, Perfetto F.

J Nucl Cardiol. 2017 May 23. doi: 10.1007/s12350-017-0922-z. [Epub ahead of print]


Microproteome of dentoalveolar tissues.

Salmon CR, Giorgetti APO, Paes Leme AF, Domingues RR, Kolli TN, Foster BL, Nociti FH Jr.

Bone. 2017 Aug;101:219-229. doi: 10.1016/j.bone.2017.05.014. Epub 2017 May 17.


Genetic Rescue of Mitochondrial and Skeletal Muscle Impairment in an Induced Pluripotent Stem Cells Model of Coenzyme Q10 Deficiency.

Romero-Moya D, Santos-Ocaña C, Castaño J, Garrabou G, Rodríguez-Gómez JA, Ruiz-Bonilla V, Bueno C, González-Rodríguez P, Giorgetti A, Perdiguero E, Prieto C, Moren-Nuñez C, Fernández-Ayala DJ, Victoria Cascajo M, Velasco I, Canals JM, Montero R, Yubero D, Jou C, López-Barneo J, Cardellach F, Muñoz-Cánoves P, Artuch R, Navas P, Menendez P.

Stem Cells. 2017 Jul;35(7):1687-1703. doi: 10.1002/stem.2634. Epub 2017 May 23.


Hypomorphic mutations in POLR3A are a frequent cause of sporadic and recessive spastic ataxia.

Minnerop M, Kurzwelly D, Wagner H, Soehn AS, Reichbauer J, Tao F, Rattay TW, Peitz M, Rehbach K, Giorgetti A, Pyle A, Thiele H, Altmüller J, Timmann D, Karaca I, Lennarz M, Baets J, Hengel H, Synofzik M, Atasu B, Feely S, Kennerson M, Stendel C, Lindig T, Gonzalez MA, Stirnberg R, Sturm M, Roeske S, Jung J, Bauer P, Lohmann E, Herms S, Heilmann-Heimbach S, Nicholson G, Mahanjah M, Sharkia R, Carloni P, Brüstle O, Klopstock T, Mathews KD, Shy ME, de Jonghe P, Chinnery PF, Horvath R, Kohlhase J, Schmitt I, Wolf M, Greschus S, Amunts K, Maier W, Schöls L, Nürnberg P, Zuchner S, Klockgether T, Ramirez A, Schüle R.

Brain. 2017 Jun 1;140(6):1561-1578. doi: 10.1093/brain/awx095.


Flutamide-induced hepatotoxicity: ethical and scientific issues.

Giorgetti R, di Muzio M, Giorgetti A, Girolami D, Borgia L, Tagliabracci A.

Eur Rev Med Pharmacol Sci. 2017 Mar;21(1 Suppl):69-77. Review.


Structural heterogeneity of the μ-opioid receptor's conformational ensemble in the apo state.

Sena DM Jr, Cong X, Giorgetti A, Kless A, Carloni P.

Sci Rep. 2017 Apr 3;8:45761. doi: 10.1038/srep45761.


Stress-induced alteration of left ventricular eccentricity: An additional marker of multivessel CAD.

Gimelli A, Liga R, Giorgetti A, Casagranda M, Marzullo P.

J Nucl Cardiol. 2017 Mar 28. doi: 10.1007/s12350-017-0862-7. [Epub ahead of print]


Identification of new BMP6 pro-peptide mutations in patients with iron overload.

Piubelli C, Castagna A, Marchi G, Rizzi M, Busti F, Badar S, Marchetti M, De Gobbi M, Roetto A, Xumerle L, Suku E, Giorgetti A, Delledonne M, Olivieri O, Girelli D.

Am J Hematol. 2017 Jun;92(6):562-568. doi: 10.1002/ajh.24730. Epub 2017 Apr 29.


PET-CT evaluation of amyloid systemic involvement with [18F]-florbetaben in patient with proved cardiac amyloidosis: a case report.

Genovesi D, Vergaro G, Emdin M, Giorgetti A, Marzullo P.

J Nucl Cardiol. 2017 Dec;24(6):2025-2029. doi: 10.1007/s12350-017-0856-5. Epub 2017 Mar 21.


Toward a new data standard for combined marine biological and environmental datasets - expanding OBIS beyond species occurrences.

De Pooter D, Appeltans W, Bailly N, Bristol S, Deneudt K, Eliezer M, Fujioka E, Giorgetti A, Goldstein P, Lewis M, Lipizer M, Mackay K, Marin M, Moncoiffé G, Nikolopoulou S, Provoost P, Rauch S, Roubicek A, Torres C, van de Putte A, Vandepitte L, Vanhoorne B, Vinci M, Wambiji N, Watts D, Klein Salas E, Hernandez F.

Biodivers Data J. 2017 Jan 9;(5):e10989. doi: 10.3897/BDJ.5.e10989. eCollection 2017. No abstract available.


Conserved charged amino acids are key determinants for fatty acid binding proteins (FABPs)-membrane interactions. A multi-methodological computational approach.

Zamarreño F, Giorgetti A, Amundarain MJ, Viso JF, Córsico B, Costabel MD.

J Biomol Struct Dyn. 2018 Mar;36(4):861-877. doi: 10.1080/07391102.2017.1301271. Epub 2017 Mar 16.


Effect of prolonged fasting and low molecular weight heparin or warfarin therapies on 2-deoxy-2-[18F]-fluoro-D-glucose PET cardiac uptake.

Giorgetti A, Marras G, Genovesi D, Filidei E, Bottoni A, Mangione M, Emdin M, Marzullo P.

J Nucl Cardiol. 2018 Aug;25(4):1364-1371. doi: 10.1007/s12350-017-0800-8. Epub 2017 Feb 3.


Unifying view of mechanical and functional hotspots across class A GPCRs.

Ponzoni L, Rossetti G, Maggi L, Giorgetti A, Carloni P, Micheletti C.

PLoS Comput Biol. 2017 Feb 3;13(2):e1005381. doi: 10.1371/journal.pcbi.1005381. eCollection 2017 Feb.


P001. Trigeminal neuralgia-like symptoms: an unusual case.

Giorgetti A, Perrone P, Calloni MV, Leva S, Muscia F, Politini L, Vecchio E.

J Headache Pain. 2015 Dec;16(Suppl 1):A102. doi: 10.1186/1129-2377-16-S1-A102. No abstract available.


Protein Aggregation and Molecular Crowding: Perspectives From Multiscale Simulations.

Musiani F, Giorgetti A.

Int Rev Cell Mol Biol. 2017;329:49-77. doi: 10.1016/bs.ircmb.2016.08.009. Epub 2016 Oct 22. Review.


Induced Pluripotency and Gene Editing in Fanconi Anemia.

Navarro S, Giorgetti A, Raya A, Tolar J.

Curr Gene Ther. 2017;16(5):321-328. doi: 10.2174/1566523217666170118112050. Review.


Survival benefits of interferon-based therapy in patients with recurrent hepatitis C after orthotopic liver transplantation.

Zanaga LP, Vigani AG, Angerami RN, Giorgetti A, Escanhoela CA, Ataíde EC, Boin IF, Stucchi RS.

Braz J Med Biol Res. 2017 Jan 9;50(1):e5540. doi: 10.1590/1414-431X20165540.


Striatal Dopamine Transporter Modulation After Rotigotine: Results From a Pilot Single-Photon Emission Computed Tomography Study in a Group of Early Stage Parkinson Disease Patients.

Rossi C, Genovesi D, Marzullo P, Giorgetti A, Filidei E, Corsini GU, Bonuccelli U, Ceravolo R.

Clin Neuropharmacol. 2017 Jan/Feb;40(1):34-36. doi: 10.1097/WNF.0000000000000198.


Genome-wide characterisation and expression profile of the grapevine ATL ubiquitin ligase family reveal biotic and abiotic stress-responsive and development-related members.

Ariani P, Regaiolo A, Lovato A, Giorgetti A, Porceddu A, Camiolo S, Wong D, Castellarin S, Vandelle E, Polverari A.

Sci Rep. 2016 Dec 2;6:38260. doi: 10.1038/srep38260.


Proinflammatory signals are insufficient to drive definitive hematopoietic specification of human HSCs in vitro.

Giorgetti A, Castaño J, Bueno C, Díaz de la Guardia R, Delgado M, Bigas A, Espinosa L, Menendez P.

Exp Hematol. 2017 Jan;45:85-93.e2. doi: 10.1016/j.exphem.2016.09.007. Epub 2016 Sep 28.


Effects of interface mutations on the dimerization of alanine glyoxylate aminotransferase and implications in the mistargeting of the pathogenic variants F152I and I244T.

Dindo M, Montioli R, Busato M, Giorgetti A, Cellini B, Borri Voltattorni C.

Biochimie. 2016 Dec;131:137-148. doi: 10.1016/j.biochi.2016.10.001. Epub 2016 Oct 5.


Development Refractoriness of MLL-Rearranged Human B Cell Acute Leukemias to Reprogramming into Pluripotency.

Muñoz-López A, Romero-Moya D, Prieto C, Ramos-Mejía V, Agraz-Doblas A, Varela I, Buschbeck M, Palau A, Carvajal-Vergara X, Giorgetti A, Ford A, Lako M, Granada I, Ruiz-Xivillé N, Rodríguez-Perales S, Torres-Ruíz R, Stam RW, Fuster JL, Fraga MF, Nakanishi M, Cazzaniga G, Bardini M, Cobo I, Bayon GF, Fernandez AF, Bueno C, Menendez P.

Stem Cell Reports. 2016 Oct 11;7(4):602-618. doi: 10.1016/j.stemcr.2016.08.013. Epub 2016 Sep 22.


Bioinformatics Applications in Life Sciences and Technologies.

Sousa SA, Leitão JH, Martins RC, Sanches JM, Suri JS, Giorgetti A.

Biomed Res Int. 2016;2016:3603827. doi: 10.1155/2016/3603827. Epub 2016 May 4. No abstract available.


Residues in the Distal Heme Pocket of Arabidopsis Non-Symbiotic Hemoglobins: Implication for Nitrite Reductase Activity.

Kumar N, Astegno A, Chen J, Giorgetti A, Dominici P.

Int J Mol Sci. 2016 Apr 28;17(5). pii: E640. doi: 10.3390/ijms17050640.


Metal binding affinity and structural properties of calmodulin-like protein 14 from Arabidopsis thaliana.

Vallone R, La Verde V, D'Onofrio M, Giorgetti A, Dominici P, Astegno A.

Protein Sci. 2016 Aug;25(8):1461-71. doi: 10.1002/pro.2942. Epub 2016 May 18.


Structural modeling of G-protein coupled receptors: An overview on automatic web-servers.

Busato M, Giorgetti A.

Int J Biochem Cell Biol. 2016 Aug;77(Pt B):264-74. doi: 10.1016/j.biocel.2016.04.004. Epub 2016 Apr 19.


Global proteome profiling of dental cementum under experimentally-induced apposition.

Salmon CR, Giorgetti AP, Paes Leme AF, Domingues RR, Sallum EA, Alves MC, Kolli TN, Foster BL, Nociti FH Jr.

J Proteomics. 2016 Jun 1;141:12-23. doi: 10.1016/j.jprot.2016.03.036. Epub 2016 Apr 16.


Prognostic Significance of 2-Deoxy-2-[18F]-Fluoro-D-Glucose PET/CT in Patients With Locally Advanced Esophageal Cancer Undergoing Neoadjuvant Chemoradiotherapy Before Surgery: A Nonparametric Approach.

Giorgetti A, Pallabazzer G, Ripoli A, Solito B, Genovesi D, Lencioni M, Fabrini MG, D'Imporzano S, Pieraccini L, Marzullo P, Santi S.

Medicine (Baltimore). 2016 Mar;95(13):e3151. doi: 10.1097/MD.0000000000003151.


Molecular characterization of HIV-1 Nef and ACOT8 interaction: insights from in silico structural predictions and in vitro functional assays.

Serena M, Giorgetti A, Busato M, Gasparini F, Diani E, Romanelli MG, Zipeto D.

Sci Rep. 2016 Mar 1;6:22319. doi: 10.1038/srep22319.


Identification of novel mutations in hemochromatosis genes by targeted next generation sequencing in Italian patients with unexplained iron overload.

Badar S, Busti F, Ferrarini A, Xumerle L, Bozzini P, Capelli P, Pozzi-Mucelli R, Campostrini N, De Matteis G, Marin Vargas S, Giorgetti A, Delledonne M, Olivieri O, Girelli D.

Am J Hematol. 2016 Jun;91(4):420-5. doi: 10.1002/ajh.24304.


Evidence for a Transient Additional Ligand Binding Site in the TAS2R46 Bitter Taste Receptor.

Sandal M, Behrens M, Brockhoff A, Musiani F, Giorgetti A, Carloni P, Meyerhof W.

J Chem Theory Comput. 2015 Sep 8;11(9):4439-49. doi: 10.1021/acs.jctc.5b00472. Epub 2015 Aug 24.


A Multimodal Approach for Protein Remote Homology Detection.

Lovato P, Giorgetti A, Bicego M.

IEEE/ACM Trans Comput Biol Bioinform. 2015 Sep-Oct;12(5):1193-8. doi: 10.1109/TCBB.2015.2424417.


Transient Interactions of a Cytosolic Protein with Macromolecular and Vesicular Cosolutes: Unspecific and Specific Effects.

Ceccon A, Busato M, Pérez Santero S, D'Onofrio M, Musiani F, Giorgetti A, Assfalg M.

Chembiochem. 2015 Dec;16(18):2633-45. doi: 10.1002/cbic.201500451. Epub 2015 Nov 6.


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