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Items: 1 to 50 of 58

1.

Molecular Basis of the Functional Differences between Soluble Human Versus Murine MD-2: Role of Val135 in Transfer of Lipopolysaccharide from CD14 to MD-2.

Vašl J, Oblak A, Peternelj TT, Klett J, Martín-Santamaría S, Gioannini TL, Weiss JP, Jerala R.

J Immunol. 2016 Mar 1;196(5):2309-18. doi: 10.4049/jimmunol.1502074. Epub 2016 Jan 29.

2.

Purified monomeric ligand.MD-2 complexes reveal molecular and structural requirements for activation and antagonism of TLR4 by Gram-negative bacterial endotoxins.

Gioannini TL, Teghanemt A, Zhang D, Esparza G, Yu L, Weiss J.

Immunol Res. 2014 Aug;59(1-3):3-11. doi: 10.1007/s12026-014-8543-y. Review.

3.

Tetraacylated lipid A and paclitaxel-selective activation of TLR4/MD-2 conferred through hydrophobic interactions.

Resman N, Oblak A, Gioannini TL, Weiss JP, Jerala R.

J Immunol. 2014 Feb 15;192(4):1887-95. doi: 10.4049/jimmunol.1302119. Epub 2014 Jan 13.

4.

The TLR4 antagonist Eritoran protects mice from lethal influenza infection.

Shirey KA, Lai W, Scott AJ, Lipsky M, Mistry P, Pletneva LM, Karp CL, McAlees J, Gioannini TL, Weiss J, Chen WH, Ernst RK, Rossignol DP, Gusovsky F, Blanco JC, Vogel SN.

Nature. 2013 May 23;497(7450):498-502. doi: 10.1038/nature12118. Epub 2013 May 1.

5.

Radioiodination of an endotoxin·MD-2 complex generates a novel sensitive, high-affinity ligand for TLR4.

Teghanemt A, Weiss JP, Gioannini TL.

Innate Immun. 2013 Oct;19(5):545-60. doi: 10.1177/1753425913475688. Epub 2013 Feb 25.

6.

Respiratory syncytial virus fusion protein-induced toll-like receptor 4 (TLR4) signaling is inhibited by the TLR4 antagonists Rhodobacter sphaeroides lipopolysaccharide and eritoran (E5564) and requires direct interaction with MD-2.

Rallabhandi P, Phillips RL, Boukhvalova MS, Pletneva LM, Shirey KA, Gioannini TL, Weiss JP, Chow JC, Hawkins LD, Vogel SN, Blanco JC.

MBio. 2012 Aug 7;3(4). pii: e00218-12. doi: 10.1128/mBio.00218-12. Print 2012.

7.

The role of microRNAs miR-200b and miR-200c in TLR4 signaling and NF-κB activation.

Wendlandt EB, Graff JW, Gioannini TL, McCaffrey AP, Wilson ME.

Innate Immun. 2012 Dec;18(6):846-55. doi: 10.1177/1753425912443903. Epub 2012 Apr 20.

8.

NMR studies of hexaacylated endotoxin bound to wild-type and F126A mutant MD-2 and MD-2·TLR4 ectodomain complexes.

Yu L, Phillips RL, Zhang D, Teghanemt A, Weiss JP, Gioannini TL.

J Biol Chem. 2012 May 11;287(20):16346-55. doi: 10.1074/jbc.M112.343467. Epub 2012 Mar 20.

9.

Endotoxin{middle dot}albumin complexes transfer endotoxin monomers to MD-2 resulting in activation of TLR4.

Esparza GA, Teghanemt A, Zhang D, Gioannini TL, Weiss JP.

Innate Immun. 2012 Jun;18(3):478-91. doi: 10.1177/1753425911422723. Epub 2011 Oct 12.

10.

Hemin and a metabolic derivative coprohemin modulate the TLR4 pathway differently through different molecular targets.

Piazza M, Damore G, Costa B, Gioannini TL, Weiss JP, Peri F.

Innate Immun. 2011 Feb;17(3):293-301. doi: 10.1177/1753425910369020. Epub 2010 May 14.

11.

Expression of functional D299G.T399I polymorphic variant of TLR4 depends more on coexpression of MD-2 than does wild-type TLR4.

Prohinar P, Rallabhandi P, Weiss JP, Gioannini TL.

J Immunol. 2010 Apr 15;184(8):4362-7. doi: 10.4049/jimmunol.0903142. Epub 2010 Mar 8.

12.

Novel roles of lysines 122, 125, and 58 in functional differences between human and murine MD-2.

Vasl J, Oblak A, Gioannini TL, Weiss JP, Jerala R.

J Immunol. 2009 Oct 15;183(8):5138-45. doi: 10.4049/jimmunol.0901544. Epub 2009 Sep 25.

13.

Essential roles of hydrophobic residues in both MD-2 and toll-like receptor 4 in activation by endotoxin.

Resman N, Vasl J, Oblak A, Pristovsek P, Gioannini TL, Weiss JP, Jerala R.

J Biol Chem. 2009 May 29;284(22):15052-60. doi: 10.1074/jbc.M901429200. Epub 2009 Mar 24.

14.

Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein.

Trompette A, Divanovic S, Visintin A, Blanchard C, Hegde RS, Madan R, Thorne PS, Wills-Karp M, Gioannini TL, Weiss JP, Karp CL.

Nature. 2009 Jan 29;457(7229):585-8. doi: 10.1038/nature07548. Epub 2008 Dec 7.

15.

Isolation of monomeric and dimeric secreted MD-2. Endotoxin.sCD14 and Toll-like receptor 4 ectodomain selectively react with the monomeric form of secreted MD-2.

Teghanemt A, Widstrom RL, Gioannini TL, Weiss JP.

J Biol Chem. 2008 Aug 8;283(32):21881-9. doi: 10.1074/jbc.M800672200. Epub 2008 Jun 2.

17.

Novel roles in human MD-2 of phenylalanines 121 and 126 and tyrosine 131 in activation of Toll-like receptor 4 by endotoxin.

Teghanemt A, Re F, Prohinar P, Widstrom R, Gioannini TL, Weiss JP.

J Biol Chem. 2008 Jan 18;283(3):1257-66. Epub 2007 Oct 30.

18.

Transfer of monomeric endotoxin from MD-2 to CD14: characterization and functional consequences.

Teghanemt A, Prohinar P, Gioannini TL, Weiss JP.

J Biol Chem. 2007 Dec 14;282(50):36250-6. Epub 2007 Oct 13.

19.

Regulation of interactions of Gram-negative bacterial endotoxins with mammalian cells.

Gioannini TL, Weiss JP.

Immunol Res. 2007;39(1-3):249-60. Review.

PMID:
17917069
20.
21.

Endotoxin-binding proteins modulate the susceptibility of bacterial endotoxin to deacylation by acyloxyacyl hydrolase.

Gioannini TL, Teghanemt A, Zhang D, Prohinar P, Levis EN, Munford RS, Weiss JP.

J Biol Chem. 2007 Mar 16;282(11):7877-84. Epub 2007 Jan 16.

22.

Specific high affinity interactions of monomeric endotoxin.protein complexes with Toll-like receptor 4 ectodomain.

Prohinar P, Re F, Widstrom R, Zhang D, Teghanemt A, Weiss JP, Gioannini TL.

J Biol Chem. 2007 Jan 12;282(2):1010-7. Epub 2006 Nov 22.

23.

Molecular basis of reduced potency of underacylated endotoxins.

Teghanemt A, Zhang D, Levis EN, Weiss JP, Gioannini TL.

J Immunol. 2005 Oct 1;175(7):4669-76.

24.

Monomeric endotoxin:protein complexes are essential for TLR4-dependent cell activation.

Gioannini TL, Teghanemt A, Zhang D, Levis EN, Weiss JP.

J Endotoxin Res. 2005;11(2):117-23.

PMID:
15949139
25.

Endotoxin responsiveness of human airway epithelia is limited by low expression of MD-2.

Jia HP, Kline JN, Penisten A, Apicella MA, Gioannini TL, Weiss J, McCray PB Jr.

Am J Physiol Lung Cell Mol Physiol. 2004 Aug;287(2):L428-37. Epub 2004 Apr 30.

26.

Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations.

Gioannini TL, Teghanemt A, Zhang D, Coussens NP, Dockstader W, Ramaswamy S, Weiss JP.

Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4186-91. Epub 2004 Mar 9.

27.

Regulation of interactions of endotoxin with host cells.

Gioannini TL, Teghanemt A, Zarember KA, Weiss JP.

J Endotoxin Res. 2003;9(6):401-8.

PMID:
14733729
28.

An essential role for albumin in the interaction of endotoxin with lipopolysaccharide-binding protein and sCD14 and resultant cell activation.

Gioannini TL, Zhang D, Teghanemt A, Weiss JP.

J Biol Chem. 2002 Dec 6;277(49):47818-25. Epub 2002 Oct 7.

29.

The carboxyl-terminal domain of closely related endotoxin-binding proteins determines the target of protein-lipopolysaccharide complexes.

Iovine N, Eastvold J, Elsbach P, Weiss JP, Gioannini TL.

J Biol Chem. 2002 Mar 8;277(10):7970-8. Epub 2001 Dec 31.

30.

Inactivation of the purified bovine mu opioid receptor by sulfhydryl reagents.

Gioannini TL, Onoprishvili I, Hiller JM, Simon EJ.

Neurochem Res. 1999 Jan;24(1):37-42.

PMID:
9973235
31.

Functional significance of cysteine residues in the delta opioid receptor studied by site-directed mutagenesis.

Ehrlich GK, Andria ML, Zheng X, Kieffer B, Gioannini TL, Hiller JM, Rosenkranz JE, Veksler BM, Zukin RS, Simon EJ.

Can J Physiol Pharmacol. 1998 Mar;76(3):269-77.

PMID:
9673790
32.

Functional reconstitution of a highly purified mu-opioid receptor protein with purified G proteins in liposomes.

Fan LQ, Gioannini TL, Wolinsky T, Hiller JM, Simon EJ.

J Neurochem. 1995 Dec;65(6):2537-42.

PMID:
7595548
33.
34.
35.

Reconstitution of a purified mu-opioid binding protein in liposomes: selective, high affinity, GTP gamma S-sensitive mu-opioid agonist binding is restored.

Gioannini TL, Fan LQ, Hyde L, Ofri D, Yao YH, Hiller JM, Simon EJ.

Biochem Biophys Res Commun. 1993 Jul 30;194(2):901-8.

PMID:
8393673
36.

Characterization of solubilized opioid receptors: reconstitution and uncoupling of guanine nucleotide-sensitive agonist binding.

Ofri D, Ritter AM, Liu YF, Gioannini TL, Hiller JM, Simon EJ.

J Neurochem. 1992 Feb;58(2):628-35.

PMID:
1309566
37.

Studies on mu-opioid-binding sites with peptide antibodies.

Simon EJ, Gioannini TL, Yao YH, Hiller JM.

NIDA Res Monogr. 1992;126:57-65. Review. No abstract available.

PMID:
1337152
38.

Recent studies on a mu opioid binding protein purified from bovine striatal membranes.

Gioannini TL, Yao YH, Hiller JM, Simon EJ.

NIDA Res Monogr. 1992;119:34-8. Review. No abstract available.

PMID:
1331797
39.

Opioid receptors and their biochemistry.

Simon EJ, Gioannini TL, Yao YH, Hiller JM.

Clin Neuropharmacol. 1992;15 Suppl 1 Pt A:48A-49A. No abstract available.

PMID:
1323402
40.
41.

Cross-linking of human [125I]beta-endorphin to opioid receptors in rat striatal membranes: biochemical evidence for the existence of a mu/delta opioid receptor complex.

Schoffelmeer AN, Yao YH, Gioannini TL, Hiller JM, Ofri D, Roques BP, Simon EJ.

J Pharmacol Exp Ther. 1990 Apr;253(1):419-26.

PMID:
2158552
42.

Evidence for the presence of disulfide bridges in opioid receptors essential for ligand binding. Possible role in receptor activation.

Gioannini TL, Liu YF, Park YH, Hiller JM, Simon EJ.

J Mol Recognit. 1989 Jul;2(1):44-8.

PMID:
2561526
43.
44.

Antibodies to dynorphin A(1-13) but not beta-endorphin inhibit electrically elicited feeding in the rat.

Carr KD, Bak TH, Gioannini TL, Simon EJ.

Brain Res. 1987 Oct 6;422(2):384-8.

PMID:
2890420
45.

Identification of distinct binding site subunits of mu and delta opioid receptors.

Howard AD, Sarne Y, Gioannini TL, Hiller JM, Simon EJ.

Biochemistry. 1986 Jan 28;25(2):357-60.

PMID:
3006757
46.
47.
48.

Purification of an active opioid-binding protein from bovine striatum.

Gioannini TL, Howard AD, Hiller JM, Simon EJ.

J Biol Chem. 1985 Dec 5;260(28):15117-21.

49.

Hybromet: a ligand for purifying opioid receptors.

Archer S, Michael J, Osei-Gyimah P, Seyed-Mozaffari A, Zukin RS, Maneckjee R, Simon EJ, Gioannini TL.

J Med Chem. 1985 Dec;28(12):1950-3.

PMID:
2999408
50.

Covalent labeling of opioid receptors with radioiodinated human beta-endorphin. Identification of binding site subunit.

Howard AD, de La Baume S, Gioannini TL, Hiller JM, Simon EJ.

J Biol Chem. 1985 Sep 5;260(19):10833-9.

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