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Items: 1 to 50 of 112

1.

Harnessing endogenous opioids for pain relief: Fantasy vs reality.

Gintzler AR, Liu NJ.

J Opioid Manag. 2019 Jan/Feb;16(1):67-72. doi: 10.5055/jom.2020.0552.

PMID:
32091619
2.

Phosphorylation of unique C-terminal sites of the mu-opioid receptor variants 1B2 and 1C1 influences their Gs association following chronic morphine.

Chakrabarti S, Liu NJ, Gintzler AR.

J Neurochem. 2020 Feb;152(4):449-467. doi: 10.1111/jnc.14863. Epub 2019 Oct 20.

PMID:
31479519
3.

Estrogens as arbiters of sex-specific and reproductive cycle-dependent opioid analgesic mechanisms.

Gintzler AR, Storman EM, Liu NJ.

Vitam Horm. 2019;111:227-246. doi: 10.1016/bs.vh.2019.06.002. Epub 2019 Jul 2.

4.

Exploiting endogenous opioids: Lessons learned from endomorphin 2 in the female rat.

Gintzler AR, Liu NJ, Storman EM, Wessendorf MW.

Peptides. 2019 Feb;112:133-138. doi: 10.1016/j.peptides.2018.12.002. Epub 2018 Dec 14. Review.

PMID:
30557590
5.

Pharmacological Modulation of Endogenous Opioid Activity to Attenuate Neuropathic Pain in Rats.

Liu NJ, Storman EM, Gintzler AR.

J Pain. 2019 Feb;20(2):235-243. doi: 10.1016/j.jpain.2018.10.003. Epub 2018 Oct 23.

6.

Physical Linkage of Estrogen Receptor α and Aromatase in Rat: Oligocrine and Endocrine Actions of CNS-Produced Estrogens.

Storman EM, Liu NJ, Wessendorf MW, Gintzler AR.

Endocrinology. 2018 Jul 1;159(7):2683-2697. doi: 10.1210/en.2018-00319.

7.

Plasticity of Signaling by Spinal Estrogen Receptor α, κ-Opioid Receptor, and Metabotropic Glutamate Receptors over the Rat Reproductive Cycle Regulates Spinal Endomorphin 2 Antinociception: Relevance of Endogenous-Biased Agonism.

Liu NJ, Murugaiyan V, Storman EM, Schnell SA, Kumar A, Wessendorf MW, Gintzler AR.

J Neurosci. 2017 Nov 15;37(46):11181-11191. doi: 10.1523/JNEUROSCI.1927-17.2017. Epub 2017 Oct 12.

8.

Estrogens synthesized and acting within a spinal oligomer suppress spinal endomorphin 2 antinociception: ebb and flow over the rat reproductive cycle.

Liu NJ, Murugaiyan V, Storman EM, Schnell SA, Wessendorf MW, Gintzler AR.

Pain. 2017 Oct;158(10):1903-1914. doi: 10.1097/j.pain.0000000000000991.

9.

Chronic opioid treatment augments caveolin-1 scaffolding: relevance to stimulatory μ-opioid receptor adenylyl cyclase signaling.

Chakrabarti S, Chang A, Liu NJ, Gintzler AR.

J Neurochem. 2016 Dec;139(5):737-747. doi: 10.1111/jnc.13852. Epub 2016 Oct 18.

10.

Selective up-regulation of functional mu-opioid receptor splice variants by chronic opioids.

Chakrabarti S, Madia PA, Gintzler AR.

J Neurochem. 2016 Mar;136(6):1119-1130. doi: 10.1111/jnc.13519. Epub 2016 Jan 20.

11.

Contribution of Endogenous Spinal Endomorphin 2 to Intrathecal Opioid Antinociception in Rats Is Agonist Dependent and Sexually Dimorphic.

Kumar A, Liu NJ, Madia PA, Gintzler AR.

J Pain. 2015 Nov;16(11):1200-10. doi: 10.1016/j.jpain.2015.08.003. Epub 2015 Sep 2.

12.

Estrogens Suppress Spinal Endomorphin 2 Release in Female Rats in Phase with the Estrous Cycle.

Kumar A, Storman EM, Liu NJ, Gintzler AR.

Neuroendocrinology. 2015;102(1-2):33-43. doi: 10.1159/000430817. Epub 2015 Apr 29.

13.

Mu-opioid receptor splice variants: sex-dependent regulation by chronic morphine.

Verzillo V, Madia PA, Liu NJ, Chakrabarti S, Gintzler AR.

J Neurochem. 2014 Sep;130(6):790-6. doi: 10.1111/jnc.12768. Epub 2014 Jun 11.

14.

Spinal endomorphin 2 antinociception and the mechanisms that produce it are both sex- and stage of estrus cycle-dependent in rats.

Liu NJ, Gintzler AR.

J Pain. 2013 Nov;14(11):1522-30. doi: 10.1016/j.jpain.2013.09.002. Epub 2013 Sep 29.

15.

Sex, pain, and opioids: interdependent influences of sex and pain modality on dynorphin-mediated antinociception in rats.

Liu NJ, Schnell S, Wessendorf MW, Gintzler AR.

J Pharmacol Exp Ther. 2013 Feb;344(2):522-30. doi: 10.1124/jpet.112.199851. Epub 2012 Dec 10.

PMID:
23230215
16.

Importance of sex to pain and its amelioration; relevance of spinal estrogens and its membrane receptors.

Gintzler AR, Liu NJ.

Front Neuroendocrinol. 2012 Oct;33(4):412-24. doi: 10.1016/j.yfrne.2012.09.004. Epub 2012 Oct 2. Review.

17.

Pleiotropic opioid regulation of spinal endomorphin 2 release and its adaptations to opioid withdrawal are sexually dimorphic.

Chakrabarti S, Liu NJ, Zadina JE, Sharma T, Gintzler AR.

J Pharmacol Exp Ther. 2012 Jan;340(1):56-63. doi: 10.1124/jpet.111.186874. Epub 2011 Oct 4.

18.

Spinal synthesis of estrogen and concomitant signaling by membrane estrogen receptors regulate spinal κ- and μ-opioid receptor heterodimerization and female-specific spinal morphine antinociception.

Liu NJ, Chakrabarti S, Schnell S, Wessendorf M, Gintzler AR.

J Neurosci. 2011 Aug 17;31(33):11836-45. doi: 10.1523/JNEUROSCI.1901-11.2011. Erratum in: J Neurosci. 2011 Nov 30;31(48):17752.

19.

Formation of mu-/kappa-opioid receptor heterodimer is sex-dependent and mediates female-specific opioid analgesia.

Chakrabarti S, Liu NJ, Gintzler AR.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20115-9. doi: 10.1073/pnas.1009923107. Epub 2010 Nov 1.

20.

Regulation of spinal dynorphin 1-17 release by endogenous pituitary adenylyl cyclase-activating polypeptide in the male rat: relevance of excitation via disinhibition.

Liu NJ, Schnell SA, Schulz S, Wessendorf MW, Gintzler AR.

J Pharmacol Exp Ther. 2011 Feb;336(2):328-35. doi: 10.1124/jpet.110.173039. Epub 2010 Oct 25.

21.

Subcellular localization of mu-opioid receptor G(s) signaling.

Chakrabarti S, Chang A, Gintzler AR.

J Pharmacol Exp Ther. 2010 Apr;333(1):193-200. doi: 10.1124/jpet.109.165142. Epub 2010 Jan 22.

22.

Relationship of spinal dynorphin neurons to delta-opioid receptors and estrogen receptor alpha: anatomical basis for ovarian sex steroid opioid antinociception.

Gintzler AR, Schnell SA, Gupta DS, Liu NJ, Wessendorf MW.

J Pharmacol Exp Ther. 2008 Sep;326(3):725-31. doi: 10.1124/jpet.108.139816. Epub 2008 Jun 9.

PMID:
18541716
23.

The ambiguities of opioid tolerance mechanisms: barriers to pain therapeutics or new pain therapeutic possibilities.

Gintzler AR, Chakrabarti S.

J Pharmacol Exp Ther. 2008 Jun;325(3):709-13. doi: 10.1124/jpet.107.135533. Epub 2008 Mar 19.

PMID:
18354057
24.

Plasticity of adenylyl cyclase-related signaling sequelae after long-term morphine treatment.

Shy M, Chakrabarti S, Gintzler AR.

Mol Pharmacol. 2008 Mar;73(3):868-79. Epub 2007 Nov 28.

PMID:
18045853
25.
26.

Sexually dimorphic recruitment of spinal opioid analgesic pathways by the spinal application of morphine.

Liu NJ, von Gizycki H, Gintzler AR.

J Pharmacol Exp Ther. 2007 Aug;322(2):654-60. Epub 2007 May 8.

PMID:
17488879
27.

Sex-/ovarian steroid-dependent release of endomorphin 2 from spinal cord.

Gupta DS, von Gizycki H, Gintzler AR.

J Pharmacol Exp Ther. 2007 May;321(2):635-41. Epub 2007 Feb 16.

PMID:
17308039
28.

Post-opioid receptor adaptations to chronic morphine; altered functionality and associations of signaling molecules.

Gintzler AR, Chakrabarti S.

Life Sci. 2006 Jul 17;79(8):717-22. Epub 2006 Mar 6. Review.

PMID:
16581089
29.

Phospholipase Cbeta1 modulates pain sensitivity, opioid antinociception and opioid tolerance formation.

Liu NJ, vonGizycki H, Gintzler AR.

Brain Res. 2006 Jan 19;1069(1):47-53. Epub 2006 Jan 6.

PMID:
16405873
31.

Biochemical demonstration of mu-opioid receptor association with Gsalpha: enhancement following morphine exposure.

Chakrabarti S, Regec A, Gintzler AR.

Brain Res Mol Brain Res. 2005 Apr 27;135(1-2):217-24. Epub 2005 Feb 19.

PMID:
15857684
32.

Chronic morphine-induced plasticity among signalling molecules.

Gintzler AR, Chakrabarti S.

Novartis Found Symp. 2004;261:167-76; discussion 176-80, 191-3. Review.

PMID:
15469050
35.

Phosphorylation of Gbeta is augmented by chronic morphine and enhances Gbetagamma stimulation of adenylyl cyclase activity.

Chakrabarti S, Gintzler AR.

Brain Res Mol Brain Res. 2003 Nov 26;119(2):144-51.

PMID:
14625081
36.

Reciprocal modulation of phospholipase Cbeta isoforms: adaptation to chronic morphine.

Chakrabarti S, Liu NJ, Gintzler AR.

Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13686-91. Epub 2003 Nov 3.

37.

Influence of ovarian sex steroids on spinal methionine-enkephalin release: comparison with dynorphin reveals asymmetrical regulation.

Gupta DS, Gintzler AR.

J Pharmacol Exp Ther. 2003 Feb;304(2):738-44. Erratum in: J Pharmacol Exp Ther. 2003 Mar;304(3):1341.

PMID:
12538829
39.
40.

Ovarian sex steroid-dependent plasticity of nociceptin/orphanin FQ and opioid modulation of spinal dynorphin release.

Gupta DS, Kelson AB, Polgar WE, Toll L, Szücs M, Gintzler AR.

J Pharmacol Exp Ther. 2001 Sep;298(3):1213-20.

PMID:
11504823
41.

Opioid tolerance and the emergence of new opioid receptor-coupled signaling.

Gintzler AR, Chakrabarti S.

Mol Neurobiol. 2000 Feb-Apr;21(1-2):21-33. Review.

PMID:
11327148
42.
45.

Modulation of prohormone convertase 2 in spinal cord during gestation and hormone-simulated pregnancy.

Varshney C, Rivera M, Gintzler AR.

Neuroendocrinology. 1999 Oct;70(4):268-79.

PMID:
10529622
46.

Chronic morphine augments adenylyl cyclase phosphorylation: relevance to altered signaling during tolerance/dependence.

Chakrabarti S, Wang L, Tang WJ, Gintzler AR.

Mol Pharmacol. 1998 Dec;54(6):949-53.

PMID:
9855621
47.

Chronic morphine augments G(beta)(gamma)/Gs(alpha) stimulation of adenylyl cyclase: relevance to opioid tolerance.

Chakrabarti S, Rivera M, Yan SZ, Tang WJ, Gintzler AR.

Mol Pharmacol. 1998 Oct;54(4):655-62.

PMID:
9765508
48.
50.

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