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Frontline Science: A flexible kink in the transmembrane domain impairs β2 integrin extension and cell arrest from rolling.

Sun H, Fan Z, Gingras AR, Lopez-Ramirez MA, Ginsberg MH, Ley K.

J Leukoc Biol. 2019 Sep 1. doi: 10.1002/JLB.1HI0219-073RR. [Epub ahead of print]


Biomarkers of cavernous angioma with symptomatic hemorrhage.

Lyne SB, Girard R, Koskimäki J, Zeineddine HA, Zhang D, Cao Y, Li Y, Stadnik A, Moore T, Lightle R, Shi C, Shenkar R, Carrión-Penagos J, Polster SP, Romanos S, Akers A, Lopez-Ramirez M, Whitehead KJ, Kahn ML, Ginsberg MH, Marchuk DA, Awad IA.

JCI Insight. 2019 Jun 20;4(12). pii: 128577. doi: 10.1172/jci.insight.128577. eCollection 2019 Jun 20.


Rap1 binding and a lipid-dependent helix in talin F1 domain promote integrin activation in tandem.

Gingras AR, Lagarrigue F, Cuevas MN, Valadez AJ, Zorovich M, McLaughlin W, Lopez-Ramirez MA, Seban N, Ley K, Kiosses WB, Ginsberg MH.

J Cell Biol. 2019 Jun 3;218(6):1799-1809. doi: 10.1083/jcb.201810061. Epub 2019 Apr 15.


High-Affinity Bent β2-Integrin Molecules in Arresting Neutrophils Face Each Other through Binding to ICAMs In cis.

Fan Z, Kiosses WB, Sun H, Orecchioni M, Ghosheh Y, Zajonc DM, Arnaout MA, Gutierrez E, Groisman A, Ginsberg MH, Ley K.

Cell Rep. 2019 Jan 2;26(1):119-130.e5. doi: 10.1016/j.celrep.2018.12.038.


Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice.

Lopez-Ramirez MA, Pham A, Girard R, Wyseure T, Hale P, Yamashita A, Koskimäki J, Polster S, Saadat L, Romero IA, Esmon CT, Lagarrigue F, Awad IA, Mosnier LO, Ginsberg MH.

Blood. 2019 Jan 17;133(3):193-204. doi: 10.1182/blood-2018-06-856062. Epub 2018 Nov 15.


Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation.

Lagarrigue F, Gingras AR, Paul DS, Valadez AJ, Cuevas MN, Sun H, Lopez-Ramirez MA, Goult BT, Shattil SJ, Bergmeier W, Ginsberg MH.

Blood Adv. 2018 Sep 25;2(18):2358-2368. doi: 10.1182/bloodadvances.2018020487.


Integrin Activation Controls Regulatory T Cell-Mediated Peripheral Tolerance.

Klann JE, Kim SH, Remedios KA, He Z, Metz PJ, Lopez J, Tysl T, Olvera JG, Ablack JN, Cantor JM, Boland BS, Yeo G, Zheng Y, Lu LF, Bui JD, Ginsberg MH, Petrich BG, Chang JT.

J Immunol. 2018 Jun 15;200(12):4012-4023. doi: 10.4049/jimmunol.1800112. Epub 2018 Apr 27.


Transmission of integrin β7 transmembrane domain topology enables gut lymphoid tissue development.

Sun H, Lagarrigue F, Gingras AR, Fan Z, Ley K, Ginsberg MH.

J Cell Biol. 2018 Apr 2;217(4):1453-1465. doi: 10.1083/jcb.201707055. Epub 2018 Mar 13.


Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations.

Lopez-Ramirez MA, Fonseca G, Zeineddine HA, Girard R, Moore T, Pham A, Cao Y, Shenkar R, de Kreuk BJ, Lagarrigue F, Lawler J, Glass CK, Awad IA, Ginsberg MH.

J Exp Med. 2017 Nov 6;214(11):3331-3346. doi: 10.1084/jem.20171178. Epub 2017 Sep 28.


Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool.

Klann JE, Remedios KA, Kim SH, Metz PJ, Lopez J, Mack LA, Zheng Y, Ginsberg MH, Petrich BG, Chang JT.

J Immunol. 2017 Jun 15;198(12):4639-4651. doi: 10.4049/jimmunol.1601165. Epub 2017 May 17.


Tissue Factor Prothrombotic Activity Is Regulated by Integrin-arf6 Trafficking.

Rothmeier AS, Marchese P, Langer F, Kamikubo Y, Schaffner F, Cantor J, Ginsberg MH, Ruggeri ZM, Ruf W.

Arterioscler Thromb Vasc Biol. 2017 Jul;37(7):1323-1331. doi: 10.1161/ATVBAHA.117.309315. Epub 2017 May 11.


Epigallocatechin gallate has pleiotropic effects on transmembrane signaling by altering the embedding of transmembrane domains.

Ye F, Yang C, Kim J, MacNevin CJ, Hahn KM, Park D, Ginsberg MH, Kim C.

J Biol Chem. 2017 Jun 16;292(24):9858-9864. doi: 10.1074/jbc.C117.787309. Epub 2017 May 9.


Cutting Edge: Loss of T Cell RIAM Precludes Conjugate Formation with APC and Prevents Immune-Mediated Diabetes.

Lagarrigue F, Gertler FB, Ginsberg MH, Cantor JM.

J Immunol. 2017 May 1;198(9):3410-3415. doi: 10.4049/jimmunol.1601743. Epub 2017 Mar 27.


CD98 regulates vascular smooth muscle cell proliferation in atherosclerosis.

Baumer Y, McCurdy S, Alcala M, Mehta N, Lee BH, Ginsberg MH, Boisvert WA.

Atherosclerosis. 2017 Jan;256:105-114. doi: 10.1016/j.atherosclerosis.2016.11.017. Epub 2016 Nov 16.


CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia.

Bajaj J, Konuma T, Lytle NK, Kwon HY, Ablack JN, Cantor JM, Rizzieri D, Chuah C, Oehler VG, Broome EH, Ball ED, van der Horst EH, Ginsberg MH, Reya T.

Cancer Cell. 2016 Nov 14;30(5):792-805. doi: 10.1016/j.ccell.2016.10.003. Epub 2016 Oct 27.


Structural Basis of Dimeric Rasip1 RA Domain Recognition of the Ras Subfamily of GTP-Binding Proteins.

Gingras AR, Puzon-McLaughlin W, Bobkov AA, Ginsberg MH.

Structure. 2016 Dec 6;24(12):2152-2162. doi: 10.1016/j.str.2016.10.001. Epub 2016 Nov 10.


Enhanced Integrin α4β1-Mediated Adhesion Contributes to a Mobilization Defect of Endothelial Progenitor Cells in Diabetes.

Abplanalp WT, Conklin DJ, Cantor JM, Ginsberg MH, Wysoczynski M, Bhatnagar A, O'Toole TE.

Diabetes. 2016 Nov;65(11):3505-3515. Epub 2016 Aug 5.


A Conserved Ectodomain-Transmembrane Domain Linker Motif Tunes the Allosteric Regulation of Cell Surface Receptors.

Schmidt T, Ye F, Situ AJ, An W, Ginsberg MH, Ulmer TS.

J Biol Chem. 2016 Aug 19;291(34):17536-46. doi: 10.1074/jbc.M116.733683. Epub 2016 Jun 30.


The Rap1-RIAM-talin axis of integrin activation and blood cell function.

Lagarrigue F, Kim C, Ginsberg MH.

Blood. 2016 Jul 28;128(4):479-87. doi: 10.1182/blood-2015-12-638700. Epub 2016 May 20. Review.


Amino Acid Transport Associated to Cluster of Differentiation 98 Heavy Chain (CD98hc) Is at the Cross-road of Oxidative Stress and Amino Acid Availability.

de la Ballina LR, Cano-Crespo S, González-Muñoz E, Bial S, Estrach S, Cailleteau L, Tissot F, Daniel H, Zorzano A, Ginsberg MH, Palacín M, Féral CC.

J Biol Chem. 2016 Apr 29;291(18):9700-11. doi: 10.1074/jbc.M115.704254. Epub 2016 Mar 5.


Heart of glass anchors Rasip1 at endothelial cell-cell junctions to support vascular integrity.

de Kreuk BJ, Gingras AR, Knight JD, Liu JJ, Gingras AC, Ginsberg MH.

Elife. 2016 Jan 19;5:e11394. doi: 10.7554/eLife.11394.


RLIP76 regulates Arf6-dependent cell spreading and migration by linking ARNO with activated R-Ras at recycling endosomes.

Wurtzel JG, Lee S, Singhal SS, Awasthi S, Ginsberg MH, Goldfinger LE.

Biochem Biophys Res Commun. 2015 Nov 27;467(4):785-91. doi: 10.1016/j.bbrc.2015.10.064. Epub 2015 Oct 20.


Ubiquitylation of CD98 limits cell proliferation and clonal expansion.

Ablack JN, Metz PJ, Chang JT, Cantor JM, Ginsberg MH.

J Cell Sci. 2015 Dec 1;128(23):4273-8. doi: 10.1242/jcs.178129. Epub 2015 Oct 22.


A RIAM/lamellipodin-talin-integrin complex forms the tip of sticky fingers that guide cell migration.

Lagarrigue F, Vikas Anekal P, Lee HS, Bachir AI, Ablack JN, Horwitz AF, Ginsberg MH.

Nat Commun. 2015 Sep 30;6:8492. doi: 10.1038/ncomms9492.


The Structure of a Full-length Membrane-embedded Integrin Bound to a Physiological Ligand.

Dai A, Ye F, Taylor DW, Hu G, Ginsberg MH, Taylor KA.

J Biol Chem. 2015 Nov 6;290(45):27168-75. doi: 10.1074/jbc.M115.682377. Epub 2015 Sep 21.


An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes.

Zhang P, Ye F, Bastidas AC, Kornev AP, Wu J, Ginsberg MH, Taylor SS.

Structure. 2015 Sep 1;23(9):1563-1572. doi: 10.1016/j.str.2015.07.007. Epub 2015 Aug 13.


Blocking neutrophil integrin activation prevents ischemia-reperfusion injury.

Yago T, Petrich BG, Zhang N, Liu Z, Shao B, Ginsberg MH, McEver RP.

J Exp Med. 2015 Jul 27;212(8):1267-81. doi: 10.1084/jem.20142358. Epub 2015 Jul 13.


Caspase-1-mediated pathway promotes generation of thromboinflammatory microparticles.

Rothmeier AS, Marchese P, Petrich BG, Furlan-Freguia C, Ginsberg MH, Ruggeri ZM, Ruf W.

J Clin Invest. 2015 Apr;125(4):1471-84. doi: 10.1172/JCI79329. Epub 2015 Feb 23.


Annular anionic lipids stabilize the integrin αIIbβ3 transmembrane complex.

Schmidt T, Suk JE, Ye F, Situ AJ, Mazumder P, Ginsberg MH, Ulmer TS.

J Biol Chem. 2015 Mar 27;290(13):8283-93. doi: 10.1074/jbc.M114.623504. Epub 2015 Jan 29.


Fine-tuning Tumor Immunity with Integrin Trans-regulation.

Cantor JM, Rose DM, Slepak M, Ginsberg MH.

Cancer Immunol Res. 2015 Jun;3(6):661-7. doi: 10.1158/2326-6066.CIR-13-0226. Epub 2015 Jan 19.


Interaction of kindlin-2 with integrin β3 promotes outside-in signaling responses by the αVβ3 vitronectin receptor.

Liao Z, Kato H, Pandey M, Cantor JM, Ablooglu AJ, Ginsberg MH, Shattil SJ.

Blood. 2015 Mar 19;125(12):1995-2004. doi: 10.1182/blood-2014-09-603035. Epub 2015 Jan 13.


Antitumor activity of an anti-CD98 antibody.

Hayes GM, Chinn L, Cantor JM, Cairns B, Levashova Z, Tran H, Velilla T, Duey D, Lippincott J, Zachwieja J, Ginsberg MH, H van der Horst E.

Int J Cancer. 2015 Aug 1;137(3):710-20. doi: 10.1002/ijc.29415. Epub 2015 Jan 14.


Integrin activation.

Ginsberg MH.

BMB Rep. 2014 Dec;47(12):655-9. Review.


CD98hc (SLC3A2) loss protects against ras-driven tumorigenesis by modulating integrin-mediated mechanotransduction.

Estrach S, Lee SA, Boulter E, Pisano S, Errante A, Tissot FS, Cailleteau L, Pons C, Ginsberg MH, Féral CC.

Cancer Res. 2014 Dec 1;74(23):6878-89. doi: 10.1158/0008-5472.CAN-14-0579. Epub 2014 Sep 29.


High mutation detection rates in cerebral cavernous malformation upon stringent inclusion criteria: one-third of probands are minors.

Spiegler S, Najm J, Liu J, Gkalympoudis S, Schröder W, Borck G, Brockmann K, Elbracht M, Fauth C, Ferbert A, Freudenberg L, Grasshoff U, Hellenbroich Y, Henn W, Hoffjan S, Hüning I, Korenke GC, Kroisel PM, Kunstmann E, Mair M, Munk-Schulenburg S, Nikoubashman O, Pauli S, Rudnik-Schöneborn S, Sudholt I, Sure U, Tinschert S, Wiednig M, Zoll B, Ginsberg MH, Felbor U.

Mol Genet Genomic Med. 2014 Mar;2(2):176-85. doi: 10.1002/mgg3.60. Epub 2014 Jan 14.


SnapShot: talin and the modular nature of the integrin adhesome.

Ye F, Lagarrigue F, Ginsberg MH.

Cell. 2014 Mar 13;156(6):1340-1340.e1. doi: 10.1016/j.cell.2014.02.048.


ADAP interactions with talin and kindlin promote platelet integrin αIIbβ3 activation and stable fibrinogen binding.

Kasirer-Friede A, Kang J, Kahner B, Ye F, Ginsberg MH, Shattil SJ.

Blood. 2014 May 15;123(20):3156-65. doi: 10.1182/blood-2013-08-520627. Epub 2014 Feb 12.


Talin and kindlin: the one-two punch in integrin activation.

Ye F, Snider AK, Ginsberg MH.

Front Med. 2014 Mar;8(1):6-16. doi: 10.1007/s11684-014-0317-3. Epub 2014 Jan 29. Review.


The mechanism of kindlin-mediated activation of integrin αIIbβ3.

Ye F, Petrich BG, Anekal P, Lefort CT, Kasirer-Friede A, Shattil SJ, Ruppert R, Moser M, Fässler R, Ginsberg MH.

Curr Biol. 2013 Nov 18;23(22):2288-2295. doi: 10.1016/j.cub.2013.09.050. Epub 2013 Nov 7.


The nucleus of endothelial cell as a sensor of blood flow direction.

Tkachenko E, Gutierrez E, Saikin SK, Fogelstrand P, Kim C, Groisman A, Ginsberg MH.

Biol Open. 2013 Aug 14;2(10):1007-12. doi: 10.1242/bio.20134622. eCollection 2013.


Reconstructing integrin activation in vitro.

Gingras AR, Ye F, Ginsberg MH.

Methods Mol Biol. 2013;1046:1-17. doi: 10.1007/978-1-62703-538-5_1.


The structure of the ternary complex of Krev interaction trapped 1 (KRIT1) bound to both the Rap1 GTPase and the heart of glass (HEG1) cytoplasmic tail.

Gingras AR, Puzon-McLaughlin W, Ginsberg MH.

J Biol Chem. 2013 Aug 16;288(33):23639-49. doi: 10.1074/jbc.M113.462911. Epub 2013 Jun 27.


Two modes of integrin activation form a binary molecular switch in adhesion maturation.

Lee HS, Anekal P, Lim CJ, Liu CC, Ginsberg MH.

Mol Biol Cell. 2013 May;24(9):1354-62. doi: 10.1091/mbc.E12-09-0695. Epub 2013 Mar 6.


Talin1 and Rap1 are critical for osteoclast function.

Zou W, Izawa T, Zhu T, Chappel J, Otero K, Monkley SJ, Critchley DR, Petrich BG, Morozov A, Ginsberg MH, Teitelbaum SL.

Mol Cell Biol. 2013 Feb;33(4):830-44. doi: 10.1128/MCB.00790-12. Epub 2012 Dec 10.


Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration.

Wang S, Watanabe T, Matsuzawa K, Katsumi A, Kakeno M, Matsui T, Ye F, Sato K, Murase K, Sugiyama I, Kimura K, Mizoguchi A, Ginsberg MH, Collard JG, Kaibuchi K.

J Cell Biol. 2012 Oct 15;199(2):331-45. doi: 10.1083/jcb.201202041.


Structural basis of the junctional anchorage of the cerebral cavernous malformations complex.

Gingras AR, Liu JJ, Ginsberg MH.

J Cell Biol. 2012 Oct 1;199(1):39-48. doi: 10.1083/jcb.201205109. Epub 2012 Sep 24.


Talin activates integrins by altering the topology of the β transmembrane domain.

Kim C, Ye F, Hu X, Ginsberg MH.

J Cell Biol. 2012 May 28;197(5):605-11. doi: 10.1083/jcb.201112141.


CD98 at the crossroads of adaptive immunity and cancer.

Cantor JM, Ginsberg MH.

J Cell Sci. 2012 Mar 15;125(Pt 6):1373-82. doi: 10.1242/jcs.096040. Epub 2012 Apr 12. Review.


Kindlins, integrin activation and the regulation of talin recruitment to αIIbβ3.

Kahner BN, Kato H, Banno A, Ginsberg MH, Shattil SJ, Ye F.

PLoS One. 2012;7(3):e34056. doi: 10.1371/journal.pone.0034056. Epub 2012 Mar 23.


Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation.

Lefort CT, Rossaint J, Moser M, Petrich BG, Zarbock A, Monkley SJ, Critchley DR, Ginsberg MH, Fässler R, Ley K.

Blood. 2012 May 3;119(18):4275-82. doi: 10.1182/blood-2011-08-373118. Epub 2012 Mar 19.

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