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Publisher Correction: Studying tissue macrophages in vitro: are iPSC-derived cells the answer?

Lee CZW, Kozaki T, Ginhoux F.

Nat Rev Immunol. 2018 Aug 30. doi: 10.1038/s41577-018-0060-0. [Epub ahead of print]


Microglia heterogeneity along a spatio-temporal axis: More questions than answers.

Silvin A, Ginhoux F.

Glia. 2018 Aug 25. doi: 10.1002/glia.23458. [Epub ahead of print] Review.


Studying tissue macrophages in vitro: are iPSC-derived cells the answer?

Lee CZW, Kozaki T, Ginhoux F.

Nat Rev Immunol. 2018 Aug 23. doi: 10.1038/s41577-018-0054-y. [Epub ahead of print] Review. Erratum in: Nat Rev Immunol. 2018 Aug 30;:.


Editorial for Cellular Immunology special issue on "Tissue Macrophages".

Ginhoux F, Guilliams M.

Cell Immunol. 2018 Aug;330:1-4. doi: 10.1016/j.cellimm.2018.07.010. No abstract available.


Macrophage depletion in cancer therapy: A double-edged sword.

Blériot C, Ginhoux F.

Cell Immunol. 2018 Sep;331:178-179. doi: 10.1016/j.cellimm.2018.07.012. Epub 2018 Aug 1. No abstract available.


Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen.

Lim HY, Lim SY, Tan CK, Thiam CH, Goh CC, Carbajo D, Chew SHS, See P, Chakarov S, Wang XN, Lim LH, Johnson LA, Lum J, Fong CY, Bongso A, Biswas A, Goh C, Evrard M, Yeo KP, Basu R, Wang JK, Tan Y, Jain R, Tikoo S, Choong C, Weninger W, Poidinger M, Stanley RE, Collin M, Tan NS, Ng LG, Jackson DG, Ginhoux F, Angeli V.

Immunity. 2018 Aug 21;49(2):326-341.e7. doi: 10.1016/j.immuni.2018.06.008. Epub 2018 Jul 24.


The mysterious origins of microglia.

Ginhoux F, Garel S.

Nat Neurosci. 2018 Jul;21(7):897-899. doi: 10.1038/s41593-018-0176-3. No abstract available.


Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis.

Giladi A, Paul F, Herzog Y, Lubling Y, Weiner A, Yofe I, Jaitin D, Cabezas-Wallscheid N, Dress R, Ginhoux F, Trumpp A, Tanay A, Amit I.

Nat Cell Biol. 2018 Jul;20(7):836-846. doi: 10.1038/s41556-018-0121-4. Epub 2018 Jun 18.


Hemogenic Endothelial Fate Mapping Reveals Dual Developmental Origin of Mast Cells.

Gentek R, Ghigo C, Hoeffel G, Bulle MJ, Msallam R, Gautier G, Launay P, Chen J, Ginhoux F, Bajénoff M.

Immunity. 2018 Jun 19;48(6):1160-1171.e5. doi: 10.1016/j.immuni.2018.04.025. Epub 2018 May 29.


Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency.

Simoni Y, Fehlings M, Kløverpris HN, McGovern N, Koo SL, Loh CY, Lim S, Kurioka A, Fergusson JR, Tang CL, Kam MH, Dennis K, Lim TKH, Fui ACY, Hoong CW, Chan JKY, Curotto de Lafaille M, Narayanan S, Baig S, Shabeer M, Toh SES, Tan HKK, Anicete R, Tan EH, Takano A, Klenerman P, Leslie A, Tan DSW, Tan IB, Ginhoux F, Newell EW.

Immunity. 2018 May 15;48(5):1060. doi: 10.1016/j.immuni.2018.04.028. No abstract available.


Human dendritic cells.

Collin M, Ginhoux F.

Semin Cell Dev Biol. 2018 May 19. pii: S1084-9521(18)30103-4. doi: 10.1016/j.semcdb.2018.04.015. [Epub ahead of print] No abstract available.


Bevacizumab Promotes T-Cell-Mediated Collagen Deposition in the Mouse Model of Conjunctival Scarring.

Seet LF, Toh LZ, Chu S, Finger SN, Ginhoux F, Hong W, Wong TT.

Invest Ophthalmol Vis Sci. 2018 Mar 1;59(3):1682-1692. doi: 10.1167/iovs.17-22694.


Calcineurin-mediated IL-2 production by CD11chighMHCII+ myeloid cells is crucial for intestinal immune homeostasis.

Mencarelli A, Khameneh HJ, Fric J, Vacca M, El Daker S, Janela B, Tang JP, Nabti S, Balachander A, Lim TS, Ginhoux F, Ricciardi-Castagnoli P, Mortellaro A.

Nat Commun. 2018 Mar 16;9(1):1102. doi: 10.1038/s41467-018-03495-3.


Fetal monocytes and the origins of tissue-resident macrophages.

Hoeffel G, Ginhoux F.

Cell Immunol. 2018 Aug;330:5-15. doi: 10.1016/j.cellimm.2018.01.001. Epub 2018 Jan 12.


Homeostatic control of dendritic cell numbers and differentiation.

Dress RJ, Wong AY, Ginhoux F.

Immunol Cell Biol. 2018 May;96(5):463-476. doi: 10.1111/imcb.12028. Epub 2018 Mar 23. Review.


Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions.

Evrard M, Kwok IWH, Chong SZ, Teng KWW, Becht E, Chen J, Sieow JL, Penny HL, Ching GC, Devi S, Adrover JM, Li JLY, Liong KH, Tan L, Poon Z, Foo S, Chua JW, Su IH, Balabanian K, Bachelerie F, Biswas SK, Larbi A, Hwang WYK, Madan V, Koeffler HP, Wong SC, Newell EW, Hidalgo A, Ginhoux F, Ng LG.

Immunity. 2018 Feb 20;48(2):364-379.e8. doi: 10.1016/j.immuni.2018.02.002.


Recent advances in the understanding of microglial development and homeostasis.

Low D, Ginhoux F.

Cell Immunol. 2018 Aug;330:68-78. doi: 10.1016/j.cellimm.2018.01.004. Epub 2018 Jan 10.


Neutrophil derived CSF1 induces macrophage polarization and promotes transplantation tolerance.

Braza MS, Conde P, Garcia M, Cortegano I, Brahmachary M, Pothula V, Fay F, Boros P, Werner SA, Ginhoux F, Mulder WJM, Ochando J.

Am J Transplant. 2018 May;18(5):1247-1255. doi: 10.1111/ajt.14645. Epub 2018 Feb 7.


Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner.

Thion MS, Low D, Silvin A, Chen J, Grisel P, Schulte-Schrepping J, Blecher R, Ulas T, Squarzoni P, Hoeffel G, Coulpier F, Siopi E, David FS, Scholz C, Shihui F, Lum J, Amoyo AA, Larbi A, Poidinger M, Buttgereit A, Lledo PM, Greter M, Chan JKY, Amit I, Beyer M, Schultze JL, Schlitzer A, Pettersson S, Ginhoux F, Garel S.

Cell. 2018 Jan 25;172(3):500-516.e16. doi: 10.1016/j.cell.2017.11.042. Epub 2017 Dec 21.


Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2.

Sander J, Schmidt SV, Cirovic B, McGovern N, Papantonopoulou O, Hardt AL, Aschenbrenner AC, Kreer C, Quast T, Xu AM, Schmidleithner LM, Theis H, Thi Huong LD, Sumatoh HRB, Lauterbach MAR, Schulte-Schrepping J, Günther P, Xue J, Baßler K, Ulas T, Klee K, Katzmarski N, Herresthal S, Krebs W, Martin B, Latz E, Händler K, Kraut M, Kolanus W, Beyer M, Falk CS, Wiegmann B, Burgdorf S, Melosh NA, Newell EW, Ginhoux F, Schlitzer A, Schultze JL.

Immunity. 2017 Dec 19;47(6):1051-1066.e12. doi: 10.1016/j.immuni.2017.11.024.


Blood-brain barrier development: Systems modeling and predictive toxicology.

Saili KS, Zurlinden TJ, Schwab AJ, Silvin A, Baker NC, Hunter ES 3rd, Ginhoux F, Knudsen TB.

Birth Defects Res. 2017 Dec 1;109(20):1680-1710. doi: 10.1002/bdr2.1180. Review.


Constructing cell lineages from single-cell transcriptomes.

Chen J, Rénia L, Ginhoux F.

Mol Aspects Med. 2018 Feb;59:95-113. doi: 10.1016/j.mam.2017.10.004. Epub 2017 Nov 26. Review.


New beginnings.

Ginhoux F.

Nat Rev Immunol. 2017 Dec;17(12):732. doi: 10.1038/nri.2017.91. Epub 2017 Oct 30. No abstract available.


High fat diet exacerbates murine psoriatic dermatitis by increasing the number of IL-17-producing γδ T cells.

Nakamizo S, Honda T, Adachi A, Nagatake T, Kunisawa J, Kitoh A, Otsuka A, Dainichi T, Nomura T, Ginhoux F, Ikuta K, Egawa G, Kabashima K.

Sci Rep. 2017 Oct 26;7(1):14076. doi: 10.1038/s41598-017-14292-1.


Enterococcus faecalis Modulates Immune Activation and Slows Healing During Wound Infection.

Chong KKL, Tay WH, Janela B, Yong AMH, Liew TH, Madden L, Keogh D, Barkham TMS, Ginhoux F, Becker DL, Kline KA.

J Infect Dis. 2017 Dec 19;216(12):1644-1654. doi: 10.1093/infdis/jix541.


Multiplex peptide-MHC tetramer staining using mass cytometry for deep analysis of the influenza-specific T-cell response in mice.

Fehlings M, Chakarov S, Simoni Y, Sivasankar B, Ginhoux F, Newell EW.

J Immunol Methods. 2018 Feb;453:30-36. doi: 10.1016/j.jim.2017.09.010. Epub 2017 Sep 30.


Enterococcus faecalis Promotes Innate Immune Suppression and Polymicrobial Catheter-Associated Urinary Tract Infection.

Tien BYQ, Goh HMS, Chong KKL, Bhaduri-Tagore S, Holec S, Dress R, Ginhoux F, Ingersoll MA, Williams RBH, Kline KA.

Infect Immun. 2017 Nov 17;85(12). pii: e00378-17. doi: 10.1128/IAI.00378-17. Print 2017 Dec.


Cbfβ2 deficiency preserves Langerhans cell precursors by lack of selective TGFβ receptor signaling.

Tenno M, Shiroguchi K, Muroi S, Kawakami E, Koseki K, Kryukov K, Imanishi T, Ginhoux F, Taniuchi I.

J Exp Med. 2017 Oct 2;214(10):2933-2946. doi: 10.1084/jem.20170729. Epub 2017 Aug 16.


A Liver Capsular Network of Monocyte-Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment.

Sierro F, Evrard M, Rizzetto S, Melino M, Mitchell AJ, Florido M, Beattie L, Walters SB, Tay SS, Lu B, Holz LE, Roediger B, Wong YC, Warren A, Ritchie W, McGuffog C, Weninger W, Le Couteur DG, Ginhoux F, Britton WJ, Heath WR, Saunders BM, McCaughan GW, Luciani F, MacDonald KPA, Ng LG, Bowen DG, Bertolino P.

Immunity. 2017 Aug 15;47(2):374-388.e6. doi: 10.1016/j.immuni.2017.07.018.


Human lymphoid organ dendritic cell identity is predominantly dictated by ontogeny, not tissue microenvironment.

Heidkamp GF, Sander J, Lehmann CHK, Heger L, Eissing N, Baranska A, Lühr JJ, Hoffmann A, Reimer KC, Lux A, Söder S, Hartmann A, Zenk J, Ulas T, McGovern N, Alexiou C, Spriewald B, Mackensen A, Schuler G, Schauf B, Forster A, Repp R, Fasching PA, Purbojo A, Cesnjevar R, Ullrich E, Ginhoux F, Schlitzer A, Nimmerjahn F, Schultze JL, Dudziak D.

Sci Immunol. 2016 Dec 16;1(6). pii: eaai7677. doi: 10.1126/sciimmunol.aai7677. Epub 2016 Dec 16.


Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function.

Takata K, Kozaki T, Lee CZW, Thion MS, Otsuka M, Lim S, Utami KH, Fidan K, Park DS, Malleret B, Chakarov S, See P, Low D, Low G, Garcia-Miralles M, Zeng R, Zhang J, Goh CC, Gul A, Hubert S, Lee B, Chen J, Low I, Shadan NB, Lum J, Wei TS, Mok E, Kawanishi S, Kitamura Y, Larbi A, Poidinger M, Renia L, Ng LG, Wolf Y, Jung S, Önder T, Newell E, Huber T, Ashihara E, Garel S, Pouladi MA, Ginhoux F.

Immunity. 2017 Jul 18;47(1):183-198.e6. doi: 10.1016/j.immuni.2017.06.017.


Dying for a Cause: Regulated Necrosis of Tissue-Resident Macrophages upon Infection.

Ginhoux F, Bleriot C, Lecuit M.

Trends Immunol. 2017 Oct;38(10):693-695. doi: 10.1016/ Epub 2017 Jun 20. No abstract available.


Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2.

McGovern N, Shin A, Low G, Low D, Duan K, Yao LJ, Msallam R, Low I, Shadan NB, Sumatoh HR, Soon E, Lum J, Mok E, Hubert S, See P, Kunxiang EH, Lee YH, Janela B, Choolani M, Mattar CNZ, Fan Y, Lim TKH, Chan DKH, Tan KK, Tam JKC, Schuster C, Elbe-Bürger A, Wang XN, Bigley V, Collin M, Haniffa M, Schlitzer A, Poidinger M, Albani S, Larbi A, Newell EW, Chan JKY, Ginhoux F.

Nature. 2017 Jun 29;546(7660):662-666. doi: 10.1038/nature22795. Epub 2017 Jun 14.


Intrahepatic CD206+ macrophages contribute to inflammation in advanced viral-related liver disease.

Tan-Garcia A, Wai LE, Zheng D, Ceccarello E, Jo J, Banu N, Khakpoor A, Chia A, Tham CYL, Tan AT, Hong M, Keng CT, Rivino L, Tan KC, Lee KH, Lim SG, Newell EW, Pavelka N, Chen J, Ginhoux F, Chen Q, Bertoletti A, Dutertre CA.

J Hepatol. 2017 Sep;67(3):490-500. doi: 10.1016/j.jhep.2017.04.023. Epub 2017 May 5.


Mapping the human DC lineage through the integration of high-dimensional techniques.

See P, Dutertre CA, Chen J, Günther P, McGovern N, Irac SE, Gunawan M, Beyer M, Händler K, Duan K, Sumatoh HRB, Ruffin N, Jouve M, Gea-Mallorquí E, Hennekam RCM, Lim T, Yip CC, Wen M, Malleret B, Low I, Shadan NB, Fen CFS, Tay A, Lum J, Zolezzi F, Larbi A, Poidinger M, Chan JKY, Chen Q, Rénia L, Haniffa M, Benaroch P, Schlitzer A, Schultze JL, Newell EW, Ginhoux F.

Science. 2017 Jun 9;356(6342). pii: eaag3009. doi: 10.1126/science.aag3009. Epub 2017 May 4.


Cross-reactive dengue human monoclonal antibody prevents severe pathologies and death from Zika virus infections.

Kam YW, Lee CY, Teo TH, Howland SW, Amrun SN, Lum FM, See P, Kng NQ, Huber RG, Xu MH, Tan HL, Choo A, Maurer-Stroh S, Ginhoux F, Fink K, Wang CI, Ng LFP, Rénia L.

JCI Insight. 2017 Apr 20;2(8). pii: 92428. doi: 10.1172/jci.insight.92428. [Epub ahead of print]


RIG-I antiviral signaling drives interleukin-23 production and psoriasis-like skin disease.

Zhu H, Lou F, Yin Q, Gao Y, Sun Y, Bai J, Xu Z, Liu Z, Cai W, Ke F, Zhang L, Zhou H, Wang H, Wang G, Chen X, Zhang H, Wang Z, Ginhoux F, Lu C, Su B, Wang H.

EMBO Mol Med. 2017 May;9(5):589-604. doi: 10.15252/emmm.201607027.


Zika Virus Infects Human Fetal Brain Microglia and Induces Inflammation.

Lum FM, Low DK, Fan Y, Tan JJ, Lee B, Chan JK, Rénia L, Ginhoux F, Ng LF.

Clin Infect Dis. 2017 Apr 1;64(7):914-920. doi: 10.1093/cid/ciw878.


Exposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding Regulatory Lung Interstitial Macrophages.

Sabatel C, Radermecker C, Fievez L, Paulissen G, Chakarov S, Fernandes C, Olivier S, Toussaint M, Pirottin D, Xiao X, Quatresooz P, Sirard JC, Cataldo D, Gillet L, Bouabe H, Desmet CJ, Ginhoux F, Marichal T, Bureau F.

Immunity. 2017 Mar 21;46(3):457-473. doi: 10.1016/j.immuni.2017.02.016.


Intravital multiphoton imaging of mouse tibialis anterior muscle.

Lau J, Goh CC, Devi S, Keeble J, See P, Ginhoux F, Ng LG.

Intravital. 2016 Apr 8;5(2):e1156272. doi: 10.1080/21659087.2016.1156272. eCollection 2016.


Reversal of Phenotypic Abnormalities by CRISPR/Cas9-Mediated Gene Correction in Huntington Disease Patient-Derived Induced Pluripotent Stem Cells.

Xu X, Tay Y, Sim B, Yoon SI, Huang Y, Ooi J, Utami KH, Ziaei A, Ng B, Radulescu C, Low D, Ng AYJ, Loh M, Venkatesh B, Ginhoux F, Augustine GJ, Pouladi MA.

Stem Cell Reports. 2017 Mar 14;8(3):619-633. doi: 10.1016/j.stemcr.2017.01.022. Epub 2017 Feb 23.


Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency.

Simoni Y, Fehlings M, Kløverpris HN, McGovern N, Koo SL, Loh CY, Lim S, Kurioka A, Fergusson JR, Tang CL, Kam MH, Dennis K, Lim TKH, Fui ACY, Hoong CW, Chan JKY, Curotto de Lafaille M, Narayanan S, Baig S, Shabeer M, Toh SES, Tan HKK, Anicete R, Tan EH, Takano A, Klenerman P, Leslie A, Tan DSW, Tan IB, Ginhoux F, Newell EW.

Immunity. 2017 Jan 17;46(1):148-161. doi: 10.1016/j.immuni.2016.11.005. Epub 2016 Dec 13. Erratum in: Immunity. 2018 May 15;48(5):1060.


Unlocking bat immunology: establishment of Pteropus alecto bone marrow-derived dendritic cells and macrophages.

Zhou P, Chionh YT, Irac SE, Ahn M, Jia Ng JH, Fossum E, Bogen B, Ginhoux F, Irving AT, Dutertre CA, Wang LF.

Sci Rep. 2016 Dec 9;6:38597. doi: 10.1038/srep38597.


Phenotypic and functional characterization of the major lymphocyte populations in the fruit-eating bat Pteropus alecto.

Martínez Gómez JM, Periasamy P, Dutertre CA, Irving AT, Ng JH, Crameri G, Baker ML, Ginhoux F, Wang LF, Alonso S.

Sci Rep. 2016 Nov 24;6:37796. doi: 10.1038/srep37796.


CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses.

Chong SZ, Evrard M, Devi S, Chen J, Lim JY, See P, Zhang Y, Adrover JM, Lee B, Tan L, Li JL, Liong KH, Phua C, Balachander A, Boey A, Liebl D, Tan SM, Chan JK, Balabanian K, Harris JE, Bianchini M, Weber C, Duchene J, Lum J, Poidinger M, Chen Q, Rénia L, Wang CI, Larbi A, Randolph GJ, Weninger W, Looney MR, Krummel MF, Biswas SK, Ginhoux F, Hidalgo A, Bachelerie F, Ng LG.

J Exp Med. 2016 Oct 17;213(11):2293-2314. Epub 2016 Oct 10.


Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species.

Guilliams M, Dutertre CA, Scott CL, McGovern N, Sichien D, Chakarov S, Van Gassen S, Chen J, Poidinger M, De Prijck S, Tavernier SJ, Low I, Irac SE, Mattar CN, Sumatoh HR, Low GHL, Chung TJK, Chan DKH, Tan KK, Hon TLK, Fossum E, Bogen B, Choolani M, Chan JKY, Larbi A, Luche H, Henri S, Saeys Y, Newell EW, Lambrecht BN, Malissen B, Ginhoux F.

Immunity. 2016 Sep 20;45(3):669-684. doi: 10.1016/j.immuni.2016.08.015. Epub 2016 Sep 13.


Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma.

Penny HL, Sieow JL, Adriani G, Yeap WH, See Chi Ee P, San Luis B, Lee B, Lee T, Mak SY, Ho YS, Lam KP, Ong CK, Huang RY, Ginhoux F, Rotzschke O, Kamm RD, Wong SC.

Oncoimmunology. 2016 Jun 21;5(8):e1191731. doi: 10.1080/2162402X.2016.1191731. eCollection 2016 Aug.


Whole metagenome profiling reveals skin microbiome-dependent susceptibility to atopic dermatitis flare.

Chng KR, Tay AS, Li C, Ng AH, Wang J, Suri BK, Matta SA, McGovern N, Janela B, Wong XF, Sio YY, Au BV, Wilm A, De Sessions PF, Lim TC, Tang MB, Ginhoux F, Connolly JE, Lane EB, Chew FT, Common JE, Nagarajan N.

Nat Microbiol. 2016 Jul 11;1(9):16106. doi: 10.1038/nmicrobiol.2016.106.


A High-Dimensional Atlas of Human T Cell Diversity Reveals Tissue-Specific Trafficking and Cytokine Signatures.

Wong MT, Ong DE, Lim FS, Teng KW, McGovern N, Narayanan S, Ho WQ, Cerny D, Tan HK, Anicete R, Tan BK, Lim TK, Chan CY, Cheow PC, Lee SY, Takano A, Tan EH, Tam JK, Tan EY, Chan JK, Fink K, Bertoletti A, Ginhoux F, Curotto de Lafaille MA, Newell EW.

Immunity. 2016 Aug 16;45(2):442-56. doi: 10.1016/j.immuni.2016.07.007. Epub 2016 Aug 9.


Complete human CD1a deficiency on Langerhans cells due to a rare point mutation in the coding sequence.

Cerny D, Thi Le DH, The TD, Zuest R, Kg S, Velumani S, Khor CC, Mori L, Simmons CP, Poidinger M, Zolezzi F, Ginhoux F, Haniffa M, Wills B, Fink K.

J Allergy Clin Immunol. 2016 Dec;138(6):1709-1712.e11. doi: 10.1016/j.jaci.2016.05.028. Epub 2016 Jun 29. No abstract available.

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