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Items: 1 to 50 of 66

1.

Serotonin regulates mitochondrial biogenesis and function in rodent cortical neurons via the 5-HT2A receptor and SIRT1-PGC-1α axis.

Fanibunda SE, Deb S, Maniyadath B, Tiwari P, Ghai U, Gupta S, Figueiredo D, Weisstaub N, Gingrich JA, Vaidya ADB, Kolthur-Seetharam U, Vaidya VA.

Proc Natl Acad Sci U S A. 2019 May 28;116(22):11028-11037. doi: 10.1073/pnas.1821332116. Epub 2019 May 9.

2.

5-HT2C receptor blockade reverses SSRI-associated basal ganglia dysfunction and potentiates therapeutic efficacy.

Demireva EY, Suri D, Morelli E, Mahadevia D, Chuhma N, Teixeira CM, Ziolkowski A, Hersh M, Fifer J, Bagchi S, Chemiakine A, Moore H, Gingrich JA, Balsam P, Rayport S, Ansorge MS.

Mol Psychiatry. 2018 Aug 17. doi: 10.1038/s41380-018-0227-x. [Epub ahead of print]

3.

Associations Between Brain Structure and Connectivity in Infants and Exposure to Selective Serotonin Reuptake Inhibitors During Pregnancy.

Lugo-Candelas C, Cha J, Hong S, Bastidas V, Weissman M, Fifer WP, Myers M, Talati A, Bansal R, Peterson BS, Monk C, Gingrich JA, Posner J.

JAMA Pediatr. 2018 Jun 1;172(6):525-533. doi: 10.1001/jamapediatrics.2017.5227.

4.

New Insights into How Serotonin Selective Reuptake Inhibitors Shape the Developing Brain.

Gingrich JA, Malm H, Ansorge MS, Brown A, Sourander A, Suri D, Teixeira CM, Caffrey Cagliostro MK, Mahadevia D, Weissman MM.

Birth Defects Res. 2017 Jul 17;109(12):924-932. doi: 10.1002/bdr2.1085. Review.

PMID:
28714607
5.

5-HT2A receptor deficiency alters the metabolic and transcriptional, but not the behavioral, consequences of chronic unpredictable stress.

Jaggar M, Weisstaub N, Gingrich JA, Vaidya VA.

Neurobiol Stress. 2017 Jun 5;7:89-102. doi: 10.1016/j.ynstr.2017.06.001. eCollection 2017 Dec.

6.

Associations between serotonin transporter and behavioral traits and diagnoses related to anxiety.

Talati A, Odgerel Z, Wickramaratne PJ, Norcini-Pala A, Skipper JL, Gingrich JA, Weissman MM.

Psychiatry Res. 2017 Jul;253:211-219. doi: 10.1016/j.psychres.2017.03.033. Epub 2017 Mar 21.

7.

Developmental expression of mGlu2 and mGlu3 in the mouse brain.

McOmish CE, Demireva EY, Gingrich JA.

Gene Expr Patterns. 2016 Nov;22(2):46-53. doi: 10.1016/j.gep.2016.10.001. Epub 2016 Nov 4.

8.

Association of Selective Serotonin Reuptake Inhibitor Exposure During Pregnancy With Speech, Scholastic, and Motor Disorders in Offspring.

Brown AS, Gyllenberg D, Malm H, McKeague IW, Hinkka-Yli-Salomäki S, Artama M, Gissler M, Cheslack-Postava K, Weissman MM, Gingrich JA, Sourander A.

JAMA Psychiatry. 2016 Nov 1;73(11):1163-1170. doi: 10.1001/jamapsychiatry.2016.2594.

PMID:
27732704
9.

Gestational Exposure to Selective Serotonin Reuptake Inhibitors and Offspring Psychiatric Disorders: A National Register-Based Study.

Malm H, Brown AS, Gissler M, Gyllenberg D, Hinkka-Yli-Salomäki S, McKeague IW, Weissman M, Wickramaratne P, Artama M, Gingrich JA, Sourander A.

J Am Acad Child Adolesc Psychiatry. 2016 May;55(5):359-66. doi: 10.1016/j.jaac.2016.02.013. Epub 2016 Mar 3.

10.

5-HT2 Receptor Regulation of Mitochondrial Genes: Unexpected Pharmacological Effects of Agonists and Antagonists.

Harmon JL, Wills LP, McOmish CE, Demireva EY, Gingrich JA, Beeson CC, Schnellmann RG.

J Pharmacol Exp Ther. 2016 Apr;357(1):1-9. doi: 10.1124/jpet.115.228395. Epub 2016 Jan 19.

11.

Serotonin 2a Receptor and Serotonin 1a Receptor Interact Within the Medial Prefrontal Cortex During Recognition Memory in Mice.

Morici JF, Ciccia L, Malleret G, Gingrich JA, Bekinschtein P, Weisstaub NV.

Front Pharmacol. 2015 Dec 23;6:298. doi: 10.3389/fphar.2015.00298. eCollection 2015.

12.

Modulation of GABA release from the thalamic reticular nucleus by cocaine and caffeine: role of serotonin receptors.

Goitia B, Rivero-Echeto MC, Weisstaub NV, Gingrich JA, Garcia-Rill E, Bisagno V, Urbano FJ.

J Neurochem. 2016 Feb;136(3):526-35. doi: 10.1111/jnc.13398. Epub 2015 Nov 12.

13.

Genetic variants within the serotonin transporter associated with familial risk for major depression.

Talati A, Guffanti G, Odgerel Z, Ionita-Laza I, Malm H, Sourander A, Brown AS, Wickramaratne PJ, Gingrich JA, Weissman MM.

Psychiatry Res. 2015 Jul 30;228(1):170-3. doi: 10.1016/j.psychres.2015.04.015. Epub 2015 Apr 18.

14.

Postnatal day 2 to 11 constitutes a 5-HT-sensitive period impacting adult mPFC function.

Rebello TJ, Yu Q, Goodfellow NM, Caffrey Cagliostro MK, Teissier A, Morelli E, Demireva EY, Chemiakine A, Rosoklija GB, Dwork AJ, Lambe EK, Gingrich JA, Ansorge MS.

J Neurosci. 2014 Sep 10;34(37):12379-93. doi: 10.1523/JNEUROSCI.1020-13.2014.

15.

Age-related sperm DNA methylation changes are transmitted to offspring and associated with abnormal behavior and dysregulated gene expression.

Milekic MH, Xin Y, O'Donnell A, Kumar KK, Bradley-Moore M, Malaspina D, Moore H, Brunner D, Ge Y, Edwards J, Paul S, Haghighi FG, Gingrich JA.

Mol Psychiatry. 2015 Aug;20(8):995-1001. doi: 10.1038/mp.2014.84. Epub 2014 Aug 5.

PMID:
25092244
16.

Optogenetic stimulation of DAergic VTA neurons increases aggression.

Yu Q, Teixeira CM, Mahadevia D, Huang YY, Balsam D, Mann JJ, Gingrich JA, Ansorge MS.

Mol Psychiatry. 2014 Jun;19(6):635. doi: 10.1038/mp.2014.45. No abstract available.

PMID:
24847796
17.

Mice with compromised 5-HTT function lack phosphotyrosine-mediated inhibitory control over prefrontal 5-HT responses.

Goodfellow NM, Sargin D, Ansorge MS, Gingrich JA, Lambe EK.

J Neurosci. 2014 Apr 23;34(17):6107-11. doi: 10.1523/JNEUROSCI.3762-13.2014.

18.

Dopamine and serotonin signaling during two sensitive developmental periods differentially impact adult aggressive and affective behaviors in mice.

Yu Q, Teixeira CM, Mahadevia D, Huang Y, Balsam D, Mann JJ, Gingrich JA, Ansorge MS.

Mol Psychiatry. 2014 Jun;19(6):688-98. doi: 10.1038/mp.2014.10. Epub 2014 Mar 4.

19.

Clozapine-induced locomotor suppression is mediated by 5-HT2A receptors in the forebrain.

McOmish CE, Lira A, Hanks JB, Gingrich JA.

Neuropsychopharmacology. 2012 Dec;37(13):2747-55. doi: 10.1038/npp.2012.139. Epub 2012 Aug 8.

20.

Chronic 5-HT transporter blockade reduces DA signaling to elicit basal ganglia dysfunction.

Morelli E, Moore H, Rebello TJ, Gray N, Steele K, Esposito E, Gingrich JA, Ansorge MS.

J Neurosci. 2011 Nov 2;31(44):15742-50. doi: 10.1523/JNEUROSCI.2989-11.2011.

21.

Role of CpG context and content in evolutionary signatures of brain DNA methylation.

Xin Y, O'Donnell AH, Ge Y, Chanrion B, Milekic M, Rosoklija G, Stankov A, Arango V, Dwork AJ, Gingrich JA, Haghighi FG.

Epigenetics. 2011 Nov;6(11):1308-18. doi: 10.4161/epi.6.11.17876. Epub 2011 Nov 1.

22.

Stress and the baby brain.

McOmish CE, Gingrich JA.

Biol Psychiatry. 2011 Dec 1;70(11):1006-7. doi: 10.1016/j.biopsych.2011.10.011. No abstract available.

PMID:
22045037
23.

Serotonin transporter deficient mice are vulnerable to escape deficits following inescapable shocks.

Muller JM, Morelli E, Ansorge M, Gingrich JA.

Genes Brain Behav. 2011 Mar;10(2):166-75. doi: 10.1111/j.1601-183X.2010.00652.x. Epub 2010 Oct 19.

24.

Chromatin and sequence features that define the fine and gross structure of genomic methylation patterns.

Edwards JR, O'Donnell AH, Rollins RA, Peckham HE, Lee C, Milekic MH, Chanrion B, Fu Y, Su T, Hibshoosh H, Gingrich JA, Haghighi F, Nutter R, Bestor TH.

Genome Res. 2010 Jul;20(7):972-80. doi: 10.1101/gr.101535.109. Epub 2010 May 20.

25.

Dopamine release induced by atypical antipsychotics in prefrontal cortex requires 5-HT(1A) receptors but not 5-HT(2A) receptors.

Bortolozzi A, Masana M, Díaz-Mataix L, Cortés R, Scorza MC, Gingrich JA, Toth M, Artigas F.

Int J Neuropsychopharmacol. 2010 Nov;13(10):1299-314. doi: 10.1017/S146114571000009X. Epub 2010 Feb 17.

26.

Sustained neurobehavioral effects of exposure to SSRI antidepressants during development: molecular to clinical evidence.

Oberlander TF, Gingrich JA, Ansorge MS.

Clin Pharmacol Ther. 2009 Dec;86(6):672-7. doi: 10.1038/clpt.2009.201. Epub 2009 Nov 4.

27.

A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure.

Yadav VK, Oury F, Suda N, Liu ZW, Gao XB, Confavreux C, Klemenhagen KC, Tanaka KF, Gingrich JA, Guo XE, Tecott LH, Mann JJ, Hen R, Horvath TL, Karsenty G.

Cell. 2009 Sep 4;138(5):976-89. doi: 10.1016/j.cell.2009.06.051.

28.

5-HT(2A) and 5-HT(2C) receptors exert opposing effects on locomotor activity in mice.

Halberstadt AL, van der Heijden I, Ruderman MA, Risbrough VB, Gingrich JA, Geyer MA, Powell SB.

Neuropsychopharmacology. 2009 Jul;34(8):1958-67. doi: 10.1038/npp.2009.29. Epub 2009 Mar 25.

29.

Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum.

Yadav VK, Ryu JH, Suda N, Tanaka KF, Gingrich JA, Schütz G, Glorieux FH, Chiang CY, Zajac JD, Insogna KL, Mann JJ, Hen R, Ducy P, Karsenty G.

Cell. 2008 Nov 28;135(5):825-37. doi: 10.1016/j.cell.2008.09.059.

30.

Chronic reductions in serotonin transporter function prevent 5-HT1B-induced behavioral effects in mice.

Shanahan NA, Holick Pierz KA, Masten VL, Waeber C, Ansorge M, Gingrich JA, Geyer MA, Hen R, Dulawa SC.

Biol Psychiatry. 2009 Mar 1;65(5):401-8. doi: 10.1016/j.biopsych.2008.09.026. Epub 2008 Nov 14.

31.

c-Src tyrosine kinase, a critical component for 5-HT2A receptor-mediated contraction in rat aorta.

Lu R, Alioua A, Kumar Y, Kundu P, Eghbali M, Weisstaub NV, Gingrich JA, Stefani E, Toro L.

J Physiol. 2008 Aug 15;586(16):3855-69. doi: 10.1113/jphysiol.2008.153593. Epub 2008 Jul 3.

32.

Type III neuregulin-1 is required for normal sensorimotor gating, memory-related behaviors, and corticostriatal circuit components.

Chen YJ, Johnson MA, Lieberman MD, Goodchild RE, Schobel S, Lewandowski N, Rosoklija G, Liu RC, Gingrich JA, Small S, Moore H, Dwork AJ, Talmage DA, Role LW.

J Neurosci. 2008 Jul 2;28(27):6872-83. doi: 10.1523/JNEUROSCI.1815-08.2008.

33.

Identification of a serotonin/glutamate receptor complex implicated in psychosis.

González-Maeso J, Ang RL, Yuen T, Chan P, Weisstaub NV, López-Giménez JF, Zhou M, Okawa Y, Callado LF, Milligan G, Gingrich JA, Filizola M, Meana JJ, Sealfon SC.

Nature. 2008 Mar 6;452(7183):93-7. doi: 10.1038/nature06612. Epub 2008 Feb 24.

34.

Inhibition of serotonin but not norepinephrine transport during development produces delayed, persistent perturbations of emotional behaviors in mice.

Ansorge MS, Morelli E, Gingrich JA.

J Neurosci. 2008 Jan 2;28(1):199-207. doi: 10.1523/JNEUROSCI.3973-07.2008.

35.

Role of spinal serotonin 5-HT2A receptor in 2',3'-dideoxycytidine-induced neuropathic pain in the rat and the mouse.

Van Steenwinckel J, Brisorgueil MJ, Fischer J, Vergé D, Gingrich JA, Bourgoin S, Hamon M, Bernard R, Conrath M.

Pain. 2008 Jul;137(1):66-80. Epub 2007 Sep 20.

PMID:
17888573
36.

Mechanism of the 5-hydroxytryptamine 2A receptor-mediated facilitation of synaptic activity in prefrontal cortex.

Béïque JC, Imad M, Mladenovic L, Gingrich JA, Andrade R.

Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9870-5. Epub 2007 May 29.

37.

Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior.

González-Maeso J, Weisstaub NV, Zhou M, Chan P, Ivic L, Ang R, Lira A, Bradley-Moore M, Ge Y, Zhou Q, Sealfon SC, Gingrich JA.

Neuron. 2007 Feb 1;53(3):439-52.

38.

Mechanical, thermal and formalin-induced nociception is differentially altered in 5-HT1A-/-, 5-HT1B-/-, 5-HT2A-/-, 5-HT3A-/- and 5-HTT-/- knock-out male mice.

Kayser V, Elfassi IE, Aubel B, Melfort M, Julius D, Gingrich JA, Hamon M, Bourgoin S.

Pain. 2007 Aug;130(3):235-48. Epub 2007 Jan 23.

PMID:
17250964
39.

Neurodevelopmental origins of depressive disorders.

Ansorge MS, Hen R, Gingrich JA.

Curr Opin Pharmacol. 2007 Feb;7(1):8-17. Epub 2006 Dec 21. Review. Erratum in: Curr Opin Pharmacol. 2007 Apr;7(2):234.

PMID:
17188022
40.

Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice.

Weisstaub NV, Zhou M, Lira A, Lambe E, González-Maeso J, Hornung JP, Sibille E, Underwood M, Itohara S, Dauer WT, Ansorge MS, Morelli E, Mann JJ, Toth M, Aghajanian G, Sealfon SC, Hen R, Gingrich JA.

Science. 2006 Jul 28;313(5786):536-40.

41.

Oxidative stress is the new stress.

Gingrich JA.

Nat Med. 2005 Dec;11(12):1281-2. No abstract available.

PMID:
16333265
42.

Serotonergic regulation of calcium-activated potassium currents in rodent prefrontal cortex.

Villalobos C, Beique JC, Gingrich JA, Andrade R.

Eur J Neurosci. 2005 Sep;22(5):1120-6.

PMID:
16176353
43.

Targeted gene expression in dopamine and serotonin neurons of the mouse brain.

Zhuang X, Masson J, Gingrich JA, Rayport S, Hen R.

J Neurosci Methods. 2005 Apr 15;143(1):27-32. Epub 2004 Nov 24.

PMID:
15763133
44.

Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice.

Ansorge MS, Zhou M, Lira A, Hen R, Gingrich JA.

Science. 2004 Oct 29;306(5697):879-81.

45.

Late measures of brain injury after neonatal hypoxia-ischemia in mice.

Ten VS, Wu EX, Tang H, Bradley-Moore M, Fedarau MV, Ratner VI, Stark RI, Gingrich JA, Pinsky DJ.

Stroke. 2004 Sep;35(9):2183-8. Epub 2004 Jul 22.

PMID:
15272130
46.

Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice.

Lira A, Zhou M, Castanon N, Ansorge MS, Gordon JA, Francis JH, Bradley-Moore M, Lira J, Underwood MD, Arango V, Kung HF, Hofer MA, Hen R, Gingrich JA.

Biol Psychiatry. 2003 Nov 15;54(10):960-71.

PMID:
14625138
47.

Brain injury and neurofunctional deficit in neonatal mice with hypoxic-ischemic encephalopathy.

Ten VS, Bradley-Moore M, Gingrich JA, Stark RI, Pinsky DJ.

Behav Brain Res. 2003 Oct 17;145(1-2):209-19.

PMID:
14529818
48.

Transcriptome fingerprints distinguish hallucinogenic and nonhallucinogenic 5-hydroxytryptamine 2A receptor agonist effects in mouse somatosensory cortex.

González-Maeso J, Yuen T, Ebersole BJ, Wurmbach E, Lira A, Zhou M, Weisstaub N, Hen R, Gingrich JA, Sealfon SC.

J Neurosci. 2003 Oct 1;23(26):8836-43.

49.

New lessons from knockout mice: The role of serotonin during development and its possible contribution to the origins of neuropsychiatric disorders.

Gingrich JA, Ansorge MS, Merker R, Weisstaub N, Zhou M.

CNS Spectr. 2003 Aug;8(8):572-7. Review.

PMID:
12907920
50.

Sharing genes? How mice can help us understand our biology.

Gingrich JA.

CNS Spectr. 2003 Aug;8(8):571. No abstract available.

PMID:
12907919

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