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The SCRIB Paralog LANO/LRRC1 Regulates Breast Cancer Stem Cell Fate through WNT/β-Catenin Signaling.

Lopez Almeida L, Sebbagh M, Bertucci F, Finetti P, Wicinski J, Marchetto S, Castellano R, Josselin E, Charafe-Jauffret E, Ginestier C, Borg JP, Santoni MJ.

Stem Cell Reports. 2018 Nov 13;11(5):1040-1050. doi: 10.1016/j.stemcr.2018.09.008. Epub 2018 Oct 18.


Development of parallel reaction monitoring (PRM)-based quantitative proteomics applied to HER2-Positive breast cancer.

Guerin M, Gonçalves A, Toiron Y, Baudelet E, Pophillat M, Granjeaud S, Fourquet P, Jacot W, Tarpin C, Sabatier R, Agavnian E, Finetti P, Adelaide J, Birnbaum D, Ginestier C, Charafe-Jauffret E, Viens P, Bertucci F, Borg JP, Camoin L.

Oncotarget. 2018 Sep 18;9(73):33762-33777. doi: 10.18632/oncotarget.26031. eCollection 2018 Sep 18.


[Cancer stem cells: Definition and isolation techniques].

Ginestier C.

Bull Cancer. 2017 Dec;104(12):1060-1063. doi: 10.1016/j.bulcan.2017.10.009. Epub 2017 Nov 21. French. No abstract available.


HTS-Net: An integrated regulome-interactome approach for establishing network regulation models in high-throughput screenings.

Rioualen C, Da Costa Q, Chetrit B, Charafe-Jauffret E, Ginestier C, Bidaut G.

PLoS One. 2017 Sep 26;12(9):e0185400. doi: 10.1371/journal.pone.0185400. eCollection 2017.


Salinomycin kills cancer stem cells by sequestering iron in lysosomes.

Mai TT, Hamaï A, Hienzsch A, Cañeque T, Müller S, Wicinski J, Cabaud O, Leroy C, David A, Acevedo V, Ryo A, Ginestier C, Birnbaum D, Charafe-Jauffret E, Codogno P, Mehrpour M, Rodriguez R.

Nat Chem. 2017 Oct;9(10):1025-1033. doi: 10.1038/nchem.2778. Epub 2017 May 16.


Flick the cancer stem cells' switch to turn cancer off.

Ginestier C, Birnbaum D, Charafe-Jauffret E.

Mol Cell Oncol. 2017 Apr 28;4(4):e1319896. doi: 10.1080/23723556.2017.1319896. eCollection 2017.


An iron hand over cancer stem cells.

Hamaï A, Cañeque T, Müller S, Mai TT, Hienzsch A, Ginestier C, Charafe-Jauffret E, Codogno P, Mehrpour M, Rodriguez R.

Autophagy. 2017 Aug 3;13(8):1465-1466. doi: 10.1080/15548627.2017.1327104. Epub 2017 Jun 14.


A stemness-related ZEB1-MSRB3 axis governs cellular pliancy and breast cancer genome stability.

Morel AP, Ginestier C, Pommier RM, Cabaud O, Ruiz E, Wicinski J, Devouassoux-Shisheboran M, Combaret V, Finetti P, Chassot C, Pinatel C, Fauvet F, Saintigny P, Thomas E, Moyret-Lalle C, Lachuer J, Despras E, Jauffret JL, Bertucci F, Guitton J, Wierinckx A, Wang Q, Radosevic-Robin N, Penault-Llorca F, Cox DG, Hollande F, Ansieau S, Caramel J, Birnbaum D, Vigneron AM, Tissier A, Charafe-Jauffret E, Puisieux A.

Nat Med. 2017 May;23(5):568-578. doi: 10.1038/nm.4323. Epub 2017 Apr 10.


miR-600 Acts as a Bimodal Switch that Regulates Breast Cancer Stem Cell Fate through WNT Signaling.

El Helou R, Pinna G, Cabaud O, Wicinski J, Bhajun R, Guyon L, Rioualen C, Finetti P, Gros A, Mari B, Barbry P, Bertucci F, Bidaut G, Harel-Bellan A, Birnbaum D, Charafe-Jauffret E, Ginestier C.

Cell Rep. 2017 Feb 28;18(9):2256-2268. doi: 10.1016/j.celrep.2017.02.016.


Nectin-4: a new prognostic biomarker for efficient therapeutic targeting of primary and metastatic triple-negative breast cancer.

M-Rabet M, Cabaud O, Josselin E, Finetti P, Castellano R, Farina A, Agavnian-Couquiaud E, Saviane G, Collette Y, Viens P, Gonçalves A, Ginestier C, Charafe-Jauffret E, Birnbaum D, Olive D, Bertucci F, Lopez M.

Ann Oncol. 2017 Apr 1;28(4):769-776. doi: 10.1093/annonc/mdw678.


Targeted NGS, array-CGH, and patient-derived tumor xenografts for precision medicine in advanced breast cancer: a single-center prospective study.

Gonçalves A, Bertucci F, Guille A, Garnier S, Adelaide J, Carbuccia N, Cabaud O, Finetti P, Brunelle S, Piana G, Tomassin-Piana J, Paciencia M, Lambaudie E, Popovici C, Sabatier R, Tarpin C, Provansal M, Extra JM, Eisinger F, Sobol H, Viens P, Lopez M, Ginestier C, Charafe-Jauffret E, Chaffanet M, Birnbaum D.

Oncotarget. 2016 Nov 29;7(48):79428-79441. doi: 10.18632/oncotarget.12714.


Pregnane X-receptor promotes stem cell-mediated colon cancer relapse.

Planque C, Rajabi F, Grillet F, Finetti P, Bertucci F, Gironella M, Lozano JJ, Beucher B, Giraud J, Garambois V, Vincent C, Brown D, Caillo L, Kantar J, Pelegrin A, Prudhomme M, Ripoche J, Bourgaux JF, Ginestier C, Castells A, Hollande F, Pannequin J, Pascussi JM.

Oncotarget. 2016 Aug 30;7(35):56558-56573. doi: 10.18632/oncotarget.10646.


Breast cancer stem cells programs: enter the (non)-code.

Salvador MA, Birnbaum D, Charafe-Jauffret E, Ginestier C.

Brief Funct Genomics. 2016 May;15(3):186-99. doi: 10.1093/bfgp/elw003. Epub 2016 Mar 8. Review.


Depleting MET-Expressing Tumor Cells by ADCC Provides a Therapeutic Advantage over Inhibiting HGF/MET Signaling.

Hultberg A, Morello V, Huyghe L, De Jonge N, Blanchetot C, Hanssens V, De Boeck G, Silence K, Festjens E, Heukers R, Roux B, Lamballe F, Ginestier C, Charafe-Jauffret E, Maina F, Brouckaert P, Saunders M, Thibault A, Dreier T, de Haard H, Michieli P.

Cancer Res. 2015 Aug 15;75(16):3373-83. doi: 10.1158/0008-5472.CAN-15-0356. Epub 2015 Jul 3.


Role of microRNA221 in regulating normal mammary epithelial hierarchy and breast cancer stem-like cells.

Ke J, Zhao Z, Hong SH, Bai S, He Z, Malik F, Xu J, Zhou L, Chen W, Martin-Trevino R, Wu X, Lan P, Yi Y, Ginestier C, Ibarra I, Shang L, McDermott S, Luther T, Clouthier SG, Wicha MS, Liu S.

Oncotarget. 2015 Feb 28;6(6):3709-21.


MicroRNA100 inhibits self-renewal of breast cancer stem-like cells and breast tumor development.

Deng L, Shang L, Bai S, Chen J, He X, Martin-Trevino R, Chen S, Li XY, Meng X, Yu B, Wang X, Liu Y, McDermott SP, Ariazi AE, Ginestier C, Ibarra I, Ke J, Luther T, Clouthier SG, Xu L, Shan G, Song E, Yao H, Hannon GJ, Weiss SJ, Wicha MS, Liu S.

Cancer Res. 2014 Nov 15;74(22):6648-60. doi: 10.1158/0008-5472.CAN-13-3710. Epub 2014 Sep 12.


Poly(ADP-ribose) polymerase 1 (PARP1) overexpression in human breast cancer stem cells and resistance to olaparib.

Gilabert M, Launay S, Ginestier C, Bertucci F, Audebert S, Pophillat M, Toiron Y, Baudelet E, Finetti P, Noguchi T, Sobol H, Birnbaum D, Borg JP, Charafe-Jauffret E, Gonçalves A.

PLoS One. 2014 Aug 21;9(8):e104302. doi: 10.1371/journal.pone.0104302. eCollection 2014.


Brief reports: A distinct DNA methylation signature defines breast cancer stem cells and predicts cancer outcome.

El Helou R, Wicinski J, Guille A, Adélaïde J, Finetti P, Bertucci F, Chaffanet M, Birnbaum D, Charafe-Jauffret E, Ginestier C.

Stem Cells. 2014 Nov;32(11):3031-6. doi: 10.1002/stem.1792.


Growth hormone is secreted by normal breast epithelium upon progesterone stimulation and increases proliferation of stem/progenitor cells.

Lombardi S, Honeth G, Ginestier C, Shinomiya I, Marlow R, Buchupalli B, Gazinska P, Brown J, Catchpole S, Liu S, Barkan A, Wicha M, Purushotham A, Burchell J, Pinder S, Dontu G.

Stem Cell Reports. 2014 Jun 3;2(6):780-93. doi: 10.1016/j.stemcr.2014.05.005. eCollection 2014 Jun 3.


Aldehyde dehydrogenase and estrogen receptor define a hierarchy of cellular differentiation in the normal human mammary epithelium.

Honeth G, Lombardi S, Ginestier C, Hur M, Marlow R, Buchupalli B, Shinomiya I, Gazinska P, Bombelli S, Ramalingam V, Purushotham AD, Pinder SE, Dontu G.

Breast Cancer Res. 2014 May 27;16(3):R52. doi: 10.1186/bcr3663.


Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts.

Liu S, Cong Y, Wang D, Sun Y, Deng L, Liu Y, Martin-Trevino R, Shang L, McDermott SP, Landis MD, Hong S, Adams A, D'Angelo R, Ginestier C, Charafe-Jauffret E, Clouthier SG, Birnbaum D, Wong ST, Zhan M, Chang JC, Wicha MS.

Stem Cell Reports. 2013 Dec 27;2(1):78-91. doi: 10.1016/j.stemcr.2013.11.009. eCollection 2014 Jan 14.


ALDH1-positive cancer stem cells predict engraftment of primary breast tumors and are governed by a common stem cell program.

Charafe-Jauffret E, Ginestier C, Bertucci F, Cabaud O, Wicinski J, Finetti P, Josselin E, Adelaide J, Nguyen TT, Monville F, Jacquemier J, Thomassin-Piana J, Pinna G, Jalaguier A, Lambaudie E, Houvenaeghel G, Xerri L, Harel-Bellan A, Chaffanet M, Viens P, Birnbaum D.

Cancer Res. 2013 Dec 15;73(24):7290-300. doi: 10.1158/0008-5472.CAN-12-4704. Epub 2013 Oct 18.


The histone deacetylase inhibitor abexinostat induces cancer stem cells differentiation in breast cancer with low Xist expression.

Salvador MA, Wicinski J, Cabaud O, Toiron Y, Finetti P, Josselin E, Lelièvre H, Kraus-Berthier L, Depil S, Bertucci F, Collette Y, Birnbaum D, Charafe-Jauffret E, Ginestier C.

Clin Cancer Res. 2013 Dec 1;19(23):6520-31. doi: 10.1158/1078-0432.CCR-13-0877. Epub 2013 Oct 18.


[Molecular entities of the breast cancer: the difference is in the origin].

Charafe-Jauffret E, Ginestier C.

Ann Pathol. 2012 Nov;32(5 Suppl):S35-6. doi: 10.1016/j.annpat.2012.09.008. Epub 2012 Oct 12. French. No abstract available.


p53 and cancer stem cells: the mevalonate connexion.

Ginestier C, Charafe-Jauffret E, Birnbaum D.

Cell Cycle. 2012 Jul 15;11(14):2583-4. doi: 10.4161/cc.21092. Epub 2012 Jul 15. No abstract available.


MicroRNA93 regulates proliferation and differentiation of normal and malignant breast stem cells.

Liu S, Patel SH, Ginestier C, Ibarra I, Martin-Trevino R, Bai S, McDermott SP, Shang L, Ke J, Ou SJ, Heath A, Zhang KJ, Korkaya H, Clouthier SG, Charafe-Jauffret E, Birnbaum D, Hannon GJ, Wicha MS.

PLoS Genet. 2012;8(6):e1002751. doi: 10.1371/journal.pgen.1002751. Epub 2012 Jun 7.


Mevalonate metabolism regulates Basal breast cancer stem cells and is a potential therapeutic target.

Ginestier C, Monville F, Wicinski J, Cabaud O, Cervera N, Josselin E, Finetti P, Guille A, Larderet G, Viens P, Sebti S, Bertucci F, Birnbaum D, Charafe-Jauffret E.

Stem Cells. 2012 Jul;30(7):1327-37. doi: 10.1002/stem.1122.


Cancer stem cell vaccination confers significant antitumor immunity.

Ning N, Pan Q, Zheng F, Teitz-Tennenbaum S, Egenti M, Yet J, Li M, Ginestier C, Wicha MS, Moyer JS, Prince ME, Xu Y, Zhang XL, Huang S, Chang AE, Li Q.

Cancer Res. 2012 Apr 1;72(7):1853-64. doi: 10.1158/0008-5472.CAN-11-1400.


What drives breast cancer heterogeneity: oncogenic events or cell of origin?

Ginestier C, Charafe-Jauffret E, Birnbaum D.

J Pathol. 2012 Jul;227(3):267-9. doi: 10.1002/path.4028. Epub 2012 May 8.


Breast tumor microenvironment: in the eye of the cytokine storm.

Ginestier C, Charafe-Jauffret E, Birnbaum D.

Cell Cycle. 2011 Aug 1;10(15):2420-1. Epub 2011 Aug 1. No abstract available.


[ZNF703: a novel oncogene involved in breast cancer].

Ginestier C, Sircoulomb F, Charafe-Jauffret E, Chaffanet M, Birnbaum D.

Med Sci (Paris). 2011 Apr;27(4):357-9. doi: 10.1051/medsci/2011274008. Epub 2011 Apr 28. French. No abstract available.


Aldehyde dehydrogenase in combination with CD133 defines angiogenic ovarian cancer stem cells that portend poor patient survival.

Silva IA, Bai S, McLean K, Yang K, Griffith K, Thomas D, Ginestier C, Johnston C, Kueck A, Reynolds RK, Wicha MS, Buckanovich RJ.

Cancer Res. 2011 Jun 1;71(11):3991-4001. doi: 10.1158/0008-5472.CAN-10-3175. Epub 2011 Apr 15.


ZNF703 gene amplification at 8p12 specifies luminal B breast cancer.

Sircoulomb F, Nicolas N, Ferrari A, Finetti P, Bekhouche I, Rousselet E, Lonigro A, Adélaïde J, Baudelet E, Esteyriès S, Wicinski J, Audebert S, Charafe-Jauffret E, Jacquemier J, Lopez M, Borg JP, Sotiriou C, Popovici C, Bertucci F, Birnbaum D, Chaffanet M, Ginestier C.

EMBO Mol Med. 2011 Mar;3(3):153-66. doi: 10.1002/emmm.201100121. Epub 2011 Feb 15. Erratum in: EMBO Mol Med. 2011 Mar;3(3). doi:10.1002/emmm.201000121.


Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks.

Liu S, Ginestier C, Ou SJ, Clouthier SG, Patel SH, Monville F, Korkaya H, Heath A, Dutcher J, Kleer CG, Jung Y, Dontu G, Taichman R, Wicha MS.

Cancer Res. 2011 Jan 15;71(2):614-24. doi: 10.1158/0008-5472.CAN-10-0538. Epub 2011 Jan 11. Erratum in: Cancer Res. 2011 Mar 15;71(6):2407.


Targeting breast cancer stem cells: fishing season open!

Ginestier C, Charafe-Jauffret E, Birnbaum D.

Breast Cancer Res. 2010;12(5):312. doi: 10.1186/bcr2636. Epub 2010 Sep 21.


Cancer stem cells: just sign here!

Charafe-Jauffret E, Ginestier C, Birnbaum D.

Cell Cycle. 2010 Jan 15;9(2):229-30. Epub 2010 Jan 15. No abstract available.


CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts.

Ginestier C, Liu S, Diebel ME, Korkaya H, Luo M, Brown M, Wicinski J, Cabaud O, Charafe-Jauffret E, Birnbaum D, Guan JL, Dontu G, Wicha MS.

J Clin Invest. 2010 Feb;120(2):485-97. doi: 10.1172/JCI39397. Epub 2010 Jan 4.


Aldehyde dehydrogenase 1-positive cancer stem cells mediate metastasis and poor clinical outcome in inflammatory breast cancer.

Charafe-Jauffret E, Ginestier C, Iovino F, Tarpin C, Diebel M, Esterni B, Houvenaeghel G, Extra JM, Bertucci F, Jacquemier J, Xerri L, Dontu G, Stassi G, Xiao Y, Barsky SH, Birnbaum D, Viens P, Wicha MS.

Clin Cancer Res. 2010 Jan 1;16(1):45-55. doi: 10.1158/1078-0432.CCR-09-1630. Epub 2009 Dec 22.


Targeting breast stem cells with the cancer preventive compounds curcumin and piperine.

Kakarala M, Brenner DE, Korkaya H, Cheng C, Tazi K, Ginestier C, Liu S, Dontu G, Wicha MS.

Breast Cancer Res Treat. 2010 Aug;122(3):777-85. doi: 10.1007/s10549-009-0612-x. Epub 2009 Nov 7.


Retinoid signaling regulates breast cancer stem cell differentiation.

Ginestier C, Wicinski J, Cervera N, Monville F, Finetti P, Bertucci F, Wicha MS, Birnbaum D, Charafe-Jauffret E.

Cell Cycle. 2009 Oct 15;8(20):3297-302. Epub 2009 Oct 10.


Getting to the root of BRCA1-deficient breast cancer.

Ginestier C, Liu S, Wicha MS.

Cell Stem Cell. 2009 Sep 4;5(3):229-30. doi: 10.1016/j.stem.2009.08.007.


Breast cancer stem cells: tools and models to rely on.

Charafe-Jauffret E, Ginestier C, Birnbaum D.

BMC Cancer. 2009 Jun 25;9:202. doi: 10.1186/1471-2407-9-202. Review.


Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling.

Korkaya H, Paulson A, Charafe-Jauffret E, Ginestier C, Brown M, Dutcher J, Clouthier SG, Wicha MS.

PLoS Biol. 2009 Jun 2;7(6):e1000121. doi: 10.1371/journal.pbio.1000121. Epub 2009 Jun 2.


Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis.

Huang EH, Hynes MJ, Zhang T, Ginestier C, Dontu G, Appelman H, Fields JZ, Wicha MS, Boman BM.

Cancer Res. 2009 Apr 15;69(8):3382-9. doi: 10.1158/0008-5472.CAN-08-4418. Epub 2009 Mar 31.


Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature.

Charafe-Jauffret E, Ginestier C, Iovino F, Wicinski J, Cervera N, Finetti P, Hur MH, Diebel ME, Monville F, Dutcher J, Brown M, Viens P, Xerri L, Bertucci F, Stassi G, Dontu G, Birnbaum D, Wicha MS.

Cancer Res. 2009 Feb 15;69(4):1302-13. doi: 10.1158/0008-5472.CAN-08-2741. Epub 2009 Feb 3.


[Stem cells and epithelial cancers: the example of breast cancer].

Charafe-Jauffret E, Ginestier C, Monville F, Wicinski J, Bertucci F, Viens P, Xerri L, Cabaud O, Dontu G, Wicha MS, Birnbaum D.

Ann Pathol. 2008 Nov;28 Spec No 1(1):S30-2. doi: 10.1016/j.annpat.2008.09.005. Epub 2008 Oct 17. French. No abstract available.


Cancer stem cells in breast: current opinion and future challenges.

Charafe-Jauffret E, Monville F, Ginestier C, Dontu G, Birnbaum D, Wicha MS.

Pathobiology. 2008;75(2):75-84. doi: 10.1159/000123845. Epub 2008 Jun 10. Review.


ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome.

Ginestier C, Hur MH, Charafe-Jauffret E, Monville F, Dutcher J, Brown M, Jacquemier J, Viens P, Kleer CG, Liu S, Schott A, Hayes D, Birnbaum D, Wicha MS, Dontu G.

Cell Stem Cell. 2007 Nov;1(5):555-67. doi: 10.1016/j.stem.2007.08.014.


BRCA1 regulates human mammary stem/progenitor cell fate.

Liu S, Ginestier C, Charafe-Jauffret E, Foco H, Kleer CG, Merajver SD, Dontu G, Wicha MS.

Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1680-5. doi: 10.1073/pnas.0711613105. Epub 2008 Jan 29.


[The cancer stem cell: the breast cancer driver].

Ginestier C, Korkaya H, Dontu G, Birnbaum D, Wicha MS, Charafe-Jauffret E.

Med Sci (Paris). 2007 Dec;23(12):1133-9. Review. French.

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