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Items: 1 to 50 of 67

1.

Disruption of the MBD2-NuRD complex but not MBD3-NuRD induces high level HbF expression in human adult erythroid cells.

Yu X, Azzo A, Bilinovich SM, Li X, Dozmorov M, Kurita R, Nakamura Y, Williams DC Jr, Ginder GD.

Haematologica. 2019 Dec;104(12):2361-2371. doi: 10.3324/haematol.2018.210963. Epub 2019 Apr 19.

2.

Corrigendum to "Readers of DNA methylation, the MBD family as potential therapeutic targets" [Pharmacology & Therapeutics 184 (1) (2018) 98-111].

Ginder GD, Williams DC Jr.

Pharmacol Ther. 2018 Oct;190:237-238. doi: 10.1016/j.pharmthera.2018.09.006. No abstract available.

PMID:
30268235
3.

Readers of DNA methylation, the MBD family as potential therapeutic targets.

Ginder GD, Williams DC Jr.

Pharmacol Ther. 2018 Apr;184:98-111. doi: 10.1016/j.pharmthera.2017.11.002. Epub 2017 Nov 8. Review. Erratum in: Pharmacol Ther. 2018 Oct;190:237-238.

4.

In Vitro Erythroid Differentiation and Lentiviral Knockdown in Human CD34+ Cells from Umbilical Cord Blood.

Kovilakath A, Mohamad S, Hermes F, Wang SZ, Ginder GD, Lloyd JA.

Methods Mol Biol. 2018;1698:259-274. doi: 10.1007/978-1-4939-7428-3_16.

PMID:
29076096
5.

Depletion of the chromatin remodeler CHD4 sensitizes AML blasts to genotoxic agents and reduces tumor formation.

Sperlazza J, Rahmani M, Beckta J, Aust M, Hawkins E, Wang SZ, Zu Zhu S, Podder S, Dumur C, Archer K, Grant S, Ginder GD.

Blood. 2015 Sep 17;126(12):1462-72. doi: 10.1182/blood-2015-03-631606. Epub 2015 Aug 11.

6.

An intrinsically disordered region of methyl-CpG binding domain protein 2 (MBD2) recruits the histone deacetylase core of the NuRD complex.

Desai MA, Webb HD, Sinanan LM, Scarsdale JN, Walavalkar NM, Ginder GD, Williams DC Jr.

Nucleic Acids Res. 2015 Mar 31;43(6):3100-13. doi: 10.1093/nar/gkv168. Epub 2015 Mar 9.

7.

Epigenetic regulation of fetal globin gene expression in adult erythroid cells.

Ginder GD.

Transl Res. 2015 Jan;165(1):115-25. doi: 10.1016/j.trsl.2014.05.002. Epub 2014 May 11. Review.

8.

Probing the dynamic distribution of bound states for methylcytosine-binding domains on DNA.

Cramer JM, Scarsdale JN, Walavalkar NM, Buchwald WA, Ginder GD, Williams DC Jr.

J Biol Chem. 2014 Jan 17;289(3):1294-302. doi: 10.1074/jbc.M113.512236. Epub 2013 Dec 4.

9.

Mi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cells.

Amaya M, Desai M, Gnanapragasam MN, Wang SZ, Zu Zhu S, Williams DC Jr, Ginder GD.

Blood. 2013 Apr 25;121(17):3493-501. doi: 10.1182/blood-2012-11-466227. Epub 2013 Feb 26.

10.

Methyl-binding domain protein 2-dependent proliferation and survival of breast cancer cells.

Mian OY, Wang SZ, Zhu SZ, Gnanapragasam MN, Graham L, Bear HD, Ginder GD.

Mol Cancer Res. 2011 Aug;9(8):1152-62. doi: 10.1158/1541-7786.MCR-11-0252. Epub 2011 Jun 21.

11.

Solution structure and dynamic analysis of chicken MBD2 methyl binding domain bound to a target-methylated DNA sequence.

Scarsdale JN, Webb HD, Ginder GD, Williams DC Jr.

Nucleic Acids Res. 2011 Aug;39(15):6741-52. doi: 10.1093/nar/gkr262. Epub 2011 Apr 29.

12.

p66Alpha-MBD2 coiled-coil interaction and recruitment of Mi-2 are critical for globin gene silencing by the MBD2-NuRD complex.

Gnanapragasam MN, Scarsdale JN, Amaya ML, Webb HD, Desai MA, Walavalkar NM, Wang SZ, Zu Zhu S, Ginder GD, Williams DC Jr.

Proc Natl Acad Sci U S A. 2011 May 3;108(18):7487-92. doi: 10.1073/pnas.1015341108. Epub 2011 Apr 13.

13.

Acute myeloid leukemia: how the uninsured fare.

Bradley CJ, Dahman B, Jin Y, Shickle LM, Ginder GD.

Cancer. 2011 Oct 15;117(20):4772-8. doi: 10.1002/cncr.26095. Epub 2011 Mar 31.

14.

MBD2 contributes to developmental silencing of the human ε-globin gene.

Rupon JW, Wang SZ, Gnanapragasam M, Labropoulos S, Ginder GD.

Blood Cells Mol Dis. 2011 Mar 15;46(3):212-9. doi: 10.1016/j.bcmd.2011.01.001. Epub 2011 Feb 4.

15.

EV(I1)olution of AML DNA methylation.

Ginder GD.

Blood. 2011 Jan 6;117(1):4-5. doi: 10.1182/blood-2010-10-311720. No abstract available.

PMID:
21212288
16.

The role of the epigenetic signal, DNA methylation, in gene regulation during erythroid development.

Ginder GD, Gnanapragasam MN, Mian OY.

Curr Top Dev Biol. 2008;82:85-116. doi: 10.1016/S0070-2153(07)00004-X. Review.

PMID:
18282518
17.

Differential IFN-gamma stimulation of HLA-A gene expression through CRM-1-dependent nuclear RNA export.

Browne SK, Roesser JR, Zhu SZ, Ginder GD.

J Immunol. 2006 Dec 15;177(12):8612-9.

18.

MBD2 is a critical component of a methyl cytosine-binding protein complex isolated from primary erythroid cells.

Kransdorf EP, Wang SZ, Zhu SZ, Langston TB, Rupon JW, Ginder GD.

Blood. 2006 Oct 15;108(8):2836-45. Epub 2006 Jun 15.

19.

Methyl binding domain protein 2 mediates gamma-globin gene silencing in adult human betaYAC transgenic mice.

Rupon JW, Wang SZ, Gaensler K, Lloyd J, Ginder GD.

Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6617-22. Epub 2006 Apr 11.

20.

A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element.

Zhang P, Basu P, Redmond LC, Morris PE, Rupon JW, Ginder GD, Lloyd JA.

Blood Cells Mol Dis. 2005 Sep-Oct;35(2):227-35.

PMID:
16023392
21.

Evolutionary conservation of KLF transcription factors and functional conservation of human gamma-globin gene regulation in chicken.

Basu P, Sargent TG, Redmond LC, Aisenberg JC, Kransdorf EP, Wang SZ, Ginder GD, Lloyd JA.

Genomics. 2004 Aug;84(2):311-9.

PMID:
15233995
22.

A GATA factor mediates cell type-restricted induction of HLA-E gene transcription by gamma interferon.

Barrett DM, Gustafson KS, Wang J, Wang SZ, Ginder GD.

Mol Cell Biol. 2004 Jul;24(14):6194-204.

24.

A 3'-transcribed region of the HLA-A2 gene mediates posttranscriptional stimulation by IFN-gamma.

Snyder SR, Waring JF, Zhu SZ, Kaplan S, Schultz J, Ginder GD.

J Immunol. 2001 Mar 15;166(6):3966-74.

25.
26.

Modulation of the connexin26 tumor suppressor gene expression through methylation in human mammary epithelial cell lines.

Singal R, Tu ZJ, Vanwert JM, Ginder GD, Kiang DT.

Anticancer Res. 2000 Jan-Feb;20(1A):59-64.

PMID:
10769635
27.

Amelioration of retroviral vector silencing in locus control region beta-globin-transgenic mice and transduced F9 embryonic cells.

Osborne CS, Pasceri P, Singal R, Sukonnik T, Ginder GD, Ellis J.

J Virol. 1999 Jul;73(7):5490-6.

28.

DNA methylation.

Singal R, Ginder GD.

Blood. 1999 Jun 15;93(12):4059-70. Review. No abstract available.

PMID:
10361102
29.

Elimination of transfusions through induction of fetal hemoglobin synthesis in Cooley's anemia.

Olivieri NF, Rees DC, Ginder GD, Thein SL, Waye JS, Chang L, Brittenham GM, Weatherall DJ.

Ann N Y Acad Sci. 1998 Jun 30;850:100-9.

PMID:
9668532
30.

Silencing and activation of embryonic globin gene expression.

Ginder GD, Singal R, Little JA, Dempsey N, Ferris R, Wang SZ.

Ann N Y Acad Sci. 1998 Jun 30;850:70-9. Review.

PMID:
9668529
31.

Methylation of the minimal promoter of an embryonic globin gene silences transcription in primary erythroid cells.

Singal R, Ferris R, Little JA, Wang SZ, Ginder GD.

Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13724-9.

32.

Treatment of thalassaemia major with phenylbutyrate and hydroxyurea.

Olivieri NF, Rees DC, Ginder GD, Thein SL, Brittenham GM, Waye JS, Weatherall DJ.

Lancet. 1997 Aug 16;350(9076):491-2. No abstract available.

PMID:
9274590
33.

Impact of technology change and managed care on medical oncology.

Ginder GD, Kennedy BJ.

J Cancer Educ. 1997 Summer;12(2):73-6. No abstract available.

PMID:
9229268
35.
36.

Extended therapy with intravenous arginine butyrate in patients with beta-hemoglobinopathies.

Sher GD, Ginder GD, Little J, Yang S, Dover GJ, Olivieri NF.

N Engl J Med. 1995 Jun 15;332(24):1606-10.

37.
38.

Metabolic persistence of fetal hemoglobin.

Little JA, Dempsey NJ, Tuchman M, Ginder GD.

Blood. 1995 Apr 1;85(7):1712-8.

PMID:
7535584
39.

Butyrate derivatives. New agents for stimulating fetal globin production in the beta-globin disorders.

Perrine SP, Olivieri NF, Faller DV, Vichinsky EP, Dover GJ, Ginder GD.

Am J Pediatr Hematol Oncol. 1994 Feb;16(1):67-71.

PMID:
7508690
40.

Stimulation of MHC class I transcription by interferon-gamma involves a non-A, non-C kinase in addition to protein kinase C.

Radford JE Jr, Waring JF, Pohlman JK, Ginder GD.

J Interferon Res. 1993 Apr;13(2):133-41.

PMID:
8099599
41.

Only the HLA class I gene minimal promoter elements are required for transactivation by human cytomegalovirus immediate early genes.

Burns LJ, Waring JF, Reuter JJ, Stinski MF, Ginder GD.

Blood. 1993 Mar 15;81(6):1558-66.

PMID:
8384027
42.

A short-term trial of butyrate to stimulate fetal-globin-gene expression in the beta-globin disorders.

Perrine SP, Ginder GD, Faller DV, Dover GH, Ikuta T, Witkowska HE, Cai SP, Vichinsky EP, Olivieri NF.

N Engl J Med. 1993 Jan 14;328(2):81-6.

43.

5'-flanking sequences mediate butyrate stimulation of embryonic globin gene expression in adult erythroid cells.

Glauber JG, Wandersee NJ, Little JA, Ginder GD.

Mol Cell Biol. 1991 Sep;11(9):4690-7.

44.

Cell-type specificity of interferon-gamma-mediated HLA class I gene transcription in human hematopoietic tumor cells.

Radford JE Jr, Chen E, Hromas R, Ginder GD.

Blood. 1991 May 1;77(9):2008-15.

PMID:
1902124
45.

BVAC ablative chemotherapy followed by autologous bone marrow transplantation for patients with advanced lymphoma.

Gingrich RD, Ginder GD, Burns LJ, Wen BC, Fyfe MA.

Blood. 1990 Jun 15;75(12):2276-81.

PMID:
2350574
46.

A nuclear matrix protein binds very tightly to DNA in the avian beta-globin gene enhancer.

Zenk DW, Ginder GD, Brotherton TW.

Biochemistry. 1990 Jun 5;29(22):5221-6.

PMID:
2383542
47.
48.

Heparin binds to intact mononucleosomes and induces a novel unfolded structure.

Brotherton TW, Jagannadham MV, Ginder GD.

Biochemistry. 1989 Apr 18;28(8):3518-25.

PMID:
2742851
49.

Nuclear matrix attachment regions of the chicken beta-type globin gene cluster.

Bennett JP, Brotherton TW, Ginder GD.

Prog Clin Biol Res. 1989;316B:47-55. No abstract available.

PMID:
2616580
50.

Topoisomerase II activity is not involved in the maintenance of active beta-globin chromatin structure in avian reticulocytes.

Brotherton TW, Zenk DW, Bennett JP, Ginder GD.

Prog Clin Biol Res. 1989;316B:57-67. No abstract available.

PMID:
2559411

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