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Items: 1 to 50 of 146

1.

Survival Outcomes of Patients with Clinical Stage III Melanoma in the Era of Novel Systemic Therapies.

Song Y, Tieniber AD, Gimotty PA, Mitchell TC, Amaravadi RK, Schuchter LM, Fraker DL, Karakousis GC.

Ann Surg Oncol. 2019 Jul 3. doi: 10.1245/s10434-019-07599-y. [Epub ahead of print]

PMID:
31270717
2.

The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice.

Engle DD, Tiriac H, Rivera KD, Pommier A, Whalen S, Oni TE, Alagesan B, Lee EJ, Yao MA, Lucito MS, Spielman B, Da Silva B, Schoepfer C, Wright K, Creighton B, Afinowicz L, Yu KH, Grützmann R, Aust D, Gimotty PA, Pollard KS, Hruban RH, Goggins MG, Pilarsky C, Park Y, Pappin DJ, Hollingsworth MA, Tuveson DA.

Science. 2019 Jun 21;364(6446):1156-1162. doi: 10.1126/science.aaw3145.

PMID:
31221853
3.

Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors.

Dangaj D, Bruand M, Grimm AJ, Ronet C, Barras D, Duttagupta PA, Lanitis E, Duraiswamy J, Tanyi JL, Benencia F, Conejo-Garcia J, Ramay HR, Montone KT, Powell DJ Jr, Gimotty PA, Facciabene A, Jackson DG, Weber JS, Rodig SJ, Hodi SF, Kandalaft LE, Irving M, Zhang L, Foukas P, Rusakiewicz S, Delorenzi M, Coukos G.

Cancer Cell. 2019 Jun 10;35(6):885-900.e10. doi: 10.1016/j.ccell.2019.05.004.

PMID:
31185212
4.

Stromal inflammatory cells are associated with poorer prognosis in primary cutaneous melanoma.

Yun SJ, Liu S, Buckley M, Wang T, Jin S, Karakousis G, Peters MG, Elder DE, Gimotty PA, Xu X.

Hum Pathol. 2019 Jun;88:78-86. doi: 10.1016/j.humpath.2019.03.008. Epub 2019 Apr 6.

PMID:
30965022
5.

Gene-based FVIIa prophylaxis modulates the spontaneous bleeding phenotype of hemophilia A rats.

Zintner SM, Small JC, Pavani G, Dankner L, Marcos-Contreras OA, Gimotty PA, Kjelgaard-Hansen M, Wiinberg B, Margaritis P.

Blood Adv. 2019 Feb 12;3(3):301-311. doi: 10.1182/bloodadvances.2018027219.

6.

Statistical methods for building better biomarkers of chronic kidney disease.

Pencina MJ, Parikh CR, Kimmel PL, Cook NR, Coresh J, Feldman HI, Foulkes A, Gimotty PA, Hsu CY, Lemley K, Song P, Wilkins K, Gossett DR, Xie Y, Star RA.

Stat Med. 2019 May 20;38(11):1903-1917. doi: 10.1002/sim.8091. Epub 2019 Jan 21.

PMID:
30663113
7.

Autophagy Inhibition to Augment mTOR Inhibition: a Phase I/II Trial of Everolimus and Hydroxychloroquine in Patients with Previously Treated Renal Cell Carcinoma.

Haas NB, Appleman LJ, Stein M, Redlinger M, Wilks M, Xu X, Onorati A, Kalavacharla A, Kim T, Zhen CJ, Kadri S, Segal JP, Gimotty PA, Davis LE, Amaravadi RK.

Clin Cancer Res. 2019 Apr 1;25(7):2080-2087. doi: 10.1158/1078-0432.CCR-18-2204. Epub 2019 Jan 11.

PMID:
30635337
8.

PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer.

Rebecca VW, Nicastri MC, Fennelly C, Chude CI, Barber-Rotenberg JS, Ronghe A, McAfee Q, McLaughlin NP, Zhang G, Goldman AR, Ojha R, Piao S, Noguera-Ortega E, Martorella A, Alicea GM, Lee JJ, Schuchter LM, Xu X, Herlyn M, Marmorstein R, Gimotty PA, Speicher DW, Winkler JD, Amaravadi RK.

Cancer Discov. 2019 Feb;9(2):220-229. doi: 10.1158/2159-8290.CD-18-0706. Epub 2018 Nov 15.

PMID:
30442709
9.

Microsatellitosis in Patients with Melanoma.

Karakousis GC, Gimotty PA, Leong SP, Pockaj BA, White RL, O'Donoghue C, Sinnamon AJ, Bartlett EK, Dueck AC, Gould Rothberg BE, Messina JL, Vetto JT, Sondak VK, Schneebaum S, Kashani-Sabet M, Han D, Faries MB, Zager JS; with the Sentinel Lymph Node Working Group.

Ann Surg Oncol. 2019 Jan;26(1):33-41. doi: 10.1245/s10434-018-7006-4. Epub 2018 Nov 12.

PMID:
30421045
10.

Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice.

Albrengues J, Shields MA, Ng D, Park CG, Ambrico A, Poindexter ME, Upadhyay P, Uyeminami DL, Pommier A, Küttner V, Bružas E, Maiorino L, Bautista C, Carmona EM, Gimotty PA, Fearon DT, Chang K, Lyons SK, Pinkerton KE, Trotman LC, Goldberg MS, Yeh JT, Egeblad M.

Science. 2018 Sep 28;361(6409). pii: eaao4227. doi: 10.1126/science.aao4227.

PMID:
30262472
11.

Interpreting the Association of First-in-Class Immune Checkpoint Inhibition and Targeted Therapy With Survival in Patients With Stage IV Melanoma-Reply.

Sinnamon AJ, Gimotty PA, Karakousis GC.

JAMA Oncol. 2018 Aug 1;4(8):1136-1137. doi: 10.1001/jamaoncol.2018.0898. No abstract available.

PMID:
29902301
12.

Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer.

Tiriac H, Belleau P, Engle DD, Plenker D, Deschênes A, Somerville TDD, Froeling FEM, Burkhart RA, Denroche RE, Jang GH, Miyabayashi K, Young CM, Patel H, Ma M, LaComb JF, Palmaira RLD, Javed AA, Huynh JC, Johnson M, Arora K, Robine N, Shah M, Sanghvi R, Goetz AB, Lowder CY, Martello L, Driehuis E, LeComte N, Askan G, Iacobuzio-Donahue CA, Clevers H, Wood LD, Hruban RH, Thompson E, Aguirre AJ, Wolpin BM, Sasson A, Kim J, Wu M, Bucobo JC, Allen P, Sejpal DV, Nealon W, Sullivan JD, Winter JM, Gimotty PA, Grem JL, DiMaio DJ, Buscaglia JM, Grandgenett PM, Brody JR, Hollingsworth MA, O'Kane GM, Notta F, Kim E, Crawford JM, Devoe C, Ocean A, Wolfgang CL, Yu KH, Li E, Vakoc CR, Hubert B, Fischer SE, Wilson JM, Moffitt R, Knox J, Krasnitz A, Gallinger S, Tuveson DA.

Cancer Discov. 2018 Sep;8(9):1112-1129. doi: 10.1158/2159-8290.CD-18-0349. Epub 2018 May 31.

PMID:
29853643
13.

The receptor repertoire and functional profile of follicular T cells in HIV-infected lymph nodes.

Wendel BS, Del Alcazar D, He C, Del Río-Estrada PM, Aiamkitsumrit B, Ablanedo-Terrazas Y, Hernandez SM, Ma KY, Betts MR, Pulido L, Huang J, Gimotty PA, Reyes-Terán G, Jiang N, Su LF.

Sci Immunol. 2018 Apr 6;3(22). pii: eaan8884. doi: 10.1126/sciimmunol.aan8884.

14.

Quality of direct oral anticoagulant prescribing in elderly patients with non-valvular atrial fibrillation: results from a large urban health system.

Grant SJ, Kothari S, Gimotty PA, Gooneratne NS, Cuker A.

J Thromb Thrombolysis. 2018 Jul;46(1):1-6. doi: 10.1007/s11239-018-1651-0.

PMID:
29611105
15.

The prognostic significance of tumor-infiltrating lymphocytes for primary melanoma varies by sex.

Sinnamon AJ, Sharon CE, Song Y, Neuwirth MG, Elder DE, Xu X, Chu EY, Ming ME, Fraker DL, Gimotty PA, Karakousis GC.

J Am Acad Dermatol. 2018 Aug;79(2):245-251. doi: 10.1016/j.jaad.2018.02.066. Epub 2018 Mar 5.

PMID:
29518458
16.

Targeting JARID1B's demethylase activity blocks a subset of its functions in oral cancer.

Facompre ND, Harmeyer KM, Sahu V, Gimotty PA, Rustgi AK, Nakagawa H, Basu D.

Oncotarget. 2017 Dec 15;9(10):8985-8998. doi: 10.18632/oncotarget.23739. eCollection 2018 Feb 6.

17.

Histological immune response patterns in sentinel lymph nodes involved by metastatic melanoma and prognostic significance.

Abbott J, Buckley M, Taylor LA, Xu G, Karakousis G, Czerniecki BJ, Gimotty PA, Zhang PJ.

J Cutan Pathol. 2018 Jun;45(6):377-386. doi: 10.1111/cup.13127. Epub 2018 Mar 23.

PMID:
29446846
18.

Prevalence of and risk factors for cerebral microbleeds among adult patients with haemophilia A or B.

Husseinzadeh H, Chiasakul T, Gimotty PA, Pukenas B, Wolf R, Kelty M, Chiang E, Fogarty PF, Cuker A.

Haemophilia. 2018 Mar;24(2):271-277. doi: 10.1111/hae.13398. Epub 2017 Dec 28.

PMID:
29282815
19.

Association of First-in-Class Immune Checkpoint Inhibition and Targeted Therapy With Survival in Patients With Stage IV Melanoma.

Sinnamon AJ, Neuwirth MG, Gimotty PA, Gangadhar TC, Amaravadi RK, Schuchter LM, Karakousis GC.

JAMA Oncol. 2018 Jan 1;4(1):126-128. doi: 10.1001/jamaoncol.2017.3462. No abstract available.

20.

A Multicenter Phase I Study Evaluating Dual PI3K and BRAF Inhibition with PX-866 and Vemurafenib in Patients with Advanced BRAF V600-Mutant Solid Tumors.

Yam C, Xu X, Davies MA, Gimotty PA, Morrissette JJD, Tetzlaff MT, Wani KM, Liu S, Deng W, Buckley M, Zhao J, Amaravadi RK, Haas NB, Kudchadkar RR, Pavlick AC, Sosman JA, Tawbi H, Walker L, Schuchter LM, Karakousis GC, Gangadhar TC.

Clin Cancer Res. 2018 Jan 1;24(1):22-32. doi: 10.1158/1078-0432.CCR-17-1807. Epub 2017 Oct 19.

21.

ALDH1A1 and HLTF modulate the activity of lysosomal autophagy inhibitors in cancer cells.

Piao S, Ojha R, Rebecca VW, Samanta A, Ma XH, Mcafee Q, Nicastri MC, Buckley M, Brown E, Winkler JD, Gimotty PA, Amaravadi RK.

Autophagy. 2017;13(12):2056-2071. doi: 10.1080/15548627.2017.1377377. Epub 2017 Oct 5.

22.

Revascularization strategies and in-hospital management in acute coronary syndromes complicated by hemophilia A or hemophilia B.

Reilley MJ, Blair A, Matthai WH, Vega R, Buckley M, Gimotty PA, Fogarty PF.

Blood Coagul Fibrinolysis. 2017 Dec;28(8):650-657. doi: 10.1097/MBC.0000000000000655.

PMID:
28763308
23.

Barriers to generating PDX models of HPV-related head and neck cancer.

Facompre ND, Sahu V, Montone KT, Harmeyer KM, Nakagawa H, Rustgi AK, Weinstein GS, Gimotty PA, Basu D.

Laryngoscope. 2017 Dec;127(12):2777-2783. doi: 10.1002/lary.26679. Epub 2017 May 31.

24.

Oncogenic RAS Regulates Long Noncoding RNA Orilnc1 in Human Cancer.

Zhang D, Zhang G, Hu X, Wu L, Feng Y, He S, Zhang Y, Hu Z, Yang L, Tian T, Xu W, Wei Z, Lu Y, Flaherty KT, Zhong X, Mills GB, Gimotty PA, Xu X, Herlyn M, Zhang L.

Cancer Res. 2017 Jul 15;77(14):3745-3757. doi: 10.1158/0008-5472.CAN-16-1768. Epub 2017 May 4.

25.

Diagnostic accuracy of IgG-specific versus polyspecific enzyme-linked immunoassays in heparin-induced thrombocytopenia: a systematic review and meta-analysis.

Husseinzadeh HD, Gimotty PA, Pishko AM, Buckley M, Warkentin TE, Cuker A.

J Thromb Haemost. 2017 Jun;15(6):1203-1212. doi: 10.1111/jth.13692. Epub 2017 May 11. Review.

26.

Interventional therapies and in-hospital outcomes in acute coronary syndromes complicated by von Willebrand disease.

Fogarty PF, Blair A, Vega R, Matthai WH, Gimotty PA.

Haemophilia. 2017 May;23(3):400-407. doi: 10.1111/hae.13149. Epub 2016 Dec 14.

PMID:
27976460
27.

Thin Melanoma with Nodal Involvement: Analysis of Demographic, Pathologic, and Treatment Factors with Regard to Prognosis.

Karakousis G, Gimotty PA, Bartlett EK, Sim MS, Neuwirth MG, Fraker D, Czerniecki BJ, Faries MB.

Ann Surg Oncol. 2017 Apr;24(4):952-959. doi: 10.1245/s10434-016-5646-9. Epub 2016 Nov 2.

28.

Contemporary Trends in Radiation Oncology Resident Research.

Verma V, Burt L, Gimotty PA, Ojerholm E.

Int J Radiat Oncol Biol Phys. 2016 Nov 15;96(4):915-918. doi: 10.1016/j.ijrobp.2016.08.005. Epub 2016 Aug 11.

PMID:
27663761
29.

Miscoding of Melanoma Thickness in SEER: Research and Clinical Implications.

Gimotty PA, Shore R, Lozon NL, Whitlock J, He S, Vigneau FD, Dickie L, Elder DE, Xu X, Schwartz AG, Guerry D.

J Invest Dermatol. 2016 Nov;136(11):2168-2172. doi: 10.1016/j.jid.2016.05.121. Epub 2016 Jun 25.

30.

Delays in postremission chemotherapy for Philadelphia chromosome negative acute lymphoblastic leukemia are associated with inferior outcomes in patients who undergo allogeneic transplant: An analysis from ECOG 2993/MRC UK ALLXII.

Kumar AJ, Gimotty PA, Gelfand JM, Buck G, Rowe JM, Goldstone AH, Fielding A, Marks DI, Litzow M, Paietta E, Lazarus HM, Tallman MS, Luger SM, Loren AW.

Am J Hematol. 2016 Nov;91(11):1107-1112. doi: 10.1002/ajh.24497. Epub 2016 Aug 22. Erratum in: Am J Hematol. 2017 May;92 (5):E85.

31.

Immune checkpoint blockade reveals the stimulatory capacity of tumor-associated CD103(+) dendritic cells in late-stage ovarian cancer.

Flies DB, Higuchi T, Harris JC, Jha V, Gimotty PA, Adams SF.

Oncoimmunology. 2016 May 13;5(8):e1185583. doi: 10.1080/2162402X.2016.1185583. eCollection 2016 Aug.

32.

JARID1B Enables Transit between Distinct States of the Stem-like Cell Population in Oral Cancers.

Facompre ND, Harmeyer KM, Sole X, Kabraji S, Belden Z, Sahu V, Whelan K, Tanaka K, Weinstein GS, Montone KT, Roesch A, Gimotty PA, Herlyn M, Rustgi AK, Nakagawa H, Ramaswamy S, Basu D.

Cancer Res. 2016 Sep 15;76(18):5538-49. doi: 10.1158/0008-5472.CAN-15-3377. Epub 2016 Aug 3. Erratum in: Cancer Res. 2017 Dec 15;77(24):7136.

33.

A rapid pro-hemostatic approach to overcome direct oral anticoagulants.

Thalji NK, Ivanciu L, Davidson R, Gimotty PA, Krishnaswamy S, Camire RM.

Nat Med. 2016 Aug;22(8):924-32. doi: 10.1038/nm.4149. Epub 2016 Jul 25.

PMID:
27455511
34.

PIM kinases as therapeutic targets against advanced melanoma.

Shannan B, Watters A, Chen Q, Mollin S, Dörr M, Meggers E, Xu X, Gimotty PA, Perego M, Li L, Benci J, Krepler C, Brafford P, Zhang J, Wei Z, Zhang G, Liu Q, Yin X, Nathanson KL, Herlyn M, Vultur A.

Oncotarget. 2016 Aug 23;7(34):54897-54912. doi: 10.18632/oncotarget.10703.

35.

A clinical measure of DNA methylation predicts outcome in de novo acute myeloid leukemia.

Luskin MR, Gimotty PA, Smith C, Loren AW, Figueroa ME, Harrison J, Sun Z, Tallman MS, Paietta EM, Litzow MR, Melnick AM, Levine RL, Fernandez HF, Luger SM, Carroll M, Master SR, Wertheim GB.

JCI Insight. 2016 Jun 16;1(9). pii: e87323.

36.

A Modified Integrated Genetic Model for Risk Prediction in Younger Patients with Acute Myeloid Leukemia.

Sloan CE, Luskin MR, Boccuti AM, Sehgal AR, Zhao J, Daber RD, Morrissette JJ, Luger SM, Bagg A, Gimotty PA, Carroll M.

PLoS One. 2016 Apr 6;11(4):e0153016. doi: 10.1371/journal.pone.0153016. eCollection 2016.

37.

Enhancing the evaluation of PI3K inhibitors through 3D melanoma models.

Shannan B, Chen Q, Watters A, Perego M, Krepler C, Thombre R, Li L, Rajan G, Peterson S, Gimotty PA, Wilson M, Nathanson KL, Gangadhar TC, Schuchter LM, Weeraratna AT, Herlyn M, Vultur A.

Pigment Cell Melanoma Res. 2016 May;29(3):317-28. doi: 10.1111/pcmr.12465. Epub 2016 Mar 21.

38.

American Joint Committee on Cancer acceptance criteria for inclusion of risk models for individualized prognosis in the practice of precision medicine.

Kattan MW, Hess KR, Amin MB, Lu Y, Moons KG, Gershenwald JE, Gimotty PA, Guinney JH, Halabi S, Lazar AJ, Mahar AL, Patel T, Sargent DJ, Weiser MR, Compton C; members of the AJCC Precision Medicine Core.

CA Cancer J Clin. 2016 Sep;66(5):370-4. doi: 10.3322/caac.21339. Epub 2016 Jan 19.

39.

Diagnostic accuracy of rapid immunoassays for heparin-induced thrombocytopenia. A systematic review and meta-analysis.

Sun L, Gimotty PA, Lakshmanan S, Cuker A.

Thromb Haemost. 2016 May 2;115(5):1044-55. doi: 10.1160/TH15-06-0523. Epub 2016 Jan 14. Review.

PMID:
26763074
40.

Identification of Patients with Intermediate Thickness Melanoma at Low Risk for Sentinel Lymph Node Positivity.

Bartlett EK, Peters MG, Blair A, Etherington MS, Elder DE, Xu XG, Guerry D, Ming ME, Fraker DL, Czerniecki BJ, Gimotty PA, Karakousis GC.

Ann Surg Oncol. 2016 Jan;23(1):250-6. doi: 10.1245/s10434-015-4766-y. Epub 2015 Jul 28.

41.

Correction of human hemophilia A whole blood abnormalities with a novel bypass agent: zymogen-like FXa(I16L).

George LA, Thalji NK, Raffini LJ, Gimotty PA, Camire RM.

J Thromb Haemost. 2015 Sep;13(9):1694-8. doi: 10.1111/jth.13059. Epub 2015 Aug 10.

42.

CTLA-4 Blockade Synergizes Therapeutically with PARP Inhibition in BRCA1-Deficient Ovarian Cancer.

Higuchi T, Flies DB, Marjon NA, Mantia-Smaldone G, Ronner L, Gimotty PA, Adams SF.

Cancer Immunol Res. 2015 Nov;3(11):1257-68. doi: 10.1158/2326-6066.CIR-15-0044. Epub 2015 Jul 2.

43.

Radiofrequency Ablation Is Associated With Decreased Neoplastic Progression in Patients With Barrett's Esophagus and Confirmed Low-Grade Dysplasia.

Small AJ, Araujo JL, Leggett CL, Mendelson AH, Agarwalla A, Abrams JA, Lightdale CJ, Wang TC, Iyer PG, Wang KK, Rustgi AK, Ginsberg GG, Forde KA, Gimotty PA, Lewis JD, Falk GW, Bewtra M.

Gastroenterology. 2015 Sep;149(3):567-76.e3; quiz e13-4. doi: 10.1053/j.gastro.2015.04.013. Epub 2015 Apr 24.

44.

DNMT3A Mutational Status Affects the Results of Dose-Escalated Induction Therapy in Acute Myelogenous Leukemia.

Sehgal AR, Gimotty PA, Zhao J, Hsu JM, Daber R, Morrissette JD, Luger S, Loren AW, Carroll M.

Clin Cancer Res. 2015 Apr 1;21(7):1614-20. doi: 10.1158/1078-0432.CCR-14-0327. Epub 2015 Jan 21.

45.

Cellular senescence checkpoint function determines differential Notch1-dependent oncogenic and tumor-suppressor activities.

Kagawa S, Natsuizaka M, Whelan KA, Facompre N, Naganuma S, Ohashi S, Kinugasa H, Egloff AM, Basu D, Gimotty PA, Klein-Szanto AJ, Bass AJ, Wong KK, Diehl JA, Rustgi AK, Nakagawa H.

Oncogene. 2015 Apr 30;34(18):2347-59. doi: 10.1038/onc.2014.169. Epub 2014 Jun 16.

46.

The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells.

Gerhardt DM, Pajcini KV, D'altri T, Tu L, Jain R, Xu L, Chen MJ, Rentschler S, Shestova O, Wertheim GB, Tobias JW, Kluk M, Wood AW, Aster JC, Gimotty PA, Epstein JA, Speck N, Bigas A, Pear WS.

Genes Dev. 2014 Mar 15;28(6):576-93. doi: 10.1101/gad.227496.113.

47.

Age as a predictor of sentinel node metastasis among patients with localized melanoma: an inverse correlation of melanoma mortality and incidence of sentinel node metastasis among young and old patients.

Balch CM, Thompson JF, Gershenwald JE, Soong SJ, Ding S, McMasters KM, Coit DG, Eggermont AM, Gimotty PA, Johnson TM, Kirkwood JM, Leong SP, Ross MI, Byrd DR, Cochran AJ, Mihm MC Jr, Morton DL, Atkins MB, Flaherty KT, Sondak VK.

Ann Surg Oncol. 2014 Apr;21(4):1075-81. doi: 10.1245/s10434-013-3464-x. Epub 2014 Feb 15.

48.

IGFBP3 promotes esophageal cancer growth by suppressing oxidative stress in hypoxic tumor microenvironment.

Natsuizaka M, Kinugasa H, Kagawa S, Whelan KA, Naganuma S, Subramanian H, Chang S, Nakagawa KJ, Rustgi NL, Kita Y, Natsugoe S, Basu D, Gimotty PA, Klein-Szanto AJ, Diehl JA, Nakagawa H.

Am J Cancer Res. 2014 Jan 15;4(1):29-41. eCollection 2014.

49.

Lymphatic invasion as a prognostic biomarker in primary cutaneous melanoma.

Xu X, Gimotty PA, Guerry D, Karakousis G, Elder DE.

Methods Mol Biol. 2014;1102:275-86. doi: 10.1007/978-1-62703-727-3_15.

50.

Prognosis of patients with melanoma and microsatellitosis undergoing sentinel lymph node biopsy.

Bartlett EK, Gupta M, Datta J, Gimotty PA, Guerry D, Xu X, Elder DE, Czerniecki BJ, Fraker DL, Karakousis GC.

Ann Surg Oncol. 2014 Mar;21(3):1016-23. doi: 10.1245/s10434-013-3388-5. Epub 2013 Nov 21.

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