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Items: 21


The GPCR accessory protein MRAP2 regulates both biased signaling and constitutive activity of the ghrelin receptor GHSR1a.

Rouault AAJ, Rosselli-Murai LK, Hernandez CC, Gimenez LE, Tall GG, Sebag JA.

Sci Signal. 2020 Jan 7;13(613). pii: eaax4569. doi: 10.1126/scisignal.aax4569.


60 YEARS OF POMC: Regulation of feeding and energy homeostasis by α-MSH.

Anderson EJ, Çakir I, Carrington SJ, Cone RD, Ghamari-Langroudi M, Gillyard T, Gimenez LE, Litt MJ.

J Mol Endocrinol. 2016 May;56(4):T157-74. doi: 10.1530/JME-16-0014. Epub 2016 Mar 3. Review.


A G Protein-biased Designer G Protein-coupled Receptor Useful for Studying the Physiological Relevance of Gq/11-dependent Signaling Pathways.

Hu J, Stern M, Gimenez LE, Wanka L, Zhu L, Rossi M, Meister J, Inoue A, Beck-Sickinger AG, Gurevich VV, Wess J.

J Biol Chem. 2016 Apr 8;291(15):7809-20. doi: 10.1074/jbc.M115.702282. Epub 2016 Feb 5.


Salmeterol Efficacy and Bias in the Activation and Kinase-Mediated Desensitization of β2-Adrenergic Receptors.

Gimenez LE, Baameur F, Vayttaden SJ, Clark RB.

Mol Pharmacol. 2015 Jun;87(6):954-64. doi: 10.1124/mol.114.096800. Epub 2015 Mar 17.


Mutations in arrestin-3 differentially affect binding to neuropeptide Y receptor subtypes.

Gimenez LE, Babilon S, Wanka L, Beck-Sickinger AG, Gurevich VV.

Cell Signal. 2014 Jul;26(7):1523-31. doi: 10.1016/j.cellsig.2014.03.019. Epub 2014 Mar 29.


Arrestin-3 binds the MAP kinase JNK3α2 via multiple sites on both domains.

Zhan X, Perez A, Gimenez LE, Vishnivetskiy SA, Gurevich VV.

Cell Signal. 2014 Apr;26(4):766-76. doi: 10.1016/j.cellsig.2014.01.001. Epub 2014 Jan 8.


Targeting individual GPCRs with redesigned nonvisual arrestins.

Gimenez LE, Vishnivetskiy SA, Gurevich VV.

Handb Exp Pharmacol. 2014;219:153-70. doi: 10.1007/978-3-642-41199-1_8.


A role for an Hsp70 nucleotide exchange factor in the regulation of synaptic vesicle endocytosis.

Morgan JR, Jiang J, Oliphint PA, Jin S, Gimenez LE, Busch DJ, Foldes AE, Zhuo Y, Sousa R, Lafer EM.

J Neurosci. 2013 May 1;33(18):8009-21. doi: 10.1523/JNEUROSCI.4505-12.2013.


Modulation of methuselah expression targeted to Drosophila insulin-producing cells extends life and enhances oxidative stress resistance.

Gimenez LE, Ghildyal P, Fischer KE, Hu H, Ja WW, Eaton BA, Wu Y, Austad SN, Ranjan R.

Aging Cell. 2013 Feb;12(1):121-9. doi: 10.1111/acel.12027. Epub 2012 Dec 6.


Manipulation of very few receptor discriminator residues greatly enhances receptor specificity of non-visual arrestins.

Gimenez LE, Vishnivetskiy SA, Baameur F, Gurevich VV.

J Biol Chem. 2012 Aug 24;287(35):29495-505. doi: 10.1074/jbc.M112.366674. Epub 2012 Jul 11.


Silent scaffolds: inhibition OF c-Jun N-terminal kinase 3 activity in cell by dominant-negative arrestin-3 mutant.

Breitman M, Kook S, Gimenez LE, Lizama BN, Palazzo MC, Gurevich EV, Gurevich VV.

J Biol Chem. 2012 Jun 1;287(23):19653-64. doi: 10.1074/jbc.M112.358192. Epub 2012 Apr 20.


Role of receptor-attached phosphates in binding of visual and non-visual arrestins to G protein-coupled receptors.

Gimenez LE, Kook S, Vishnivetskiy SA, Ahmed MR, Gurevich EV, Gurevich VV.

J Biol Chem. 2012 Mar 16;287(12):9028-40. doi: 10.1074/jbc.M111.311803. Epub 2012 Jan 24.


Few residues within an extensive binding interface drive receptor interaction and determine the specificity of arrestin proteins.

Vishnivetskiy SA, Gimenez LE, Francis DJ, Hanson SM, Hubbell WL, Klug CS, Gurevich VV.

J Biol Chem. 2011 Jul 8;286(27):24288-99. doi: 10.1074/jbc.M110.213835. Epub 2011 Apr 6.


Crystal structure of arrestin-3 reveals the basis of the difference in receptor binding between two non-visual subtypes.

Zhan X, Gimenez LE, Gurevich VV, Spiller BW.

J Mol Biol. 2011 Feb 25;406(3):467-78. doi: 10.1016/j.jmb.2010.12.034. Epub 2011 Jan 6.


Ligand-induced internalization and recycling of the human neuropeptide Y2 receptor is regulated by its carboxyl-terminal tail.

Walther C, Nagel S, Gimenez LE, Mörl K, Gurevich VV, Beck-Sickinger AG.

J Biol Chem. 2010 Dec 31;285(53):41578-90. doi: 10.1074/jbc.M110.162156. Epub 2010 Oct 18.


Autoantibodies enhance agonist action and binding to cardiac muscarinic receptors in chronic Chagas' disease.

Hernandez CC, Nascimento JH, Chaves EA, Costa PC, Masuda MO, Kurtenbach E, Campos DE Carvalho AC, Gimenez LE.

J Recept Signal Transduct Res. 2008;28(4):375-401. doi: 10.1080/10799890802262319 .


Structure of the Hsp110:Hsc70 nucleotide exchange machine.

Schuermann JP, Jiang J, Cuellar J, Llorca O, Wang L, Gimenez LE, Jin S, Taylor AB, Demeler B, Morano KA, Hart PJ, Valpuesta JM, Lafer EM, Sousa R.

Mol Cell. 2008 Jul 25;31(2):232-43. doi: 10.1016/j.molcel.2008.05.006. Epub 2008 Jun 12.


Characterization of cardiopulmonary function and cardiac muscarinic and adrenergic receptor density adaptation in C57BL/6 mice with chronic Trypanosoma cruzi infection.

Rocha NN, Garcia S, Giménez LE, Hernández CC, Senra JF, Lima RS, Cyrino F, Bouskela E, Soares MB, Ribeiro dos Santos R, Campos de Carvalho AC.

Parasitology. 2006 Dec;133(Pt 6):729-37. Epub 2006 Sep 18.


Early occurrence of anti-muscarinic autoantibodies and abnormal vagal modulation in Chagas disease.

Ribeiro AL, Giménez LE, Hernández CC, de Carvalho AC, Teixeira MM, Guedes VC, Barros MV, Lombardi F, Rocha MO.

Int J Cardiol. 2007 Apr 12;117(1):59-63. Epub 2006 Jul 21.


DNA immunizations with M2 muscarinic and beta1 adrenergic receptor coding plasmids impair cardiac function in mice.

Giménez LE, Hernández CC, Mattos EC, Brandão IT, Olivieri B, Campelo RP, Araújo-Jorge T, Silva CL, Campos de Carvalho AC, Kurtenbach E.

J Mol Cell Cardiol. 2005 May;38(5):703-14.


Human chagasic IgGs bind to cardiac muscarinic receptors and impair L-type Ca2+ currents.

Hernández CC, Barcellos LC, Giménez LE, Cabarcas RA, Garcia S, Pedrosa RC, Nascimento JH, Kurtenbach E, Masuda MO, Campos de Carvalho AC.

Cardiovasc Res. 2003 Apr 1;58(1):55-65.


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