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Items: 31


MaGIC: a machine learning tool set and web application for monoallelic gene inference from chromatin.

Vinogradova S, Saksena SD, Ward HN, Vigneau S, Gimelbrant AA.

BMC Bioinformatics. 2019 Feb 28;20(1):106. doi: 10.1186/s12859-019-2679-7.


KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance.

Hinohara K, Wu HJ, Sébastien Vigneau, McDonald TO, Igarashi KJ, Yamamoto KN, Madsen T, Fassl A, Egri SB, Papanastasiou M, Ding L, Peluffo G, Cohen O, Kales SC, Lal-Nag M, Rai G, Maloney DJ, Jadhav A, Simeonov A, Wagle N, Brown M, Meissner A, Sicinski P, Jaffe JD, Jeselsohn R, Gimelbrant AA, Michor F, Polyak K.

Cancer Cell. 2019 Feb 11;35(2):330-332. doi: 10.1016/j.ccell.2019.01.012. No abstract available.


KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance.

Hinohara K, Wu HJ, Vigneau S, McDonald TO, Igarashi KJ, Yamamoto KN, Madsen T, Fassl A, Egri SB, Papanastasiou M, Ding L, Peluffo G, Cohen O, Kales SC, Lal-Nag M, Rai G, Maloney DJ, Jadhav A, Simeonov A, Wagle N, Brown M, Meissner A, Sicinski P, Jaffe JD, Jeselsohn R, Gimelbrant AA, Michor F, Polyak K.

Cancer Cell. 2018 Dec 10;34(6):939-953.e9. doi: 10.1016/j.ccell.2018.10.014. Epub 2018 Nov 21. Erratum in: Cancer Cell. 2019 Feb 11;35(2):330-332.


High prevalence of clonal monoallelic expression.

Vigneau S, Vinogradova S, Savova V, Gimelbrant A.

Nat Genet. 2018 Sep;50(9):1198-1199. doi: 10.1038/s41588-018-0188-7. No abstract available.


Risk alleles of genes with monoallelic expression are enriched in gain-of-function variants and depleted in loss-of-function variants for neurodevelopmental disorders.

Savova V, Vinogradova S, Pruss D, Gimelbrant AA, Weiss LA.

Mol Psychiatry. 2017 Dec;22(12):1785-1794. doi: 10.1038/mp.2017.13. Epub 2017 Mar 7.


Tumor-suppressor genes that escape from X-inactivation contribute to cancer sex bias.

Dunford A, Weinstock DM, Savova V, Schumacher SE, Cleary JP, Yoda A, Sullivan TJ, Hess JM, Gimelbrant AA, Beroukhim R, Lawrence MS, Getz G, Lane AA.

Nat Genet. 2017 Jan;49(1):10-16. doi: 10.1038/ng.3726. Epub 2016 Nov 21.


Genes with monoallelic expression contribute disproportionately to genetic diversity in humans.

Savova V, Chun S, Sohail M, McCole RB, Witwicki R, Gai L, Lenz TL, Wu CT, Sunyaev SR, Gimelbrant AA.

Nat Genet. 2016 Mar;48(3):231-237. doi: 10.1038/ng.3493. Epub 2016 Jan 25.


dbMAE: the database of autosomal monoallelic expression.

Savova V, Patsenker J, Vigneau S, Gimelbrant AA.

Nucleic Acids Res. 2016 Jan 4;44(D1):D753-6. doi: 10.1093/nar/gkv1106. Epub 2015 Oct 25.


Chromatin Signature Identifies Monoallelic Gene Expression Across Mammalian Cell Types.

Nag A, Vigneau S, Savova V, Zwemer LM, Gimelbrant AA.

G3 (Bethesda). 2015 Jun 18;5(8):1713-20. doi: 10.1534/g3.115.018853.


Somatic Cell Fusions Reveal Extensive Heterogeneity in Basal-like Breast Cancer.

Su Y, Subedee A, Bloushtain-Qimron N, Savova V, Krzystanek M, Li L, Marusyk A, Tabassum DP, Zak A, Flacker MJ, Li M, Lin JJ, Sukumar S, Suzuki H, Long H, Szallasi Z, Gimelbrant A, Maruyama R, Polyak K.

Cell Rep. 2015 Jun 16;11(10):1549-63. doi: 10.1016/j.celrep.2015.05.011. Epub 2015 Jun 4.


Monoallelic expression of the human FOXP2 speech gene.

Adegbola AA, Cox GF, Bradshaw EM, Hafler DA, Gimelbrant A, Chess A.

Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):6848-54. doi: 10.1073/pnas.1411270111. Epub 2014 Nov 24.


(Epi)Genetic analyses of age-related macular degeneration: case-control and discordant twin studies.

Hutchinson JN, Fagerness J, Kirby A, Reynolds R, Zak A, Gimelbrant A, Plenge R, Daly M, Chess A, Seddon JM.

Hum Hered. 2014;78(2):59-72. doi: 10.1159/000362814. Epub 2014 Jul 12.


Allele-specific methylation occurs at genetic variants associated with complex disease.

Hutchinson JN, Raj T, Fagerness J, Stahl E, Viloria FT, Gimelbrant A, Seddon J, Daly M, Chess A, Plenge R.

PLoS One. 2014 Jun 9;9(6):e98464. doi: 10.1371/journal.pone.0098464. eCollection 2014.


Chromatin signature of widespread monoallelic expression.

Nag A, Savova V, Fung HL, Miron A, Yuan GC, Zhang K, Gimelbrant AA.

Elife. 2013 Dec 31;2:e01256. doi: 10.7554/eLife.01256.


Autosomal monoallelic expression: genetics of epigenetic diversity?

Savova V, Vigneau S, Gimelbrant AA.

Curr Opin Genet Dev. 2013 Dec;23(6):642-8. doi: 10.1016/j.gde.2013.09.001. Epub 2013 Sep 24. Review.


Molecular signatures of human induced pluripotent stem cells highlight sex differences and cancer genes.

Anguera MC, Sadreyev R, Zhang Z, Szanto A, Payer B, Sheridan SD, Kwok S, Haggarty SJ, Sur M, Alvarez J, Gimelbrant A, Mitalipova M, Kirby JE, Lee JT.

Cell Stem Cell. 2012 Jul 6;11(1):75-90. doi: 10.1016/j.stem.2012.03.008.


Autosomal monoallelic expression in the mouse.

Zwemer LM, Zak A, Thompson BR, Kirby A, Daly MJ, Chess A, Gimelbrant AA.

Genome Biol. 2012 Feb 20;13(2):R10. doi: 10.1186/gb-2012-13-2-r10.


Lung stem cell self-renewal relies on BMI1-dependent control of expression at imprinted loci.

Zacharek SJ, Fillmore CM, Lau AN, Gludish DW, Chou A, Ho JW, Zamponi R, Gazit R, Bock C, Jäger N, Smith ZD, Kim TM, Saunders AH, Wong J, Lee JH, Roach RR, Rossi DJ, Meissner A, Gimelbrant AA, Park PJ, Kim CF.

Cell Stem Cell. 2011 Sep 2;9(3):272-81. doi: 10.1016/j.stem.2011.07.007.


Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations.

Lengner CJ, Gimelbrant AA, Erwin JA, Cheng AW, Guenther MG, Welstead GG, Alagappan R, Frampton GM, Xu P, Muffat J, Santagata S, Powers D, Barrett CB, Young RA, Lee JT, Jaenisch R, Mitalipova M.

Cell. 2010 May 28;141(5):872-83. doi: 10.1016/j.cell.2010.04.010. Epub 2010 May 13.


Widespread monoallelic expression on human autosomes.

Gimelbrant A, Hutchinson JN, Thompson BR, Chess A.

Science. 2007 Nov 16;318(5853):1136-40.


An epigenetic state associated with areas of gene duplication.

Gimelbrant AA, Chess A.

Genome Res. 2006 Jun;16(6):723-9. Epub 2006 May 10. Erratum in: Genome Res. 2006 Aug;16(8):1073.


Monoallelic expression and asynchronous replication of p120 catenin in mouse and human cells.

Gimelbrant AA, Ensminger AW, Qi P, Zucker J, Chess A.

J Biol Chem. 2005 Jan 14;280(2):1354-9. Epub 2004 Nov 1.


Selective pressures on the olfactory receptor repertoire since the human-chimpanzee divergence.

Gimelbrant AA, Skaletsky H, Chess A.

Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):9019-22. Epub 2004 Jun 3.


Coordination of the random asynchronous replication of autosomal loci.

Singh N, Ebrahimi FA, Gimelbrant AA, Ensminger AW, Tackett MR, Qi P, Gribnau J, Chess A.

Nat Genet. 2003 Mar;33(3):339-41. Epub 2003 Feb 10.


Olfactory-enriched transcripts are cell-specific markers in the lobster olfactory organ.

Hollins B, Hardin D, Gimelbrant AA, McClintock TS.

J Comp Neurol. 2003 Jan 1;455(1):125-38.


Olfactory receptor trafficking involves conserved regulatory steps.

Gimelbrant AA, Haley SL, McClintock TS.

J Biol Chem. 2001 Mar 9;276(10):7285-90. Epub 2000 Nov 1.


Truncation releases olfactory receptors from the endoplasmic reticulum of heterologous cells.

Gimelbrant AA, Stoss TD, Landers TM, McClintock TS.

J Neurochem. 1999 Jun;72(6):2301-11.


Consensus translational initiation sites of marine invertebrate phyla.

Mankad RV, Gimelbrant AA, McClintock TS.

Biol Bull. 1998 Dec;195(3):251-4.


Functional expression of olfactory-adrenergic receptor chimeras and intracellular retention of heterologously expressed olfactory receptors.

McClintock TS, Landers TM, Gimelbrant AA, Fuller LZ, Jackson BA, Jayawickreme CK, Lerner MR.

Brain Res Mol Brain Res. 1997 Sep;48(2):270-8.


A nuclear matrix attachment region is highly homologous to a conserved domain of olfactory receptors.

Gimelbrant AA, McClintock TS.

J Mol Neurosci. 1997 Aug;9(1):61-3. No abstract available.


Recoverin mediates the calcium effect upon rhodopsin phosphorylation and cGMP hydrolysis in bovine retina rod cells.

Gorodovikova EN, Gimelbrant AA, Senin II, Philippov PP.

FEBS Lett. 1994 Aug 1;349(2):187-90.

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