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Items: 1 to 50 of 224

1.

Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis.

Gimbrone MA Jr, García-Cardeña G.

Circ Res. 2016 Feb 19;118(4):620-36. doi: 10.1161/CIRCRESAHA.115.306301. Review.

2.

Vascular endothelium, hemodynamics, and the pathobiology of atherosclerosis.

Gimbrone MA Jr, García-Cardeña G.

Cardiovasc Pathol. 2013 Jan-Feb;22(1):9-15. doi: 10.1016/j.carpath.2012.06.006. Epub 2012 Jul 18. Review.

4.

Judah Folkman, MD, 1933-2008.

Nathan DG, Gimbrone MA.

Pharos Alpha Omega Alpha Honor Med Soc. 2009 Winter:4-8. No abstract available.

PMID:
19263646
5.

Biomechanical forces in atherosclerosis-resistant vascular regions regulate endothelial redox balance via phosphoinositol 3-kinase/Akt-dependent activation of Nrf2.

Dai G, Vaughn S, Zhang Y, Wang ET, Garcia-Cardena G, Gimbrone MA Jr.

Circ Res. 2007 Sep 28;101(7):723-33. Epub 2007 Aug 2.

PMID:
17673673
6.

Biomechanical modulation of endothelial phenotype: implications for health and disease.

García-Cardeña G, Gimbrone MA Jr.

Handb Exp Pharmacol. 2006;(176 Pt 2):79-95. Review.

PMID:
16999225
7.

Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2.

Parmar KM, Larman HB, Dai G, Zhang Y, Wang ET, Moorthy SN, Kratz JR, Lin Z, Jain MK, Gimbrone MA Jr, García-Cardeña G.

J Clin Invest. 2006 Jan;116(1):49-58. Epub 2005 Dec 8.

8.

Statins exert endothelial atheroprotective effects via the KLF2 transcription factor.

Parmar KM, Nambudiri V, Dai G, Larman HB, Gimbrone MA Jr, García-Cardeña G.

J Biol Chem. 2005 Jul 22;280(29):26714-9. Epub 2005 May 4.

9.

Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic function.

Lin Z, Kumar A, SenBanerjee S, Staniszewski K, Parmar K, Vaughan DE, Gimbrone MA Jr, Balasubramanian V, García-Cardeña G, Jain MK.

Circ Res. 2005 Mar 18;96(5):e48-57. Epub 2005 Feb 17.

PMID:
15718498
10.

Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature.

Dai G, Kaazempur-Mofrad MR, Natarajan S, Zhang Y, Vaughn S, Blackman BR, Kamm RD, García-Cardeña G, Gimbrone MA Jr.

Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14871-6. Epub 2004 Oct 4.

11.

KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation.

SenBanerjee S, Lin Z, Atkins GB, Greif DM, Rao RM, Kumar A, Feinberg MW, Chen Z, Simon DI, Luscinskas FW, Michel TM, Gimbrone MA Jr, García-Cardeña G, Jain MK.

J Exp Med. 2004 May 17;199(10):1305-15. Epub 2004 May 10.

12.

Improving the statistical detection of regulated genes from microarray data using intensity-based variance estimation.

Comander J, Natarajan S, Gimbrone MA Jr, García-Cardeña G.

BMC Genomics. 2004 Feb 27;5(1):17.

13.

Role of endothelial nitric oxide synthase in endothelial activation: insights from eNOS knockout endothelial cells.

Kuhlencordt PJ, Rosel E, Gerszten RE, Morales-Ruiz M, Dombkowski D, Atkinson WJ, Han F, Preffer F, Rosenzweig A, Sessa WC, Gimbrone MA Jr, Ertl G, Huang PL.

Am J Physiol Cell Physiol. 2004 May;286(5):C1195-202. Epub 2004 Jan 28.

14.

Early adaptive responses of the vascular wall during venous arterialization in mice.

Kwei S, Stavrakis G, Takahas M, Taylor G, Folkman MJ, Gimbrone MA Jr, García-Cardeña G.

Am J Pathol. 2004 Jan;164(1):81-9.

15.

Lipid raft localization of cell surface E-selectin is required for ligation-induced activation of phospholipase C gamma.

Kiely JM, Hu Y, García-Cardeña G, Gimbrone MA Jr.

J Immunol. 2003 Sep 15;171(6):3216-24.

16.

Heterogeneity of endothelial cells from different organ sites in T-cell subset recruitment.

Lim YC, Garcia-Cardena G, Allport JR, Zervoglos M, Connolly AJ, Gimbrone MA Jr, Luscinskas FW.

Am J Pathol. 2003 May;162(5):1591-601.

17.

Future research directions in acute lung injury: summary of a National Heart, Lung, and Blood Institute working group.

Matthay MA, Zimmerman GA, Esmon C, Bhattacharya J, Coller B, Doerschuk CM, Floros J, Gimbrone MA Jr, Hoffman E, Hubmayr RD, Leppert M, Matalon S, Munford R, Parsons P, Slutsky AS, Tracey KJ, Ward P, Gail DB, Harabin AL.

Am J Respir Crit Care Med. 2003 Apr 1;167(7):1027-35. Review.

PMID:
12663342
18.

Prostaglandin E2 suppresses chemokine production in human macrophages through the EP4 receptor.

Takayama K, García-Cardena G, Sukhova GK, Comander J, Gimbrone MA Jr, Libby P.

J Biol Chem. 2002 Nov 15;277(46):44147-54. Epub 2002 Sep 4.

19.

A new in vitro model to evaluate differential responses of endothelial cells to simulated arterial shear stress waveforms.

Blackman BR, García-Cardeña G, Gimbrone MA Jr.

J Biomech Eng. 2002 Aug;124(4):397-407.

PMID:
12188206
21.

Endothelial IKK beta signaling is required for monocyte adhesion under laminar flow conditions.

Meiler SE, Hung RR, Gerszten RE, Gianetti J, Li L, Matsui T, Gimbrone MA Jr, Rosenzweig A.

J Mol Cell Cardiol. 2002 Mar;34(3):349-59.

PMID:
11945026
22.

Mechanosensitive endothelial gene expression profiles: scripts for the role of hemodynamics in atherogenesis?

García-Cardeña G, Comander JI, Blackman BR, Anderson KR, Gimbrone MA.

Ann N Y Acad Sci. 2001 Dec;947:1-6.

PMID:
11795257
23.

Molecular events in transmembrane signaling via E-selectin. SHP2 association, adaptor protein complex formation and ERK1/2 activation.

Hu Y, Szente B, Kiely JM, Gimbrone MA Jr.

J Biol Chem. 2001 Dec 21;276(51):48549-53. Epub 2001 Oct 15.

24.

Argus--a new database system for Web-based analysis of multiple microarray data sets.

Comander J, Weber GM, Gimbrone MA Jr, García-Cardeña G.

Genome Res. 2001 Sep;11(9):1603-10.

25.

Ramzi S. Cotran, M.D., 1932-2000.

Schoen FJ, Gimbrone MA Jr.

Cardiovasc Pathol. 2001 May-Jun;10(3):107-8. No abstract available.

PMID:
11485853
26.

Hmg-CoA reductase inhibitor modulates monocyte-endothelial cell interaction under physiological flow conditions in vitro: involvement of Rho GTPase-dependent mechanism.

Yoshida M, Sawada T, Ishii H, Gerszten RE, Rosenzweig A, Gimbrone MA Jr, Yasukochi Y, Numano F.

Arterioscler Thromb Vasc Biol. 2001 Jul;21(7):1165-71.

PMID:
11451746
27.

Biomechanical activation of vascular endothelium as a determinant of its functional phenotype.

Garcia-Cardeña G, Comander J, Anderson KR, Blackman BR, Gimbrone MA Jr.

Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4478-85.

28.

Expression of ephrinB2 identifies a stable genetic difference between arterial and venous vascular smooth muscle as well as endothelial cells, and marks subsets of microvessels at sites of adult neovascularization.

Shin D, Garcia-Cardena G, Hayashi S, Gerety S, Asahara T, Stavrakis G, Isner J, Folkman J, Gimbrone MA Jr, Anderson DJ.

Dev Biol. 2001 Feb 15;230(2):139-50.

PMID:
11161568
29.

Adenoviral transduction of human E-selectin into isolated, perfused, rat aortic segments: an ex vivo model for studying leukocyte-endothelial interactions.

Ishii H, Yoshida M, Rosenzweig A, Gimbrone MA Jr, Yasukochi Y, Numano F.

J Leukoc Biol. 2000 Nov;68(5):687-92.

PMID:
11073108
30.
31.

E-selectin-dependent signaling via the mitogen-activated protein kinase pathway in vascular endothelial cells.

Hu Y, Kiely JM, Szente BE, Rosenzweig A, Gimbrone MA Jr.

J Immunol. 2000 Aug 15;165(4):2142-8.

32.

Distinct mechanical stimuli differentially regulate the PI3K/Akt survival pathway in endothelial cells.

García-Cardeña G, Anderson KR, Mauri L, Gimbrone MA Jr.

Ann N Y Acad Sci. 2000 May;902:294-7. No abstract available.

PMID:
10865850
33.

C-C and C-X-C chemokines trigger firm adhesion of monocytes to vascular endothelium under flow conditions.

Luscinskas FW, Gerszten RE, Garcia-Zepeda EA, Lim YC, Yoshida M, Ding HA, Gimbrone MA Jr, Luster AD, Rosenzweig A.

Ann N Y Acad Sci. 2000 May;902:288-93.

PMID:
10865849
34.

Endothelial dysfunction, hemodynamic forces, and atherogenesis.

Gimbrone MA Jr, Topper JN, Nagel T, Anderson KR, Garcia-Cardeña G.

Ann N Y Acad Sci. 2000 May;902:230-9; discussion 239-40. Review.

PMID:
10865843
35.

A role for smad6 in development and homeostasis of the cardiovascular system.

Galvin KM, Donovan MJ, Lynch CA, Meyer RI, Paul RJ, Lorenz JN, Fairchild-Huntress V, Dixon KL, Dunmore JH, Gimbrone MA Jr, Falb D, Huszar D.

Nat Genet. 2000 Feb;24(2):171-4.

PMID:
10655064
36.

Endothelial dysfunction, hemodynamic forces, and atherosclerosis.

Gimbrone MA Jr.

Thromb Haemost. 1999 Aug;82(2):722-6. Review. No abstract available.

PMID:
10605774
37.

Vascular endothelial cells respond to spatial gradients in fluid shear stress by enhanced activation of transcription factors.

Nagel T, Resnick N, Dewey CF Jr, Gimbrone MA Jr.

Arterioscler Thromb Vasc Biol. 1999 Aug;19(8):1825-34.

PMID:
10446060
38.

Vascular endothelium, hemodynamic forces, and atherogenesis.

Gimbrone MA Jr.

Am J Pathol. 1999 Jul;155(1):1-5. Review. No abstract available.

39.

Special communicationthe critical role of mechanical forces in blood vessel development, physiology and pathology

Gimbrone MA Jr, Anderson KR, Topper JN, Langille BL, Clowes AW, Bercel S, Davies MG, Stenmark KR, Frid MG, Weiser-Evans MC, Aldashev AA, Nemenoff RA, Majesky MW, Landerholm TE, Lu J, Ito WD, Arras M, Scholz D, Imhof B, Aurrand-Lions M, Schaper W, Nagel TE, Resnick N, Dewey CF, Gimbrone MA, Davies PF.

J Vasc Surg. 1999 Jun;29(6):1104-51.

PMID:
10359945
40.

MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions.

Gerszten RE, Garcia-Zepeda EA, Lim YC, Yoshida M, Ding HA, Gimbrone MA Jr, Luster AD, Luscinskas FW, Rosenzweig A.

Nature. 1999 Apr 22;398(6729):718-23.

PMID:
10227295
41.

Leukocyte-endothelial monolayer adhesion assay (static conditions).

Kiely JM, Luscinskas FW, Gimbrone MA Jr.

Methods Mol Biol. 1999;96:131-6. Review. No abstract available.

PMID:
10098130
42.

Blood flow and vascular gene expression: fluid shear stress as a modulator of endothelial phenotype.

Topper JN, Gimbrone MA Jr.

Mol Med Today. 1999 Jan;5(1):40-6. Review.

PMID:
10088131
44.

Human prostaglandin transporter gene (hPGT) is regulated by fluid mechanical stimuli in cultured endothelial cells and expressed in vascular endothelium in vivo.

Topper JN, Cai J, Stavrakis G, Anderson KR, Woolf EA, Sampson BA, Schoen FJ, Falb D, Gimbrone MA Jr.

Circulation. 1998 Dec 1;98(22):2396-403.

PMID:
9832484
45.

Mice lacking E-selectin show normal numbers of rolling leukocytes but reduced leukocyte stable arrest on cytokine-activated microvascular endothelium.

Milstone DS, Fukumura D, Padgett RC, O'Donnell PE, Davis VM, Benavidez OJ, Monsky WL, Melder RJ, Jain RK, Gimbrone MA Jr.

Microcirculation. 1998;5(2-3):153-71.

PMID:
9789256
46.

Mechanisms of proliferative and obliterative vascular diseases. Insights from the pulmonary and systemic circulations. NHLBI Workshop summary.

Fishman AP, Fishman MC, Freeman BA, Gimbrone MA, Rabinovitch M, Robinson D, Gail DB.

Am J Respir Crit Care Med. 1998 Aug;158(2):670-4. No abstract available.

PMID:
9700149
47.

CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor beta transcriptional responses in endothelial cells.

Topper JN, DiChiara MR, Brown JD, Williams AJ, Falb D, Collins T, Gimbrone MA Jr.

Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9506-11. Erratum in: Ptov Natl Acad Sci U S A 1998 Oct 13;95(21):12735.

48.

Phosphorylation of the cytoplasmic domain of E-selectin is regulated during leukocyte-endothelial adhesion.

Yoshida M, Szente BE, Kiely JM, Rosenzweig A, Gimbrone MA Jr.

J Immunol. 1998 Jul 15;161(2):933-41.

49.

Adhesion of monocytes to vascular cell adhesion molecule-1-transduced human endothelial cells: implications for atherogenesis.

Gerszten RE, Lim YC, Ding HT, Snapp K, Kansas G, Dichek DA, Cabañas C, Sánchez-Madrid F, Gimbrone MA Jr, Rosenzweig A, Luscinskas FW.

Circ Res. 1998 May 4;82(8):871-8.

PMID:
9580553
50.

Regulation of PDGF-B in endothelial cells exposed to cyclic strain.

Sumpio BE, Du W, Galagher G, Wang X, Khachigian LM, Collins T, Gimbrone MA Jr, Resnick N.

Arterioscler Thromb Vasc Biol. 1998 Mar;18(3):349-55.

PMID:
9514402

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