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2003 1
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Page 1
GIMAP5 maintains liver endothelial cell homeostasis and prevents portal hypertension.
Drzewiecki K, Choi J, Brancale J, Leney-Greene MA, Sari S, Dalgiç B, Ünlüsoy Aksu A, Evirgen Şahin G, Ozen A, Baris S, Karakoc-Aydiner E, Jain D, Kleiner D, Schmalz M, Radhakrishnan K, Zhang J, Hoebe K, Su HC, Pereira JP, Lenardo MJ, Lifton RP, Vilarinho S. Drzewiecki K, et al. J Exp Med. 2021 Jul 5;218(7):e20201745. doi: 10.1084/jem.20201745. Epub 2021 May 6. J Exp Med. 2021. PMID: 33956074 Free PMC article.
We show that GIMAP5 is expressed in hepatic endothelial cells and that its loss in both humans and mice results in capillarization of liver sinusoidal endothelial cells (LSECs); this effect is also seen when GIMAP5 is selectively deleted in endothelial cells. ...Thu …
We show that GIMAP5 is expressed in hepatic endothelial cells and that its loss in both humans and mice results in capillarization of …
Gimap5 promoted RSV degradation through interaction with M6PR.
Dai P, Ruan P, Mao Y, Tang Z, Qiu X, Bajinka O, Tan Y. Dai P, et al. J Med Virol. 2023 Jan;95(1):e28390. doi: 10.1002/jmv.28390. J Med Virol. 2023. PMID: 36484389
GIMAP5 and M6PR were significantly downregulated after RSV infection. ...Three small molecule compounds targeting Gimap5 were confirmed to be the agonists of Gimap5. The three compounds effectively inhibited RSV infection and RSV-induced complications. ...
GIMAP5 and M6PR were significantly downregulated after RSV infection. ...Three small molecule compounds targeting Gimap5 were …
Essential role of MFSD1-GLMP-GIMAP5 in lymphocyte survival and liver homeostasis.
Zhong X, Moresco JJ, Diedrich JK, Pinto AM, SoRelle JA, Wang J, Keller K, Ludwig S, Moresco EMY, Beutler B, Choi JH. Zhong X, et al. Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):e2314429120. doi: 10.1073/pnas.2314429120. Epub 2023 Dec 6. Proc Natl Acad Sci U S A. 2023. PMID: 38055739
By proteomic analysis, we identified association between MFSD1 and both GLMP (glycosylated lysosomal membrane protein) and GIMAP5 (GTPase of immunity-associated protein 5). Germline knockout alleles of Mfsd1, Glmp, and Gimap5 each caused lymphopenia, liver pathology …
By proteomic analysis, we identified association between MFSD1 and both GLMP (glycosylated lysosomal membrane protein) and GIMAP5 (GT …
GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway.
Park AY, Leney-Greene M, Lynberg M, Gabrielski JQ, Xu X, Schwarz B, Zheng L, Balasubramaniyam A, Ham H, Chao B, Zhang Y, Matthews HF, Cui J, Yao Y, Kubo S, Chanchu JM, Morawski AR, Cook SA, Jiang P, Ravell JC, Cheng YH, George A, Faruqi A, Pagalilauan AM, Bergerson JRE, Ganesan S, Chauvin SD, Aluri J, Edwards-Hicks J, Bohrnsen E, Tippett C, Omar H, Xu L, Butcher GW, Pascall J, Karakoc-Aydiner E, Kiykim A, Maecker H, Tezcan İ, Esenboga S, Heredia RJ, Akata D, Tekin S, Kara A, Kuloglu Z, Unal E, Kendirli T, Dogu F, Karabiber E, Atkinson TP, Cochet C, Filhol O, Bosio CM, Davis MM, Lifton RP, Pearce EL, Daumke O, Aytekin C, Şahin GE, Aksu AÜ, Uzel G, Koneti Rao V, Sari S, Dalgıç B, Boztug K, Cagdas D, Haskologlu S, Ikinciogullari A, Schwefel D, Vilarinho S, Baris S, Ozen A, Su HC, Lenardo MJ. Park AY, et al. Nat Immunol. 2024 Feb;25(2):282-293. doi: 10.1038/s41590-023-01691-y. Epub 2024 Jan 3. Nat Immunol. 2024. PMID: 38172257
We show that GIMAP5 restricts the pathological accumulation of long-chain ceramides (CERs), thereby regulating longevity. ...Thus, GIMAP5 controls longevity assurance pathways crucial for immune function and healthspan in mammals....
We show that GIMAP5 restricts the pathological accumulation of long-chain ceramides (CERs), thereby regulating longevity. ...Thus, …
Gimap5 Inhibits Lung Cancer Growth by Interacting With M6PR.
Dai P, Tang Z, Ruan P, Bajinka O, Liu D, Tan Y. Dai P, et al. Front Oncol. 2021 Sep 15;11:699847. doi: 10.3389/fonc.2021.699847. eCollection 2021. Front Oncol. 2021. PMID: 34604035 Free PMC article.
After the survival rates of the cells were analyzed, we constructed Gimap5 over-expressed lung cancer cell lines and assessed the effects of Gimap5 on cell migration, cell invasion, cell proliferation and the epithelial-mesenchymal transition (EMT). ...Moreover, we …
After the survival rates of the cells were analyzed, we constructed Gimap5 over-expressed lung cancer cell lines and assessed the eff …
Central role of gimap5 in maintaining peripheral tolerance and T cell homeostasis in the gut.
Endale M, Aksoylar HI, Hoebe K. Endale M, et al. Mediators Inflamm. 2015;2015:436017. doi: 10.1155/2015/436017. Epub 2015 Apr 7. Mediators Inflamm. 2015. PMID: 25944983 Free PMC article. Review.
In this review, we summarize recent findings derived from studies involving a novel early-onset model of colitis as it develops in GTPase of immunity-associated protein 5- (Gimap5-) deficient mice. In humans, GIMAP5 has been associated with autoimmune diseases altho …
In this review, we summarize recent findings derived from studies involving a novel early-onset model of colitis as it develops in GTPase of …
Exploring the expression and preliminary function of chicken Gimap5 gene.
Zhang W, Xu S, Wu G, Liu Y, Wang Q, Man C. Zhang W, et al. PeerJ. 2019 Sep 26;7:e7618. doi: 10.7717/peerj.7618. eCollection 2019. PeerJ. 2019. PMID: 31579581 Free PMC article.
The transcriptional activities of the Gimap5 gene in immune response were identified. The results showed that full-length cDNA sequence of Gimap5 contained 771 bp and encoded a 256-amino acid protein. ...These data can provide the foundation for further study of …
The transcriptional activities of the Gimap5 gene in immune response were identified. The results showed that full-length cDNA sequen …
Gimap5-dependent inactivation of GSK3beta is required for CD4(+) T cell homeostasis and prevention of immune pathology.
Patterson AR, Endale M, Lampe K, Aksoylar HI, Flagg A, Woodgett JR, Hildeman D, Jordan MB, Singh H, Kucuk Z, Bleesing J, Hoebe K. Patterson AR, et al. Nat Commun. 2018 Jan 30;9(1):430. doi: 10.1038/s41467-018-02897-7. Nat Commun. 2018. PMID: 29382851 Free PMC article.
GTPase of immunity-associated protein 5 (Gimap5) is linked with lymphocyte survival, autoimmunity, and colitis, but its mechanisms of action are unclear. Here, we show that Gimap5 is essential for the inactivation of glycogen synthase kinase-3beta (GSK3beta) followi …
GTPase of immunity-associated protein 5 (Gimap5) is linked with lymphocyte survival, autoimmunity, and colitis, but its mechanisms of …
GIMAP5 Deficiency Is Associated with Increased AKT Activity in T Lymphocytes.
Chen XL, Serrano D, Mayhue M, Hoebe K, Ilangumaran S, Ramanathan S. Chen XL, et al. PLoS One. 2015 Oct 6;10(10):e0139019. doi: 10.1371/journal.pone.0139019. eCollection 2015. PLoS One. 2015. PMID: 26440416 Free PMC article.
The underlying mechanism responsible for the disruption of quiescence in Gimap5 deficient T cells remains largely unknown. In this study, we show that loss of functional Gimap5 results in increased basal activation of mammalian target of rapamycin (mTOR), independen …
The underlying mechanism responsible for the disruption of quiescence in Gimap5 deficient T cells remains largely unknown. In this st …
Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse.
Yano K, Carter C, Yoshida N, Abe T, Yamada A, Nitta T, Ishimaru N, Takada K, Butcher GW, Takahama Y. Yano K, et al. Eur J Immunol. 2014 Feb;44(2):561-72. doi: 10.1002/eji.201343750. Epub 2013 Oct 23. Eur J Immunol. 2014. PMID: 24510501 Free article.
Gimap3 (IAN4) and Gimap5 (IAN5) are highly homologous GTP-binding proteins of the Gimap family. ...Here we report the preparation and characteristics of mouse strains lacking Gimap3 and/or Gimap5. We found that the number of T cells was markedly reduced in mice defi …
Gimap3 (IAN4) and Gimap5 (IAN5) are highly homologous GTP-binding proteins of the Gimap family. ...Here we report the preparation and …
73 results