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Items: 1 to 50 of 53

1.

An Early mtUPR: Redistribution of the Nuclear Transcription Factor Rox1 to Mitochondria Protects against Intramitochondrial Proteotoxic Aggregates.

Poveda-Huertes D, Matic S, Marada A, Habernig L, Licheva M, Myketin L, Gilsbach R, Tosal-Castano S, Papinski D, Mulica P, Kretz O, Kücükköse C, Taskin AA, Hein L, Kraft C, Büttner S, Meisinger C, Vögtle FN.

Mol Cell. 2019 Oct 14. pii: S1097-2765(19)30731-2. doi: 10.1016/j.molcel.2019.09.026. [Epub ahead of print]

2.

The in vivo specificity of synaptic Gβ and Gγ subunits to the α2a adrenergic receptor at CNS synapses.

Yim YY, Betke KM, McDonald WH, Gilsbach R, Chen Y, Hyde K, Wang Q, Hein L, Hamm H.

Sci Rep. 2019 Feb 8;9(1):1718. doi: 10.1038/s41598-018-37222-1.

3.

Uncontrolled Diabetes Mellitus Has No Major Influence on the Platelet Transcriptome.

Nührenberg TG, Cederqvist M, Marini F, Stratz C, Grüning BA, Trenk D, Binder H, Gilsbach R, Neumann FJ, Hein L.

Biomed Res Int. 2018 Nov 1;2018:8989252. doi: 10.1155/2018/8989252. eCollection 2018.

4.

A Dual Noradrenergic Mechanism for the Relief of Neuropathic Allodynia by the Antidepressant Drugs Duloxetine and Amitriptyline.

Kremer M, Yalcin I, Goumon Y, Wurtz X, Nexon L, Daniel D, Megat S, Ceredig RA, Ernst C, Turecki G, Chavant V, Théroux JF, Lacaud A, Joganah LE, Lelievre V, Massotte D, Lutz PE, Gilsbach R, Salvat E, Barrot M.

J Neurosci. 2018 Nov 14;38(46):9934-9954. doi: 10.1523/JNEUROSCI.1004-18.2018. Epub 2018 Sep 24.

5.

Dorsal BNST α2A-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors.

Harris NA, Isaac AT, Günther A, Merkel K, Melchior J, Xu M, Eguakun E, Perez R, Nabit BP, Flavin S, Gilsbach R, Shonesy B, Hein L, Abel T, Baumann A, Matthews R, Centanni SW, Winder DG.

J Neurosci. 2018 Oct 17;38(42):8922-8942. doi: 10.1523/JNEUROSCI.0963-18.2018. Epub 2018 Aug 27.

6.

The Transcription Factor ETV1 Induces Atrial Remodeling and Arrhythmia.

Rommel C, Rösner S, Lother A, Barg M, Schwaderer M, Gilsbach R, Bömicke T, Schnick T, Mayer S, Doll S, Hesse M, Kretz O, Stiller B, Neumann FJ, Mann M, Krane M, Fleischmann BK, Ravens U, Hein L.

Circ Res. 2018 Aug 17;123(5):550-563. doi: 10.1161/CIRCRESAHA.118.313036.

PMID:
29930145
7.

Galaxy HiCExplorer: a web server for reproducible Hi-C data analysis, quality control and visualization.

Wolff J, Bhardwaj V, Nothjunge S, Richard G, Renschler G, Gilsbach R, Manke T, Backofen R, Ramírez F, Grüning BA.

Nucleic Acids Res. 2018 Jul 2;46(W1):W11-W16. doi: 10.1093/nar/gky504.

8.

Reactivation of the Nkx2.5 cardiac enhancer after myocardial infarction does not presage myogenesis.

Deutsch MA, Doppler SA, Li X, Lahm H, Santamaria G, Cuda G, Eichhorn S, Ratschiller T, Dzilic E, Dreßen M, Eckart A, Stark K, Massberg S, Bartels A, Rischpler C, Gilsbach R, Hein L, Fleischmann BK, Wu SM, Lange R, Krane M.

Cardiovasc Res. 2018 Jul 1;114(8):1098-1114. doi: 10.1093/cvr/cvy069.

9.

Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo.

Gilsbach R, Schwaderer M, Preissl S, Grüning BA, Kranzhöfer D, Schneider P, Nührenberg TG, Mulero-Navarro S, Weichenhan D, Braun C, Dreßen M, Jacobs AR, Lahm H, Doenst T, Backofen R, Krane M, Gelb BD, Hein L.

Nat Commun. 2018 Jan 26;9(1):391. doi: 10.1038/s41467-017-02762-z.

10.

DNA methylation signatures follow preformed chromatin compartments in cardiac myocytes.

Nothjunge S, Nührenberg TG, Grüning BA, Doppler SA, Preissl S, Schwaderer M, Rommel C, Krane M, Hein L, Gilsbach R.

Nat Commun. 2017 Nov 21;8(1):1667. doi: 10.1038/s41467-017-01724-9.

11.

Inhibition of the cardiac myocyte mineralocorticoid receptor ameliorates doxorubicin-induced cardiotoxicity.

Lother A, Bergemann S, Kowalski J, Huck M, Gilsbach R, Bode C, Hein L.

Cardiovasc Res. 2018 Feb 1;114(2):282-290. doi: 10.1093/cvr/cvx078.

PMID:
28430882
12.

Cingulate Overexpression of Mitogen-Activated Protein Kinase Phosphatase-1 as a Key Factor for Depression.

Barthas F, Humo M, Gilsbach R, Waltisperger E, Karatas M, Leman S, Hein L, Belzung C, Boutillier AL, Barrot M, Yalcin I.

Biol Psychiatry. 2017 Sep 1;82(5):370-379. doi: 10.1016/j.biopsych.2017.01.019. Epub 2017 Feb 14.

PMID:
28359564
13.

Interleukin-4 Protects Dopaminergic Neurons In vitro but Is Dispensable for MPTP-Induced Neurodegeneration In vivo.

Hühner L, Rilka J, Gilsbach R, Zhou X, Machado V, Spittau B.

Front Mol Neurosci. 2017 Mar 9;10:62. doi: 10.3389/fnmol.2017.00062. eCollection 2017.

14.

5'-Hydroxymethylcytosine Precedes Loss of CpG Methylation in Enhancers and Genes Undergoing Activation in Cardiomyocyte Maturation.

Kranzhöfer DK, Gilsbach R, Grüning BA, Backofen R, Nührenberg TG, Hein L.

PLoS One. 2016 Nov 16;11(11):e0166575. doi: 10.1371/journal.pone.0166575. eCollection 2016.

15.

Ablation of biglycan attenuates cardiac hypertrophy and fibrosis after left ventricular pressure overload.

Beetz N, Rommel C, Schnick T, Neumann E, Lother A, Monroy-Ordonez EB, Zeeb M, Preissl S, Gilsbach R, Melchior-Becker A, Rylski B, Stoll M, Schaefer L, Beyersdorf F, Stiller B, Hein L.

J Mol Cell Cardiol. 2016 Dec;101:145-155. doi: 10.1016/j.yjmcc.2016.10.011. Epub 2016 Oct 24.

PMID:
27789290
16.

MOF Acetyl Transferase Regulates Transcription and Respiration in Mitochondria.

Chatterjee A, Seyfferth J, Lucci J, Gilsbach R, Preissl S, Böttinger L, Mårtensson CU, Panhale A, Stehle T, Kretz O, Sahyoun AH, Avilov S, Eimer S, Hein L, Pfanner N, Becker T, Akhtar A.

Cell. 2016 Oct 20;167(3):722-738.e23. doi: 10.1016/j.cell.2016.09.052.

17.

Gdf-15 deficiency does not alter vulnerability of nigrostriatal dopaminergic system in MPTP-intoxicated mice.

Machado V, Gilsbach R, Das R, Schober A, Bogatyreva L, Hauschke D, Krieglstein K, Unsicker K, Spittau B.

Cell Tissue Res. 2016 Aug;365(2):209-23. doi: 10.1007/s00441-016-2406-x. Epub 2016 Apr 26.

PMID:
27115420
18.

Atheroprotection through SYK inhibition fails in established disease when local macrophage proliferation dominates lesion progression.

Lindau A, Härdtner C, Hergeth SP, Blanz KD, Dufner B, Hoppe N, Anto-Michel N, Kornemann J, Zou J, Gerhardt LM, Heidt T, Willecke F, Geis S, Stachon P, Wolf D, Libby P, Swirski FK, Robbins CS, McPheat W, Hawley S, Braddock M, Gilsbach R, Hein L, von zur Mühlen C, Bode C, Zirlik A, Hilgendorf I.

Basic Res Cardiol. 2016 Mar;111(2):20. doi: 10.1007/s00395-016-0535-8. Epub 2016 Feb 18.

19.

Deoxycorticosterone Acetate/Salt-Induced Cardiac But Not Renal Injury Is Mediated By Endothelial Mineralocorticoid Receptors Independently From Blood Pressure.

Lother A, Fürst D, Bergemann S, Gilsbach R, Grahammer F, Huber TB, Hilgendorf I, Bode C, Moser M, Hein L.

Hypertension. 2016 Jan;67(1):130-8. doi: 10.1161/HYPERTENSIONAHA.115.06530. Epub 2015 Nov 9.

PMID:
26553231
20.

Adrenergic Repression of the Epigenetic Reader MeCP2 Facilitates Cardiac Adaptation in Chronic Heart Failure.

Mayer SC, Gilsbach R, Preissl S, Monroy Ordonez EB, Schnick T, Beetz N, Lother A, Rommel C, Ihle H, Bugger H, Rühle F, Schrepper A, Schwarzer M, Heilmann C, Bönisch U, Gupta SK, Wilpert J, Kretz O, von Elverfeldt D, Orth J, Aktories K, Beyersdorf F, Bode C, Stiller B, Krüger M, Thum T, Doenst T, Stoll M, Hein L.

Circ Res. 2015 Sep 11;117(7):622-33. doi: 10.1161/CIRCRESAHA.115.306721. Epub 2015 Jul 20.

21.

Deciphering the Epigenetic Code of Cardiac Myocyte Transcription.

Preissl S, Schwaderer M, Raulf A, Hesse M, Grüning BA, Köbele C, Backofen R, Fleischmann BK, Hein L, Gilsbach R.

Circ Res. 2015 Aug 14;117(5):413-23. doi: 10.1161/CIRCRESAHA.115.306337. Epub 2015 Jun 23.

PMID:
26105955
22.

Cardiac Myocyte De Novo DNA Methyltransferases 3a/3b Are Dispensable for Cardiac Function and Remodeling after Chronic Pressure Overload in Mice.

Nührenberg TG, Hammann N, Schnick T, Preißl S, Witten A, Stoll M, Gilsbach R, Neumann FJ, Hein L.

PLoS One. 2015 Jun 22;10(6):e0131019. doi: 10.1371/journal.pone.0131019. eCollection 2015.

23.

A systemic Pasteurella multocida toxin aggravates cardiac hypertrophy and fibrosis in mice.

Weise M, Vettel C, Spiger K, Gilsbach R, Hein L, Lorenz K, Wieland T, Aktories K, Orth JH.

Cell Microbiol. 2015 Sep;17(9):1320-31. doi: 10.1111/cmi.12436. Epub 2015 Mar 30.

PMID:
25759205
24.

Neuropeptide Y in the noradrenergic neurones induces obesity and inhibits sympathetic tone in mice.

Vähätalo LH, Ruohonen ST, Mäkelä S, Kovalainen M, Huotari A, Mäkelä KA, Määttä JA, Miinalainen I, Gilsbach R, Hein L, Ailanen L, Mattila M, Eerola K, Röyttä M, Ruohonen S, Herzig KH, Savontaus E.

Acta Physiol (Oxf). 2015 Apr;213(4):902-19. doi: 10.1111/apha.12436. Epub 2014 Dec 26.

PMID:
25482272
25.

Noncanonical G-protein-dependent modulation of osteoclast differentiation and bone resorption mediated by Pasteurella multocida toxin.

Strack J, Heni H, Gilsbach R, Hein L, Aktories K, Orth JH.

MBio. 2014 Nov 11;5(6):e02190. doi: 10.1128/mBio.02190-14.

26.

Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease.

Gilsbach R, Preissl S, Grüning BA, Schnick T, Burger L, Benes V, Würch A, Bönisch U, Günther S, Backofen R, Fleischmann BK, Schübeler D, Hein L.

Nat Commun. 2014 Oct 22;5:5288. doi: 10.1038/ncomms6288.

27.

Epigenetics in cardiac development, function, and disease.

Nührenberg T, Gilsbach R, Preissl S, Schnick T, Hein L.

Cell Tissue Res. 2014 Jun;356(3):585-600. doi: 10.1007/s00441-014-1887-8. Epub 2014 May 13. Review.

PMID:
24817102
28.

REEP1 and REEP2 proteins are preferentially expressed in neuronal and neuronal-like exocytotic tissues.

Hurt CM, Björk S, Ho VK, Gilsbach R, Hein L, Angelotti T.

Brain Res. 2014 Jan 30;1545:12-22. doi: 10.1016/j.brainres.2013.12.008. Epub 2013 Dec 16.

29.

β1-Adrenoceptor mRNA level reveals distinctions between infantile hemangioma and vascular malformations.

Rössler J, Haubold M, Gilsbach R, Jüttner E, Schmitt D, Niemeyer CM, Hein L.

Pediatr Res. 2013 Apr;73(4 Pt 1):409-13. doi: 10.1038/pr.2013.16. Epub 2013 Jan 31.

PMID:
23370410
30.

Involvement of α2-adrenoceptor subtypes A and C in glucose homeostasis and adrenaline-induced hyperglycaemia.

Ruohonen ST, Ruohonen S, Gilsbach R, Savontaus E, Scheinin M, Hein L.

Neuroendocrinology. 2012;96(1):51-9. doi: 10.1159/000334629. Epub 2012 Feb 7.

PMID:
22327786
31.

[α -Adrenoceptors: three subtypes for a broad spectrum of activity].

Gilsbach R, Preissl S, Hein L.

Pharm Unserer Zeit. 2011 Nov;40(6):462-8. doi: 10.1002/pauz.201100440. Review. German. No abstract available.

PMID:
22028129
32.

Pre- versus postsynaptic signaling by α(2)-adrenoceptors.

Gilsbach R, Albarrán-Juárez J, Hein L.

Curr Top Membr. 2011;67:139-60. doi: 10.1016/B978-0-12-384921-2.00007-0. Review. No abstract available.

PMID:
21771489
33.

Are the pharmacology and physiology of α₂ adrenoceptors determined by α₂-heteroreceptors and autoreceptors respectively?

Gilsbach R, Hein L.

Br J Pharmacol. 2012 Jan;165(1):90-102. doi: 10.1111/j.1476-5381.2011.01533.x. Review.

34.

Chronic cardiac pressure overload induces adrenal medulla hypertrophy and increased catecholamine synthesis.

Schneider J, Lother A, Hein L, Gilsbach R.

Basic Res Cardiol. 2011 Jun;106(4):591-602. doi: 10.1007/s00395-011-0166-z. Epub 2011 Mar 10.

PMID:
21547520
35.

Cardiovascular effects of chronic treatment with a β2-adrenoceptor agonist relieving neuropathic pain in mice.

Choucair-Jaafar N, Beetz N, Gilsbach R, Yalcin I, Waltisperger E, Freund-Mercier MJ, Monassier L, Hein L, Barrot M.

Neuropharmacology. 2011 Jul-Aug;61(1-2):51-60. doi: 10.1016/j.neuropharm.2011.02.015. Epub 2011 Feb 23.

PMID:
21352833
36.

Ablation of mineralocorticoid receptors in myocytes but not in fibroblasts preserves cardiac function.

Lother A, Berger S, Gilsbach R, Rösner S, Ecke A, Barreto F, Bauersachs J, Schütz G, Hein L.

Hypertension. 2011 Apr;57(4):746-54. doi: 10.1161/HYPERTENSIONAHA.110.163287. Epub 2011 Feb 14.

PMID:
21321305
37.

{Alpha}2B-adrenoceptor deficiency leads to postnatal respiratory failure in mice.

Haubold M, Gilsbach R, Hein L.

J Biol Chem. 2010 Oct 29;285(44):34213-9. doi: 10.1074/jbc.M110.129205. Epub 2010 Aug 20.

38.

Induction of heart failure by minimally invasive aortic constriction in mice: reduced peroxisome proliferator-activated receptor γ coactivator levels and mitochondrial dysfunction.

Faerber G, Barreto-Perreia F, Schoepe M, Gilsbach R, Schrepper A, Schwarzer M, Mohr FW, Hein L, Doenst T.

J Thorac Cardiovasc Surg. 2011 Feb;141(2):492-500, 500.e1. doi: 10.1016/j.jtcvs.2010.03.029. Epub 2010 May 5.

39.

Sympathetic alpha(2)-adrenoceptors prevent cardiac hypertrophy and fibrosis in mice at baseline but not after chronic pressure overload.

Gilsbach R, Schneider J, Lother A, Schickinger S, Leemhuis J, Hein L.

Cardiovasc Res. 2010 Jun 1;86(3):432-42. doi: 10.1093/cvr/cvq014. Epub 2010 Jan 18.

PMID:
20083574
40.

Transgenic simulation of human heart failure-like L-type Ca2+-channels: implications for fibrosis and heart rate in mice.

Beetz N, Hein L, Meszaros J, Gilsbach R, Barreto F, Meissner M, Hoppe UC, Schwartz A, Herzig S, Matthes J.

Cardiovasc Res. 2009 Dec 1;84(3):396-406. doi: 10.1093/cvr/cvp251. Epub 2009 Jul 20.

41.

Modulation of alpha2-adrenoceptor functions by heterotrimeric Galphai protein isoforms.

Albarrán-Juárez J, Gilsbach R, Piekorz RP, Pexa K, Beetz N, Schneider J, Nürnberg B, Birnbaumer L, Hein L.

J Pharmacol Exp Ther. 2009 Oct;331(1):35-44. doi: 10.1124/jpet.109.157230. Epub 2009 Jul 9. Erratum in: J Pharmacol Exp Ther. 2010 Apr;333(1):351. Birnbaumer, Lutz [added].

42.

Genetic dissection of alpha2-adrenoceptor functions in adrenergic versus nonadrenergic cells.

Gilsbach R, Röser C, Beetz N, Brede M, Hadamek K, Haubold M, Leemhuis J, Philipp M, Schneider J, Urbanski M, Szabo B, Weinshenker D, Hein L.

Mol Pharmacol. 2009 May;75(5):1160-70. doi: 10.1124/mol.109.054544. Epub 2009 Feb 27.

PMID:
19251826
43.

Association of major depression with rare functional variants in norepinephrine transporter and serotonin1A receptor genes.

Haenisch B, Linsel K, Brüss M, Gilsbach R, Propping P, Nöthen MM, Rietschel M, Fimmers R, Maier W, Zobel A, Höfels S, Guttenthaler V, Göthert M, Bönisch H.

Am J Med Genet B Neuropsychiatr Genet. 2009 Oct 5;150B(7):1013-6. doi: 10.1002/ajmg.b.30912.

PMID:
19105200
44.

Neurotrophin and neuropeptide expression in mouse brain is regulated by knockout of the norepinephrine transporter.

Haenisch B, Gilsbach R, Bönisch H.

J Neural Transm (Vienna). 2008 Jul;115(7):973-82. doi: 10.1007/s00702-008-0039-2. Epub 2008 Mar 12.

PMID:
18335160
45.

Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline.

Gilsbach R, Hein L.

Handb Exp Pharmacol. 2008;(184):261-88. Review.

PMID:
18064417
46.

Molecular cloning and functional expression of the murine noradrenaline transporter.

Muck A, Gilsbach R, Löbbe-Werner S, Brüss M, Bönisch H.

Naunyn Schmiedebergs Arch Pharmacol. 2007 Oct;376(1-2):65-71. Epub 2007 Sep 19.

PMID:
17882401
47.

Upregulation of soluble vascular endothelial growth factor receptor 1 contributes to angiogenesis defects in the placenta of alpha 2B-adrenoceptor deficient mice.

Muthig V, Gilsbach R, Haubold M, Philipp M, Ivacevic T, Gessler M, Hein L.

Circ Res. 2007 Sep 28;101(7):682-91. Epub 2007 Aug 2.

PMID:
17673674
48.

Alpha2-adrenoceptor subtypes--unexpected functions for receptors and ligands derived from gene-targeted mouse models.

Knaus AE, Muthig V, Schickinger S, Moura E, Beetz N, Gilsbach R, Hein L.

Neurochem Int. 2007 Oct;51(5):277-81. Epub 2007 Jul 4. Review.

PMID:
17664025
49.

Heterozygous alpha 2C-adrenoceptor-deficient mice develop heart failure after transverse aortic constriction.

Gilsbach R, Brede M, Beetz N, Moura E, Muthig V, Gerstner C, Barreto F, Neubauer S, Vieira-Coelho MA, Hein L.

Cardiovasc Res. 2007 Sep 1;75(4):728-37. Epub 2007 May 24.

PMID:
17597596
50.

Increased expression of the auxiliary beta(2)-subunit of ventricular L-type Ca(2)+ channels leads to single-channel activity characteristic of heart failure.

Hullin R, Matthes J, von Vietinghoff S, Bodi I, Rubio M, D'Souza K, Friedrich Khan I, Rottländer D, Hoppe UC, Mohacsi P, Schmitteckert E, Gilsbach R, Bünemann M, Hein L, Schwartz A, Herzig S.

PLoS One. 2007 Mar 14;2(3):e292.

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