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Silver spoons and other personal reflections.

Gilman AG.

Annu Rev Pharmacol Toxicol. 2012;52:1-19. doi: 10.1146/annurev-pharmtox-010611-134652. Epub 2011 Aug 1.


Gialpha and Gbeta subunits both define selectivity of G protein activation by alpha2-adrenergic receptors.

Gibson SK, Gilman AG.

Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):212-7. Epub 2005 Dec 21.


Cross talk: interview with Al Gilman.

Gilman AG.

Mol Interv. 2001 Apr;1(1):14-21.


Allosteric determinants in guanine nucleotide-binding proteins.

Hatley ME, Lockless SW, Gibson SK, Gilman AG, Ranganathan R.

Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14445-50. Epub 2003 Nov 17.


TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors.

Chen Z, Raman M, Chen L, Lee SF, Gilman AG, Cobb MH.

J Biol Chem. 2003 Jun 20;278(25):22278-83. Epub 2003 Mar 28.


Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor.

Tall GG, Krumins AM, Gilman AG.

J Biol Chem. 2003 Mar 7;278(10):8356-62. Epub 2002 Dec 30.


Overview of the Alliance for Cellular Signaling.

Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O'Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O'Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR; Participating investigators and scientists of the Alliance for Cellular Signaling.

Nature. 2002 Dec 12;420(6916):703-6.


Assay of RGS protein activity in vitro using purified components.

Krumins AM, Gilman AG.

Methods Enzymol. 2002;344:673-85.


Crystallization of complex between soluble domains of adenylyl cyclase and activated Gs alpha.

Tesmer JJ, Sunahara RK, Fancy DA, Gilman AG, Sprang SR.

Methods Enzymol. 2002;345:198-206. No abstract available.


Wrong signals about alliance's scope and aim.

Gilman AG.

Nature. 2000 Nov 9;408(6809):133. No abstract available.


Molecular basis for P-site inhibition of adenylyl cyclase.

Tesmer JJ, Dessauer CW, Sunahara RK, Murray LD, Johnson RA, Gilman AG, Sprang SR.

Biochemistry. 2000 Nov 28;39(47):14464-71.


Isolation and characterization of constitutively active mutants of mammalian adenylyl cyclase.

Hatley ME, Benton BK, Xu J, Manfredi JP, Gilman AG, Sunahara RK.

J Biol Chem. 2000 Dec 8;275(49):38626-32.


Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2.

Carman CV, Parent JL, Day PW, Pronin AN, Sternweis PM, Wedegaertner PB, Gilman AG, Benovic JL, Kozasa T.

J Biol Chem. 1999 Nov 26;274(48):34483-92.


A candidate target for G protein action in brain.

Chen LT, Gilman AG, Kozasa T.

J Biol Chem. 1999 Sep 17;274(38):26931-8.


Two-metal-Ion catalysis in adenylyl cyclase.

Tesmer JJ, Sunahara RK, Johnson RA, Gosselin G, Gilman AG, Sprang SR.

Science. 1999 Jul 30;285(5428):756-60.


Modulation of the affinity and selectivity of RGS protein interaction with G alpha subunits by a conserved asparagine/serine residue.

Posner BA, Mukhopadhyay S, Tesmer JJ, Gilman AG, Ross EM.

Biochemistry. 1999 Jun 15;38(24):7773-9.


The interactions of adenylate cyclases with P-site inhibitors.

Dessauer CW, Tesmer JJ, Sprang SR, Gilman AG.

Trends Pharmacol Sci. 1999 May;20(5):205-10. Review.


Persistent membrane association of activated and depalmitoylated G protein alpha subunits.

Huang C, Duncan JA, Gilman AG, Mumby SM.

Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):412-7.


A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits.

Snow BE, Krumins AM, Brothers GM, Lee SF, Wall MA, Chung S, Mangion J, Arya S, Gilman AG, Siderovski DP.

Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13307-12.


Sites important for PLCbeta2 activation by the G protein betagamma subunit map to the sides of the beta propeller structure.

Panchenko MP, Saxena K, Li Y, Charnecki S, Sternweis PM, Smith TF, Gilman AG, Kozasa T, Neer EJ.

J Biol Chem. 1998 Oct 23;273(43):28298-304.


Identification of a Gialpha binding site on type V adenylyl cyclase.

Dessauer CW, Tesmer JJ, Sprang SR, Gilman AG.

J Biol Chem. 1998 Oct 2;273(40):25831-9.


Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity.

Ingi T, Krumins AM, Chidiac P, Brothers GM, Chung S, Snow BE, Barnes CA, Lanahan AA, Siderovski DP, Ross EM, Gilman AG, Worley PF.

J Neurosci. 1998 Sep 15;18(18):7178-88.


The A326S mutant of Gialpha1 as an approximation of the receptor-bound state.

Posner BA, Mixon MB, Wall MA, Sprang SR, Gilman AG.

J Biol Chem. 1998 Aug 21;273(34):21752-8.


GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain.

Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP.

J Biol Chem. 1998 Jul 10;273(28):17749-55.


Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13.

Hart MJ, Jiang X, Kozasa T, Roscoe W, Singer WD, Gilman AG, Sternweis PC, Bollag G.

Science. 1998 Jun 26;280(5372):2112-4.


p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13.

Kozasa T, Jiang X, Hart MJ, Sternweis PM, Singer WD, Gilman AG, Bollag G, Sternweis PC.

Science. 1998 Jun 26;280(5372):2109-11.


Exchange of substrate and inhibitor specificities between adenylyl and guanylyl cyclases.

Sunahara RK, Beuve A, Tesmer JJ, Sprang SR, Garbers DL, Gilman AG.

J Biol Chem. 1998 Jun 26;273(26):16332-8.


Sites for Galpha binding on the G protein beta subunit overlap with sites for regulation of phospholipase Cbeta and adenylyl cyclase.

Li Y, Sternweis PM, Charnecki S, Smith TF, Gilman AG, Neer EJ, Kozasa T.

J Biol Chem. 1998 Jun 26;273(26):16265-72.


Sequestration of the G protein beta gamma subunit complex inhibits receptor-mediated endocytosis.

Lin HC, Duncan JA, Kozasa T, Gilman AG.

Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5057-60.


Mammalian RGS proteins: barbarians at the gate.

Berman DM, Gilman AG.

J Biol Chem. 1998 Jan 16;273(3):1269-72. Review. No abstract available.


Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.

Tesmer JJ, Sunahara RK, Gilman AG, Sprang SR.

Science. 1997 Dec 12;278(5345):1907-16.


Crystal structure of the adenylyl cyclase activator Gsalpha.

Sunahara RK, Tesmer JJ, Gilman AG, Sprang SR.

Science. 1997 Dec 12;278(5345):1943-7.


Organization of G proteins and adenylyl cyclase at the plasma membrane.

Huang C, Hepler JR, Chen LT, Gilman AG, Anderson RG, Mumby SM.

Mol Biol Cell. 1997 Dec;8(12):2365-78.


Interactions of forskolin and ATP with the cytosolic domains of mammalian adenylyl cyclase.

Dessauer CW, Scully TT, Gilman AG.

J Biol Chem. 1997 Aug 29;272(35):22272-7.


Interaction of Gsalpha with the cytosolic domains of mammalian adenylyl cyclase.

Sunahara RK, Dessauer CW, Whisnant RE, Kleuss C, Gilman AG.

J Biol Chem. 1997 Aug 29;272(35):22265-71.


Activation of transducin guanosine triphosphatase by two proteins of the RGS family.

Nekrasova ER, Berman DM, Rustandi RR, Hamm HE, Gilman AG, Arshavsky VY.

Biochemistry. 1997 Jun 24;36(25):7638-43.


Attenuation of Gi- and Gq-mediated signaling by expression of RGS4 or GAIP in mammalian cells.

Huang C, Hepler JR, Gilman AG, Mumby SM.

Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6159-63.


RGS4 and GAIP are GTPase-activating proteins for Gq alpha and block activation of phospholipase C beta by gamma-thio-GTP-Gq alpha.

Hepler JR, Berman DM, Gilman AG, Kozasa T.

Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):428-32.


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