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Items: 7

1.

The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology.

Martinez Hernandez A, Urbanke H, Gillman AL, Lee J, Ryazanov S, Agbemenyah HY, Benito E, Jain G, Kaurani L, Grigorian G, Leonov A, Rezaei-Ghaleh N, Wilken P, Arce FT, Wagner J, Fuhrmann M, Caruana M, Camilleri A, Vassallo N, Zweckstetter M, Benz R, Giese A, Schneider A, Korte M, Lal R, Griesinger C, Eichele G, Fischer A.

EMBO Mol Med. 2018 Jan;10(1):32-47. doi: 10.15252/emmm.201707825.

2.

Amyloid β Ion Channels in a Membrane Comprising Brain Total Lipid Extracts.

Lee J, Kim YH, T Arce F, Gillman AL, Jang H, Kagan BL, Nussinov R, Yang J, Lal R.

ACS Chem Neurosci. 2017 Jun 21;8(6):1348-1357. doi: 10.1021/acschemneuro.7b00006. Epub 2017 Feb 20.

PMID:
28135799
3.

Small molecule NPT-440-1 inhibits ionic flux through Aβ1-42 pores: Implications for Alzheimer's disease therapeutics.

Gillman AL, Lee J, Ramachandran S, Capone R, Gonzalez T, Wrasidlo W, Masliah E, Lal R.

Nanomedicine. 2016 Nov;12(8):2331-2340. doi: 10.1016/j.nano.2016.06.001. Epub 2016 Jun 19.

4.

Computational Methods for Structural and Functional Studies of Alzheimer's Amyloid Ion Channels.

Jang H, Arce FT, Lee J, Gillman AL, Ramachandran S, Kagan BL, Lal R, Nussinov R.

Methods Mol Biol. 2016;1345:251-68. doi: 10.1007/978-1-4939-2978-8_16.

PMID:
26453217
5.

Role of the fast kinetics of pyroglutamate-modified amyloid-β oligomers in membrane binding and membrane permeability.

Lee J, Gillman AL, Jang H, Ramachandran S, Kagan BL, Nussinov R, Teran Arce F.

Biochemistry. 2014 Jul 22;53(28):4704-14. doi: 10.1021/bi500587p. Epub 2014 Jul 9.

6.

Activity and architecture of pyroglutamate-modified amyloid-β (AβpE3-42) pores.

Gillman AL, Jang H, Lee J, Ramachandran S, Kagan BL, Nussinov R, Teran Arce F.

J Phys Chem B. 2014 Jul 3;118(26):7335-44. doi: 10.1021/jp5040954. Epub 2014 Jun 24.

7.

Graphene nanopore support system for simultaneous high-resolution AFM imaging and conductance measurements.

Connelly LS, Meckes B, Larkin J, Gillman AL, Wanunu M, Lal R.

ACS Appl Mater Interfaces. 2014 Apr 9;6(7):5290-6. doi: 10.1021/am500639q. Epub 2014 Mar 24.

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