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Identification and Validation Model for Informative Liquid Biopsy-Based microRNA Biomarkers: Insights from Germ Cell Tumor In Vitro, In Vivo and Patient-Derived Data.

Lobo J, Gillis AJM, van den Berg A, Dorssers LCJ, Belge G, Dieckmann KP, Roest HP, van der Laan LJW, Gietema J, Hamilton RJ, Jerónimo C, Henrique R, Salvatori D, Looijenga LHJ.

Cells. 2019 Dec 14;8(12). pii: E1637. doi: 10.3390/cells8121637.


XIST-Promoter Demethylation as Tissue Biomarker for Testicular Germ Cell Tumors and Spermatogenesis Quality.

Lobo J, Nunes SP, Gillis AJM, Barros-Silva D, Miranda-Gonçalves V, Berg AVD, Cantante M, Guimarães R, Henrique R, Jerónimo C, Looijenga LHJ.

Cancers (Basel). 2019 Sep 17;11(9). pii: E1385. doi: 10.3390/cancers11091385.


Interobserver Agreement in Vascular Invasion Scoring and the Added Value of Immunohistochemistry for Vascular Markers to Predict Disease Relapse in Stage I Testicular Nonseminomas.

Lobo J, Stoop H, Gillis AJM, Looijenga LHJ, Oosterhuis W.

Am J Surg Pathol. 2019 Dec;43(12):1711-1719. doi: 10.1097/PAS.0000000000001352.


Cellular origin of microRNA-371a-3p in healthy males based on systematic urogenital tract tissue evaluation.

Boellaard WPA, Gillis AJM, van Leenders GJLH, Stoop H, van Agthoven T, Dorssers LCJ, Dinkelman-Smit M, Boormans JL, Looijenga LHJ.

Andrology. 2019 Jul;7(4):463-468. doi: 10.1111/andr.12595. Epub 2019 Feb 20.


Molecular heterogeneity and early metastatic clone selection in testicular germ cell cancer development.

Dorssers LCJ, Gillis AJM, Stoop H, van Marion R, Nieboer MM, van Riet J, van de Werken HJG, Oosterhuis JW, de Ridder J, Looijenga LHJ.

Br J Cancer. 2019 Feb;120(4):444-452. doi: 10.1038/s41416-019-0381-1. Epub 2019 Feb 11.


Human Germ Cell Tumors are Developmental Cancers: Impact of Epigenetics on Pathobiology and Clinic.

Lobo J, Gillis AJM, Jerónimo C, Henrique R, Looijenga LHJ.

Int J Mol Sci. 2019 Jan 10;20(2). pii: E258. doi: 10.3390/ijms20020258. Review.


The MicroRNA-371 Family as Plasma Biomarkers for Monitoring Undifferentiated and Potentially Malignant Human Pluripotent Stem Cells in Teratoma Assays.

Salvatori DCF, Dorssers LCJ, Gillis AJM, Perretta G, van Agthoven T, Gomes Fernandes M, Stoop H, Prins JB, Oosterhuis JW, Mummery C, Looijenga LHJ.

Stem Cell Reports. 2018 Dec 11;11(6):1493-1505. doi: 10.1016/j.stemcr.2018.11.002. Epub 2018 Nov 29.


Cell-free MicroRNA miR-505-3p in Graft Preservation Fluid Is an Independent Predictor of Delayed Graft Function After Kidney Transplantation.

Roest HP, Ooms LSS, Gillis AJM, IJzermans JNM, Looijenga LHJ, Dorssers LCJ, Dor FJMF, van der Laan LJW.

Transplantation. 2019 Feb;103(2):329-335. doi: 10.1097/TP.0000000000002527.


Serum microRNA profiles in athyroid patients on and off levothyroxine therapy.

Massolt ET, Chaker L, Visser TJ, Gillis AJM, Dorssers LCJ, Beukhof CM, Kam BLR, Franssen GJ, Brigante G, van Ginhoven TM, Visser WE, Looijenga LHJ, Peeters RP.

PLoS One. 2018 Apr 12;13(4):e0194259. doi: 10.1371/journal.pone.0194259. eCollection 2018.


Malignant testicular germ cell tumors in postpubertal individuals with androgen insensitivity: prevalence, pathology and relevance of single nucleotide polymorphism-based susceptibility profiling.

Cools M, Wolffenbuttel KP, Hersmus R, Mendonca BB, Kaprová J, Drop SLS, Stoop H, Gillis AJM, Oosterhuis JW, Costa EMF, Domenice S, Nishi MY, Wunsch L, Quigley CA, T'Sjoen G, Looijenga LHJ.

Hum Reprod. 2017 Dec 1;32(12):2561-2573. doi: 10.1093/humrep/dex300.


VASA mRNA (DDX4) detection is more specific than immunohistochemistry using poly- or monoclonal antibodies for germ cells in the male urogenital tract.

Boellaard WPA, Stoop H, Gillis AJM, Oosterhuis JW, Looijenga LHJ.

Medicine (Baltimore). 2017 Jul;96(30):e7489. doi: 10.1097/MD.0000000000007489.


Whole-genome sequencing of spermatocytic tumors provides insights into the mutational processes operating in the male germline.

Giannoulatou E, Maher GJ, Ding Z, Gillis AJM, Dorssers LCJ, Hoischen A, Rajpert-De Meyts E; WGS500 Consortium, McVean G, Wilkie AOM, Looijenga LHJ, Goriely A.

PLoS One. 2017 May 22;12(5):e0178169. doi: 10.1371/journal.pone.0178169. eCollection 2017.


Imprints and DPPA3 are bypassed during pluripotency- and differentiation-coupled methylation reprogramming in testicular germ cell tumors.

Killian JK, Dorssers LC, Trabert B, Gillis AJ, Cook MB, Wang Y, Waterfall JJ, Stevenson H, Smith WI Jr, Noyes N, Retnakumar P, Stoop JH, Oosterhuis JW, Meltzer PS, McGlynn KA, Looijenga LH.

Genome Res. 2016 Nov;26(11):1490-1504. Epub 2016 Oct 20.


A pipeline to quantify serum and cerebrospinal fluid microRNAs for diagnosis and detection of relapse in paediatric malignant germ-cell tumours.

Murray MJ, Bell E, Raby KL, Rijlaarsdam MA, Gillis AJ, Looijenga LH, Brown H, Destenaves B, Nicholson JC, Coleman N.

Br J Cancer. 2016 Jan 19;114(2):151-62. doi: 10.1038/bjc.2015.429. Epub 2015 Dec 15.


Cripto: Expression, epigenetic regulation and potential diagnostic use in testicular germ cell tumors.

Spiller CM, Gillis AJ, Burnet G, Stoop H, Koopman P, Bowles J, Looijenga LH.

Mol Oncol. 2016 Apr;10(4):526-37. doi: 10.1016/j.molonc.2015.11.003. Epub 2015 Nov 18.



Gillis AJ, Bath E.

Child Adolesc Psychiatr Clin N Am. 2016 Jan;25(1):1-17. doi: 10.1016/j.chc.2015.08.001. Epub 2015 Oct 16. Review.


Widespread somatic L1 retrotransposition occurs early during gastrointestinal cancer evolution.

Ewing AD, Gacita A, Wood LD, Ma F, Xing D, Kim MS, Manda SS, Abril G, Pereira G, Makohon-Moore A, Looijenga LH, Gillis AJ, Hruban RH, Anders RA, Romans KE, Pandey A, Iacobuzio-Donahue CA, Vogelstein B, Kinzler KW, Kazazian HH Jr, Solyom S.

Genome Res. 2015 Oct;25(10):1536-45. doi: 10.1101/gr.196238.115. Epub 2015 Aug 10.


Genome wide DNA methylation profiles provide clues to the origin and pathogenesis of germ cell tumors.

Rijlaarsdam MA, Tax DM, Gillis AJ, Dorssers LC, Koestler DC, de Ridder J, Looijenga LH.

PLoS One. 2015 Apr 10;10(4):e0122146. doi: 10.1371/journal.pone.0122146. eCollection 2015. Erratum in: PLoS One. 2015;10(7):e0132981.


Identification of known and novel germ cell cancer-specific (embryonic) miRs in serum by high-throughput profiling.

Rijlaarsdam MA, van Agthoven T, Gillis AJ, Patel S, Hayashibara K, Lee KY, Looijenga LH.

Andrology. 2015 Jan;3(1):85-91. doi: 10.1111/andr.298. Epub 2014 Nov 7.


Seminoma and embryonal carcinoma footprints identified by analysis of integrated genome-wide epigenetic and expression profiles of germ cell cancer cell lines.

van der Zwan YG, Rijlaarsdam MA, Rossello FJ, Notini AJ, de Boer S, Watkins DN, Gillis AJ, Dorssers LC, White SJ, Looijenga LH.

PLoS One. 2014 Jun 2;9(6):e98330. doi: 10.1371/journal.pone.0098330. eCollection 2014.


Role of SOX2 in the etiology of embryonal carcinoma, based on analysis of the NCCIT and NT2 cell lines.

Eini R, Stoop H, Gillis AJ, Biermann K, Dorssers LC, Looijenga LH.

PLoS One. 2014 Jan 3;9(1):e83585. doi: 10.1371/journal.pone.0083585. eCollection 2014.


Proteome analysis of the effects of all-trans retinoic acid on human germ cell tumor cell lines.

Honecker F, Rohlfing T, Harder S, Braig M, Gillis AJ, Glaesener S, Barett C, Bokemeyer C, Buck F, Brümmendorf TH, Looijenga LH, Balabanov S.

J Proteomics. 2014 Jan 16;96:300-13. doi: 10.1016/j.jprot.2013.11.010. Epub 2013 Nov 22.


Targeted serum miRNA (TSmiR) test for diagnosis and follow-up of (testicular) germ cell cancer patients: a proof of principle.

Gillis AJ, Rijlaarsdam MA, Eini R, Dorssers LC, Biermann K, Murray MJ, Nicholson JC, Coleman N, Dieckmann KP, Belge G, Bullerdiek J, Xu T, Bernard N, Looijenga LH.

Mol Oncol. 2013 Dec;7(6):1083-92. doi: 10.1016/j.molonc.2013.08.002. Epub 2013 Aug 20.


miMsg: a target enrichment algorithm for predicted miR-mRNA interactions based on relative ranking of matched expression data.

Rijlaarsdam MA, Rijlaarsdam DJ, Gillis AJ, Dorssers LC, Looijenga LH.

Bioinformatics. 2013 Jul 1;29(13):1638-46. doi: 10.1093/bioinformatics/btt246. Epub 2013 May 1.


Mutations in LRRC50 predispose zebrafish and humans to seminomas.

Basten SG, Davis EE, Gillis AJ, van Rooijen E, Stoop H, Babala N, Logister I, Heath ZG, Jonges TN, Katsanis N, Voest EE, van Eeden FJ, Medema RH, Ketting RF, Schulte-Merker S, Looijenga LH, Giles RH.

PLoS Genet. 2013 Apr;9(4):e1003384. doi: 10.1371/journal.pgen.1003384. Epub 2013 Apr 11.


Endogenous Nodal signaling regulates germ cell potency during mammalian testis development.

Spiller CM, Feng CW, Jackson A, Gillis AJ, Rolland AD, Looijenga LH, Koopman P, Bowles J.

Development. 2012 Nov;139(22):4123-32. doi: 10.1242/dev.083006. Epub 2012 Oct 3.


Specific detection of OCT3/4 isoform A/B/B1 expression in solid (germ cell) tumours and cell lines: confirmation of OCT3/4 specificity for germ cell tumours.

Rijlaarsdam MA, van Herk HA, Gillis AJ, Stoop H, Jenster G, Martens J, van Leenders GJ, Dinjens W, Hoogland AM, Timmermans M, Looijenga LH.

Br J Cancer. 2011 Sep 6;105(6):854-63. doi: 10.1038/bjc.2011.270. Epub 2011 Aug 16. Erratum in: Br J Cancer. 2012 Feb 14;106(4):791.


TGF-β1, EGF and FGF4 synergistically induce differentiation of the seminoma cell line TCam-2 into a cell type resembling mixed non-seminoma.

Nettersheim D, Gillis AJ, Looijenga LH, Schorle H.

Int J Androl. 2011 Aug;34(4 Pt 2):e189-203. doi: 10.1111/j.1365-2605.2011.01172.x. Epub 2011 Jun 8.


Expression and interdependencies of pluripotency factors LIN28, OCT3/4, NANOG and SOX2 in human testicular germ cells and tumours of the testis.

Gillis AJ, Stoop H, Biermann K, van Gurp RJ, Swartzman E, Cribbes S, Ferlinz A, Shannon M, Oosterhuis JW, Looijenga LH.

Int J Androl. 2011 Aug;34(4 Pt 2):e160-74. doi: 10.1111/j.1365-2605.2011.01148.x. Epub 2011 Jun 2.


Dissecting the molecular pathways of (testicular) germ cell tumour pathogenesis; from initiation to treatment-resistance.

Looijenga LH, Gillis AJ, Stoop H, Biermann K, Oosterhuis JW.

Int J Androl. 2011 Aug;34(4 Pt 2):e234-51. doi: 10.1111/j.1365-2605.2011.01157.x. Epub 2011 May 12. Review.


Diagnosis of testicular carcinoma in situ '(intratubular and microinvasive)' seminoma and embryonal carcinoma using direct enzymatic alkaline phosphatase reactivity on frozen histological sections.

Stoop H, Kirkels W, Dohle GR, Gillis AJ, den Bakker MA, Biermann K, Oosterhuis W, Looijenga LH.

Histopathology. 2011 Feb;58(3):440-6. doi: 10.1111/j.1365-2559.2011.03767.x. Epub 2011 Feb 16.


Histopathological and molecular features of late relapses in non-seminomas.

Mayer F, Wermann H, Albers P, Stoop H, Gillis AJ, Hartmann JT, Bokemeyer CC, Oosterhuis JW, Looijenga LH, Honecker F.

BJU Int. 2011 Mar;107(6):936-43. doi: 10.1111/j.1464-410X.2010.09631.x. Epub 2010 Oct 18.


NANOG promoter methylation and expression correlation during normal and malignant human germ cell development.

Nettersheim D, Biermann K, Gillis AJ, Steger K, Looijenga LH, Schorle H.

Epigenetics. 2011 Jan;6(1):114-22. doi: 10.4161/epi.6.1.13433. Epub 2011 Jan 1.


Global DNA methylation in fetal human germ cells and germ cell tumours: association with differentiation and cisplatin resistance.

Wermann H, Stoop H, Gillis AJ, Honecker F, van Gurp RJ, Ammerpohl O, Richter J, Oosterhuis JW, Bokemeyer C, Looijenga LH.

J Pathol. 2010 Aug;221(4):433-42. doi: 10.1002/path.2725.


Critical function of AP-2 gamma/TCFAP2C in mouse embryonic germ cell maintenance.

Weber S, Eckert D, Nettersheim D, Gillis AJ, Schäfer S, Kuckenberg P, Ehlermann J, Werling U, Biermann K, Looijenga LH, Schorle H.

Biol Reprod. 2010 Jan;82(1):214-23. doi: 10.1095/biolreprod.109.078717. Epub 2009 Sep 23.


Microsatellite instability, mismatch repair deficiency, and BRAF mutation in treatment-resistant germ cell tumors.

Honecker F, Wermann H, Mayer F, Gillis AJ, Stoop H, van Gurp RJ, Oechsle K, Steyerberg E, Hartmann JT, Dinjens WN, Oosterhuis JW, Bokemeyer C, Looijenga LH.

J Clin Oncol. 2009 May 1;27(13):2129-36. doi: 10.1200/JCO.2008.18.8623. Epub 2009 Mar 16.


Expression of BLIMP1/PRMT5 and concurrent histone H2A/H4 arginine 3 dimethylation in fetal germ cells, CIS/IGCNU and germ cell tumors.

Eckert D, Biermann K, Nettersheim D, Gillis AJ, Steger K, Jäck HM, Müller AM, Looijenga LH, Schorle H.

BMC Dev Biol. 2008 Nov 7;8:106. doi: 10.1186/1471-213X-8-106.


Structure of the Tribolium castaneum telomerase catalytic subunit TERT.

Gillis AJ, Schuller AP, Skordalakes E.

Nature. 2008 Oct 2;455(7213):633-7. doi: 10.1038/nature07283. Epub 2008 Aug 31.


Comparative proteome, transcriptome, and genome analysis of a gonadal and an extragonadal germ cell tumor cell line.

Glaesener S, Honecker F, Veltman IM, Gillis AJ, Rohlfing T, Streichert T, Otto B, Brummendorf TH, Looijenga LH, Bokemeyer C, Balabanov S.

J Proteome Res. 2008 Sep;7(9):3890-9. doi: 10.1021/pr800173g. Epub 2008 Jul 22.


Stem cell factor as a novel diagnostic marker for early malignant germ cells.

Stoop H, Honecker F, van de Geijn GJ, Gillis AJ, Cools MC, de Boer M, Bokemeyer C, Wolffenbuttel KP, Drop SL, de Krijger RR, Dennis N, Summersgill B, McIntyre A, Shipley J, Oosterhuis JW, Looijenga LH.

J Pathol. 2008 Sep;216(1):43-54. doi: 10.1002/path.2378.


A pure triphasic testicular wilms tumor of primordial germ cell origin.

Looijenga LH, Gillis AJ, Oosterhuis JW.

Urology. 2008 Jul;72(1):232-3; author reply 233. doi: 10.1016/j.urology.2007.11.151. Epub 2008 Apr 2. No abstract available.


Differential expression of SOX17 and SOX2 in germ cells and stem cells has biological and clinical implications.

de Jong J, Stoop H, Gillis AJ, van Gurp RJ, van de Geijn GJ, Boer Md, Hersmus R, Saunders PT, Anderson RA, Oosterhuis JW, Looijenga LH.

J Pathol. 2008 May;215(1):21-30. doi: 10.1002/path.2332.


Further characterization of the first seminoma cell line TCam-2.

de Jong J, Stoop H, Gillis AJ, Hersmus R, van Gurp RJ, van de Geijn GJ, van Drunen E, Beverloo HB, Schneider DT, Sherlock JK, Baeten J, Kitazawa S, van Zoelen EJ, van Roozendaal K, Oosterhuis JW, Looijenga LH.

Genes Chromosomes Cancer. 2008 Mar;47(3):185-96.


Chromosomes and expression in human testicular germ-cell tumors: insight into their cell of origin and pathogenesis.

Looijenga LH, Gillis AJ, Stoop HJ, Hersmus R, Oosterhuis JW.

Ann N Y Acad Sci. 2007 Dec;1120:187-214. Epub 2007 Oct 2. Review.


High-throughput microRNAome analysis in human germ cell tumours.

Gillis AJ, Stoop HJ, Hersmus R, Oosterhuis JW, Sun Y, Chen C, Guenther S, Sherlock J, Veltman I, Baeten J, van der Spek PJ, de Alarcon P, Looijenga LH.

J Pathol. 2007 Nov;213(3):319-28.


JKT-1 is not a human seminoma cell line.

de Jong J, Stoop H, Gillis AJ, van Gurp RJ, van Drunen E, Beverloo HB, Lau YF, Schneider DT, Sherlock JK, Baeten J, Hatakeyama S, Ohyama C, Oosterhuis JW, Looijenga LH.

Int J Androl. 2007 Aug;30(4):350-65.


A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors.

Voorhoeve PM, le Sage C, Schrier M, Gillis AJ, Stoop H, Nagel R, Liu YP, van Duijse J, Drost J, Griekspoor A, Zlotorynski E, Yabuta N, De Vita G, Nojima H, Looijenga LH, Agami R.

Adv Exp Med Biol. 2007;604:17-46.


Gene expression profiling and gene copy-number changes in malignant mesothelioma cell lines.

Zanazzi C, Hersmus R, Veltman IM, Gillis AJ, van Drunen E, Beverloo HB, Hegmans JP, Verweij M, Lambrecht BN, Oosterhuis JW, Looijenga LH.

Genes Chromosomes Cancer. 2007 Oct;46(10):895-908.


Relevance of microRNAs in normal and malignant development, including human testicular germ cell tumours.

Looijenga LH, Gillis AJ, Stoop H, Hersmus R, Oosterhuis JW.

Int J Androl. 2007 Aug;30(4):304-14; discussion 314-5. Epub 2007 Jun 15.


Genomic and expression profiling of human spermatocytic seminomas: pathogenetic implications.

Looijenga LH, Stoop H, Hersmus R, Gillis AJ, Wolter Oosterhuis J.

Int J Androl. 2007 Aug;30(4):328-35; discussion 335-6. Epub 2007 Jun 15.


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