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Direct and indirect assessment of cancer metabolism explored by MRI.

Kishimoto S, Oshima N, Krishna MC, Gillies RJ.

NMR Biomed. 2018 Aug 31:e3966. doi: 10.1002/nbm.3966. [Epub ahead of print]


Systems analysis of intracellular pH vulnerabilities for cancer therapy.

Persi E, Duran-Frigola M, Damaghi M, Roush WR, Aloy P, Cleveland JL, Gillies RJ, Ruppin E.

Nat Commun. 2018 Jul 31;9(1):2997. doi: 10.1038/s41467-018-05261-x.


Eco-evolutionary causes and consequences of temporal changes in intratumoural blood flow.

Gillies RJ, Brown JS, Anderson ARA, Gatenby RA.

Nat Rev Cancer. 2018 Sep;18(9):576-585. doi: 10.1038/s41568-018-0030-7. Review.


Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice.

Matsumoto S, Kishimoto S, Saito K, Takakusagi Y, Munasinghe JP, Devasahayam N, Hart CP, Gillies RJ, Mitchell JB, Krishna MC.

Cancer Res. 2018 Jul 15;78(14):3783-3792. doi: 10.1158/0008-5472.CAN-18-0491. Epub 2018 May 23.


Perfusion MR Imaging of Breast Cancer: Insights Using "Habitat Imaging".

Gillies RJ, Balagurunathan Y.

Radiology. 2018 Jul;288(1):36-37. doi: 10.1148/radiol.2018180271. Epub 2018 May 1. No abstract available.


Prediction of pathological nodal involvement by CT-based Radiomic features of the primary tumor in patients with clinically node-negative peripheral lung adenocarcinomas.

Liu Y, Kim J, Balagurunathan Y, Hawkins S, Stringfield O, Schabath MB, Li Q, Qu F, Liu S, Garcia AL, Ye Z, Gillies RJ.

Med Phys. 2018 Jun;45(6):2518-2526. doi: 10.1002/mp.12901. Epub 2018 Apr 29.


Predicting malignant nodules by fusing deep features with classical radiomics features.

Paul R, Hawkins SH, Schabath MB, Gillies RJ, Hall LO, Goldgof DB.

J Med Imaging (Bellingham). 2018 Jan;5(1):011021. doi: 10.1117/1.JMI.5.1.011021. Epub 2018 Mar 21.


Hypoxia and acidosis: immune suppressors and therapeutic targets.

Damgaci S, Ibrahim-Hashim A, Enriquez-Navas PM, Pilon-Thomas S, Guvenis A, Gillies RJ.

Immunology. 2018 Jul;154(3):354-362. doi: 10.1111/imm.12917. Epub 2018 Mar 30. Review.


Accounting for reconstruction kernel-induced variability in CT radiomic features using noise power spectra.

Shafiq-Ul-Hassan M, Zhang GG, Hunt DC, Latifi K, Ullah G, Gillies RJ, Moros EG.

J Med Imaging (Bellingham). 2018 Jan;5(1):011013. doi: 10.1117/1.JMI.5.1.011013. Epub 2017 Dec 14.


Radial gradient and radial deviation radiomic features from pre-surgical CT scans are associated with survival among lung adenocarcinoma patients.

Tunali I, Stringfield O, Guvenis A, Wang H, Liu Y, Balagurunathan Y, Lambin P, Gillies RJ, Schabath MB.

Oncotarget. 2017 Oct 6;8(56):96013-96026. doi: 10.18632/oncotarget.21629. eCollection 2017 Nov 10.


Comparison Between Radiological Semantic Features and Lung-RADS in Predicting Malignancy of Screen-Detected Lung Nodules in the National Lung Screening Trial.

Li Q, Balagurunathan Y, Liu Y, Qi J, Schabath MB, Ye Z, Gillies RJ.

Clin Lung Cancer. 2018 Mar;19(2):148-156.e3. doi: 10.1016/j.cllc.2017.10.002. Epub 2017 Oct 13.


Metabolic Profiling of healthy and cancerous tissues in 2D and 3D.

Russell S, Wojtkowiak J, Neilson A, Gillies RJ.

Sci Rep. 2017 Nov 10;7(1):15285. doi: 10.1038/s41598-017-15325-5.


CT imaging features associated with recurrence in non-small cell lung cancer patients after stereotactic body radiotherapy.

Li Q, Kim J, Balagurunathan Y, Qi J, Liu Y, Latifi K, Moros EG, Schabath MB, Ye Z, Gillies RJ, Dilling TJ.

Radiat Oncol. 2017 Sep 25;12(1):158. doi: 10.1186/s13014-017-0892-y.


MDA-MB-231 breast cancer cells fuel osteoclast metabolism and activity: A new rationale for the pathogenesis of osteolytic bone metastases.

Lemma S, Di Pompo G, Porporato PE, Sboarina M, Russell S, Gillies RJ, Baldini N, Sonveaux P, Avnet S.

Biochim Biophys Acta Mol Basis Dis. 2017 Dec;1863(12):3254-3264. doi: 10.1016/j.bbadis.2017.08.030. Epub 2017 Sep 1.


Delineation of Tumor Habitats based on Dynamic Contrast Enhanced MRI.

Chang YC, Ackerstaff E, Tschudi Y, Jimenez B, Foltz W, Fisher C, Lilge L, Cho H, Carlin S, Gillies RJ, Balagurunathan Y, Yechieli RL, Subhawong T, Turkbey B, Pollack A, Stoyanova R.

Sci Rep. 2017 Aug 29;7(1):9746. doi: 10.1038/s41598-017-09932-5.


Radiologic Features of Small Pulmonary Nodules and Lung Cancer Risk in the National Lung Screening Trial: A Nested Case-Control Study.

Liu Y, Wang H, Li Q, McGettigan MJ, Balagurunathan Y, Garcia AL, Thompson ZJ, Heine JJ, Ye Z, Gillies RJ, Schabath MB.

Radiology. 2018 Jan;286(1):298-306. doi: 10.1148/radiol.2017161458. Epub 2017 Aug 24.


Defining the biological basis of radiomic phenotypes in lung cancer.

Grossmann P, Stringfield O, El-Hachem N, Bui MM, Rios Velazquez E, Parmar C, Leijenaar RT, Haibe-Kains B, Lambin P, Gillies RJ, Aerts HJ.

Elife. 2017 Jul 21;6. pii: e23421. doi: 10.7554/eLife.23421.


Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Metabolic Networks in Cancer.

Baldini N, De Milito A, Feron O, Gillies RJ, Michiels C, Otto AM, Pastoreková S, Pedersen SF, Porporato PE, Sonveaux P, Supuran CT, Avnet S.

Front Pharmacol. 2017 Jul 4;8:411. doi: 10.3389/fphar.2017.00411. eCollection 2017.


Associations between radiologist-defined semantic and automatically computed radiomic features in non-small cell lung cancer.

Yip SSF, Liu Y, Parmar C, Li Q, Liu S, Qu F, Ye Z, Gillies RJ, Aerts HJWL.

Sci Rep. 2017 Jun 14;7(1):3519. doi: 10.1038/s41598-017-02425-5.


Tris-base buffer: a promising new inhibitor for cancer progression and metastasis.

Ibrahim-Hashim A, Abrahams D, Enriquez-Navas PM, Luddy K, Gatenby RA, Gillies RJ.

Cancer Med. 2017 Jul;6(7):1720-1729. doi: 10.1002/cam4.1032. Epub 2017 May 29.


Imaging features from pretreatment CT scans are associated with clinical outcomes in nonsmall-cell lung cancer patients treated with stereotactic body radiotherapy.

Li Q, Kim J, Balagurunathan Y, Liu Y, Latifi K, Stringfield O, Garcia A, Moros EG, Dilling TJ, Schabath MB, Ye Z, Gillies RJ.

Med Phys. 2017 Aug;44(8):4341-4349. doi: 10.1002/mp.12309. Epub 2017 Jun 24.


The future of personalised radiotherapy for head and neck cancer.

Caudell JJ, Torres-Roca JF, Gillies RJ, Enderling H, Kim S, Rishi A, Moros EG, Harrison LB.

Lancet Oncol. 2017 May;18(5):e266-e273. doi: 10.1016/S1470-2045(17)30252-8. Epub 2017 Apr 26. Review.


Defining Cancer Subpopulations by Adaptive Strategies Rather Than Molecular Properties Provides Novel Insights into Intratumoral Evolution.

Ibrahim-Hashim A, Robertson-Tessi M, Enriquez-Navas PM, Damaghi M, Balagurunathan Y, Wojtkowiak JW, Russell S, Yoonseok K, Lloyd MC, Bui MM, Brown JS, Anderson ARA, Gillies RJ, Gatenby RA.

Cancer Res. 2017 May 1;77(9):2242-2254. doi: 10.1158/0008-5472.CAN-16-2844. Epub 2017 Mar 1.


Multi-site quality and variability analysis of 3D FDG PET segmentations based on phantom and clinical image data.

Beichel RR, Smith BJ, Bauer C, Ulrich EJ, Ahmadvand P, Budzevich MM, Gillies RJ, Goldgof D, Grkovski M, Hamarneh G, Huang Q, Kinahan PE, Laymon CM, Mountz JM, Muzi JP, Muzi M, Nehmeh S, Oborski MJ, Tan Y, Zhao B, Sunderland JJ, Buatti JM.

Med Phys. 2017 Feb;44(2):479-496. doi: 10.1002/mp.12041.


Intrinsic dependencies of CT radiomic features on voxel size and number of gray levels.

Shafiq-Ul-Hassan M, Zhang GG, Latifi K, Ullah G, Hunt DC, Balagurunathan Y, Abdalah MA, Schabath MB, Goldgof DG, Mackin D, Court LE, Gillies RJ, Moros EG.

Med Phys. 2017 Mar;44(3):1050-1062. doi: 10.1002/mp.12123.


Deep Feature Transfer Learning in Combination with Traditional Features Predicts Survival Among Patients with Lung Adenocarcinoma.

Paul R, Hawkins SH, Balagurunathan Y, Schabath MB, Gillies RJ, Hall LO, Goldgof DB.

Tomography. 2016 Dec;2(4):388-395. doi: 10.18383/j.tom.2016.00211.


Cancer-associated mesenchymal stroma fosters the stemness of osteosarcoma cells in response to intratumoral acidosis via NF-κB activation.

Avnet S, Di Pompo G, Chano T, Errani C, Ibrahim-Hashim A, Gillies RJ, Donati DM, Baldini N.

Int J Cancer. 2017 Mar 15;140(6):1331-1345. doi: 10.1002/ijc.30540.


PET and MRI: Is the Whole Greater than the Sum of Its Parts?

Gillies RJ, Beyer T.

Cancer Res. 2016 Nov 1;76(21):6163-6166. Epub 2016 Oct 11.


Imaging biomarker roadmap for cancer studies.

O'Connor JP, Aboagye EO, Adams JE, Aerts HJ, Barrington SF, Beer AJ, Boellaard R, Bohndiek SE, Brady M, Brown G, Buckley DL, Chenevert TL, Clarke LP, Collette S, Cook GJ, deSouza NM, Dickson JC, Dive C, Evelhoch JL, Faivre-Finn C, Gallagher FA, Gilbert FJ, Gillies RJ, Goh V, Griffiths JR, Groves AM, Halligan S, Harris AL, Hawkes DJ, Hoekstra OS, Huang EP, Hutton BF, Jackson EF, Jayson GC, Jones A, Koh DM, Lacombe D, Lambin P, Lassau N, Leach MO, Lee TY, Leen EL, Lewis JS, Liu Y, Lythgoe MF, Manoharan P, Maxwell RJ, Miles KA, Morgan B, Morris S, Ng T, Padhani AR, Parker GJ, Partridge M, Pathak AP, Peet AC, Punwani S, Reynolds AR, Robinson SP, Shankar LK, Sharma RA, Soloviev D, Stroobants S, Sullivan DC, Taylor SA, Tofts PS, Tozer GM, van Herk M, Walker-Samuel S, Wason J, Williams KJ, Workman P, Yankeelov TE, Brindle KM, McShane LM, Jackson A, Waterton JC.

Nat Rev Clin Oncol. 2017 Mar;14(3):169-186. doi: 10.1038/nrclinonc.2016.162. Epub 2016 Oct 11. Review.


Clinical and CT characteristics of surgically resected lung adenocarcinomas harboring ALK rearrangements or EGFR mutations.

Wang H, Schabath MB, Liu Y, Han Y, Li Q, Gillies RJ, Ye Z.

Eur J Radiol. 2016 Nov;85(11):1934-1940. doi: 10.1016/j.ejrad.2016.08.023. Epub 2016 Aug 30.


Identifying spatial imaging biomarkers of glioblastoma multiforme for survival group prediction.

Zhou M, Chaudhury B, Hall LO, Goldgof DB, Gillies RJ, Gatenby RA.

J Magn Reson Imaging. 2017 Jul;46(1):115-123. doi: 10.1002/jmri.25497. Epub 2016 Sep 28.


Radiological Image Traits Predictive of Cancer Status in Pulmonary Nodules.

Liu Y, Balagurunathan Y, Atwater T, Antic S, Li Q, Walker RC, Smith GT, Massion PP, Schabath MB, Gillies RJ.

Clin Cancer Res. 2017 Mar 15;23(6):1442-1449. doi: 10.1158/1078-0432.CCR-15-3102. Epub 2016 Sep 23.


Differences in Patient Outcomes of Prevalence, Interval, and Screen-Detected Lung Cancers in the CT Arm of the National Lung Screening Trial.

Schabath MB, Massion PP, Thompson ZJ, Eschrich SA, Balagurunathan Y, Goldof D, Aberle DR, Gillies RJ.

PLoS One. 2016 Aug 10;11(8):e0159880. doi: 10.1371/journal.pone.0159880. eCollection 2016.


Prostate cancer radiomics and the promise of radiogenomics.

Stoyanova R, Takhar M, Tschudi Y, Ford JC, Solórzano G, Erho N, Balagurunathan Y, Punnen S, Davicioni E, Gillies RJ, Pollack A.

Transl Cancer Res. 2016 Aug;5(4):432-447.


Association of multiparametric MRI quantitative imaging features with prostate cancer gene expression in MRI-targeted prostate biopsies.

Stoyanova R, Pollack A, Takhar M, Lynne C, Parra N, Lam LL, Alshalalfa M, Buerki C, Castillo R, Jorda M, Ashab HA, Kryvenko ON, Punnen S, Parekh DJ, Abramowitz MC, Gillies RJ, Davicioni E, Erho N, Ishkanian A.

Oncotarget. 2016 Aug 16;7(33):53362-53376. doi: 10.18632/oncotarget.10523.


Predicting Malignant Nodules from Screening CT Scans.

Hawkins S, Wang H, Liu Y, Garcia A, Stringfield O, Krewer H, Li Q, Cherezov D, Gatenby RA, Balagurunathan Y, Goldgof D, Schabath MB, Hall L, Gillies RJ.

J Thorac Oncol. 2016 Dec;11(12):2120-2128. doi: 10.1016/j.jtho.2016.07.002. Epub 2016 Jul 13. Erratum in: J Thorac Oncol. 2018 Feb;13(2):280-281.


Algorithm Variability in the Estimation of Lung Nodule Volume From Phantom CT Scans: Results of the QIBA 3A Public Challenge.

Athelogou M, Kim HJ, Dima A, Obuchowski N, Peskin A, Gavrielides MA, Petrick N, Saiprasad G, Colditz Colditz D, Beaumont H, Oubel E, Tan Y, Zhao B, Kuhnigk JM, Moltz JH, Orieux G, Gillies RJ, Gu Y, Mantri N, Goldmacher G, Zhang L, Vega E, Bloom M, Jarecha R, Soza G, Tietjen C, Takeguchi T, Yamagata H, Peterson S, Masoud O, Buckler AJ.

Acad Radiol. 2016 Aug;23(8):940-52. doi: 10.1016/j.acra.2016.02.018. Epub 2016 May 20.


Design and automated production of 11C-alpha-methyl-l-tryptophan (11C-AMT).

Huang X, Xiao X, Gillies RJ, Tian H.

Nucl Med Biol. 2016 May;43(5):303-8. doi: 10.1016/j.nucmedbio.2016.02.001. Epub 2016 Feb 24.


Lysosomal protein relocation as an adaptation mechanism to extracellular acidosis.

Damaghi M, Gillies RJ.

Cell Cycle. 2016 Jul 2;15(13):1659-60. doi: 10.1080/15384101.2016.1176394. Epub 2016 Apr 20. No abstract available.


Radiomic Features Are Associated With EGFR Mutation Status in Lung Adenocarcinomas.

Liu Y, Kim J, Balagurunathan Y, Li Q, Garcia AL, Stringfield O, Ye Z, Gillies RJ.

Clin Lung Cancer. 2016 Sep;17(5):441-448.e6. doi: 10.1016/j.cllc.2016.02.001. Epub 2016 Feb 16.


Darwinian Dynamics of Intratumoral Heterogeneity: Not Solely Random Mutations but Also Variable Environmental Selection Forces.

Lloyd MC, Cunningham JJ, Bui MM, Gillies RJ, Brown JS, Gatenby RA.

Cancer Res. 2016 Jun 1;76(11):3136-44. doi: 10.1158/0008-5472.CAN-15-2962. Epub 2016 Mar 23.


CT Features Associated with Epidermal Growth Factor Receptor Mutation Status in Patients with Lung Adenocarcinoma.

Liu Y, Kim J, Qu F, Liu S, Wang H, Balagurunathan Y, Ye Z, Gillies RJ.

Radiology. 2016 Jul;280(1):271-80. doi: 10.1148/radiol.2016151455. Epub 2016 Mar 3.


Exploiting evolutionary principles to prolong tumor control in preclinical models of breast cancer.

Enriquez-Navas PM, Kam Y, Das T, Hassan S, Silva A, Foroutan P, Ruiz E, Martinez G, Minton S, Gillies RJ, Gatenby RA.

Sci Transl Med. 2016 Feb 24;8(327):327ra24. doi: 10.1126/scitranslmed.aad7842.


Quantitative Imaging in Cancer Clinical Trials.

Yankeelov TE, Mankoff DA, Schwartz LH, Lieberman FS, Buatti JM, Mountz JM, Erickson BJ, Fennessy FM, Huang W, Kalpathy-Cramer J, Wahl RL, Linden HM, Kinahan PE, Zhao B, Hylton NM, Gillies RJ, Clarke L, Nordstrom R, Rubin DL.

Clin Cancer Res. 2016 Jan 15;22(2):284-90. doi: 10.1158/1078-0432.CCR-14-3336. Review.


Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy.

Pilon-Thomas S, Kodumudi KN, El-Kenawi AE, Russell S, Weber AM, Luddy K, Damaghi M, Wojtkowiak JW, Mulé JJ, Ibrahim-Hashim A, Gillies RJ.

Cancer Res. 2016 Mar 15;76(6):1381-90. doi: 10.1158/0008-5472.CAN-15-1743. Epub 2015 Dec 30. Erratum in: Cancer Res. 2017 May 1;77(9):2552.


Association Between Computed Tomographic Features and Kirsten Rat Sarcoma Viral Oncogene Mutations in Patients With Stage I Lung Adenocarcinoma and Their Prognostic Value.

Wang H, Schabath MB, Liu Y, Stringfield O, Balagurunathan Y, Heine JJ, Eschrich SA, Ye Z, Gillies RJ.

Clin Lung Cancer. 2016 Jul;17(4):271-8. doi: 10.1016/j.cllc.2015.11.002. Epub 2015 Nov 12.


Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane.

Damaghi M, Tafreshi NK, Lloyd MC, Sprung R, Estrella V, Wojtkowiak JW, Morse DL, Koomen JM, Bui MM, Gatenby RA, Gillies RJ.

Nat Commun. 2015 Dec 10;6:8752. doi: 10.1038/ncomms9752.


Radiomics: Images Are More than Pictures, They Are Data.

Gillies RJ, Kinahan PE, Hricak H.

Radiology. 2016 Feb;278(2):563-77. doi: 10.1148/radiol.2015151169. Epub 2015 Nov 18.


Noninvasive Quantitative Imaging-based Biomarkers and Lung Cancer Screening.

Schabath MB, Gillies RJ.

Am J Respir Crit Care Med. 2015 Sep 15;192(6):654-6. doi: 10.1164/rccm.201506-1160ED. No abstract available.


Diffusion MRI with Semi-Automated Segmentation Can Serve as a Restricted Predictive Biomarker of the Therapeutic Response of Liver Metastasis.

Stephen RM, Jha AK, Roe DJ, Trouard TP, Galons JP, Kupinski MA, Frey G, Cui H, Squire S, Pagel MD, Rodriguez JJ, Gillies RJ, Stopeck AT.

Magn Reson Imaging. 2015 Dec;33(10):1267-1273. doi: 10.1016/j.mri.2015.08.006. Epub 2015 Aug 15.

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