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Monitoring intracellular calcium ion dynamics in hair cell populations with Fluo-4 AM.

Spinelli KJ, Gillespie PG.

PLoS One. 2012;7(12):e51874. doi: 10.1371/journal.pone.0051874. Epub 2012 Dec 17.


Probing the cochlear amplifier by immobilizing molecular motors of sensory hair cells.

Ren T, Gillespie PG.

Neuron. 2012 Dec 6;76(5):868-70. doi: 10.1016/j.neuron.2012.11.016.


Localization of PDZD7 to the stereocilia ankle-link associates this scaffolding protein with the Usher syndrome protein network.

Grati M, Shin JB, Weston MD, Green J, Bhat MA, Gillespie PG, Kachar B.

J Neurosci. 2012 Oct 10;32(41):14288-93. doi: 10.1523/JNEUROSCI.3071-12.2012.


Improved biolistic transfection of hair cells.

Zhao H, Avenarius MR, Gillespie PG.

PLoS One. 2012;7(10):e46765. doi: 10.1371/journal.pone.0046765. Epub 2012 Oct 1.


Large membrane domains in hair bundles specify spatially constricted radixin activation.

Zhao H, Williams DE, Shin JB, Brügger B, Gillespie PG.

J Neurosci. 2012 Mar 28;32(13):4600-9. doi: 10.1523/JNEUROSCI.6184-11.2012.


Digenic inheritance of deafness caused by 8J allele of myosin-VIIA and mutations in other Usher I genes.

Zheng QY, Scarborough JD, Zheng Y, Yu H, Choi D, Gillespie PG.

Hum Mol Genet. 2012 Jun 1;21(11):2588-98. doi: 10.1093/hmg/dds084. Epub 2012 Feb 29.


Stereocilia membrane deformation: implications for the gating spring and mechanotransduction channel.

Powers RJ, Roy S, Atilgan E, Brownell WE, Sun SX, Gillespie PG, Spector AA.

Biophys J. 2012 Jan 18;102(2):201-10. doi: 10.1016/j.bpj.2011.12.022.


Distinct energy metabolism of auditory and vestibular sensory epithelia revealed by quantitative mass spectrometry using MS2 intensity.

Spinelli KJ, Klimek JE, Wilmarth PA, Shin JB, Choi D, David LL, Gillespie PG.

Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):E268-77. doi: 10.1073/pnas.1115866109. Epub 2012 Jan 17.


Reply to "on cochlear impedances and the miscomputation of power gain" by Shera et Al. J. Assoc. Re. Otolaryngol.

Ren T, He W, Gillespie PG.

J Assoc Res Otolaryngol. 2011 Dec;12(6):677-80. doi: 10.1007/s10162-011-0295-y. Epub 2011 Oct 21.


Myosin 1c participates in B cell cytoskeleton rearrangements, is recruited to the immunologic synapse, and contributes to antigen presentation.

Maravillas-Montero JL, Gillespie PG, Patiño-López G, Shaw S, Santos-Argumedo L.

J Immunol. 2011 Sep 15;187(6):3053-63. doi: 10.4049/jimmunol.1004018. Epub 2011 Aug 12.


Measurement of cochlear power gain in the sensitive gerbil ear.

Ren T, He W, Gillespie PG.

Nat Commun. 2011;2:216. doi: 10.1038/ncomms1226.


Na+/K+-ATPase α1 identified as an abundant protein in the blood-labyrinth barrier that plays an essential role in the barrier integrity.

Yang Y, Dai M, Wilson TM, Omelchenko I, Klimek JE, Wilmarth PA, David LL, Nuttall AL, Gillespie PG, Shi X.

PLoS One. 2011 Jan 31;6(1):e16547. doi: 10.1371/journal.pone.0016547.


Loss-of-function mutations of ILDR1 cause autosomal-recessive hearing impairment DFNB42.

Borck G, Ur Rehman A, Lee K, Pogoda HM, Kakar N, von Ameln S, Grillet N, Hildebrand MS, Ahmed ZM, Nürnberg G, Ansar M, Basit S, Javed Q, Morell RJ, Nasreen N, Shearer AE, Ahmad A, Kahrizi K, Shaikh RS, Ali RA, Khan SN, Goebel I, Meyer NC, Kimberling WJ, Webster JA, Stephan DA, Schiller MR, Bahlo M, Najmabadi H, Gillespie PG, Nürnberg P, Wollnik B, Riazuddin S, Smith RJ, Ahmad W, Müller U, Hammerschmidt M, Friedman TB, Riazuddin S, Leal SM, Ahmad J, Kubisch C.

Am J Hum Genet. 2011 Feb 11;88(2):127-37. doi: 10.1016/j.ajhg.2010.12.011. Epub 2011 Jan 20.


The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA/2J mice.

Shin JB, Longo-Guess CM, Gagnon LH, Saylor KW, Dumont RA, Spinelli KJ, Pagana JM, Wilmarth PA, David LL, Gillespie PG, Johnson KR.

J Neurosci. 2010 Jul 21;30(29):9683-94. doi: 10.1523/JNEUROSCI.1541-10.2010.


Mechanotransduction by hair cells: models, molecules, and mechanisms.

Gillespie PG, Müller U.

Cell. 2009 Oct 2;139(1):33-44. doi: 10.1016/j.cell.2009.09.010. Review.


Harmonin mutations cause mechanotransduction defects in cochlear hair cells.

Grillet N, Xiong W, Reynolds A, Kazmierczak P, Sato T, Lillo C, Dumont RA, Hintermann E, Sczaniecka A, Schwander M, Williams D, Kachar B, Gillespie PG, Müller U.

Neuron. 2009 May 14;62(3):375-87. doi: 10.1016/j.neuron.2009.04.006.


Bottoms up: transduction channels at tip link bases.

Spinelli KJ, Gillespie PG.

Nat Neurosci. 2009 May;12(5):529-30. doi: 10.1038/nn0509-529. No abstract available.


Unraveling cadherin 23's role in development and mechanotransduction.

Shin JB, Gillespie PG.

Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):4959-60. doi: 10.1073/pnas.0902008106. Epub 2009 Mar 25. Review. No abstract available.


Twist-off purification of hair bundles.

Shin JB, Pagana J, Gillespie PG.

Methods Mol Biol. 2009;493:241-55. doi: 10.1007/978-1-59745-523-7_14.


The enteropathogenic E. coli effector EspB facilitates microvillus effacing and antiphagocytosis by inhibiting myosin function.

Iizumi Y, Sagara H, Kabe Y, Azuma M, Kume K, Ogawa M, Nagai T, Gillespie PG, Sasakawa C, Handa H.

Cell Host Microbe. 2007 Dec 13;2(6):383-92.


Chemical-genetic inhibition of sensitized mutant unconventional myosins.

Karcher RL, Provance DW, Gillespie PG, Mercer JA.

Methods Mol Biol. 2007;392:231-40.


A mechanism for active hearing.

Ren T, Gillespie PG.

Curr Opin Neurobiol. 2007 Aug;17(4):498-503. Epub 2007 Aug 17. Review.


Apical phosphatidylserine externalization in auditory hair cells.

Shi X, Gillespie PG, Nuttall AL.

Mol Membr Biol. 2007 Jan-Feb;24(1):16-27.


Hair bundles are specialized for ATP delivery via creatine kinase.

Shin JB, Streijger F, Beynon A, Peters T, Gadzala L, McMillen D, Bystrom C, Van der Zee CE, Wallimann T, Gillespie PG.

Neuron. 2007 Feb 1;53(3):371-86.


Hair bundles: keeping it together.

LeMasurier M, Gillespie PG.

Nat Neurosci. 2007 Jan;10(1):11-2. No abstract available.


The chloride intracellular channel protein CLIC5 is expressed at high levels in hair cell stereocilia and is essential for normal inner ear function.

Gagnon LH, Longo-Guess CM, Berryman M, Shin JB, Saylor KW, Yu H, Gillespie PG, Johnson KR.

J Neurosci. 2006 Oct 4;26(40):10188-98.


Vestibular hair bundles control pH with (Na+, K+)/H+ exchangers NHE6 and NHE9.

Hill JK, Brett CL, Chyou A, Kallay LM, Sakaguchi M, Rao R, Gillespie PG.

J Neurosci. 2006 Sep 27;26(39):9944-55.


Differential localization of unconventional myosin I and nonmuscle myosin II during B cell spreading.

Sumoza-Toledo A, Gillespie PG, Romero-Ramirez H, Ferreira-Ishikawa HC, Larson RE, Santos-Argumedo L.

Exp Cell Res. 2006 Oct 15;312(17):3312-22. Epub 2006 Jul 14.


Splice-site A choice targets plasma-membrane Ca2+-ATPase isoform 2 to hair bundles.

Hill JK, Williams DE, LeMasurier M, Dumont RA, Strehler EE, Gillespie PG.

J Neurosci. 2006 Jun 7;26(23):6172-80.


Topical radiant heating in wound healing: an experimental study in a donor site wound model*.

Khan AA, Banwell PE, Bakker MC, Gillespie PG, McGrouther DA, Roberts AH.

Int Wound J. 2004 Dec;1(4):233-40.


Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells.

Senften M, Schwander M, Kazmierczak P, Lillo C, Shin JB, Hasson T, Géléoc GS, Gillespie PG, Williams D, Holt JR, Müller U.

J Neurosci. 2006 Feb 15;26(7):2060-71.


Hair-cell mechanotransduction and cochlear amplification.

LeMasurier M, Gillespie PG.

Neuron. 2005 Nov 3;48(3):403-15. Review.


Xenopus TRPN1 (NOMPC) localizes to microtubule-based cilia in epithelial cells, including inner-ear hair cells.

Shin JB, Adams D, Paukert M, Siba M, Sidi S, Levin M, Gillespie PG, Gründer S.

Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12572-7. Epub 2005 Aug 22.


Fast adaptation in vestibular hair cells requires myosin-1c activity.

Stauffer EA, Scarborough JD, Hirono M, Miller ED, Shah K, Mercer JA, Holt JR, Gillespie PG.

Neuron. 2005 Aug 18;47(4):541-53.


Have we found the tip link, transduction channel, and gating spring of the hair cell?

Gillespie PG, Dumont RA, Kachar B.

Curr Opin Neurobiol. 2005 Aug;15(4):389-96. Review.


Na+ influx triggers bleb formation on inner hair cells.

Shi X, Gillespie PG, Nuttall AL.

Am J Physiol Cell Physiol. 2005 Jun;288(6):C1332-41. Epub 2005 Feb 2. Erratum in: Am J Physiol Cell Physiol. 2005 Sep;289(3):C774.


Myosin I and adaptation of mechanical transduction by the inner ear.

Gillespie PG.

Philos Trans R Soc Lond B Biol Sci. 2004 Dec 29;359(1452):1945-51. Review.


Hair cells require phosphatidylinositol 4,5-bisphosphate for mechanical transduction and adaptation.

Hirono M, Denis CS, Richardson GP, Gillespie PG.

Neuron. 2004 Oct 14;44(2):309-20.


Cadherin 23 is a component of the tip link in hair-cell stereocilia.

Siemens J, Lillo C, Dumont RA, Reynolds A, Williams DS, Gillespie PG, Müller U.

Nature. 2004 Apr 29;428(6986):950-5. Epub 2004 Mar 31.


Myosin-1c, the hair cell's adaptation motor.

Gillespie PG, Cyr JL.

Annu Rev Physiol. 2004;66:521-45. Review.


Chemical-genetic inhibition of a sensitized mutant myosin Vb demonstrates a role in peripheral-pericentriolar membrane traffic.

Provance DW Jr, Gourley CR, Silan CM, Cameron LC, Shokat KM, Goldenring JR, Shah K, Gillespie PG, Mercer JA.

Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):1868-73. Epub 2004 Feb 6.


Seeing touch: moving closer to the worm mechanotransduction complex.

Hill JK, Gillespie PG.

Curr Biol. 2003 Dec 16;13(24):R967-9. Review. No abstract available.


Developmental assembly of transduction apparatus in chick basilar papilla.

Si F, Brodie H, Gillespie PG, Vazquez AE, Yamoah EN.

J Neurosci. 2003 Nov 26;23(34):10815-26.


Fast adaptation in the mammalian cochlea: a conserved mechanism for cochlear amplification.

Strassmaier M, Gillespie PG.

Nat Neurosci. 2003 Aug;6(8):790-1. No abstract available.


Ion channels: hearing aid.

Dumont RA, Gillespie PG.

Nature. 2003 Jul 3;424(6944):28-9. No abstract available.


Myosin-I isozymes in neonatal rodent auditory and vestibular epithelia.

Dumont RA, Zhao YD, Holt JR, Bähler M, Gillespie PG.

J Assoc Res Otolaryngol. 2002 Dec;3(4):375-89. Epub 2002 Feb 27.


Calmodulin binding to recombinant myosin-1c and myosin-1c IQ peptides.

Gillespie PG, Cyr JL.

BMC Biochem. 2002 Nov 26;3:31. Epub 2002 Nov 26.


The hair cell's transduction channel.

Strassmaier M, Gillespie PG.

Curr Opin Neurobiol. 2002 Aug;12(4):380-6. Review.


Myosin-1c interacts with hair-cell receptors through its calmodulin-binding IQ domains.

Cyr JL, Dumont RA, Gillespie PG.

J Neurosci. 2002 Apr 1;22(7):2487-95.


A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells.

Holt JR, Gillespie SK, Provance DW, Shah K, Shokat KM, Corey DP, Mercer JA, Gillespie PG.

Cell. 2002 Feb 8;108(3):371-81.

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