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Enhanced Mitochondrial DNA Repair Resuscitates Transplantable Lungs Donated After Circulatory Death.

Tan YB, Pastukh VM, Gorodnya OM, Mulekar MS, Simmons JD, Machuca TN, Beaver TM, Wilson GL, Gillespie MN.

J Surg Res. 2020 Jan;245:273-280. doi: 10.1016/j.jss.2019.07.057. Epub 2019 Aug 14.


Plasma Transfusion Products and Contamination with Cellular and Associated Pro-Inflammatory Debris.

Tan YB, Rieske RR, Audia JP, Pastukh VM, Capley GC, Gillespie MN, Smith AA, Tatum DM, Duchesne JC, Kutcher ME, Kerby JD, Simmons JD.

J Am Coll Surg. 2019 Sep;229(3):252-258. doi: 10.1016/j.jamcollsurg.2019.04.017. Epub 2019 Apr 25.


Fifty Years of Monocrotaline-Induced Pulmonary Hypertension: What Has It Meant to the Field?

Hill NS, Gillespie MN, McMurtry IF.

Chest. 2017 Dec;152(6):1106-1108. doi: 10.1016/j.chest.2017.10.007. No abstract available.


A novel mtDNA repair fusion protein attenuates maladaptive remodeling and preserves cardiac function in heart failure.

Bradley JM, Li Z, Organ CL, Polhemus DJ, Otsuka H, Islam KN, Bhushan S, Gorodnya OM, Ruchko MV, Gillespie MN, Wilson GL, Lefer DJ.

Am J Physiol Heart Circ Physiol. 2018 Feb 1;314(2):H311-H321. doi: 10.1152/ajpheart.00515.2017. Epub 2017 Nov 3.


Pharmacologic Protection of Mitochondrial DNA Integrity May Afford a New Strategy for Suppressing Lung Ischemia-Reperfusion Injury.

Tan YB, Mulekar S, Gorodnya O, Weyant MJ, Zamora MR, Simmons JD, Machuka T, Gillespie MN.

Ann Am Thorac Soc. 2017 Sep;14(Supplement_3):S210-S215. doi: 10.1513/AnnalsATS.201706-438MG. Review.


Potential contribution of mitochondrial DNA damage associated molecular patterns in transfusion products to the development of acute respiratory distress syndrome after multiple transfusions.

Simmons JD, Lee YL, Pastukh VM, Capley G, Muscat CA, Muscat DC, Marshall ML, Brevard SB, Gillespie MN.

J Trauma Acute Care Surg. 2017 Jun;82(6):1023-1029. doi: 10.1097/TA.0000000000001421.


Mitochondrial DNA Damage Initiates Acute Lung Injury and Multi-Organ System Failure Evoked in Rats by Intra-Tracheal Pseudomonas Aeruginosa.

Lee YL, Obiako B, Gorodnya OM, Ruchko MV, Kuck JL, Pastukh VM, Wilson GL, Simmons JD, Gillespie MN.

Shock. 2017 Jul;48(1):54-60. doi: 10.1097/SHK.0000000000000838.


Mitochondrial DNA damage associated molecular patterns in ventilator-associated pneumonia: Prevention and reversal by intratracheal DNase I.

Simmons JD, Freno DR, Muscat CA, Obiako B, Lee YL, Pastukh VM, Brevard SB, Gillespie MN.

J Trauma Acute Care Surg. 2017 Jan;82(1):120-125. doi: 10.1097/TA.0000000000001269.


Regulation of mitochondrial genome replication by hypoxia: The role of DNA oxidation in D-loop region.

Pastukh VM, Gorodnya OM, Gillespie MN, Ruchko MV.

Free Radic Biol Med. 2016 Jul;96:78-88. doi: 10.1016/j.freeradbiomed.2016.04.011. Epub 2016 Apr 25.


Evaluation of Microvascular Perfusion and Resuscitation after Severe Injury.

Lee YL, Simmons JD, Gillespie MN, Alvarez DF, Gonzalez RP, Brevard SB, Frotan MA, Schneider AM, Richards WO.

Am Surg. 2015 Dec;81(12):1272-8.


An oxidative DNA "damage" and repair mechanism localized in the VEGF promoter is important for hypoxia-induced VEGF mRNA expression.

Pastukh V, Roberts JT, Clark DW, Bardwell GC, Patel M, Al-Mehdi AB, Borchert GM, Gillespie MN.

Am J Physiol Lung Cell Mol Physiol. 2015 Dec 1;309(11):L1367-75. doi: 10.1152/ajplung.00236.2015. Epub 2015 Oct 2.


Plasma nuclear and mitochondrial DNA levels in acute myocardial infarction patients.

Simmons JD, Gillespie MN.

Coron Artery Dis. 2015 Jun;26(4):286-288. doi: 10.1097/MCA.0000000000000244. No abstract available.


Mitochondrial DNA damage-associated molecular patterns mediate a feed-forward cycle of bacteria-induced vascular injury in perfused rat lungs.

Kuck JL, Obiako BO, Gorodnya OM, Pastukh VM, Kua J, Simmons JD, Gillespie MN.

Am J Physiol Lung Cell Mol Physiol. 2015 May 15;308(10):L1078-85. doi: 10.1152/ajplung.00015.2015. Epub 2015 Mar 20.


Mitochondrially targeted Endonuclease III has a powerful anti-infarct effect in an in vivo rat model of myocardial ischemia/reperfusion.

Yang XM, Cui L, White J, Kuck J, Ruchko MV, Wilson GL, Alexeyev M, Gillespie MN, Downey JM, Cohen MV.

Basic Res Cardiol. 2015 Mar;110(2):3. doi: 10.1007/s00395-014-0459-0. Epub 2015 Jan 17.


Mitochondrial Targeted Endonuclease III DNA Repair Enzyme Protects against Ventilator Induced Lung Injury in Mice.

Hashizume M, Mouner M, Chouteau JM, Gorodnya OM, Ruchko MV, Wilson GL, Gillespie MN, Parker JC.

Pharmaceuticals (Basel). 2014 Aug 22;7(8):894-912. doi: 10.3390/ph7080894.


Blood transfusion products contain mitochondrial DNA damage-associated molecular patterns: a potential effector of transfusion-related acute lung injury.

Lee YL, King MB, Gonzalez RP, Brevard SB, Frotan MA, Gillespie MN, Simmons JD.

J Surg Res. 2014 Oct;191(2):286-9. doi: 10.1016/j.jss.2014.06.003. Epub 2014 Jun 19.


Mitochondria in lung biology and pathology: more than just a powerhouse.

Schumacker PT, Gillespie MN, Nakahira K, Choi AM, Crouser ED, Piantadosi CA, Bhattacharya J.

Am J Physiol Lung Cell Mol Physiol. 2014 Jun 1;306(11):L962-74. doi: 10.1152/ajplung.00073.2014. Epub 2014 Apr 18. Review.


Elevated levels of plasma mitochondrial DNA DAMPs are linked to clinical outcome in severely injured human subjects.

Simmons JD, Lee YL, Mulekar S, Kuck JL, Brevard SB, Gonzalez RP, Gillespie MN, Richards WO.

Ann Surg. 2013 Oct;258(4):591-6; discussion 596-8. doi: 10.1097/SLA.0b013e3182a4ea46.


Mitochondria in hypoxic pulmonary vasoconstriction: potential importance of compartmentalized reactive oxygen species signaling.

Gillespie MN, Al-Mehdi AB, McMurtry IF.

Am J Respir Crit Care Med. 2013 Feb 15;187(4):338-40. doi: 10.1164/rccm.201301-0037ED. No abstract available.


Mitochondrial-targeted DNA repair enzyme 8-oxoguanine DNA glycosylase 1 protects against ventilator-induced lung injury in intact mice.

Hashizume M, Mouner M, Chouteau JM, Gorodnya OM, Ruchko MV, Potter BJ, Wilson GL, Gillespie MN, Parker JC.

Am J Physiol Lung Cell Mol Physiol. 2013 Feb 15;304(4):L287-97. doi: 10.1152/ajplung.00071.2012. Epub 2012 Dec 14.


Mitochondrial DNA damage mediates hyperoxic dysmorphogenesis in rat fetal lung explants.

Gebb SA, Decoux A, Waggoner A, Wilson GL, Gillespie MN.

Neonatology. 2013;103(2):91-7. doi: 10.1159/000342632. Epub 2012 Nov 15.


Perinuclear mitochondrial clustering creates an oxidant-rich nuclear domain required for hypoxia-induced transcription.

Al-Mehdi AB, Pastukh VM, Swiger BM, Reed DJ, Patel MR, Bardwell GC, Pastukh VV, Alexeyev MF, Gillespie MN.

Sci Signal. 2012 Jul 3;5(231):ra47. doi: 10.1126/scisignal.2002712.


Promoter G-quadruplex sequences are targets for base oxidation and strand cleavage during hypoxia-induced transcription.

Clark DW, Phang T, Edwards MG, Geraci MW, Gillespie MN.

Free Radic Biol Med. 2012 Jul 1;53(1):51-9. doi: 10.1016/j.freeradbiomed.2012.04.024. Epub 2012 May 1.


Mitochondrial DNA integrity may be a determinant of endothelial barrier properties in oxidant-challenged rat lungs.

Chouteau JM, Obiako B, Gorodnya OM, Pastukh VM, Ruchko MV, Wright AJ, Wilson GL, Gillespie MN.

Am J Physiol Lung Cell Mol Physiol. 2011 Dec;301(6):L892-8. doi: 10.1152/ajplung.00210.2011. Epub 2011 Sep 2.


Oxidative DNA damage in lung tissue from patients with COPD is clustered in functionally significant sequences.

Pastukh VM, Zhang L, Ruchko MV, Gorodnya O, Bardwell GC, Tuder RM, Gillespie MN.

Int J Chron Obstruct Pulmon Dis. 2011;6:209-17. doi: 10.2147/COPD.S15922. Epub 2011 Mar 13.


The DNA glycosylase Ogg1 defends against oxidant-induced mtDNA damage and apoptosis in pulmonary artery endothelial cells.

Ruchko MV, Gorodnya OM, Zuleta A, Pastukh VM, Gillespie MN.

Free Radic Biol Med. 2011 May 1;50(9):1107-13. doi: 10.1016/j.freeradbiomed.2010.10.692. Epub 2010 Oct 20.


Controlled DNA "damage" and repair in hypoxic signaling.

Gillespie MN, Pastukh VM, Ruchko MV.

Respir Physiol Neurobiol. 2010 Dec 31;174(3):244-51. doi: 10.1016/j.resp.2010.08.025. Epub 2010 Sep 8. Review.


Polyamine regulatory pathways as pharmacologic targets in pulmonary arterial hypertension.

Gillespie MN, Olson JW.

Adv Exp Med Biol. 2010;661:375-89. doi: 10.1007/978-1-60761-500-2_24. Review.


Oxidative DNA modifications in hypoxic signaling.

Gillespie MN, Pastukh V, Ruchko MV.

Ann N Y Acad Sci. 2009 Oct;1177:140-50. doi: 10.1111/j.1749-6632.2009.05036.x.


Hypoxia-induced oxidative base modifications in the VEGF hypoxia-response element are associated with transcriptionally active nucleosomes.

Ruchko MV, Gorodnya OM, Pastukh VM, Swiger BM, Middleton NS, Wilson GL, Gillespie MN.

Free Radic Biol Med. 2009 Feb 1;46(3):352-9. doi: 10.1016/j.freeradbiomed.2008.09.038. Epub 2008 Oct 18.


Connexin-43 upregulation in micrometastases and tumor vasculature and its role in tumor cell attachment to pulmonary endothelium.

Elzarrad MK, Haroon A, Willecke K, Dobrowolski R, Gillespie MN, Al-Mehdi AB.

BMC Med. 2008 Jul 22;6:20. doi: 10.1186/1741-7015-6-20.


Sequence-specific oxidative base modifications in hypoxia-inducible genes.

Pastukh V, Ruchko M, Gorodnya O, Wilson GL, Gillespie MN.

Free Radic Biol Med. 2007 Dec 15;43(12):1616-26. Epub 2007 Sep 9.


Nuclear protein-induced bending and flexing of the hypoxic response element of the rat vascular endothelial growth factor promoter.

Breit JF, Ault-Ziel K, Al-Mehdi AB, Gillespie MN.

FASEB J. 2008 Jan;22(1):19-29. Epub 2007 Aug 31.


The hyperproliferative endothelial cell phenotype in idiopathic pulmonary arterial hypertension.

Stevens T, Gillespie MN.

Am J Physiol Lung Cell Mol Physiol. 2007 Sep;293(3):L546-7. Epub 2007 Jun 29. No abstract available.


Bending and breaking the code: dynamic changes in promoter integrity may underlie a new mechanism regulating gene expression.

Gillespie MN, Wilson GL.

Am J Physiol Lung Cell Mol Physiol. 2007 Jan;292(1):L1-3. Epub 2006 Aug 18. Review. No abstract available.


Genomic threats from physiological signals in lung vascular cells.

Gillespie MN, Ziel KA, Grishko V, Campbell CC, Wilson GL.

Chest. 2005 Dec;128(6 Suppl):611S-612S. No abstract available.


Oxidants in signal transduction: impact on DNA integrity and gene expression.

Ziel KA, Grishko V, Campbell CC, Breit JF, Wilson GL, Gillespie MN.

FASEB J. 2005 Mar;19(3):387-94.


Mitochondrial DNA damage triggers mitochondrial dysfunction and apoptosis in oxidant-challenged lung endothelial cells.

Ruchko M, Gorodnya O, LeDoux SP, Alexeyev MF, Al-Mehdi AB, Gillespie MN.

Am J Physiol Lung Cell Mol Physiol. 2005 Mar;288(3):L530-5. Epub 2004 Nov 24.


Putrescine transport in hypoxic rat main PASMCs is required for p38 MAP kinase activation.

Ruchko M, Gillespie MN, Weeks RS, Olson JW, Babal P.

Am J Physiol Lung Cell Mol Physiol. 2003 Jan;284(1):L179-86. Epub 2002 Sep 27.


Enhanced mtDNA repair capacity protects pulmonary artery endothelial cells from oxidant-mediated death.

Dobson AW, Grishko V, LeDoux SP, Kelley MR, Wilson GL, Gillespie MN.

Am J Physiol Lung Cell Mol Physiol. 2002 Jul;283(1):L205-10.


Regulation of ornithine decarboxylase and polyamine import by hypoxia in pulmonary artery endothelial cells.

Babal P, Ruchko M, Ault-Ziel K, Cronenberg L, Olson JW, Gillespie MN.

Am J Physiol Lung Cell Mol Physiol. 2002 Apr;282(4):L840-6.


Regulation of gadd153 mRNA expression by hypoxia in pulmonary artery smooth muscle cells.

Chen R, Harrod KS, Olson JW, Gillespie MN.

Res Commun Mol Pathol Pharmacol. 2000 Jul-Aug;108(1-2):3-14.


Oxygen radical-induced mitochondrial DNA damage and repair in pulmonary vascular endothelial cell phenotypes.

Grishko V, Solomon M, Wilson GL, LeDoux SP, Gillespie MN.

Am J Physiol Lung Cell Mol Physiol. 2001 Jun;280(6):L1300-8.


Hypoxia promotes oxidative base modifications in the pulmonary artery endothelial cell VEGF gene.

Grishko V, Solomon M, Breit JF, Killilea DW, Ledoux SP, Wilson GL, Gillespie MN.

FASEB J. 2001 May;15(7):1267-9. No abstract available.


Interactions between agmatine and polyamine uptake pathways in rat pulmonary artery endothelial cells.

Babál P, Ruchko M, Olson JW, Gillespie MN.

Gen Pharmacol. 2000 Apr;34(4):255-61.


Regulation of ornithine decarboxylase activity and polyamine transport by agmatine in rat pulmonary artery endothelial cells.

Babál P, Ruchko M, Campbell CC, Gilmour SP, Mitchell JL, Olson JW, Gillespie MN.

J Pharmacol Exp Ther. 2001 Feb;296(2):372-7.


Free radical production in hypoxic pulmonary artery smooth muscle cells.

Killilea DW, Hester R, Balczon R, Babal P, Gillespie MN.

Am J Physiol Lung Cell Mol Physiol. 2000 Aug;279(2):L408-12.


Cellular disposition of transported polyamines in hypoxic rat lung and pulmonary arteries.

Babal P, Manuel SM, Olson JW, Gillespie MN.

Am J Physiol Lung Cell Mol Physiol. 2000 Mar;278(3):L610-7.


Capillary filtration coefficient, vascular resistance, and compliance in isolated mouse lungs.

Parker JC, Gillespie MN, Taylor AE, Martin SL.

J Appl Physiol (1985). 1999 Oct;87(4):1421-7.

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