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Items: 1 to 50 of 89

1.

Claspin - checkpoint adaptor and DNA replication factor.

Smits VAJ, Cabrera E, Freire R, Gillespie DA.

FEBS J. 2018 Jun 22. doi: 10.1111/febs.14594. [Epub ahead of print] Review.

PMID:
29931808
2.

Charge regulation of nonpolar colloids.

Hallett JE, Gillespie DAJ, Richardson RM, Bartlett P.

Soft Matter. 2018 Jan 17;14(3):331-343. doi: 10.1039/c7sm01825h.

PMID:
29164218
3.

Charging Poly(methyl Methacrylate) Latexes in Nonpolar Solvents: Effect of Particle Concentration.

Smith GN, Ahualli S, Delgado ÁV, Gillespie DAJ, Kemp R, Peach J, Pegg JC, Rogers SE, Shebanova O, Smith N, Eastoe J.

Langmuir. 2017 Nov 28;33(47):13543-13553. doi: 10.1021/acs.langmuir.7b02257. Epub 2017 Nov 15.

PMID:
29064706
4.

AKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE11.

Piscitello D, Varshney D, Lilla S, Vizioli MG, Reid C, Gorbunova V, Seluanov A, Gillespie DA, Adams PD.

Oncogene. 2018 Jan 25;37(4):427-438. doi: 10.1038/onc.2017.340. Epub 2017 Oct 2.

5.

The internal structure of poly(methyl methacrylate) latexes in nonpolar solvents.

Smith GN, Finlayson SD, Gillespie DAJ, Peach J, Pegg JC, Rogers SE, Shebanova O, Terry AE, Armes SP, Bartlett P, Eastoe J.

J Colloid Interface Sci. 2016 Oct 1;479:234-243. doi: 10.1016/j.jcis.2016.06.027. Epub 2016 Jun 9.

6.

PERK inhibits DNA replication during the Unfolded Protein Response via Claspin and Chk1.

Cabrera E, Hernández-Pérez S, Koundrioukoff S, Debatisse M, Kim D, Smolka MB, Freire R, Gillespie DA.

Oncogene. 2017 Feb 2;36(5):678-686. doi: 10.1038/onc.2016.239. Epub 2016 Jul 4.

PMID:
27375025
7.

Autophagy is critically required for DNA repair by homologous recombination.

Gillespie DA, Ryan KM.

Mol Cell Oncol. 2015 Oct 2;3(1):e1030538. doi: 10.1080/23723556.2015.1030538. eCollection 2016 Jan.

8.

DNA damage control: regulation and functions of checkpoint kinase 1.

Smits VA, Gillespie DA.

FEBS J. 2015 Oct;282(19):3681-92. doi: 10.1111/febs.13387. Epub 2015 Aug 13. Review.

9.

KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage.

Gong EY, Smits VA, Fumagallo F, Piscitello D, Morrice N, Freire R, Gillespie DA.

Sci Rep. 2015 Jun 3;5:10856. doi: 10.1038/srep10856.

10.

Loss of autophagy causes a synthetic lethal deficiency in DNA repair.

Liu EY, Xu N, O'Prey J, Lao LY, Joshi S, Long JS, O'Prey M, Croft DR, Beaumatin F, Baudot AD, Mrschtik M, Rosenfeldt M, Zhang Y, Gillespie DA, Ryan KM.

Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):773-8. doi: 10.1073/pnas.1409563112. Epub 2015 Jan 7.

11.

Cancer therapy. Targeting the poison within.

Smits VA, Gillespie DA.

Cell Cycle. 2014;13(15):2330-3. doi: 10.4161/cc.29756. No abstract available.

12.

Counterion condensation on spheres in the salt-free limit.

Gillespie DA, Hallett JE, Elujoba O, Che Hamzah AF, Richardson RM, Bartlett P.

Soft Matter. 2014 Jan 28;10(4):566-77. doi: 10.1039/c3sm52563e.

PMID:
24651922
13.

Interaction between surfactants and colloidal latexes in nonpolar solvents studied using contrast-variation small-angle neutron scattering.

Smith GN, Alexander S, Brown P, Gillespie DA, Grillo I, Heenan RK, James C, Kemp R, Rogers SE, Eastoe J.

Langmuir. 2014 Apr 1;30(12):3422-31. doi: 10.1021/la500331u. Epub 2014 Mar 18.

PMID:
24593803
14.

Fascin 1 is transiently expressed in mouse melanoblasts during development and promotes migration and proliferation.

Ma Y, Li A, Faller WJ, Libertini S, Fiorito F, Gillespie DA, Sansom OJ, Yamashiro S, Machesky LM.

Development. 2013 May;140(10):2203-11. doi: 10.1242/dev.089789.

15.

Chk1 is essential for the development of murine epidermal melanocytes.

Smith J, Larue L, Gillespie DA.

Pigment Cell Melanoma Res. 2013 Jul;26(4):580-5. doi: 10.1111/pcmr.12100. Epub 2013 Apr 17.

PMID:
23557358
16.

Short-circuiting the cell cycle for cancer therapy.

Gillespie DA.

Cell Cycle. 2012 Aug 1;11(15):2777-8. doi: 10.4161/cc.21392. Epub 2012 Aug 1. No abstract available.

17.

Akt: a double-edged sword in cell proliferation and genome stability.

Xu N, Lao Y, Zhang Y, Gillespie DA.

J Oncol. 2012;2012:951724. doi: 10.1155/2012/951724. Epub 2012 Mar 15.

18.

ATR-Chk1 signaling pathway and homologous recombinational repair protect cells from 5-fluorouracil cytotoxicity.

Fujinaka Y, Matsuoka K, Iimori M, Tuul M, Sakasai R, Yoshinaga K, Saeki H, Morita M, Kakeji Y, Gillespie DA, Yamamoto K, Takata M, Kitao H, Maehara Y.

DNA Repair (Amst). 2012 Mar 1;11(3):247-58. doi: 10.1016/j.dnarep.2011.11.005. Epub 2011 Dec 20.

PMID:
22188649
19.

Phosphorylation at serine 331 is required for Aurora B activation.

Petsalaki E, Akoumianaki T, Black EJ, Gillespie DA, Zachos G.

J Cell Biol. 2011 Oct 31;195(3):449-66. doi: 10.1083/jcb.201104023. Epub 2011 Oct 24.

20.

Cdk phosphorylation of Chk1 regulates efficient Chk1 activation and multiple checkpoint proficiency.

Xu N, Libertini S, Zhang Y, Gillespie DA.

Biochem Biophys Res Commun. 2011 Sep 30;413(3):465-70. doi: 10.1016/j.bbrc.2011.08.119. Epub 2011 Sep 1.

PMID:
21907702
21.

Chk1 is essential for chemical carcinogen-induced mouse skin tumorigenesis.

Tho LM, Libertini S, Rampling R, Sansom O, Gillespie DA.

Oncogene. 2012 Mar 15;31(11):1366-75. doi: 10.1038/onc.2011.326. Epub 2011 Aug 1.

PMID:
21804609
22.

Cdk-mediated phosphorylation of Chk1 is required for efficient activation and full checkpoint proficiency in response to DNA damage.

Xu N, Libertini S, Black EJ, Lao Y, Hegarat N, Walker M, Gillespie DA.

Oncogene. 2012 Mar 1;31(9):1086-94. doi: 10.1038/onc.2011.310. Epub 2011 Jul 18.

PMID:
21765472
23.

The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer.

Smith J, Tho LM, Xu N, Gillespie DA.

Adv Cancer Res. 2010;108:73-112. doi: 10.1016/B978-0-12-380888-2.00003-0. Review.

PMID:
21034966
24.

Akt/PKB suppresses DNA damage processing and checkpoint activation in late G2.

Xu N, Hegarat N, Black EJ, Scott MT, Hochegger H, Gillespie DA.

J Cell Biol. 2010 Aug 9;190(3):297-305. doi: 10.1083/jcb.201003004. Epub 2010 Aug 2.

25.

Mutant p53 drives invasion by promoting integrin recycling.

Muller PA, Caswell PT, Doyle B, Iwanicki MP, Tan EH, Karim S, Lukashchuk N, Gillespie DA, Ludwig RL, Gosselin P, Cromer A, Brugge JS, Sansom OJ, Norman JC, Vousden KH.

Cell. 2009 Dec 24;139(7):1327-41. doi: 10.1016/j.cell.2009.11.026.

26.

Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity.

Walker M, Black EJ, Oehler V, Gillespie DA, Scott MT.

Oncogene. 2009 Jun 18;28(24):2314-23. doi: 10.1038/onc.2009.102. Epub 2009 May 4.

27.

Claspin is phosphorylated in the Chk1-binding domain by a kinase distinct from Chk1.

Bennett LN, Larkin C, Gillespie DA, Clarke PR.

Biochem Biophys Res Commun. 2008 May 9;369(3):973-6. doi: 10.1016/j.bbrc.2008.02.154. Epub 2008 Mar 10.

PMID:
18331829
28.

Cells deficient in the FANC/BRCA pathway are hypersensitive to plasma levels of formaldehyde.

Ridpath JR, Nakamura A, Tano K, Luke AM, Sonoda E, Arakawa H, Buerstedde JM, Gillespie DA, Sale JE, Yamazoe M, Bishop DK, Takata M, Takeda S, Watanabe M, Swenberg JA, Nakamura J.

Cancer Res. 2007 Dec 1;67(23):11117-22.

29.

Chk2 is required for optimal mitotic delay in response to irradiation-induced DNA damage incurred in G2 phase.

Rainey MD, Black EJ, Zachos G, Gillespie DA.

Oncogene. 2008 Feb 7;27(7):896-906. Epub 2007 Aug 6.

PMID:
17684483
30.

Centrifugal elutriation as a means of cell cycle phase separation and synchronisation.

Gillespie DA, Henriques C.

Subcell Biochem. 2006;40:359-61.

PMID:
17623921
31.

Mitotic index determination by flow cytometry.

Gillespie DA, Walker M.

Subcell Biochem. 2006;40:355-8.

PMID:
17623920
32.

Analysing the DNA damage and replication checkpoints in DT40 cells.

Rainey MD, Zachos G, Gillespie DA.

Subcell Biochem. 2006;40:107-17. Review.

PMID:
17623903
33.

Chk1 is required for G2/M checkpoint response induced by the catalytic topoisomerase II inhibitor ICRF-193.

Robinson HM, Bratlie-Thoresen S, Brown R, Gillespie DA.

Cell Cycle. 2007 May 15;6(10):1265-7. Epub 2007 May 1. No abstract available.

PMID:
17495539
34.

Chk1 regulates the density of active replication origins during the vertebrate S phase.

Maya-Mendoza A, Petermann E, Gillespie DA, Caldecott KW, Jackson DA.

EMBO J. 2007 Jun 6;26(11):2719-31. Epub 2007 May 10.

35.

DNA mismatch repair and Chk1-dependent centrosome amplification in response to DNA alkylation damage.

Robinson HM, Black EJ, Brown R, Gillespie DA.

Cell Cycle. 2007 Apr 15;6(8):982-92. Epub 2007 Apr 5.

PMID:
17404511
36.

Exercising restraints: role of Chk1 in regulating the onset and progression of unperturbed mitosis in vertebrate cells.

Zachos G, Gillespie DA.

Cell Cycle. 2007 Apr 1;6(7):810-3. Epub 2007 Apr 22. Review.

PMID:
17377502
37.

Phosphorylation of HuR by Chk2 regulates SIRT1 expression.

Abdelmohsen K, Pullmann R Jr, Lal A, Kim HH, Galban S, Yang X, Blethrow JD, Walker M, Shubert J, Gillespie DA, Furneaux H, Gorospe M.

Mol Cell. 2007 Feb 23;25(4):543-57.

38.

Chk1 is required for spindle checkpoint function.

Zachos G, Black EJ, Walker M, Scott MT, Vagnarelli P, Earnshaw WC, Gillespie DA.

Dev Cell. 2007 Feb;12(2):247-60.

39.

Chk1-dependent slowing of S-phase progression protects DT40 B-lymphoma cells against killing by the nucleoside analogue 5-fluorouracil.

Robinson HM, Jones R, Walker M, Zachos G, Brown R, Cassidy J, Gillespie DA.

Oncogene. 2006 Aug 31;25(39):5359-69. Epub 2006 Apr 17.

PMID:
16619043
40.

Chk1 requirement for high global rates of replication fork progression during normal vertebrate S phase.

Petermann E, Maya-Mendoza A, Zachos G, Gillespie DA, Jackson DA, Caldecott KW.

Mol Cell Biol. 2006 Apr;26(8):3319-26.

41.

Viral mutations enhance the Max binding properties of the vMyc b-HLH-LZ domain.

Crouch DH, Fisher F, La Rocca SA, Goding CR, Gillespie DA.

Nucleic Acids Res. 2005 Sep 15;33(16):5235-42. Print 2005.

42.
43.

Sab (SH3BP5), a novel mitochondria-localized JNK-interacting protein.

Wiltshire C, Gillespie DA, May GH.

Biochem Soc Trans. 2004 Dec;32(Pt 6):1075-7.

PMID:
15506969
44.

c-Jun-deficient cells undergo premature senescence as a result of spontaneous DNA damage accumulation.

MacLaren A, Black EJ, Clark W, Gillespie DA.

Mol Cell Biol. 2004 Oct;24(20):9006-18.

45.

Invasion of normal human fibroblasts induced by v-Fos is independent of proliferation, immortalization, and the tumor suppressors p16INK4a and p53.

Scott LA, Vass JK, Parkinson EK, Gillespie DA, Winnie JN, Ozanne BW.

Mol Cell Biol. 2004 Feb;24(4):1540-59.

46.
47.

The secret life of histones.

Gillespie DA, Vousden KH.

Cell. 2003 Sep 19;114(6):655-6. Review.

49.

v-Jun stimulates both cdk2 kinase activity and G1/S progression via transcriptional repression of p21 CIP1.

Maclaren A, Clark W, Black EJ, Gregory D, Fujii H, Gillespie DA.

Oncogene. 2003 Apr 24;22(16):2383-95.

PMID:
12717415
50.

Lethal errors in checkpoint control--life without Chk1.

Zachos G, Rainey M, Gillespie DA.

Cell Cycle. 2003 Jan-Feb;2(1):14-6. Review. No abstract available.

PMID:
12695676

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