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Mechanistic In Vitro Studies Indicate that the Clinical Drug-Drug Interaction between Telithromycin and Simvastatin Acid Is Driven by Time-Dependent Inhibition of CYP3A4 with Minimal Effect on OATP1B1.

Elsby R, Hare V, Neal H, Outteridge S, Pearson C, Plant K, Gill RU, Butler P, Riley RJ.

Drug Metab Dispos. 2019 Jan;47(1):1-8. doi: 10.1124/dmd.118.083832. Epub 2018 Oct 22.


Metabolic Hydrolysis of Aromatic Amides in Selected Rat, Minipig, and Human In Vitro Systems.

Bradshaw PR, Wilson ID, Gill RU, Butler PJ, Dilworth C, Athersuch TJ.

Sci Rep. 2018 Feb 5;8(1):2405. doi: 10.1038/s41598-018-20464-4.

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