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Items: 44


Therapeutic Strategies to Block the Hypoxic Response.

DiGiacomo JW, Gilkes DM.

Adv Exp Med Biol. 2019;1136:141-157. doi: 10.1007/978-3-030-12734-3_10. Review.


Solid Stress in Brain Tumors.

Gilkes DM, Wirtz D.

Trends Cancer. 2019 May;5(5):266-268. doi: 10.1016/j.trecan.2019.03.003. Epub 2019 Apr 8.


The Contribution of the Immune System in Bone Metastasis Pathogenesis.

Xiang L, Gilkes DM.

Int J Mol Sci. 2019 Feb 25;20(4). pii: E999. doi: 10.3390/ijms20040999. Review.


A software tool for the quantification of metastatic colony growth dynamics and size distributions in vitro and in vivo.

Bhoyar S, Godet I, DiGiacomo JW, Gilkes DM.

PLoS One. 2018 Dec 27;13(12):e0209591. doi: 10.1371/journal.pone.0209591. eCollection 2018.


Molecular Portrait of Hypoxia in Breast Cancer: A Prognostic Signature and Novel HIF-Regulated Genes.

Ye IC, Fertig EJ, DiGiacomo JW, Considine M, Godet I, Gilkes DM.

Mol Cancer Res. 2018 Dec;16(12):1889-1901. doi: 10.1158/1541-7786.MCR-18-0345. Epub 2018 Jul 23.


Tumor Hypoxia As an Enhancer of Inflammation-Mediated Metastasis: Emerging Therapeutic Strategies.

DiGiacomo JW, Gilkes DM.

Target Oncol. 2018 Apr;13(2):157-173. doi: 10.1007/s11523-018-0555-4. Review.


The quaternary state of polymerized human hemoglobin regulates oxygenation of breast cancer solid tumors: A theoretical and experimental study.

Belcher DA, Ju JA, Baek JH, Yalamanoglu A, Buehler PW, Gilkes DM, Palmer AF.

PLoS One. 2018 Feb 7;13(2):e0191275. doi: 10.1371/journal.pone.0191275. eCollection 2018.


RhoB: Team Oncogene or Team Tumor Suppressor?

Ju JA, Gilkes DM.

Genes (Basel). 2018 Jan 30;9(2). pii: E67. doi: 10.3390/genes9020067. Review.


BRCA1 and BRCA2 mutations and treatment strategies for breast cancer.

Godet I, Gilkes DM.

Integr Cancer Sci Ther. 2017 Feb;4(1). doi: 10.15761/ICST.1000228. Epub 2017 Feb 27.


Biophysical and biomolecular determination of cellular age in humans.

Phillip JM, Wu PH, Gilkes DM, Williams W, McGovern S, Daya J, Chen J, Aifuwa I, Lee JSH, Fan R, Walston J, Wirtz D.

Nat Biomed Eng. 2017 Jul;1(7). pii: 0093. doi: 10.1038/s41551-017-0093. Epub 2017 Jul 11.


Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration.

Jayatilaka H, Tyle P, Chen JJ, Kwak M, Ju J, Kim HJ, Lee JSH, Wu PH, Gilkes DM, Fan R, Wirtz D.

Nat Commun. 2017 May 26;8:15584. doi: 10.1038/ncomms15584.


Hypoxia Selectively Enhances Integrin α5β1 Receptor Expression in Breast Cancer to Promote Metastasis.

Ju JA, Godet I, Ye IC, Byun J, Jayatilaka H, Lee SJ, Xiang L, Samanta D, Lee MH, Wu PH, Wirtz D, Semenza GL, Gilkes DM.

Mol Cancer Res. 2017 Jun;15(6):723-734. doi: 10.1158/1541-7786.MCR-16-0338. Epub 2017 Feb 17.


Implications of Hypoxia in Breast Cancer Metastasis to Bone.

Gilkes DM.

Int J Mol Sci. 2016 Sep 30;17(10). pii: E1669. Review.


PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis.

Samanta D, Park Y, Andrabi SA, Shelton LM, Gilkes DM, Semenza GL.

Cancer Res. 2016 Aug 1;76(15):4430-42. doi: 10.1158/0008-5472.CAN-16-0530. Epub 2016 Jun 8.


HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells.

Zhang H, Lu H, Xiang L, Bullen JW, Zhang C, Samanta D, Gilkes DM, He J, Semenza GL.

Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):E6215-23. doi: 10.1073/pnas.1520032112. Epub 2015 Oct 28.


HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells.

Xiang L, Gilkes DM, Hu H, Luo W, Bullen JW, Liang H, Semenza GL.

Oncotarget. 2015 May 20;6(14):11768-78.


Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype.

Xiang L, Gilkes DM, Hu H, Takano N, Luo W, Lu H, Bullen JW, Samanta D, Liang H, Semenza GL.

Oncotarget. 2014 Dec 30;5(24):12509-27.


Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells.

Samanta D, Gilkes DM, Chaturvedi P, Xiang L, Semenza GL.

Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):E5429-38. doi: 10.1073/pnas.1421438111. Epub 2014 Dec 1.


Hypoxia-inducible factors enhance glutamate signaling in cancer cells.

Hu H, Takano N, Xiang L, Gilkes DM, Luo W, Semenza GL.

Oncotarget. 2014 Oct 15;5(19):8853-68.


Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression.

Hubbi ME, Gilkes DM, Hu H, Kshitiz, Ahmed I, Semenza GL.

Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):E3325-34. doi: 10.1073/pnas.1412840111. Epub 2014 Jul 28.


Decreased expression of cystathionine β-synthase promotes glioma tumorigenesis.

Takano N, Sarfraz Y, Gilkes DM, Chaturvedi P, Xiang L, Suematsu M, Zagzag D, Semenza GL.

Mol Cancer Res. 2014 Oct;12(10):1398-406. doi: 10.1158/1541-7786.MCR-14-0184. Epub 2014 Jul 3.


Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis.

Wang T, Gilkes DM, Takano N, Xiang L, Luo W, Bishop CJ, Chaturvedi P, Green JJ, Semenza GL.

Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):E3234-42. doi: 10.1073/pnas.1410041111. Epub 2014 Jun 17.


Hypoxia and the extracellular matrix: drivers of tumour metastasis.

Gilkes DM, Semenza GL, Wirtz D.

Nat Rev Cancer. 2014 Jun;14(6):430-9. doi: 10.1038/nrc3726. Epub 2014 May 15. Review.


Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment.

Chaturvedi P, Gilkes DM, Takano N, Semenza GL.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):E2120-9. doi: 10.1073/pnas.1406655111. Epub 2014 May 5.


Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells.

Gilkes DM, Xiang L, Lee SJ, Chaturvedi P, Hubbi ME, Wirtz D, Semenza GL.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):E384-93. doi: 10.1073/pnas.1321510111. Epub 2013 Dec 9.


Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer.

Xiang L, Gilkes DM, Chaturvedi P, Luo W, Hu H, Takano N, Liang H, Semenza GL.

J Mol Med (Berl). 2014 Feb;92(2):151-64. doi: 10.1007/s00109-013-1102-5. Epub 2013 Nov 20.


Role of hypoxia-inducible factors in breast cancer metastasis.

Gilkes DM, Semenza GL.

Future Oncol. 2013 Nov;9(11):1623-36. doi: 10.2217/fon.13.92. Review.


Sirtuin-7 inhibits the activity of hypoxia-inducible factors.

Hubbi ME, Hu H, Kshitiz, Gilkes DM, Semenza GL.

J Biol Chem. 2013 Jul 19;288(29):20768-75. doi: 10.1074/jbc.M113.476903. Epub 2013 Jun 9.


Collagen prolyl hydroxylases are essential for breast cancer metastasis.

Gilkes DM, Chaturvedi P, Bajpai S, Wong CC, Wei H, Pitcairn S, Hubbi ME, Wirtz D, Semenza GL.

Cancer Res. 2013 Jun 1;73(11):3285-96. doi: 10.1158/0008-5472.CAN-12-3963. Epub 2013 Mar 28.


Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts.

Gilkes DM, Bajpai S, Chaturvedi P, Wirtz D, Semenza GL.

J Biol Chem. 2013 Apr 12;288(15):10819-29. doi: 10.1074/jbc.M112.442939. Epub 2013 Feb 19.


A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication.

Hubbi ME, Kshitiz, Gilkes DM, Rey S, Wong CC, Luo W, Kim DH, Dang CV, Levchenko A, Semenza GL.

Sci Signal. 2013 Feb 12;6(262):ra10. doi: 10.1126/scisignal.2003417.


Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis.

Gilkes DM, Bajpai S, Wong CC, Chaturvedi P, Hubbi ME, Wirtz D, Semenza GL.

Mol Cancer Res. 2013 May;11(5):456-66. doi: 10.1158/1541-7786.MCR-12-0629. Epub 2013 Feb 1.


Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis.

Chaturvedi P, Gilkes DM, Wong CC; Kshitiz, Luo W, Zhang H, Wei H, Takano N, Schito L, Levchenko A, Semenza GL.

J Clin Invest. 2013 Jan;123(1):189-205. doi: 10.1172/JCI64993. Epub 2012 Dec 17. Erratum in: J Clin Invest. 2013 Mar 1;123(3):1402.


Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis.

Wong CC, Zhang H, Gilkes DM, Chen J, Wei H, Chaturvedi P, Hubbi ME, Semenza GL.

J Mol Med (Berl). 2012 Jul;90(7):803-15. doi: 10.1007/s00109-011-0855-y. Epub 2012 Jan 10.


Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1.

Hubbi ME, Gilkes DM, Baek JH, Semenza GL.

J Biol Chem. 2012 Feb 24;287(9):6139-49. doi: 10.1074/jbc.M111.278630. Epub 2012 Jan 4.


Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation.

Wong CC, Gilkes DM, Zhang H, Chen J, Wei H, Chaturvedi P, Fraley SI, Wong CM, Khoo US, Ng IO, Wirtz D, Semenza GL.

Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16369-74. doi: 10.1073/pnas.1113483108. Epub 2011 Sep 12.


HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs.

Zhang H, Wong CC, Wei H, Gilkes DM, Korangath P, Chaturvedi P, Schito L, Chen J, Krishnamachary B, Winnard PT Jr, Raman V, Zhen L, Mitzner WA, Sukumar S, Semenza GL.

Oncogene. 2012 Apr 5;31(14):1757-70. doi: 10.1038/onc.2011.365. Epub 2011 Aug 22.


Regulation of MDMX expression by mitogenic signaling.

Gilkes DM, Pan Y, Coppola D, Yeatman T, Reuther GW, Chen J.

Mol Cell Biol. 2008 Mar;28(6):1999-2010. doi: 10.1128/MCB.01633-07. Epub 2008 Jan 2.


Distinct roles of MDMX in the regulation of p53 response to ribosomal stress.

Gilkes DM, Chen J.

Cell Cycle. 2007 Jan 15;6(2):151-5. Epub 2007 Jan 13. Review.


MDMX regulation of p53 response to ribosomal stress.

Gilkes DM, Chen L, Chen J.

EMBO J. 2006 Nov 29;25(23):5614-25. Epub 2006 Nov 16.


MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin.

Hu B, Gilkes DM, Farooqi B, Sebti SM, Chen J.

J Biol Chem. 2006 Nov 3;281(44):33030-5. Epub 2006 Aug 11.


Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3.

LeBron C, Chen L, Gilkes DM, Chen J.

EMBO J. 2006 Mar 22;25(6):1196-206. Epub 2006 Mar 2.


ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage.

Chen L, Gilkes DM, Pan Y, Lane WS, Chen J.

EMBO J. 2005 Oct 5;24(19):3411-22. Epub 2005 Sep 15.

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