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Solution Structure of the Carboxy-Terminal Tandem Repeat Domain of Eukaryotic Elongation Factor 2 Kinase and Its Role in Substrate Recognition.

Piserchio A, Will N, Giles DH, Hajredini F, Dalby KN, Ghose R.

J Mol Biol. 2019 Jul 12;431(15):2700-2717. doi: 10.1016/j.jmb.2019.05.019. Epub 2019 May 18.


Targeting Cytokine Signaling and Lymphocyte Traffic via Small Molecules in Inflammatory Bowel Disease: JAK Inhibitors and S1PR Agonists.

Pérez-Jeldres T, Tyler CJ, Boyer JD, Karuppuchamy T, Yarur A, Giles DA, Yeasmin S, Lundborg L, Sandborn WJ, Patel DR, Rivera-Nieves J.

Front Pharmacol. 2019 Mar 13;10:212. doi: 10.3389/fphar.2019.00212. eCollection 2019. Review.


Kinematic signatures of prey capture from archival tags reveal sex differences in killer whale foraging activity.

Tennessen JB, Holt MM, Hanson MB, Emmons CK, Giles DA, Hogan JT.

J Exp Biol. 2019 Feb 4;222(Pt 3). pii: jeb191874. doi: 10.1242/jeb.191874.


The Determination of Finger-Flexor Critical Force in Rock Climbers.

Giles D, Chidley JB, Taylor N, Torr O, Hadley J, Randall T, Fryer S.

Int J Sports Physiol Perform. 2019 May 2:1-8. doi: 10.1123/ijspp.2018-0809. [Epub ahead of print]


The Tumor Necrosis Factor Superfamily Members TNFSF14 (LIGHT), Lymphotoxin β and Lymphotoxin β Receptor Interact to Regulate Intestinal Inflammation.

Giles DA, Zahner S, Krause P, Van Der Gracht E, Riffelmacher T, Morris V, Tumanov A, Kronenberg M.

Front Immunol. 2018 Nov 22;9:2585. doi: 10.3389/fimmu.2018.02585. eCollection 2018.


Pre-oil spill baseline profiling for contaminants in Southern Resident killer whale fecal samples indicates possible exposure to vessel exhaust.

Lundin JI, Ylitalo GM, Giles DA, Seely EA, Anulacion BF, Boyd DT, Hempelmann JA, Parsons KM, Booth RK, Wasser SK.

Mar Pollut Bull. 2018 Nov;136:448-453. doi: 10.1016/j.marpolbul.2018.09.015. Epub 2018 Sep 27.


Evaluating insecticide coverage in almond and pistachio for control of navel orangeworm (Amyelois transitella) (Lepidoptera: Pyralidae).

Siegel JP, Strmiska MM, Niederholzer FJ, Giles DK, Walse SS.

Pest Manag Sci. 2019 May;75(5):1435-1442. doi: 10.1002/ps.5265. Epub 2018 Dec 22.


CNS-resident classical DCs play a critical role in CNS autoimmune disease.

Giles DA, Duncker PC, Wilkinson NM, Washnock-Schmid JM, Segal BM.

J Clin Invest. 2018 Dec 3;128(12):5322-5334. doi: 10.1172/JCI123708. Epub 2018 Oct 29.


Pseudomonas aeruginosa responds to exogenous polyunsaturated fatty acids (PUFAs) by modifying phospholipid composition, membrane permeability, and phenotypes associated with virulence.

Baker LY, Hobby CR, Siv AW, Bible WC, Glennon MS, Anderson DM, Symes SJ, Giles DK.

BMC Microbiol. 2018 Sep 14;18(1):117. doi: 10.1186/s12866-018-1259-8.


Establishing an ambulatory care service using point-of-care testing diagnostics.

Weihser P, Giles D.

Br J Hosp Med (Lond). 2018 Sep 2;79(9):520-523. doi: 10.12968/hmed.2018.79.9.520.


Analyses of ovarian activity reveal repeated evolution of post-reproductive lifespans in toothed whales.

Ellis S, Franks DW, Nattrass S, Currie TE, Cant MA, Giles D, Balcomb KC, Croft DP.

Sci Rep. 2018 Aug 27;8(1):12833. doi: 10.1038/s41598-018-31047-8.


LIGHT-HVEM Signaling in Innate Lymphoid Cell Subsets Protects Against Enteric Bacterial Infection.

Seo GY, Shui JW, Takahashi D, Song C, Wang Q, Kim K, Mikulski Z, Chandra S, Giles DA, Zahner S, Kim PH, Cheroutre H, Colonna M, Kronenberg M.

Cell Host Microbe. 2018 Aug 8;24(2):249-260.e4. doi: 10.1016/j.chom.2018.07.008.


Preemptive Analgesia in Minimally Invasive Gynecologic Surgery.

Long JB, Bevil K, Giles DL.

J Minim Invasive Gynecol. 2019 Feb;26(2):198-218. doi: 10.1016/j.jmig.2018.07.018. Epub 2018 Jul 29.


An IFNγ/CXCL2 regulatory pathway determines lesion localization during EAE.

Stoolman JS, Duncker PC, Huber AK, Giles DA, Washnock-Schmid JM, Soulika AM, Segal BM.

J Neuroinflammation. 2018 Jul 16;15(1):208. doi: 10.1186/s12974-018-1237-y.


Discerning the pre-monsoon urban atmosphere aerosol characteristic and its potential source type remotely sensed by AERONET over the Bengal Gangetic plain.

Priyadharshini B, Verma S, Giles DM, Holben BN.

Environ Sci Pollut Res Int. 2018 Aug;25(22):22163-22179. doi: 10.1007/s11356-018-2290-x. Epub 2018 May 26.


Structural Dynamics of the Activation of Elongation Factor 2 Kinase by Ca2+-Calmodulin.

Will N, Lee K, Hajredini F, Giles DH, Abzalimov RR, Clarkson M, Dalby KN, Ghose R.

J Mol Biol. 2018 Aug 17;430(17):2802-2821. doi: 10.1016/j.jmb.2018.05.033. Epub 2018 May 22.


Nicotinamide adenine dinucleotide phosphate (reduced) oxidase 2 modulates inflammatory vigor during nonalcoholic fatty liver disease progression in mice.

Mukherjee R, Moreno-Fernandez ME, Giles DA, Cappelletti M, Stankiewicz TE, Chan CC, Divanovic S.

Hepatol Commun. 2018 Mar 24;2(5):546-560. doi: 10.1002/hep4.1162. eCollection 2018 May.


Exogenous fatty acids alter phospholipid composition, membrane permeability, capacity for biofilm formation, and antimicrobial peptide susceptibility in Klebsiella pneumoniae.

Hobby CR, Herndon JL, Morrow CA, Peters RE, Symes SJK, Giles DK.

Microbiologyopen. 2019 Feb;8(2):e00635. doi: 10.1002/mbo3.635. Epub 2018 Apr 27.


Peroxisomal β-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease.

Moreno-Fernandez ME, Giles DA, Stankiewicz TE, Sheridan R, Karns R, Cappelletti M, Lampe K, Mukherjee R, Sina C, Sallese A, Bridges JP, Hogan SP, Aronow BJ, Hoebe K, Divanovic S.

JCI Insight. 2018 Mar 22;3(6). pii: 93626. doi: 10.1172/jci.insight.93626.


Postreproductive lifespans are rare in mammals.

Ellis S, Franks DW, Nattrass S, Cant MA, Bradley DL, Giles D, Balcomb KC, Croft DP.

Ecol Evol. 2018 Jan 31;8(5):2482-2494. doi: 10.1002/ece3.3856. eCollection 2018 Mar.


Integrating HIV and hypertension management in low-resource settings: Lessons from Malawi.

Patel P, Speight C, Maida A, Loustalot F, Giles D, Phiri S, Gupta S, Raghunathan P.

PLoS Med. 2018 Mar 7;15(3):e1002523. doi: 10.1371/journal.pmed.1002523. eCollection 2018 Mar.


Topical lotions utilized in outpatient rehabilitation clinics as a potential source of bacterial contamination.

Spratt HG Jr, Levine D, Bage J, Giles DK, Collier AG.

Physiother Theory Pract. 2019 Feb;35(2):163-170. doi: 10.1080/09593985.2018.1441935. Epub 2018 Feb 26.


Heart Rate Variability During Exercise: A Comparison of Artefact Correction Methods.

Giles DA, Draper N.

J Strength Cond Res. 2018 Mar;32(3):726-735. doi: 10.1519/JSC.0000000000001800.


Myeloid cell plasticity in the evolution of central nervous system autoimmunity.

Giles DA, Washnock-Schmid JM, Duncker PC, Dahlawi S, Ponath G, Pitt D, Segal BM.

Ann Neurol. 2018 Jan;83(1):131-141. doi: 10.1002/ana.25128. Epub 2018 Jan 14.


Evaluating anthropogenic threats to endangered killer whales to inform effective recovery plans.

Lacy RC, Williams R, Ashe E, Balcomb Iii KC, Brent LJN, Clark CW, Croft DP, Giles DA, MacDuffee M, Paquet PC.

Sci Rep. 2017 Oct 26;7(1):14119. doi: 10.1038/s41598-017-14471-0.


Mortality risk and social network position in resident killer whales: sex differences and the importance of resource abundance.

Ellis S, Franks DW, Nattrass S, Cant MA, Weiss MN, Giles D, Balcomb KC, Croft DP.

Proc Biol Sci. 2017 Oct 25;284(1865). pii: 20171313. doi: 10.1098/rspb.2017.1313.


Exogenous polyunsaturated fatty acids (PUFAs) alter phospholipid composition, membrane permeability, biofilm formation and motility in Acinetobacter baumannii.

Eder AE, Munir SA, Hobby CR, Anderson DM, Herndon JL, Siv AW, Symes SJK, Giles DK.

Microbiology. 2017 Nov;163(11):1626-1636. doi: 10.1099/mic.0.000556. Epub 2017 Oct 23.


Erratum: Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling.

Giles DA, Moreno-Fernandez ME, Stankiewicz TE, Graspeuntner S, Cappelletti M, Wu D, Mukherjee R, Chan CC, Lawson MJ, Klarquist J, Sünderhauf A, Softic S, Kahn CR, Stemmer K, Iwakura Y, Aronow BJ, Karns R, Steinbrecher KA, Karp CL, Sheridan R, Shanmukhappa SK, Reynaud D, Haslam DB, Sina C, Rupp J, Hogan SP, Divanovic S.

Nat Med. 2017 Oct 6;23(10):1241. doi: 10.1038/nm1017-1241c.


Elevated humoral response to cytomegalovirus in HIV-infected individuals with poor CD4+ T-cell immune recovery.

Gómez-Mora E, Massanella M, García E, Giles D, Bernadó M, Urrea V, Carrillo J, Ouchi D, Puig J, Negredo E, Clotet B, Blanco J, Cabrera C.

PLoS One. 2017 Sep 21;12(9):e0184433. doi: 10.1371/journal.pone.0184433. eCollection 2017.


Exogenous Polyunsaturated Fatty Acids Impact Membrane Remodeling and Affect Virulence Phenotypes among Pathogenic Vibrio Species.

Moravec AR, Siv AW, Hobby CR, Lindsay EN, Norbash LV, Shults DJ, Symes SJK, Giles DK.

Appl Environ Microbiol. 2017 Oct 31;83(22). pii: e01415-17. doi: 10.1128/AEM.01415-17. Print 2017 Nov 15.


Differences in forearm strength, endurance, and hemodynamic kinetics between male boulderers and lead rock climbers.

Fryer S, Stone KJ, Sveen J, Dickson T, España-Romero V, Giles D, Baláš J, Stoner L, Draper N.

Eur J Sport Sci. 2017 Oct;17(9):1177-1183. doi: 10.1080/17461391.2017.1353135. Epub 2017 Jul 28.


Population growth is limited by nutritional impacts on pregnancy success in endangered Southern Resident killer whales (Orcinus orca).

Wasser SK, Lundin JI, Ayres K, Seely E, Giles D, Balcomb K, Hempelmann J, Parsons K, Booth R.

PLoS One. 2017 Jun 29;12(6):e0179824. doi: 10.1371/journal.pone.0179824. eCollection 2017.


Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling.

Giles DA, Moreno-Fernandez ME, Stankiewicz TE, Graspeuntner S, Cappelletti M, Wu D, Mukherjee R, Chan CC, Lawson MJ, Klarquist J, Sünderhauf A, Softic S, Kahn CR, Stemmer K, Iwakura Y, Aronow BJ, Karns R, Steinbrecher KA, Karp CL, Sheridan R, Shanmukhappa SK, Reynaud D, Haslam DB, Sina C, Rupp J, Hogan SP, Divanovic S.

Nat Med. 2017 Jul;23(7):829-838. doi: 10.1038/nm.4346. Epub 2017 Jun 12. Erratum in: Nat Med. 2017 Oct 6;23 (10 ):1241.


Hemodynamic and Cardiorespiratory Predictors of Sport Rock Climbing Performance.

Fryer SM, Giles D, Palomino IG, de la O Puerta A, España-Romero V.

J Strength Cond Res. 2018 Dec;32(12):3534-3541. doi: 10.1519/JSC.0000000000001860.


Type I interferons regulate susceptibility to inflammation-induced preterm birth.

Cappelletti M, Presicce P, Lawson MJ, Chaturvedi V, Stankiewicz TE, Vanoni S, Harley IT, McAlees JW, Giles DA, Moreno-Fernandez ME, Rueda CM, Senthamaraikannan P, Sun X, Karns R, Hoebe K, Janssen EM, Karp CL, Hildeman DA, Hogan SP, Kallapur SG, Chougnet CA, Way SS, Divanovic S.

JCI Insight. 2017 Mar 9;2(5):e91288. doi: 10.1172/jci.insight.91288.


Sustainability of health information systems: a three-country qualitative study in southern Africa.

Moucheraud C, Schwitters A, Boudreaux C, Giles D, Kilmarx PH, Ntolo N, Bangani Z, St Louis ME, Bossert TJ.

BMC Health Serv Res. 2017 Jan 10;17(1):23. doi: 10.1186/s12913-016-1971-8.


Impact of light exposure on thyroid-stimulating hormone results using the Siemens Advia Centaur TSH-3Ultra assay.

Armer J, Giles D, Lancaster I, Brownbill K.

Ann Clin Biochem. 2017 Sep;54(5):612-615. doi: 10.1177/0004563216688924. Epub 2017 Mar 16.


Signal Integration at Elongation Factor 2 Kinase: THE ROLES OF CALCIUM, CALMODULIN, AND SER-500 PHOSPHORYLATION.

Tavares CD, Giles DH, Stancu G, Chitjian CA, Ferguson SB, Wellmann RM, Kaoud TS, Ghose R, Dalby KN.

J Biol Chem. 2017 Feb 3;292(5):2032-2045. doi: 10.1074/jbc.M116.753277. Epub 2016 Dec 12.


Modulation of ambient temperature promotes inflammation and initiates atherosclerosis in wild type C57BL/6 mice.

Giles DA, Ramkhelawon B, Donelan EM, Stankiewicz TE, Hutchison SB, Mukherjee R, Cappelletti M, Karns R, Karp CL, Moore KJ, Divanovic S.

Mol Metab. 2016 Sep 21;5(11):1121-1130. doi: 10.1016/j.molmet.2016.09.008. eCollection 2016 Nov.


An emerging role for eotaxins in neurodegenerative disease.

Huber AK, Giles DA, Segal BM, Irani DN.

Clin Immunol. 2018 Apr;189:29-33. doi: 10.1016/j.clim.2016.09.010. Epub 2016 Sep 21. Review.


Coumarin Derivatives as Anti-inflammatory and Anticancer Agents.

Thomas V, Giles D, Basavarajaswamy GPM, Das AK, Patel A.

Anticancer Agents Med Chem. 2017;17(3):415-423. doi: 10.2174/1871520616666160902094739.


Structure of the C-Terminal Helical Repeat Domain of Eukaryotic Elongation Factor 2 Kinase.

Will N, Piserchio A, Snyder I, Ferguson SB, Giles DH, Dalby KN, Ghose R.

Biochemistry. 2016 Sep 27;55(38):5377-86. doi: 10.1021/acs.biochem.6b00711. Epub 2016 Sep 14.


Total Laparoscopic Hysterectomy and Laparoscopic-Assisted Vaginal Hysterectomy.

King CR, Giles D.

Obstet Gynecol Clin North Am. 2016 Sep;43(3):463-78. doi: 10.1016/j.ogc.2016.04.005. Review.


Structural Basis for the Recognition of Eukaryotic Elongation Factor 2 Kinase by Calmodulin.

Lee K, Alphonse S, Piserchio A, Tavares CD, Giles DH, Wellmann RM, Dalby KN, Ghose R.

Structure. 2016 Sep 6;24(9):1441-51. doi: 10.1016/j.str.2016.06.015. Epub 2016 Aug 4.


Active recovery of the finger flexors enhances intermittent handgrip performance in rock climbers.

Baláš J, Michailov M, Giles D, Kodejška J, Panáčková M, Fryer S.

Eur J Sport Sci. 2016 Oct;16(7):764-72. doi: 10.1080/17461391.2015.1119198. Epub 2015 Dec 19.


Alterations in autonomic cardiac modulation in response to normobaric hypoxia.

Giles D, Kelly J, Draper N.

Eur J Sport Sci. 2016 Nov;16(8):1023-31. doi: 10.1080/17461391.2016.1207708. Epub 2016 Jul 26.


The effect of potential fall distance on hormonal response in rock climbing.

Baláš J, Giles D, Chrastinová L, Kárníková K, Kodejška J, Hlaváčková A, Vomáčko L, Draper N.

J Sports Sci. 2017 May;35(10):989-994. doi: 10.1080/02640414.2016.1206667. Epub 2016 Jul 11.


Forearm muscle oxidative capacity index predicts sport rock-climbing performance.

Fryer S, Stoner L, Stone K, Giles D, Sveen J, Garrido I, España-Romero V.

Eur J Appl Physiol. 2016 Aug;116(8):1479-84. doi: 10.1007/s00421-016-3403-1. Epub 2016 Jun 2.


Modulation in Persistent Organic Pollutant Concentration and Profile by Prey Availability and Reproductive Status in Southern Resident Killer Whale Scat Samples.

Lundin JI, Ylitalo GM, Booth RK, Anulacion B, Hempelmann JA, Parsons KM, Giles DA, Seely EA, Hanson MB, Emmons CK, Wasser SK.

Environ Sci Technol. 2016 Jun 21;50(12):6506-16. doi: 10.1021/acs.est.6b00825. Epub 2016 Jun 8.


Differences in Oxygenation Kinetics Between the Dominant and Nondominant Flexor Digitorum Profundus in Rock Climbers.

Giles D, Romero VE, Garrido I, de la O Puerta A, Stone K, Fryer S.

Int J Sports Physiol Perform. 2017 Jan;12(1):137-139. doi: 10.1123/ijspp.2015-0651. Epub 2016 Aug 24.


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