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Items: 1 to 50 of 60

1.

Estimation of the inhibiting impact of abiraterone D4A metabolite on human steroid 21-monooxygenase (CYP21A2).

Masamrekh R, Filippova T, Haurychenka Y, Shcherbakov K, Veselovsky A, Strushkevich N, Shkel T, Gilep A, Usanov S, Shumyantseva V, Kuzikov A.

Steroids. 2019 Oct 31;154:108528. doi: 10.1016/j.steroids.2019.108528. [Epub ahead of print]

PMID:
31678135
2.

In vitro interactions of abiraterone, erythromycin, and CYP3A4: implications for drug-drug interactions.

Masamrekh RA, Kuzikov AV, Haurychenka YI, Shcherbakov KA, Veselovsky AV, Filimonov DA, Dmitriev AV, Zavialova MG, Gilep AA, Shkel TV, Strushkevich NV, Usanov SA, Archakov AI, Shumyantseva VV.

Fundam Clin Pharmacol. 2019 Jul 8. doi: 10.1111/fcp.12497. [Epub ahead of print]

PMID:
31286572
3.

Affinity Isolation and Mass Spectrometry Identification of Prostacyclin Synthase (PTGIS) Subinteractome.

Ershov PV, Mezentsev YV, Kopylov AT, Yablokov EO, Svirid AV, Lushchyk AY, Kaluzhskiy LA, Gilep AA, Usanov SA, Medvedev AE, Ivanov AS.

Biology (Basel). 2019 Jun 20;8(2). pii: E49. doi: 10.3390/biology8020049.

4.

A large-scale comparative analysis of affinity, thermodynamics and functional characteristics of interactions of twelve cytochrome P450 isoforms and their redox partners.

Yablokov EO, Sushko TA, Ershov PV, Florinskaya AV, Gnedenko OV, Shkel TV, Grabovec IP, Strushkevich NV, Kaluzhskiy LA, Usanov SA, Gilep AA, Ivanov AS.

Biochimie. 2019 Jul;162:156-166. doi: 10.1016/j.biochi.2019.04.020. Epub 2019 Apr 26.

PMID:
31034920
5.

[Interaction of prostacyclin synthase with cytochromes P450].

Gnedenko OV, Yablokov EO, Ershov PV, Svirid AV, Shkel TV, Haidukevich IV, Strushkevich NV, Gilep AA, Usanov SA, Ivanov AS.

Biomed Khim. 2019 Jan;65(1):63-66. doi: 10.18097/PBMC20196501063. Russian.

PMID:
30816099
6.

Assessment of electrocatalytic hydroxylase activity of cytochrome P450 3A4 (CYP3A4) by means of derivatization of 6β-hydroxycortisol by sulfuric acid for fluorimetric assay.

Kuzikov A, Masamrekh R, Shkel T, Strushkevich N, Gilep A, Usanov S, Archakov A, Shumyantseva V.

Talanta. 2019 May 1;196:231-236. doi: 10.1016/j.talanta.2018.12.041. Epub 2018 Dec 14.

PMID:
30683357
7.

New azole derivatives of [17(20)E]-21-norpregnene: Synthesis and inhibition of prostate carcinoma cell growth.

Dalidovich TS, Hurski AL, Morozevich GE, Latysheva AS, Sushko TA, Strushkevich NV, Gilep AA, Misharin AY, Zhabinskii VN, Khripach VA.

Steroids. 2019 Jul;147:10-18. doi: 10.1016/j.steroids.2018.08.004. Epub 2018 Aug 25.

PMID:
30149075
8.

Interaction of 17α-hydroxylase, 17(20)-lyase (CYP17A1) inhibitors - abiraterone and galeterone - with human sterol 14α-demethylase (CYP51A1).

Masamrekh R, Kuzikov A, Veselovsky A, Toropygin I, Shkel T, Strushkevich N, Gilep A, Usanov S, Archakov A, Shumyantseva V.

J Inorg Biochem. 2018 Sep;186:24-33. doi: 10.1016/j.jinorgbio.2018.05.010. Epub 2018 May 21.

PMID:
29807244
9.

Different inhibitory effects of azole-containing drugs and pesticides on CYP2C9 polymorphic forms: An in vitro study.

Haidukevich IV, Sushko TA, Tumilovich AM, Grabovec IP, Usanov SA, Gilep AA.

Toxicol In Vitro. 2018 Aug;50:249-256. doi: 10.1016/j.tiv.2018.04.002. Epub 2018 Apr 3.

PMID:
29621561
10.

[Proteomic analysis of contaminants in recombinant membrane hemeproteins expressed in E. coli and isolated by metal affinity chromatography].

Yantsevich AV, Dzichenka YV, Ivanchik AV, Shapiro MA, Trawkina M, Shkel TV, Gilep AA, Sergeev GV, Usanov SA.

Prikl Biokhim Mikrobiol. 2017 Mar-Apr;53(2):173-87. Russian.

PMID:
29508978
11.

[Study specificity of isatin interactions with P450 cytochromes].

Ershov PV, Mezentsev YV, Yablokov EO, Kalushskiy LA, Florinskaya AV, Svirid AV, Gilep AA, Usanov SA, Medvedev AE, Ivanov AS.

Biomed Khim. 2018 Jan;64(1):61-65. doi: 10.18097/PBMC20186401061. Russian.

PMID:
29460836
12.

Direct Molecular Fishing of New Protein Partners for Human Thromboxane Synthase.

Svirid AV, Ershov PV, Yablokov EO, Kaluzhskiy LA, Mezentsev YV, Florinskaya AV, Sushko TA, Strushkevich NV, Gilep AA, Usanov SA, Medvedev AE, Ivanov AS.

Acta Naturae. 2017 Oct-Dec;9(4):92-100.

13.

Isatin-induced increase in the affinity of human ferrochelatase and adrenodoxin reductase interaction.

Ershov P, Mezentsev Y, Gilep A, Usanov S, Buneeva O, Medvedev A, Ivanov A.

Protein Sci. 2017 Dec;26(12):2458-2462. doi: 10.1002/pro.3300. Epub 2017 Oct 9.

14.

[The effect of isatin on protein-protein interactions between cytochrome b5 and cytochromes P450].

Ershov PV, Yablokov EO, Mezentsev YV, Kalushskiy LA, Florinskaya AV, Veselovsky AV, Gnedenko OV, Gilep AA, Usanov SA, Medvedev AE, Ivanov AS.

Biomed Khim. 2017 Mar;63(2):170-175. doi: 10.18097/PBMC20176302170. Russian.

PMID:
28414290
15.

Thermodynamics of interactions between mammalian cytochromes P450 and b5.

Yablokov E, Florinskaya A, Medvedev A, Sergeev G, Strushkevich N, Luschik A, Shkel T, Haidukevich I, Gilep A, Usanov S, Ivanov A.

Arch Biochem Biophys. 2017 Apr 1;619:10-15. doi: 10.1016/j.abb.2017.02.006. Epub 2017 Feb 24.

PMID:
28238672
16.

Development of CYB5-fusion monitoring system for efficient periplasmic expression of multimeric proteins in Escherichia coli.

Dormeshkin D, Gilep A, Sergeev G, Usanov S.

Protein Expr Purif. 2016 Dec;128:60-6. doi: 10.1016/j.pep.2016.08.007. Epub 2016 Aug 12.

PMID:
27524697
17.

Identification of Mycobacterium tuberculosis enzyme involved in vitamin D and 7-dehydrocholesterol metabolism.

Vasilevskaya AV, Yantsevich AV, Sergeev GV, Lemish AP, Usanov SA, Gilep AA.

J Steroid Biochem Mol Biol. 2017 May;169:202-209. doi: 10.1016/j.jsbmb.2016.05.021. Epub 2016 Jun 8.

PMID:
27289046
18.

Evidence That Compound I Is the Active Species in Both the Hydroxylase and Lyase Steps by Which P450scc Converts Cholesterol to Pregnenolone: EPR/ENDOR/Cryoreduction/Annealing Studies.

Davydov R, Strushkevich N, Smil D, Yantsevich A, Gilep A, Usanov S, Hoffman BM.

Biochemistry. 2015 Dec 8;54(48):7089-97. doi: 10.1021/acs.biochem.5b00903. Epub 2015 Nov 25.

19.

Computer-aided design of aptamers for cytochrome p450.

Shcherbinin DS, Gnedenko OV, Khmeleva SA, Usanov SA, Gilep AA, Yantsevich AV, Shkel TV, Yushkevich IV, Radko SP, Ivanov AS, Veselovsky AV, Archakov AI.

J Struct Biol. 2015 Aug;191(2):112-9. doi: 10.1016/j.jsb.2015.07.003. Epub 2015 Jul 10.

PMID:
26166326
20.

[An effective scheme to produce recombinant uracil-DNA glycosylase of Escherichia coli for PCR diagnostics].

Dmitrochenko AE, Turiianskaia OM, Gilep AA, Usanov SA, Iantsevich AV.

Prikl Biokhim Mikrobiol. 2014 Jul-Aug;50(4):398-407. Russian.

PMID:
25707116
21.

[The screening of the inhibitors of the human cytochrome P450(51) (CYP51A1): the plant and animal structural lanosterol's analogs].

Kaluzhsiy LA, Gnedenko OV, Gilep AA, Strushkevich NV, Shkel TV, Chernovetsky MA, Ivanov AS, Lisitsa AV, Usanov AS, Stonik VA, Archakov AI.

Biomed Khim. 2014 Sep-Oct;60(5):528-37. Russian.

PMID:
25386880
22.

Protein interactomics based on direct molecular fishing on paramagnetic particles: practical realization and further SPR validation.

Ivanov AS, Medvedev A, Ershov P, Molnar A, Mezentsev Y, Yablokov E, Kaluzhsky L, Gnedenko O, Buneeva O, Haidukevich I, Sergeev G, Lushchyk A, Yantsevich A, Medvedeva M, Kozin S, Popov I, Novikova S, Zgoda V, Gilep A, Usanov S, Lisitsa A, Archakov A.

Proteomics. 2014 Oct;14(20):2261-74. doi: 10.1002/pmic.201400117. Epub 2014 Aug 21.

PMID:
25044858
23.

The role of cytochrome b5 structural domains in interaction with cytochromes P450.

Sergeev GV, Gilep AA, Usanov SA.

Biochemistry (Mosc). 2014 May;79(5):406-16. doi: 10.1134/S0006297914050046.

24.

Structural characterization of human cholesterol 7α-hydroxylase.

Tempel W, Grabovec I, MacKenzie F, Dichenko YV, Usanov SA, Gilep AA, Park HW, Strushkevich N.

J Lipid Res. 2014 Sep;55(9):1925-32. doi: 10.1194/jlr.M050765. Epub 2014 Jun 13.

25.

[SPR-biosensor assay for analysis of small compounds interaction with human cytochrome P450 51A1 (CYP51A1)].

Gnedenko OV, Kaluzhskiĭ LA, Mol'nar AA, Iantsevich AV, Mukha DV, Gilep AA, Usanov SA, Stonik VA, Ivanov AS, Lisitsa AV, Archakov AI.

Biomed Khim. 2013 Jul-Aug;59(4):388-98. Russian.

PMID:
24502137
26.

Human steroid and oxysterol 7α-hydroxylase CYP7B1: substrate specificity, azole binding and misfolding of clinically relevant mutants.

Yantsevich AV, Dichenko YV, Mackenzie F, Mukha DV, Baranovsky AV, Gilep AA, Usanov SA, Strushkevich NV.

FEBS J. 2014 Mar;281(6):1700-13. doi: 10.1111/febs.12733. Epub 2014 Feb 20.

27.

Genetics, structure, function, mode of actions and role in cancer development of CYP17.

Sushko TA, Gilep AA, Usanov SA.

Anticancer Agents Med Chem. 2014 Jan;14(1):66-76.

PMID:
24007292
28.

Role of microsomal steroid hydroxylases in Δ7-steroid biosynthesis.

Sushko TA, Gilep AA, Yantsevich AV, Usanov SA.

Biochemistry (Mosc). 2013 Mar;78(3):282-9. doi: 10.1134/S0006297913030103.

PMID:
23586722
29.

Structural insights into aldosterone synthase substrate specificity and targeted inhibition.

Strushkevich N, Gilep AA, Shen L, Arrowsmith CH, Edwards AM, Usanov SA, Park HW.

Mol Endocrinol. 2013 Feb;27(2):315-24. doi: 10.1210/me.2012-1287. Epub 2013 Jan 15.

30.

Compound I is the reactive intermediate in the first monooxygenation step during conversion of cholesterol to pregnenolone by cytochrome P450scc: EPR/ENDOR/cryoreduction/annealing studies.

Davydov R, Gilep AA, Strushkevich NV, Usanov SA, Hoffman BM.

J Am Chem Soc. 2012 Oct 17;134(41):17149-56. doi: 10.1021/ja3067226. Epub 2012 Oct 5.

31.

Protein interactomics based on direct molecular fishing on paramagnetic particles: experimental simulation and SPR validation.

Ershov P, Mezentsev Y, Gnedenko O, Mukha D, Yantsevich A, Britikov V, Kaluzhskiy L, Yablokov E, Molnar A, Ivanov A, Lisitsa A, Gilep A, Usanov S, Archakov A.

Proteomics. 2012 Nov;12(22):3295-8. doi: 10.1002/pmic.201200135. Epub 2012 Nov 2.

PMID:
23001861
32.

Mechanism of intermolecular interactions of microsomal cytochrome P450s CYP17 and CYP21 involved in steroid hormone biosynthesis.

Sushko TA, Gilep AA, Usanov SA.

Biochemistry (Mosc). 2012 Jun;77(6):585-92. doi: 10.1134/S0006297912060041.

PMID:
22817457
33.

Molecular modeling of human lanosterol 14α-demethylase complexes with substrates and their derivatives.

Mukha DV, Feranchuk SI, Gilep AA, Usanov SA.

Biochemistry (Mosc). 2011 Feb;76(2):175-85.

PMID:
21568850
34.

At the crossroads of steroid hormone biosynthesis: the role, substrate specificity and evolutionary development of CYP17.

Gilep AA, Sushko TA, Usanov SA.

Biochim Biophys Acta. 2011 Jan;1814(1):200-9. doi: 10.1016/j.bbapap.2010.06.021. Epub 2010 Jul 7. Review.

PMID:
20619364
35.
36.

Conformational stability of cytochrome b5, enhanced green fluorescent protein, and their fusion protein Hmwb5-EGFP.

Yantsevich AV, Gilep AA, Usanov SA.

Biochemistry (Mosc). 2009 May;74(5):518-27.

PMID:
19538125
37.

Mechanism of electron transfer in fusion protein cytochrome b5-NADH-cytochrome b5 reductase.

Yantsevich AV, Gilep AA, Usanov SA.

Biochemistry (Mosc). 2008 Oct;73(10):1096-107.

PMID:
18991555
38.

Engineering, expression, and purification of "soluble" human cytochrome P45017alpha and its functional characterization.

Pechurskaya TA, Lukashevich OP, Gilep AA, Usanov SA.

Biochemistry (Mosc). 2008 Jul;73(7):806-11.

39.
40.

Adrenodoxin supports reactions catalyzed by microsomal steroidogenic cytochrome P450s.

Pechurskaya TA, Harnastai IN, Grabovec IP, Gilep AA, Usanov SA.

Biochem Biophys Res Commun. 2007 Feb 16;353(3):598-604. Epub 2006 Dec 15.

PMID:
17188650
43.

Oxidative modification of quercetin by hemeproteins.

Cherviakovsky EM, Bolibrukh DA, Baranovsky AV, Vlasova TM, Kurchenko VP, Gilep AA, Usanov SA.

Biochem Biophys Res Commun. 2006 Apr 7;342(2):459-64. Epub 2006 Feb 9. Erratum in: Biochem Biophys Res Commun. 2007 Feb 16;353(3):848.

PMID:
16487485
44.

Molecular identification of adrenal inner zone antigen as a heme-binding protein.

Min L, Strushkevich NV, Harnastai IN, Iwamoto H, Gilep AA, Takemori H, Usanov SA, Nonaka Y, Hori H, Vinson GP, Okamoto M.

FEBS J. 2005 Nov;272(22):5832-43.

45.

The development of an efficient system for heterologous expression of cytochrome P450s in Escherichia coli using hemA gene co-expression.

Harnastai IN, Gilep AA, Usanov SA.

Protein Expr Purif. 2006 Mar;46(1):47-55. Epub 2005 Aug 8.

PMID:
16122943
46.

Engineering of proteolytically stable NADPH-cytochrome P450 reductase.

Bonina TA, Gilep AA, Estabrook RW, Usanov SA.

Biochemistry (Mosc). 2005 Mar;70(3):357-65.

PMID:
15823091
47.

The stimulatory role of human cytochrome b5 in the bioactivation activities of human CYP1A2, 2A6 and 2E1: a new cell expression system to study cytochrome P450 mediated biotransformation.

Duarte MP, Palma BB, Gilep AA, Laires A, Oliveira JS, Usanov SA, Rueff J, Kranendonk M.

Mutagenesis. 2005 Mar;20(2):93-100. Epub 2005 Feb 22. Erratum in: Mutagenesis. 2007 Jan;22(1):75-81.

PMID:
15728263
48.

Chimerogenesis in estimation of specificity and pathway directions for cytochrome p45017alpha catalyzed reactions.

Gilep AA, Estabrook RW, Usanov SA.

Biochemistry (Mosc). 2004 Apr;69(4):364-75.

PMID:
15170370
49.

A pathway for the metabolism of vitamin D3: unique hydroxylated metabolites formed during catalysis with cytochrome P450scc (CYP11A1).

Guryev O, Carvalho RA, Usanov S, Gilep A, Estabrook RW.

Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14754-9. Epub 2003 Dec 1.

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