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Items: 1 to 50 of 90

1.

The crystal structure of human forkhead box N1 in complex with DNA reveals the structural basis for forkhead box family specificity.

Newman JA, Aitkenhead H, Gavard AE, Rota IA, Handel AE, Hollander GA, Gileadi O.

J Biol Chem. 2019 Dec 30. pii: jbc.RA119.010365. doi: 10.1074/jbc.RA119.010365. [Epub ahead of print]

2.

Binding and structural analyses of potent inhibitors of the human Ca2+/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors.

Profeta GS, Dos Reis CV, Santiago ADS, Godoi PHC, Fala AM, Wells CI, Sartori R, Salmazo APT, Ramos PZ, Massirer KB, Elkins JM, Drewry DH, Gileadi O, Couñago RM.

Sci Rep. 2019 Nov 11;9(1):16452. doi: 10.1038/s41598-019-52795-1.

3.

The C-Terminal Domains SnRK2 Box and ABA Box Have a Role in Sugarcane SnRK2s Auto-Activation and Activity.

Righetto GL, Sriranganadane D, Halabelian L, Chiodi CG, Elkins JM, Massirer KB, Gileadi O, Menossi M, Couñago RM.

Front Plant Sci. 2019 Sep 17;10:1105. doi: 10.3389/fpls.2019.01105. eCollection 2019.

4.

Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72.

Laflamme C, McKeever PM, Kumar R, Schwartz J, Kolahdouzan M, Chen CX, You Z, Benaliouad F, Gileadi O, McBride HM, Durcan TM, Edwards AM, Healy LM, Robertson J, McPherson PS.

Elife. 2019 Oct 15;8. pii: e48363. doi: 10.7554/eLife.48363.

5.

Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2.

Serafim RAM, de Souza Gama FH, Dutra LA, Dos Reis CV, Vasconcelos SNS, da Silva Santiago A, Takarada JE, Di Pillo F, Azevedo H, Mascarello A, Elkins JM, Massirer KB, Gileadi O, Guimarães CRW, Couñago RM.

ACS Med Chem Lett. 2019 Aug 19;10(9):1266-1271. doi: 10.1021/acsmedchemlett.9b00082. eCollection 2019 Sep 12.

6.

Streamlining the production of proteins for structural biology.

Owens RJ, Gileadi O.

Biophys Rev. 2019 Jun 27:533-534. doi: 10.1007/s12551-019-00565-8. [Epub ahead of print] No abstract available.

7.

A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of Ubiquitin.

Lim M, Newman JA, Williams HL, Masino L, Aitkenhead H, Gravard AE, Gileadi O, Svejstrup JQ.

Structure. 2019 Aug 6;27(8):1316-1325.e6. doi: 10.1016/j.str.2019.05.003. Epub 2019 Jun 13.

8.

Role of protein structure in variant annotation: structural insight of mutations causing 6-pyruvoyl-tetrahydropterin synthase deficiency.

Muniz JRC, Szeto NW, Frise R, Lee WH, Wang XS, Thöny B, Himmelreich N, Blau N, Hsiao KJ, Liu TT, Gileadi O, Oppermann U, Von Delft F, Yue WW, Tang NL.

Pathology. 2019 Apr;51(3):274-280. doi: 10.1016/j.pathol.2018.11.011. Epub 2019 Mar 8.

PMID:
30853107
9.

WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop.

Agajanian MJ, Walker MP, Axtman AD, Ruela-de-Sousa RR, Serafin DS, Rabinowitz AD, Graham DM, Ryan MB, Tamir T, Nakamichi Y, Gammons MV, Bennett JM, Couñago RM, Drewry DH, Elkins JM, Gileadi C, Gileadi O, Godoi PH, Kapadia N, Müller S, Santiago AS, Sorrell FJ, Wells CI, Fedorov O, Willson TM, Zuercher WJ, Major MB.

Cell Rep. 2019 Jan 2;26(1):79-93.e8. doi: 10.1016/j.celrep.2018.12.023.

10.

Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors.

Santiago ADS, Couñago RM, Ramos PZ, Godoi PHC, Massirer KB, Gileadi O, Elkins JM.

Sci Rep. 2018 Oct 4;8(1):14800. doi: 10.1038/s41598-018-33043-4.

11.

Tryptophan-Mediated Interactions between Tristetraprolin and the CNOT9 Subunit Are Required for CCR4-NOT Deadenylase Complex Recruitment.

Bulbrook D, Brazier H, Mahajan P, Kliszczak M, Fedorov O, Marchese FP, Aubareda A, Chalk R, Picaud S, Strain-Damerell C, Filippakopoulos P, Gileadi O, Clark AR, Yue WW, Burgess-Brown NA, Dean JLE.

J Mol Biol. 2018 Mar 2;430(5):722-736. doi: 10.1016/j.jmb.2017.12.018. Epub 2017 Dec 29.

PMID:
29291391
12.

The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery.

Bradley AR, Echalier A, Fairhead M, Strain-Damerell C, Brennan P, Bullock AN, Burgess-Brown NA, Carpenter EP, Gileadi O, Marsden BD, Lee WH, Yue W, Bountra C, von Delft F.

Essays Biochem. 2017 Nov 8;61(5):495-503. doi: 10.1042/EBC20170051. Print 2017 Nov 8. Review.

13.

Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations.

Couñago RM, Allerston CK, Savitsky P, Azevedo H, Godoi PH, Wells CI, Mascarello A, de Souza Gama FH, Massirer KB, Zuercher WJ, Guimarães CRW, Gileadi O.

Sci Rep. 2017 Aug 8;7(1):7501. doi: 10.1038/s41598-017-07755-y.

14.

Progress towards a public chemogenomic set for protein kinases and a call for contributions.

Drewry DH, Wells CI, Andrews DM, Angell R, Al-Ali H, Axtman AD, Capuzzi SJ, Elkins JM, Ettmayer P, Frederiksen M, Gileadi O, Gray N, Hooper A, Knapp S, Laufer S, Luecking U, Michaelides M, Müller S, Muratov E, Denny RA, Saikatendu KS, Treiber DK, Zuercher WJ, Willson TM.

PLoS One. 2017 Aug 2;12(8):e0181585. doi: 10.1371/journal.pone.0181585. eCollection 2017.

15.

Structural Characterization of Maize SIRK1 Kinase Domain Reveals an Unusual Architecture of the Activation Segment.

Aquino B, Couñago RM, Verza N, Ferreira LM, Massirer KB, Gileadi O, Arruda P.

Front Plant Sci. 2017 May 26;8:852. doi: 10.3389/fpls.2017.00852. eCollection 2017.

16.

Recombinant Protein Expression in E. coli : A Historical Perspective.

Gileadi O.

Methods Mol Biol. 2017;1586:3-10. doi: 10.1007/978-1-4939-6887-9_1. Review.

PMID:
28470595
17.

Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5.

Newman JA, Aitkenhead H, Savitsky P, Gileadi O.

Nucleic Acids Res. 2017 Apr 20;45(7):4231-4243. doi: 10.1093/nar/gkw1362.

18.

Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair.

Vaz B, Popovic M, Newman JA, Fielden J, Aitkenhead H, Halder S, Singh AN, Vendrell I, Fischer R, Torrecilla I, Drobnitzky N, Freire R, Amor DJ, Lockhart PJ, Kessler BM, McKenna GW, Gileadi O, Ramadan K.

Mol Cell. 2016 Nov 17;64(4):704-719. doi: 10.1016/j.molcel.2016.09.032. Epub 2016 Oct 27.

19.

Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo.

Lee SY, Brem J, Pettinati I, Claridge TD, Gileadi O, Schofield CJ, McHugh PJ.

Chem Commun (Camb). 2016 May 10;52(40):6727-30. doi: 10.1039/c6cc00529b.

20.

Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding.

Newman JA, Cooper CD, Roos AK, Aitkenhead H, Oppermann UC, Cho HJ, Osman R, Gileadi O.

PLoS One. 2016 Feb 24;11(2):e0148762. doi: 10.1371/journal.pone.0148762. eCollection 2016.

21.

Identification of LACTB2, a metallo-β-lactamase protein, as a human mitochondrial endoribonuclease.

Levy S, Allerston CK, Liveanu V, Habib MR, Gileadi O, Schuster G.

Nucleic Acids Res. 2016 Feb 29;44(4):1813-32. doi: 10.1093/nar/gkw050. Epub 2016 Jan 29.

22.

EXD2 promotes homologous recombination by facilitating DNA end resection.

Broderick R, Nieminuszczy J, Baddock HT, Deshpande R, Gileadi O, Paull TT, McHugh PJ, Niedzwiedz W.

Nat Cell Biol. 2016 Mar;18(3):271-280. doi: 10.1038/ncb3303. Epub 2016 Jan 25.

23.

Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway.

Newman JA, Cooper CDO, Aitkenhead H, Gileadi O.

Structure. 2015 Dec 1;23(12):2319-2330. doi: 10.1016/j.str.2015.10.014.

24.

The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities.

Allerston CK, Lee SY, Newman JA, Schofield CJ, McHugh PJ, Gileadi O.

Nucleic Acids Res. 2015 Dec 15;43(22):11047-60. doi: 10.1093/nar/gkv1256. Epub 2015 Nov 17.

25.

Structural Basis of Metallo-β-Lactamase Inhibition by Captopril Stereoisomers.

Brem J, van Berkel SS, Zollman D, Lee SY, Gileadi O, McHugh PJ, Walsh TR, McDonough MA, Schofield CJ.

Antimicrob Agents Chemother. 2015 Oct 19;60(1):142-50. doi: 10.1128/AAC.01335-15. Print 2016 Jan.

26.

Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes.

Newman JA, Savitsky P, Allerston CK, Bizard AH, Özer Ö, Sarlós K, Liu Y, Pardon E, Steyaert J, Hickson ID, Gileadi O.

Nucleic Acids Res. 2015 May 26;43(10):5221-35. doi: 10.1093/nar/gkv373. Epub 2015 Apr 21.

27.

Structures of the Ets Protein DNA-binding Domains of Transcription Factors Etv1, Etv4, Etv5, and Fev: DETERMINANTS OF DNA BINDING AND REDOX REGULATION BY DISULFIDE BOND FORMATION.

Cooper CD, Newman JA, Aitkenhead H, Allerston CK, Gileadi O.

J Biol Chem. 2015 May 29;290(22):13692-709. doi: 10.1074/jbc.M115.646737. Epub 2015 Apr 12.

28.

Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: insights from DNA complex structures.

Pike AC, Gomathinayagam S, Swuec P, Berti M, Zhang Y, Schnecke C, Marino F, von Delft F, Renault L, Costa A, Gileadi O, Vindigni A.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4286-91. doi: 10.1073/pnas.1417594112. Epub 2015 Mar 23.

29.

Structural insights into the autoregulation and cooperativity of the human transcription factor Ets-2.

Newman JA, Cooper CD, Aitkenhead H, Gileadi O.

J Biol Chem. 2015 Mar 27;290(13):8539-49. doi: 10.1074/jbc.M114.619270. Epub 2015 Feb 10.

30.

CSB interacts with SNM1A and promotes DNA interstrand crosslink processing.

Iyama T, Lee SY, Berquist BR, Gileadi O, Bohr VA, Seidman MM, McHugh PJ, Wilson DM 3rd.

Nucleic Acids Res. 2015 Jan;43(1):247-58. doi: 10.1093/nar/gku1279. Epub 2014 Dec 10.

31.

Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures.

Chatterjee S, Zagelbaum J, Savitsky P, Sturzenegger A, Huttner D, Janscak P, Hickson ID, Gileadi O, Rothenberg E.

Nat Commun. 2014 Nov 24;5:5556. doi: 10.1038/ncomms6556.

32.

Recent advances in the structural molecular biology of Ets transcription factors: interactions, interfaces and inhibition.

Cooper CD, Newman JA, Gileadi O.

Biochem Soc Trans. 2014 Feb;42(1):130-8. doi: 10.1042/BST20130227. Review.

33.

Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development.

Gileadi O.

Biochem Soc Trans. 2014 Feb;42(1):108-13. doi: 10.1042/BST20130228. Review.

34.

Medium-throughput production of recombinant human proteins: protein production in insect cells.

Mahajan P, Strain-Damerell C, Gileadi O, Burgess-Brown NA.

Methods Mol Biol. 2014;1091:95-121. doi: 10.1007/978-1-62703-691-7_6.

PMID:
24203326
35.

Medium-throughput production of recombinant human proteins: protein production in E. coli.

Burgess-Brown NA, Mahajan P, Strain-Damerell C, Gileadi O, Gräslund S.

Methods Mol Biol. 2014;1091:73-94. doi: 10.1007/978-1-62703-691-7_5.

PMID:
24203325
36.

Medium-throughput production of recombinant human proteins: ligation-independent cloning.

Strain-Damerell C, Mahajan P, Gileadi O, Burgess-Brown NA.

Methods Mol Biol. 2014;1091:55-72. doi: 10.1007/978-1-62703-691-7_4.

PMID:
24203324
37.

Discovery of ML216, a Small Molecule Inhibitor of Bloom (BLM) Helicase.

Rosenthal AS, Dexheimer TS, Nguyen G, Gileadi O, Vindigni A, Simeonov A, Jadhav A, Hickson I, Maloney DJ.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2011 Apr 15 [updated 2013 Feb 28].

38.

Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase.

Rosenthal AS, Dexheimer TS, Gileadi O, Nguyen GH, Chu WK, Hickson ID, Jadhav A, Simeonov A, Maloney DJ.

Bioorg Med Chem Lett. 2013 Oct 15;23(20):5660-6. doi: 10.1016/j.bmcl.2013.08.025. Epub 2013 Aug 13.

39.

Crystal structures of malonyl-coenzyme A decarboxylase provide insights into its catalytic mechanism and disease-causing mutations.

Froese DS, Forouhar F, Tran TH, Vollmar M, Kim YS, Lew S, Neely H, Seetharaman J, Shen Y, Xiao R, Acton TB, Everett JK, Cannone G, Puranik S, Savitsky P, Krojer T, Pilka ES, Kiyani W, Lee WH, Marsden BD, von Delft F, Allerston CK, Spagnolo L, Gileadi O, Montelione GT, Oppermann U, Yue WW, Tong L.

Structure. 2013 Jul 2;21(7):1182-92. doi: 10.1016/j.str.2013.05.001. Epub 2013 Jun 20.

40.

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states.

Shintre CA, Pike AC, Li Q, Kim JI, Barr AJ, Goubin S, Shrestha L, Yang J, Berridge G, Ross J, Stansfeld PJ, Sansom MS, Edwards AM, Bountra C, Marsden BD, von Delft F, Bullock AN, Gileadi O, Burgess-Brown NA, Carpenter EP.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9710-5. doi: 10.1073/pnas.1217042110. Epub 2013 May 28.

41.

Homozygous mutations in a predicted endonuclease are a novel cause of congenital dyserythropoietic anemia type I.

Babbs C, Roberts NA, Sanchez-Pulido L, McGowan SJ, Ahmed MR, Brown JM, Sabry MA; WGS500 Consortium, Bentley DR, McVean GA, Donnelly P, Gileadi O, Ponting CP, Higgs DR, Buckle VJ.

Haematologica. 2013 Sep;98(9):1383-7. doi: 10.3324/haematol.2013.089490. Epub 2013 May 28.

42.

Crystal structures of the catalytic domain of human soluble guanylate cyclase.

Allerston CK, von Delft F, Gileadi O.

PLoS One. 2013;8(3):e57644. doi: 10.1371/journal.pone.0057644. Epub 2013 Mar 7.

43.

A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.

Nguyen GH, Dexheimer TS, Rosenthal AS, Chu WK, Singh DK, Mosedale G, Bachrati CZ, Schultz L, Sakurai M, Savitsky P, Abu M, McHugh PJ, Bohr VA, Harris CC, Jadhav A, Gileadi O, Maloney DJ, Simeonov A, Hickson ID.

Chem Biol. 2013 Jan 24;20(1):55-62. doi: 10.1016/j.chembiol.2012.10.016.

44.

Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases.

Canning P, Cooper CD, Krojer T, Murray JW, Pike AC, Chaikuad A, Keates T, Thangaratnarajah C, Hojzan V, Ayinampudi V, Marsden BD, Gileadi O, Knapp S, von Delft F, Bullock AN.

J Biol Chem. 2013 Mar 15;288(11):7803-14. doi: 10.1074/jbc.M112.437996. Epub 2013 Jan 24. Erratum in: J Biol Chem. 2013 Sep 27;388(39):28304. Ayinampudi, Vikram [added].

45.

Mutations in multidomain protein MEGF8 identify a Carpenter syndrome subtype associated with defective lateralization.

Twigg SR, Lloyd D, Jenkins D, Elçioglu NE, Cooper CD, Al-Sannaa N, Annagür A, Gillessen-Kaesbach G, Hüning I, Knight SJ, Goodship JA, Keavney BD, Beales PL, Gileadi O, McGowan SJ, Wilkie AO.

Am J Hum Genet. 2012 Nov 2;91(5):897-905. doi: 10.1016/j.ajhg.2012.08.027. Epub 2012 Oct 11.

46.

Characterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases.

Sengerová B, Allerston CK, Abu M, Lee SY, Hartley J, Kiakos K, Schofield CJ, Hartley JA, Gileadi O, McHugh PJ.

J Biol Chem. 2012 Jul 27;287(31):26254-67. doi: 10.1074/jbc.M112.367243. Epub 2012 Jun 11.

47.

The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4.

Watson AA, Mahajan P, Mertens HD, Deery MJ, Zhang W, Pham P, Du X, Bartke T, Zhang W, Edlich C, Berridge G, Chen Y, Burgess-Brown NA, Kouzarides T, Wiechens N, Owen-Hughes T, Svergun DI, Gileadi O, Laue ED.

J Mol Biol. 2012 Sep 7;422(1):3-17. doi: 10.1016/j.jmb.2012.04.031. Epub 2012 May 7.

48.

Structural and functional insights into the DNA replication factor Cdc45 reveal an evolutionary relationship to the DHH family of phosphoesterases.

Krastanova I, Sannino V, Amenitsch H, Gileadi O, Pisani FM, Onesti S.

J Biol Chem. 2012 Feb 3;287(6):4121-8. doi: 10.1074/jbc.M111.285395. Epub 2011 Dec 6.

49.

Expressing the human proteome for affinity proteomics: optimising expression of soluble protein domains and in vivo biotinylation.

Keates T, Cooper CD, Savitsky P, Allerston CK, Phillips C, Hammarström M, Daga N, Berridge G, Mahajan P, Burgess-Brown NA, Müller S, Gräslund S, Gileadi O.

N Biotechnol. 2012 Jun 15;29(5):515-25. doi: 10.1016/j.nbt.2011.10.007. Epub 2011 Oct 19.

50.

Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair.

Wang AT, Sengerová B, Cattell E, Inagawa T, Hartley JM, Kiakos K, Burgess-Brown NA, Swift LP, Enzlin JH, Schofield CJ, Gileadi O, Hartley JA, McHugh PJ.

Genes Dev. 2011 Sep 1;25(17):1859-70. doi: 10.1101/gad.15699211.

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