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Caudal-dependent cell positioning directs morphogenesis of the C. elegans ventral epidermis.

Gilbert SPR, Mullan TW, Poole RJ, Woollard A.

Dev Biol. 2020 Jan 7. pii: S0012-1606(19)30610-4. doi: 10.1016/j.ydbio.2020.01.001. [Epub ahead of print]


The ability of the kinesin-2 heterodimer KIF3AC to navigate microtubule networks is provided by the KIF3A motor domain.

Deeb SK, Guzik-Lendrum S, Jeffrey JD, Gilbert SP.

J Biol Chem. 2019 Dec 27;294(52):20070-20083. doi: 10.1074/jbc.RA119.010725. Epub 2019 Nov 20.


Kinesin-2 heterodimerization alters entry into a processive run along the microtubule but not stepping within the run.

Quinn SM, Howsmon DP, Hahn J, Gilbert SP.

J Biol Chem. 2018 Aug 31;293(35):13389-13400. doi: 10.1074/jbc.RA118.002767. Epub 2018 Jul 10.


An allosteric propofol-binding site in kinesin disrupts kinesin-mediated processive movement on microtubules.

Woll KA, Guzik-Lendrum S, Bensel BM, Bhanu NV, Dailey WP, Garcia BA, Gilbert SP, Eckenhoff RG.

J Biol Chem. 2018 Jul 20;293(29):11283-11295. doi: 10.1074/jbc.RA118.002182. Epub 2018 May 29.


Kinesin-2 motors: Kinetics and biophysics.

Gilbert SP, Guzik-Lendrum S, Rayment I.

J Biol Chem. 2018 Mar 23;293(12):4510-4518. doi: 10.1074/jbc.R117.001324. Epub 2018 Feb 14. Review.


Homodimeric Kinesin-2 KIF3CC Promotes Microtubule Dynamics.

Guzik-Lendrum S, Rayment I, Gilbert SP.

Biophys J. 2017 Oct 17;113(8):1845-1857. doi: 10.1016/j.bpj.2017.09.015.


Common general anesthetic propofol impairs kinesin processivity.

Bensel BM, Guzik-Lendrum S, Masucci EM, Woll KA, Eckenhoff RG, Gilbert SP.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4281-E4287. doi: 10.1073/pnas.1701482114. Epub 2017 May 8.


Heterodimerization of Kinesin-2 KIF3AB Modulates Entry into the Processive Run.

Albracht CD, Guzik-Lendrum S, Rayment I, Gilbert SP.

J Biol Chem. 2016 Oct 28;291(44):23248-23256. Epub 2016 Sep 16.


Family-specific Kinesin Structures Reveal Neck-linker Length Based on Initiation of the Coiled-coil.

Phillips RK, Peter LG, Gilbert SP, Rayment I.

J Biol Chem. 2016 Sep 23;291(39):20372-86. doi: 10.1074/jbc.M116.737577. Epub 2016 Jul 26.


Myosin MyTH4-FERM structures highlight important principles of convergent evolution.

Planelles-Herrero VJ, Blanc F, Sirigu S, Sirkia H, Clause J, Sourigues Y, Johnsrud DO, Amigues B, Cecchini M, Gilbert SP, Houdusse A, Titus MA.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):E2906-15. doi: 10.1073/pnas.1600736113. Epub 2016 May 10.


Fast or Slow, Either Head Can Start the Processive Run of Kinesin-2 KIF3AC.

Zhang P, Rayment I, Gilbert SP.

J Biol Chem. 2016 Feb 26;291(9):4407-16. doi: 10.1074/jbc.M115.705970. Epub 2015 Dec 28.


Kinesin-2 KIF3AC and KIF3AB Can Drive Long-Range Transport along Microtubules.

Guzik-Lendrum S, Rank KC, Bensel BM, Taylor KC, Rayment I, Gilbert SP.

Biophys J. 2015 Oct 6;109(7):1472-82. doi: 10.1016/j.bpj.2015.08.004.


Drosophila Ncd reveals an evolutionarily conserved powerstroke mechanism for homodimeric and heterodimeric kinesin-14s.

Zhang P, Dai W, Hahn J, Gilbert SP.

Proc Natl Acad Sci U S A. 2015 May 19;112(20):6359-64. doi: 10.1073/pnas.1505531112. Epub 2015 May 4.


The C. elegans TPR Containing Protein, TRD-1, Regulates Cell Fate Choice in the Developing Germ Line and Epidermis.

Hughes S, Wilkinson H, Gilbert SP, Kishida M, Ding SS, Woollard A.

PLoS One. 2014 Dec 10;9(12):e114998. doi: 10.1371/journal.pone.0114998. eCollection 2014.


Kinesin-2 KIF3AB exhibits novel ATPase characteristics.

Albracht CD, Rank KC, Obrzut S, Rayment I, Gilbert SP.

J Biol Chem. 2014 Oct 3;289(40):27836-48. doi: 10.1074/jbc.M114.583914. Epub 2014 Aug 13.


Common mechanistic themes for the powerstroke of kinesin-14 motors.

Gonzalez MA, Cope J, Rank KC, Chen CJ, Tittmann P, Rayment I, Gilbert SP, Hoenger A.

J Struct Biol. 2013 Nov;184(2):335-44. doi: 10.1016/j.jsb.2013.09.020. Epub 2013 Oct 4.


Correction: Kar3Vik1 Uses a Minus-End Directed Powerstroke for Movement along Microtubules.

Cope J, Rank KC, Gilbert SP, Rayment I, Hoenger A.

PLoS One. 2013 Feb 28;8(2). doi: 10.1371/annotation/f216b2b0-ab6b-45d8-b6ba-134a477b79b7. eCollection 2013.


Kar3Vik1 uses a minus-end directed powerstroke for movement along microtubules.

Cope J, Rank KC, Gilbert SP, Rayment I, Hoenger A.

PLoS One. 2013;8(1):e53792. doi: 10.1371/journal.pone.0053792. Epub 2013 Jan 14. Erratum in: PLoS One. 2013 Feb 28;8(2):.


The ATPase pathway that drives the kinesin-14 Kar3Vik1 powerstroke.

Chen CJ, Porche K, Rayment I, Gilbert SP.

J Biol Chem. 2012 Oct 26;287(44):36673-82. doi: 10.1074/jbc.M112.395590. Epub 2012 Sep 12.


Kar3Vik1, a member of the kinesin-14 superfamily, shows a novel kinesin microtubule binding pattern.

Rank KC, Chen CJ, Cope J, Porche K, Hoenger A, Gilbert SP, Rayment I.

J Cell Biol. 2012 Jun 25;197(7):957-70. doi: 10.1083/jcb.201201132.


Microtubule capture by mitotic kinesin centromere protein E (CENP-E).

Sardar HS, Gilbert SP.

J Biol Chem. 2012 Jul 20;287(30):24894-904. doi: 10.1074/jbc.M112.376830. Epub 2012 May 27.


Kinesin Kar3Cik1 ATPase pathway for microtubule cross-linking.

Chen CJ, Rayment I, Gilbert SP.

J Biol Chem. 2011 Aug 19;286(33):29261-72. doi: 10.1074/jbc.M111.255554. Epub 2011 Jun 16.


Mitotic kinesin CENP-E promotes microtubule plus-end elongation.

Sardar HS, Luczak VG, Lopez MM, Lister BC, Gilbert SP.

Curr Biol. 2010 Sep 28;20(18):1648-53. doi: 10.1016/j.cub.2010.08.001.


Lattice structure of cytoplasmic microtubules in a cultured Mammalian cell.

McIntosh JR, Morphew MK, Grissom PM, Gilbert SP, Hoenger A.

J Mol Biol. 2009 Nov 27;394(2):177-82. doi: 10.1016/j.jmb.2009.09.033. Epub 2009 Sep 19.


Getting in sync with dimeric Eg5. Initiation and regulation of the processive run.

Krzysiak TC, Grabe M, Gilbert SP.

J Biol Chem. 2008 Jan 25;283(4):2078-87. Epub 2007 Nov 25.


Vik1 modulates microtubule-Kar3 interactions through a motor domain that lacks an active site.

Allingham JS, Sproul LR, Rayment I, Gilbert SP.

Cell. 2007 Mar 23;128(6):1161-72.


New technology and clinical applications of nanomedicine: highlights of the second annual meeting of the American Academy of Nanomedicine (Part I).

Wei C, Lyubchenko YL, Ghandehari H, Hanes J, Stebe KJ, Mao HQ, Haynie DT, Tomalia DA, Foldvari M, Monteiro-Riviere N, Simeonova P, Nie S, Mori H, Gilbert SP, Needham D; American Academy of Nanomedicine.

Nanomedicine. 2006 Dec;2(4):253-63.


To step or not to step? How biochemistry and mechanics influence processivity in Kinesin and Eg5.

Valentine MT, Gilbert SP.

Curr Opin Cell Biol. 2007 Feb;19(1):75-81. Epub 2006 Dec 26. Review.


Dimeric Eg5 maintains processivity through alternating-site catalysis with rate-limiting ATP hydrolysis.

Krzysiak TC, Gilbert SP.

J Biol Chem. 2006 Dec 22;281(51):39444-54. Epub 2006 Oct 23.


Pathway of ATP hydrolysis by monomeric kinesin Eg5.

Cochran JC, Krzysiak TC, Gilbert SP.

Biochemistry. 2006 Oct 10;45(40):12334-44.


A structural model for monastrol inhibition of dimeric kinesin Eg5.

Krzysiak TC, Wendt T, Sproul LR, Tittmann P, Gross H, Gilbert SP, Hoenger A.

EMBO J. 2006 May 17;25(10):2263-73. Epub 2006 Apr 27.


Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro.

Valentine MT, Fordyce PM, Krzysiak TC, Gilbert SP, Block SM.

Nat Cell Biol. 2006 May;8(5):470-6. Epub 2006 Apr 2.


Full-length dimeric MCAK is a more efficient microtubule depolymerase than minimal domain monomeric MCAK.

Hertzer KM, Ems-McClung SC, Kline-Smith SL, Lipkin TG, Gilbert SP, Walczak CE.

Mol Biol Cell. 2006 Feb;17(2):700-10. Epub 2005 Nov 16.


Drosophila Nod protein binds preferentially to the plus ends of microtubules and promotes microtubule polymerization in vitro.

Cui W, Sproul LR, Gustafson SM, Matthies HJ, Gilbert SP, Hawley RS.

Mol Biol Cell. 2005 Nov;16(11):5400-9. Epub 2005 Sep 7.


Cik1 targets the minus-end kinesin depolymerase kar3 to microtubule plus ends.

Sproul LR, Anderson DJ, Mackey AT, Saunders WS, Gilbert SP.

Curr Biol. 2005 Aug 9;15(15):1420-7.


Monastrol inhibition of the mitotic kinesin Eg5.

Cochran JC, Gatial JE 3rd, Kapoor TM, Gilbert SP.

J Biol Chem. 2005 Apr 1;280(13):12658-67. Epub 2005 Jan 23.


Mechanistic analysis of the Saccharomyces cerevisiae kinesin Kar3.

Mackey AT, Sproul LR, Sontag CA, Satterwhite LL, Correia JJ, Gilbert SP.

J Biol Chem. 2004 Dec 3;279(49):51354-61. Epub 2004 Sep 21.


Mechanistic analysis of the mitotic kinesin Eg5.

Cochran JC, Sontag CA, Maliga Z, Kapoor TM, Correia JJ, Gilbert SP.

J Biol Chem. 2004 Sep 10;279(37):38861-70. Epub 2004 Jul 6.


Microtubule-kinesin interface mutants reveal a site critical for communication.

Klumpp LM, Brendza KM, Gatial JE 3rd, Hoenger A, Saxton WM, Gilbert SP.

Biochemistry. 2004 Mar 16;43(10):2792-803.


Kinesin's second step.

Klumpp LM, Hoenger A, Gilbert SP.

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3444-9. Epub 2004 Feb 25.


Modulation of kinesin binding by the C-termini of tubulin.

Skiniotis G, Cochran JC, Müller J, Mandelkow E, Gilbert SP, Hoenger A.

EMBO J. 2004 Mar 10;23(5):989-99. Epub 2004 Feb 19.


A kinesin switch I arginine to lysine mutation rescues microtubule function.

Klumpp LM, Mackey AT, Farrell CM, Rosenberg JM, Gilbert SP.

J Biol Chem. 2003 Oct 3;278(40):39059-67. Epub 2003 Jul 14.


Motor domain mutation traps kinesin as a microtubule rigor complex.

Klumpp LM, Brendza KM, Rosenberg JM, Hoenger A, Gilbert SP.

Biochemistry. 2003 Mar 11;42(9):2595-606.


The ATPase cross-bridge cycle of the Kar3 motor domain. Implications for single head motility.

Mackey AT, Gilbert SP.

J Biol Chem. 2003 Feb 7;278(6):3527-35. Epub 2002 Nov 24.


The role of ATP hydrolysis for kinesin processivity.

Farrell CM, Mackey AT, Klumpp LM, Gilbert SP.

J Biol Chem. 2002 May 10;277(19):17079-87. Epub 2002 Feb 25.


High-performance fungal motors.

Gilbert SP.

Nature. 2001 Dec 6;414(6864):597-8. No abstract available.


A mechanistic model for Ncd directionality.

Foster KA, Mackey AT, Gilbert SP.

J Biol Chem. 2001 Jun 1;276(22):19259-66. Epub 2001 Mar 2.


The diversity of molecular motors: an overview.

Titu MA, Gilbert SP.

Cell Mol Life Sci. 1999 Oct 15;56(3-4):181-3. Review.


ATP-dependent simian virus 40 T-antigen-Hsc70 complex formation.

Sullivan CS, Gilbert SP, Pipas JM.

J Virol. 2001 Feb;75(4):1601-10.

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