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Items: 1 to 50 of 61

1.

Exploring genetic interaction manifolds constructed from rich single-cell phenotypes.

Norman TM, Horlbeck MA, Replogle JM, Ge AY, Xu A, Jost M, Gilbert LA, Weissman JS.

Science. 2019 Aug 23;365(6455):786-793. doi: 10.1126/science.aax4438. Epub 2019 Aug 8.

2.

A Bounty of New Challenging Targets in Oncology for Chemical Discovery.

Lou K, Gilbert LA, Shokat KM.

Biochemistry. 2019 Aug 6;58(31):3328-3330. doi: 10.1021/acs.biochem.9b00570. Epub 2019 Jul 25. No abstract available.

PMID:
31343870
3.

DNA-Dependent Protein Kinase Drives Prostate Cancer Progression through Transcriptional Regulation of the Wnt Signaling Pathway.

Kothari V, Goodwin JF, Zhao SG, Drake JM, Yin Y, Chang SL, Evans JR, Wilder-Romans K, Gabbara K, Dylgjeri E, Chou J, Sun G, Tomlins SA, Mehra R, Hege K, Filvaroff EH, Schaeffer EM, Karnes RJ, Quigley DA, Rathkopf DE, He HH, Speers C, Spratt DE, Gilbert LA, Ashworth A, Chinnaiyan AM, Raj GV, Knudsen KE, Feng FY.

Clin Cancer Res. 2019 Sep 15;25(18):5608-5622. doi: 10.1158/1078-0432.CCR-18-2387. Epub 2019 Jul 2.

PMID:
31266829
4.

KRASG12C inhibition produces a driver-limited state revealing collateral dependencies.

Lou K, Steri V, Ge AY, Hwang YC, Yogodzinski CH, Shkedi AR, Choi ALM, Mitchell DC, Swaney DL, Hann B, Gordan JD, Shokat KM, Gilbert LA.

Sci Signal. 2019 May 28;12(583). pii: eaaw9450. doi: 10.1126/scisignal.aaw9450.

5.

Lethal clues to cancer-cell vulnerability.

Feng FY, Gilbert LA.

Nature. 2019 Apr;568(7753):463-464. doi: 10.1038/d41586-019-01086-w. No abstract available.

PMID:
31000834
6.

Cellular response to small molecules that selectively stall protein synthesis by the ribosome.

Liaud N, Horlbeck MA, Gilbert LA, Gjoni K, Weissman JS, Cate JHD.

PLoS Genet. 2019 Mar 15;15(3):e1008057. doi: 10.1371/journal.pgen.1008057. eCollection 2019 Mar.

7.

Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer.

Quigley DA, Dang HX, Zhao SG, Lloyd P, Aggarwal R, Alumkal JJ, Foye A, Kothari V, Perry MD, Bailey AM, Playdle D, Barnard TJ, Zhang L, Zhang J, Youngren JF, Cieslik MP, Parolia A, Beer TM, Thomas G, Chi KN, Gleave M, Lack NA, Zoubeidi A, Reiter RE, Rettig MB, Witte O, Ryan CJ, Fong L, Kim W, Friedlander T, Chou J, Li H, Das R, Li H, Moussavi-Baygi R, Goodarzi H, Gilbert LA, Lara PN Jr, Evans CP, Goldstein TC, Stuart JM, Tomlins SA, Spratt DE, Cheetham RK, Cheng DT, Farh K, Gehring JS, Hakenberg J, Liao A, Febbo PG, Shon J, Sickler B, Batzoglou S, Knudsen KE, He HH, Huang J, Wyatt AW, Dehm SM, Ashworth A, Chinnaiyan AM, Maher CA, Small EJ, Feng FY.

Cell. 2018 Oct 18;175(3):889. doi: 10.1016/j.cell.2018.10.019. No abstract available.

8.

A high-throughput screen of real-time ATP levels in individual cells reveals mechanisms of energy failure.

Mendelsohn BA, Bennett NK, Darch MA, Yu K, Nguyen MK, Pucciarelli D, Nelson M, Horlbeck MA, Gilbert LA, Hyun W, Kampmann M, Nakamura JL, Nakamura K.

PLoS Biol. 2018 Aug 27;16(8):e2004624. doi: 10.1371/journal.pbio.2004624. eCollection 2018 Aug.

9.

Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer.

Quigley DA, Dang HX, Zhao SG, Lloyd P, Aggarwal R, Alumkal JJ, Foye A, Kothari V, Perry MD, Bailey AM, Playdle D, Barnard TJ, Zhang L, Zhang J, Youngren JF, Cieslik MP, Parolia A, Beer TM, Thomas G, Chi KN, Gleave M, Lack NA, Zoubeidi A, Reiter RE, Rettig MB, Witte O, Ryan CJ, Fong L, Kim W, Friedlander T, Chou J, Li H, Das R, Li H, Moussavi-Baygi R, Goodarzi H, Gilbert LA, Lara PN Jr, Evans CP, Goldstein TC, Stuart JM, Tomlins SA, Spratt DE, Cheetham RK, Cheng DT, Farh K, Gehring JS, Hakenberg J, Liao A, Febbo PG, Shon J, Sickler B, Batzoglou S, Knudsen KE, He HH, Huang J, Wyatt AW, Dehm SM, Ashworth A, Chinnaiyan AM, Maher CA, Small EJ, Feng FY.

Cell. 2018 Jul 26;174(3):758-769.e9. doi: 10.1016/j.cell.2018.06.039. Epub 2018 Jul 19. Erratum in: Cell. 2018 Oct 18;175(3):889.

10.

Mapping the Genetic Landscape of Human Cells.

Horlbeck MA, Xu A, Wang M, Bennett NK, Park CY, Bogdanoff D, Adamson B, Chow ED, Kampmann M, Peterson TR, Nakamura K, Fischbach MA, Weissman JS, Gilbert LA.

Cell. 2018 Aug 9;174(4):953-967.e22. doi: 10.1016/j.cell.2018.06.010. Epub 2018 Jul 19.

11.

Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70).

Shao H, Li X, Moses MA, Gilbert LA, Kalyanaraman C, Young ZT, Chernova M, Journey SN, Weissman JS, Hann B, Jacobson MP, Neckers L, Gestwicki JE.

J Med Chem. 2018 Jul 26;61(14):6163-6177. doi: 10.1021/acs.jmedchem.8b00583. Epub 2018 Jul 13.

12.

Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform.

Wangensteen KJ, Wang YJ, Dou Z, Wang AW, Mosleh-Shirazi E, Horlbeck MA, Gilbert LA, Weissman JS, Berger SL, Kaestner KH.

Hepatology. 2018 Aug;68(2):663-676. doi: 10.1002/hep.29626. Epub 2018 May 14.

13.

The Promise and Challenge of In Vivo Delivery for Genome Therapeutics.

Wilson RC, Gilbert LA.

ACS Chem Biol. 2018 Feb 16;13(2):376-382. doi: 10.1021/acschembio.7b00680. Epub 2017 Oct 19. Review.

14.

Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent.

Jost M, Chen Y, Gilbert LA, Horlbeck MA, Krenning L, Menchon G, Rai A, Cho MY, Stern JJ, Prota AE, Kampmann M, Akhmanova A, Steinmetz MO, Tanenbaum ME, Weissman JS.

Mol Cell. 2017 Oct 5;68(1):210-223.e6. doi: 10.1016/j.molcel.2017.09.012.

15.

A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response.

Adamson B, Norman TM, Jost M, Cho MY, Nuñez JK, Chen Y, Villalta JE, Gilbert LA, Horlbeck MA, Hein MY, Pak RA, Gray AN, Gross CA, Dixit A, Parnas O, Regev A, Weissman JS.

Cell. 2016 Dec 15;167(7):1867-1882.e21. doi: 10.1016/j.cell.2016.11.048.

16.

CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells.

Liu SJ, Horlbeck MA, Cho SW, Birk HS, Malatesta M, He D, Attenello FJ, Villalta JE, Cho MY, Chen Y, Mandegar MA, Olvera MP, Gilbert LA, Conklin BR, Chang HY, Weissman JS, Lim DA.

Science. 2017 Jan 6;355(6320). pii: aah7111. doi: 10.1126/science.aah7111. Epub 2016 Dec 15.

17.

Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation.

Horlbeck MA, Gilbert LA, Villalta JE, Adamson B, Pak RA, Chen Y, Fields AP, Park CY, Corn JE, Kampmann M, Weissman JS.

Elife. 2016 Sep 23;5. pii: e19760. doi: 10.7554/eLife.19760.

18.

A senescence secretory switch mediated by PI3K/AKT/mTOR activation controls chemoprotective endothelial secretory responses.

Bent EH, Gilbert LA, Hemann MT.

Genes Dev. 2016 Aug 15;30(16):1811-21. doi: 10.1101/gad.284851.116. Epub 2016 Aug 26.

19.

Addition of buprenorphine to local anesthetic in adductor canal blocks after total knee arthroplasty improves postoperative pain relief: a randomized controlled trial.

Krishnan SH, Gilbert LA, Ghoddoussi F, Applefield DJ, Kassab SS, Ellis TA 2nd.

J Clin Anesth. 2016 Sep;33:432-7. doi: 10.1016/j.jclinane.2016.04.021. Epub 2016 Jun 5.

PMID:
27555206
20.

Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity.

Nguyen DP, Miyaoka Y, Gilbert LA, Mayerl SJ, Lee BH, Weissman JS, Conklin BR, Wells JA.

Nat Commun. 2016 Jul 1;7:12009. doi: 10.1038/ncomms12009.

21.

Versatile in vivo regulation of tumor phenotypes by dCas9-mediated transcriptional perturbation.

Braun CJ, Bruno PM, Horlbeck MA, Gilbert LA, Weissman JS, Hemann MT.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):E3892-900. doi: 10.1073/pnas.1600582113. Epub 2016 Jun 20.

22.

Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification.

Deans RM, Morgens DW, Ökesli A, Pillay S, Horlbeck MA, Kampmann M, Gilbert LA, Li A, Mateo R, Smith M, Glenn JS, Carette JE, Khosla C, Bassik MC.

Nat Chem Biol. 2016 May;12(5):361-6. doi: 10.1038/nchembio.2050. Epub 2016 Mar 28.

23.

Versatile protein tagging in cells with split fluorescent protein.

Kamiyama D, Sekine S, Barsi-Rhyne B, Hu J, Chen B, Gilbert LA, Ishikawa H, Leonetti MD, Marshall WF, Weissman JS, Huang B.

Nat Commun. 2016 Mar 18;7:11046. doi: 10.1038/ncomms11046.

24.

Nucleosomes impede Cas9 access to DNA in vivo and in vitro.

Horlbeck MA, Witkowsky LB, Guglielmi B, Replogle JM, Gilbert LA, Villalta JE, Torigoe SE, Tjian R, Weissman JS.

Elife. 2016 Mar 17;5. pii: e12677. doi: 10.7554/eLife.12677.

25.

CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs.

Mandegar MA, Huebsch N, Frolov EB, Shin E, Truong A, Olvera MP, Chan AH, Miyaoka Y, Holmes K, Spencer CI, Judge LM, Gordon DE, Eskildsen TV, Villalta JE, Horlbeck MA, Gilbert LA, Krogan NJ, Sheikh SP, Weissman JS, Qi LS, So PL, Conklin BR.

Cell Stem Cell. 2016 Apr 7;18(4):541-53. doi: 10.1016/j.stem.2016.01.022. Epub 2016 Mar 10.

26.

Next-generation libraries for robust RNA interference-based genome-wide screens.

Kampmann M, Horlbeck MA, Chen Y, Tsai JC, Bassik MC, Gilbert LA, Villalta JE, Kwon SC, Chang H, Kim VN, Weissman JS.

Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):E3384-91. doi: 10.1073/pnas.1508821112. Epub 2015 Jun 15.

27.

Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds.

Zalatan JG, Lee ME, Almeida R, Gilbert LA, Whitehead EH, La Russa M, Tsai JC, Weissman JS, Dueber JE, Qi LS, Lim WA.

Cell. 2015 Jan 15;160(1-2):339-50. doi: 10.1016/j.cell.2014.11.052. Epub 2014 Dec 18.

28.

A protein-tagging system for signal amplification in gene expression and fluorescence imaging.

Tanenbaum ME, Gilbert LA, Qi LS, Weissman JS, Vale RD.

Cell. 2014 Oct 23;159(3):635-46. doi: 10.1016/j.cell.2014.09.039. Epub 2014 Oct 9.

29.

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation.

Gilbert LA, Horlbeck MA, Adamson B, Villalta JE, Chen Y, Whitehead EH, Guimaraes C, Panning B, Ploegh HL, Bassik MC, Qi LS, Kampmann M, Weissman JS.

Cell. 2014 Oct 23;159(3):647-61. doi: 10.1016/j.cell.2014.09.029. Epub 2014 Oct 9.

30.

Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system.

Chen B, Gilbert LA, Cimini BA, Schnitzbauer J, Zhang W, Li GW, Park J, Blackburn EH, Weissman JS, Qi LS, Huang B.

Cell. 2013 Dec 19;155(7):1479-91. doi: 10.1016/j.cell.2013.12.001. Erratum in: Cell. 2014 Jan 16;156(1-2):373.

31.

CRISPR interference (CRISPRi) for sequence-specific control of gene expression.

Larson MH, Gilbert LA, Wang X, Lim WA, Weissman JS, Qi LS.

Nat Protoc. 2013 Nov;8(11):2180-96. doi: 10.1038/nprot.2013.132. Epub 2013 Oct 17.

32.

CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes.

Gilbert LA, Larson MH, Morsut L, Liu Z, Brar GA, Torres SE, Stern-Ginossar N, Brandman O, Whitehead EH, Doudna JA, Lim WA, Weissman JS, Qi LS.

Cell. 2013 Jul 18;154(2):442-51. doi: 10.1016/j.cell.2013.06.044. Epub 2013 Jul 11.

33.

Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression.

Qi LS, Larson MH, Gilbert LA, Doudna JA, Weissman JS, Arkin AP, Lim WA.

Cell. 2013 Feb 28;152(5):1173-83. doi: 10.1016/j.cell.2013.02.022.

34.

Defining principles of combination drug mechanisms of action.

Pritchard JR, Bruno PM, Gilbert LA, Capron KL, Lauffenburger DA, Hemann MT.

Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):E170-9. doi: 10.1073/pnas.1210419110. Epub 2012 Dec 18.

35.

Context-specific roles for paracrine IL-6 in lymphomagenesis.

Gilbert LA, Hemann MT.

Genes Dev. 2012 Aug 1;26(15):1758-68. doi: 10.1101/gad.197590.112.

36.

Inhibition of ectonucleotidase with ARL67156 prevents the development of calcific aortic valve disease in warfarin-treated rats.

Côté N, El Husseini D, Pépin A, Bouvet C, Gilbert LA, Audet A, Fournier D, Pibarot P, Moreau P, Mathieu P.

Eur J Pharmacol. 2012 Aug 15;689(1-3):139-46. doi: 10.1016/j.ejphar.2012.05.016. Epub 2012 May 31.

PMID:
22659116
37.

VcR-CVAD induction chemotherapy followed by maintenance rituximab in mantle cell lymphoma: a Wisconsin Oncology Network study.

Chang JE, Peterson C, Choi S, Eickhoff JC, Kim K, Yang DT, Gilbert LA, Rogers ES, Werndli JE, Huie MS, McFarland TA, Volk M, Blank J, Callander NS, Longo WL, Kahl BS.

Br J Haematol. 2011 Oct;155(2):190-7. doi: 10.1111/j.1365-2141.2011.08820.x. Epub 2011 Aug 16.

38.

Bcl-2 family genetic profiling reveals microenvironment-specific determinants of chemotherapeutic response.

Pritchard JR, Gilbert LA, Meacham CE, Ricks JL, Jiang H, Lauffenburger DA, Hemann MT.

Cancer Res. 2011 Sep 1;71(17):5850-8. doi: 10.1158/0008-5472.CAN-11-1014. Epub 2011 Jul 22.

39.

Chemotherapeutic resistance: surviving stressful situations.

Gilbert LA, Hemann MT.

Cancer Res. 2011 Aug 1;71(15):5062-6. doi: 10.1158/0008-5472.CAN-11-0277. Epub 2011 Jul 19.

40.

DNA damage-mediated induction of a chemoresistant niche.

Gilbert LA, Hemann MT.

Cell. 2010 Oct 29;143(3):355-66. doi: 10.1016/j.cell.2010.09.043.

41.

A thioredoxin family protein of the apicoplast periphery identifies abundant candidate transport vesicles in Toxoplasma gondii.

DeRocher AE, Coppens I, Karnataki A, Gilbert LA, Rome ME, Feagin JE, Bradley PJ, Parsons M.

Eukaryot Cell. 2008 Sep;7(9):1518-29. doi: 10.1128/EC.00081-08. Epub 2008 Jun 27.

42.

Distinct effects of amlodipine treatment on vascular elastocalcinosis and stiffness in a rat model of isolated systolic hypertension.

Essalihi R, Zandvliet ML, Moreau S, Gilbert LA, Bouvet C, Lenoël C, Nekka F, McKee MD, Moreau P.

J Hypertens. 2007 Sep;25(9):1879-86.

PMID:
17762652
43.

Toxoplasma gondii targets a protein phosphatase 2C to the nuclei of infected host cells.

Gilbert LA, Ravindran S, Turetzky JM, Boothroyd JC, Bradley PJ.

Eukaryot Cell. 2007 Jan;6(1):73-83. Epub 2006 Nov 3.

44.

Drilling to gabbro in intact ocean crust.

Wilson DS, Teagle DA, Alt JC, Banerjee NR, Umino S, Miyashita S, Acton GD, Anma R, Barr SR, Belghoul A, Carlut J, Christie DM, Coggon RM, Cooper KM, Cordier C, Crispini L, Durand SR, Einaudi F, Galli L, Gao Y, Geldmacher J, Gilbert LA, Hayman NW, Herrero-Bervera E, Hirano N, Holter S, Ingle S, Jiang S, Kalberkamp U, Kerneklian M, Koepke J, Laverne C, Vasquez HL, Maclennan J, Morgan S, Neo N, Nichols HJ, Park SH, Reichow MK, Sakuyama T, Sano T, Sandwell R, Scheibner B, Smith-Duque CE, Swift SA, Tartarotti P, Tikku AA, Tominaga M, Veloso EA, Yamasaki T, Yamazaki S, Ziegler C.

Science. 2006 May 19;312(5776):1016-20. Epub 2006 Apr 20.

45.

Medical School Performance, Alumni Membership, and Giving: How Do Scholarship Recipients and Non-Recipients Differ?

Elam CL, Stratton TD, Gilbert LA, Stroth HI, Vicini MB, Wilson EA.

Med Educ Online. 2005 Dec;10(1):4375. doi: 10.3402/meo.v10i.4375.

PMID:
28253141
46.

Regression of medial elastocalcinosis in rat aorta: a new vascular function for carbonic anhydrase.

Essalihi R, Dao HH, Gilbert LA, Bouvet C, Semerjian Y, McKee MD, Moreau P.

Circulation. 2005 Sep 13;112(11):1628-35. Epub 2005 Sep 6.

PMID:
16144999
47.

Different involvement of extracellular matrix components in small and large arteries during chronic NO synthase inhibition.

Bouvet C, Gilbert LA, Girardot D, deBlois D, Moreau P.

Hypertension. 2005 Mar;45(3):432-7. Epub 2005 Jan 17.

PMID:
15655118
49.

Acute proximal occlusion of a nonaneurysmal abdominal aorta and renal arteries detected by renal imaging.

Gilbert LA, Katz N, Mandal AK, Park YS, Koutoubi Z.

Clin Nucl Med. 1997 Apr;22(4):231-4.

PMID:
9099478
50.

Somatostatin receptor imaging: fatty meal-induced clearance of gallbladder activity.

Katz N, Gilbert LA, Willsey JT.

Clin Nucl Med. 1997 Jan;22(1):58-9. No abstract available.

PMID:
8993880

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