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Items: 1 to 50 of 288

1.

A surface endogalactanase in Bacteroides thetaiotaomicron confers keystone status for arabinogalactan degradation.

Cartmell A, Muñoz-Muñoz J, Briggs JA, Ndeh DA, Lowe EC, Baslé A, Terrapon N, Stott K, Heunis T, Gray J, Yu L, Dupree P, Fernandes PZ, Shah S, Williams SJ, Labourel A, Trost M, Henrissat B, Gilbert HJ.

Nat Microbiol. 2018 Nov;3(11):1314-1326. doi: 10.1038/s41564-018-0258-8. Epub 2018 Oct 22.

2.

Structure and function of a glycoside hydrolase family 8 endoxylanase from Teredinibacter turnerae.

Fowler CA, Hemsworth GR, Cuskin F, Hart S, Turkenburg J, Gilbert HJ, Walton PH, Davies GJ.

Acta Crystallogr D Struct Biol. 2018 Oct 1;74(Pt 10):946-955. doi: 10.1107/S2059798318009737. Epub 2018 Oct 2.

3.

Higher order scaffoldin assembly in Ruminococcus flavefaciens cellulosome is coordinated by a discrete cohesin-dockerin interaction.

Bule P, Pires VMR, Alves VD, Carvalho AL, Prates JAM, Ferreira LMA, Smith SP, Gilbert HJ, Noach I, Bayer EA, Najmudin S, Fontes CMGA.

Sci Rep. 2018 May 3;8(1):6987. doi: 10.1038/s41598-018-25171-8.

4.

Bacteroides thetaiotaomicron generates diverse α-mannosidase activities through subtle evolution of a distal substrate-binding motif.

Thompson AJ, Spears RJ, Zhu Y, Suits MDL, Williams SJ, Gilbert HJ, Davies GJ.

Acta Crystallogr D Struct Biol. 2018 May 1;74(Pt 5):394-404. doi: 10.1107/S2059798318002942. Epub 2018 Apr 24.

5.

Corrigendum: Complex pectin metabolism by gut bacteria reveals novel catalytic functions.

Ndeh D, Rogowski A, Cartmell A, Luis AS, Baslé A, Gray J, Venditto I, Briggs J, Zhang X, Labourel A, Terrapon N, Buffetto F, Nepogodiev S, Xiao Y, Field RA, Zhu Y, O'Neill MA, Urbanowicz BR, York WS, Davies GJ, Abbott DW, Ralet MC, Martens EC, Henrissat B, Gilbert HJ.

Nature. 2017 Aug 31;548(7669):612. doi: 10.1038/nature23659. Epub 2017 Aug 23.

PMID:
29411780
6.

Structure-function analyses generate novel specificities to assemble the components of multienzyme bacterial cellulosome complexes.

Bule P, Cameron K, Prates JAM, Ferreira LMA, Smith SP, Gilbert HJ, Bayer EA, Najmudin S, Fontes CMGA, Alves VD.

J Biol Chem. 2018 Mar 16;293(11):4201-4212. doi: 10.1074/jbc.RA117.001241. Epub 2018 Jan 24.

7.

Biochemistry of complex glycan depolymerisation by the human gut microbiota.

Ndeh D, Gilbert HJ.

FEMS Microbiol Rev. 2018 Mar 1;42(2):146-164. doi: 10.1093/femsre/fuy002. Review.

PMID:
29325042
8.

Dietary pectic glycans are degraded by coordinated enzyme pathways in human colonic Bacteroides.

Luis AS, Briggs J, Zhang X, Farnell B, Ndeh D, Labourel A, Baslé A, Cartmell A, Terrapon N, Stott K, Lowe EC, McLean R, Shearer K, Schückel J, Venditto I, Ralet MC, Henrissat B, Martens EC, Mosimann SC, Abbott DW, Gilbert HJ.

Nat Microbiol. 2018 Feb;3(2):210-219. doi: 10.1038/s41564-017-0079-1. Epub 2017 Dec 18.

9.

Expression system for structural and functional studies of human glycosylation enzymes.

Moremen KW, Ramiah A, Stuart M, Steel J, Meng L, Forouhar F, Moniz HA, Gahlay G, Gao Z, Chapla D, Wang S, Yang JY, Prabhakar PK, Johnson R, Rosa MD, Geisler C, Nairn AV, Seetharaman J, Wu SC, Tong L, Gilbert HJ, LaBaer J, Jarvis DL.

Nat Chem Biol. 2018 Feb;14(2):156-162. doi: 10.1038/nchembio.2539. Epub 2017 Dec 18.

10.

PULDB: the expanded database of Polysaccharide Utilization Loci.

Terrapon N, Lombard V, Drula É, Lapébie P, Al-Masaudi S, Gilbert HJ, Henrissat B.

Nucleic Acids Res. 2018 Jan 4;46(D1):D677-D683. doi: 10.1093/nar/gkx1022.

11.

Target highlights from the first post-PSI CASP experiment (CASP12, May-August 2016).

Kryshtafovych A, Albrecht R, Baslé A, Bule P, Caputo AT, Carvalho AL, Chao KL, Diskin R, Fidelis K, Fontes CMGA, Fredslund F, Gilbert HJ, Goulding CW, Hartmann MD, Hayes CS, Herzberg O, Hill JC, Joachimiak A, Kohring GW, Koning RI, Lo Leggio L, Mangiagalli M, Michalska K, Moult J, Najmudin S, Nardini M, Nardone V, Ndeh D, Nguyen TH, Pintacuda G, Postel S, van Raaij MJ, Roversi P, Shimon A, Singh AK, Sundberg EJ, Tars K, Zitzmann N, Schwede T.

Proteins. 2018 Mar;86 Suppl 1:27-50. doi: 10.1002/prot.25392. Epub 2017 Oct 16.

12.

An evolutionarily distinct family of polysaccharide lyases removes rhamnose capping of complex arabinogalactan proteins.

Munoz-Munoz J, Cartmell A, Terrapon N, Baslé A, Henrissat B, Gilbert HJ.

J Biol Chem. 2017 Aug 11;292(32):13271-13283. doi: 10.1074/jbc.M117.794578. Epub 2017 Jun 21.

13.

How members of the human gut microbiota overcome the sulfation problem posed by glycosaminoglycans.

Cartmell A, Lowe EC, Baslé A, Firbank SJ, Ndeh DA, Murray H, Terrapon N, Lombard V, Henrissat B, Turnbull JE, Czjzek M, Gilbert HJ, Bolam DN.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7037-7042. doi: 10.1073/pnas.1704367114. Epub 2017 Jun 19.

14.

A Bacteroidetes locus dedicated to fungal 1,6-β-glucan degradation: Unique substrate conformation drives specificity of the key endo-1,6-β-glucanase.

Temple MJ, Cuskin F, Baslé A, Hickey N, Speciale G, Williams SJ, Gilbert HJ, Lowe EC.

J Biol Chem. 2017 Jun 23;292(25):10639-10650. doi: 10.1074/jbc.M117.787606. Epub 2017 May 1.

15.

Unusual active site location and catalytic apparatus in a glycoside hydrolase family.

Munoz-Munoz J, Cartmell A, Terrapon N, Henrissat B, Gilbert HJ.

Proc Natl Acad Sci U S A. 2017 May 9;114(19):4936-4941. doi: 10.1073/pnas.1701130114. Epub 2017 Apr 10.

16.

Assembly of Ruminococcus flavefaciens cellulosome revealed by structures of two cohesin-dockerin complexes.

Bule P, Alves VD, Israeli-Ruimy V, Carvalho AL, Ferreira LMA, Smith SP, Gilbert HJ, Najmudin S, Bayer EA, Fontes CMGA.

Sci Rep. 2017 Apr 7;7(1):759. doi: 10.1038/s41598-017-00919-w.

17.

Complex pectin metabolism by gut bacteria reveals novel catalytic functions.

Ndeh D, Rogowski A, Cartmell A, Luis AS, Baslé A, Gray J, Venditto I, Briggs J, Zhang X, Labourel A, Terrapon N, Buffetto F, Nepogodiev S, Xiao Y, Field RA, Zhu Y, O'Neil MA, Urbanowicz BR, York WS, Davies GJ, Abbott DW, Ralet MC, Martens EC, Henrissat B, Gilbert HJ.

Nature. 2017 Apr 6;544(7648):65-70. doi: 10.1038/nature21725. Epub 2017 Mar 22. Erratum in: Nature. 2017 Aug 31;548(7669):612.

18.

Complexity of the Ruminococcus flavefaciens FD-1 cellulosome reflects an expansion of family-related protein-protein interactions.

Israeli-Ruimy V, Bule P, Jindou S, Dassa B, Moraïs S, Borovok I, Barak Y, Slutzki M, Hamberg Y, Cardoso V, Alves VD, Najmudin S, White BA, Flint HJ, Gilbert HJ, Lamed R, Fontes CM, Bayer EA.

Sci Rep. 2017 Feb 10;7:42355. doi: 10.1038/srep42355.

19.

Systems analysis in Cellvibrio japonicus resolves predicted redundancy of β-glucosidases and determines essential physiological functions.

Nelson CE, Rogowski A, Morland C, Wilhide JA, Gilbert HJ, Gardner JG.

Mol Microbiol. 2017 Apr;104(2):294-305. doi: 10.1111/mmi.13625. Epub 2017 Feb 28.

20.

A β-Mannanase with a Lysozyme-like Fold and a Novel Molecular Catalytic Mechanism.

Jin Y, Petricevic M, John A, Raich L, Jenkins H, Portela De Souza L, Cuskin F, Gilbert HJ, Rovira C, Goddard-Borger ED, Williams SJ, Davies GJ.

ACS Cent Sci. 2016 Dec 28;2(12):896-903. doi: 10.1021/acscentsci.6b00232. Epub 2016 Nov 8.

21.

Diverse specificity of cellulosome attachment to the bacterial cell surface.

Brás JL, Pinheiro BA, Cameron K, Cuskin F, Viegas A, Najmudin S, Bule P, Pires VM, Romão MJ, Bayer EA, Spencer HL, Smith S, Gilbert HJ, Alves VD, Carvalho AL, Fontes CM.

Sci Rep. 2016 Dec 7;6:38292. doi: 10.1038/srep38292.

22.

Editorial overview: Carbohydrate-protein interactions and glycosylation: integrating structural biology, informatics and systems modelling to understand glycan structure and glycan-protein interactions.

Gilbert HJ, Chandra N.

Curr Opin Struct Biol. 2016 Oct;40:v-viii. doi: 10.1016/j.sbi.2016.11.009. Epub 2016 Nov 27. No abstract available.

PMID:
27899244
23.

Single Binding Mode Integration of Hemicellulose-degrading Enzymes via Adaptor Scaffoldins in Ruminococcus flavefaciens Cellulosome.

Bule P, Alves VD, Leitão A, Ferreira LM, Bayer EA, Smith SP, Gilbert HJ, Najmudin S, Fontes CM.

J Biol Chem. 2016 Dec 23;291(52):26658-26669. doi: 10.1074/jbc.M116.761643. Epub 2016 Nov 14.

24.

A Novel Carbohydrate-binding Module from Sugar Cane Soil Metagenome Featuring Unique Structural and Carbohydrate Affinity Properties.

Campos BM, Liberato MV, Alvarez TM, Zanphorlin LM, Ematsu GC, Barud H, Polikarpov I, Ruller R, Gilbert HJ, Zeri AC, Squina FM.

J Biol Chem. 2016 Nov 4;291(45):23734-23743. Epub 2016 Sep 12.

25.

The Mechanism by Which Arabinoxylanases Can Recognize Highly Decorated Xylans.

Labourel A, Crouch LI, Brás JL, Jackson A, Rogowski A, Gray J, Yadav MP, Henrissat B, Fontes CM, Gilbert HJ, Najmudin S, Baslé A, Cuskin F.

J Biol Chem. 2016 Oct 14;291(42):22149-22159. Epub 2016 Aug 16.

26.

Complexity of the Ruminococcus flavefaciens cellulosome reflects an expansion in glycan recognition.

Venditto I, Luis AS, Rydahl M, Schückel J, Fernandes VO, Vidal-Melgosa S, Bule P, Goyal A, Pires VM, Dourado CG, Ferreira LM, Coutinho PM, Henrissat B, Knox JP, Baslé A, Najmudin S, Gilbert HJ, Willats WG, Fontes CM.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7136-41. doi: 10.1073/pnas.1601558113. Epub 2016 Jun 13.

27.

Corrigendum: Glycan complexity dictates microbial resource allocation in the large intestine.

Rogowski A, Briggs JA, Mortimer JC, Tryfona T, Terrapon N, Lowe EC, Baslé A, Morland C, Day AM, Zheng H, Rogers TE, Thompson P, Hawkins AR, Yadav MP, Henrissat B, Martens EC, Dupree P, Gilbert HJ, Bolam DN.

Nat Commun. 2016 Feb 5;7:10705. doi: 10.1038/ncomms10705. No abstract available.

28.

Corrigendum: Evidence for a Boat Conformation at the Transition State of GH76 α-1,6-Mannanases--Key Enzymes in Bacterial and Fungal Mannoprotein Metabolism.

Thompson AJ, Speciale G, Iglesias-Fernández J, Hakki Z, Belz T, Cartmell A, Spears RJ, Chandler E, Temple MJ, Stepper J, Gilbert HJ, Rovira C, Williams SJ, Davies GJ.

Angew Chem Int Ed Engl. 2016 Feb 5;55(6):1949. doi: 10.1002/anie.201511540. No abstract available.

PMID:
26836331
29.

The Contribution of Non-catalytic Carbohydrate Binding Modules to the Activity of Lytic Polysaccharide Monooxygenases.

Crouch LI, Labourel A, Walton PH, Davies GJ, Gilbert HJ.

J Biol Chem. 2016 Apr 1;291(14):7439-49. doi: 10.1074/jbc.M115.702365. Epub 2016 Jan 22.

30.

Coevolution of yeast mannan digestion: Convergence of the civilized human diet, distal gut microbiome, and host immunity.

Abbott DW, Martens EC, Gilbert HJ, Cuskin F, Lowe EC.

Gut Microbes. 2015;6(5):334-9. doi: 10.1080/19490976.2015.1091913.

31.

The GH130 Family of Mannoside Phosphorylases Contains Glycoside Hydrolases That Target β-1,2-Mannosidic Linkages in Candida Mannan.

Cuskin F, Baslé A, Ladevèze S, Day AM, Gilbert HJ, Davies GJ, Potocki-Véronèse G, Lowe EC.

J Biol Chem. 2015 Oct 9;290(41):25023-33. doi: 10.1074/jbc.M115.681460. Epub 2015 Aug 18.

32.

Carbohydrate-binding module assisting glycosynthase-catalysed polymerizations.

Codera V, Gilbert HJ, Faijes M, Planas A.

Biochem J. 2015 Aug 15;470(1):15-22. doi: 10.1042/BJ20150420. Epub 2015 Jun 11.

PMID:
26251443
33.

Recognition of xyloglucan by the crystalline cellulose-binding site of a family 3a carbohydrate-binding module.

Hernandez-Gomez MC, Rydahl MG, Rogowski A, Morland C, Cartmell A, Crouch L, Labourel A, Fontes CM, Willats WG, Gilbert HJ, Knox JP.

FEBS Lett. 2015 Aug 19;589(18):2297-303. doi: 10.1016/j.febslet.2015.07.009. Epub 2015 Jul 18.

34.

Glycan complexity dictates microbial resource allocation in the large intestine.

Rogowski A, Briggs JA, Mortimer JC, Tryfona T, Terrapon N, Lowe EC, Baslé A, Morland C, Day AM, Zheng H, Rogers TE, Thompson P, Hawkins AR, Yadav MP, Henrissat B, Martens EC, Dupree P, Gilbert HJ, Bolam DN.

Nat Commun. 2015 Jun 26;6:7481. doi: 10.1038/ncomms8481. Erratum in: Nat Commun. 2016;7:10705.

35.

Combined Crystal Structure of a Type I Cohesin: MUTATION AND AFFINITY BINDING STUDIES REVEAL STRUCTURAL DETERMINANTS OF COHESIN-DOCKERIN SPECIFICITIES.

Cameron K, Weinstein JY, Zhivin O, Bule P, Fleishman SJ, Alves VD, Gilbert HJ, Ferreira LM, Fontes CM, Bayer EA, Najmudin S.

J Biol Chem. 2015 Jun 26;290(26):16215-25. doi: 10.1074/jbc.M115.653303. Epub 2015 May 1.

36.

Cell-surface Attachment of Bacterial Multienzyme Complexes Involves Highly Dynamic Protein-Protein Anchors.

Cameron K, Najmudin S, Alves VD, Bayer EA, Smith SP, Bule P, Waller H, Ferreira LM, Gilbert HJ, Fontes CM.

J Biol Chem. 2015 May 22;290(21):13578-90. doi: 10.1074/jbc.M114.633339. Epub 2015 Apr 8.

37.

Evidence for a boat conformation at the transition state of GH76 α-1,6-mannanases--key enzymes in bacterial and fungal mannoprotein metabolism.

Thompson AJ, Speciale G, Iglesias-Fernández J, Hakki Z, Belz T, Cartmell A, Spears RJ, Chandler E, Temple MJ, Stepper J, Gilbert HJ, Rovira C, Williams SJ, Davies GJ.

Angew Chem Int Ed Engl. 2015 Apr 27;54(18):5378-82. doi: 10.1002/anie.201410502. Epub 2015 Mar 13. Erratum in: Angew Chem Int Ed Engl. 2016 Feb;55(6):1949.

PMID:
25772148
38.

Corrigendum: Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism.

Cuskin F, Lowe EC, Temple MJ, Zhu Y, Cameron EA, Pudlo NA, Porter NT, Urs K, Thompson AJ, Cartmell A, Rogowski A, Hamilton BS, Chen R, Tolbert TJ, Piens K, Bracke D, Vervecken W, Hakki Z, Speciale G, Munōz-Munōz JL, Day A, Peña MJ, McLean R, Suits MD, Boraston AB, Atherly T, Ziemer CJ, Williams SJ, Davies GJ, Abbott DW, Martens EC, Gilbert HJ.

Nature. 2015 Apr 16;520(7547):388. doi: 10.1038/nature14334. Epub 2015 Mar 4. No abstract available.

PMID:
25739504
39.

Family 46 Carbohydrate-binding Modules Contribute to the Enzymatic Hydrolysis of Xyloglucan and β-1,3-1,4-Glucans through Distinct Mechanisms.

Venditto I, Najmudin S, Luís AS, Ferreira LM, Sakka K, Knox JP, Gilbert HJ, Fontes CM.

J Biol Chem. 2015 Apr 24;290(17):10572-86. doi: 10.1074/jbc.M115.637827. Epub 2015 Feb 23.

40.

Structure of the GH76 α-mannanase homolog, BT2949, from the gut symbiont Bacteroides thetaiotaomicron.

Thompson AJ, Cuskin F, Spears RJ, Dabin J, Turkenburg JP, Gilbert HJ, Davies GJ.

Acta Crystallogr D Biol Crystallogr. 2015 Feb;71(Pt 2):408-15. doi: 10.1107/S1399004714026443. Epub 2015 Jan 23.

41.

The neural substrate for binaural masking level differences in the auditory cortex.

Gilbert HJ, Shackleton TM, Krumbholz K, Palmer AR.

J Neurosci. 2015 Jan 7;35(1):209-20. doi: 10.1523/JNEUROSCI.1131-14.2015.

42.

Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism.

Cuskin F, Lowe EC, Temple MJ, Zhu Y, Cameron E, Pudlo NA, Porter NT, Urs K, Thompson AJ, Cartmell A, Rogowski A, Hamilton BS, Chen R, Tolbert TJ, Piens K, Bracke D, Vervecken W, Hakki Z, Speciale G, Munōz-Munōz JL, Day A, Peña MJ, McLean R, Suits MD, Boraston AB, Atherly T, Ziemer CJ, Williams SJ, Davies GJ, Abbott DW, Martens EC, Gilbert HJ.

Nature. 2015 Jan 8;517(7533):165-169. doi: 10.1038/nature13995. Erratum in: Nature. 2015 Apr 16;520(7547):388.

43.

Automatic prediction of polysaccharide utilization loci in Bacteroidetes species.

Terrapon N, Lombard V, Gilbert HJ, Henrissat B.

Bioinformatics. 2015 Mar 1;31(5):647-55. doi: 10.1093/bioinformatics/btu716. Epub 2014 Oct 28.

PMID:
25355788
44.

Systems biology defines the biological significance of redox-active proteins during cellulose degradation in an aerobic bacterium.

Gardner JG, Crouch L, Labourel A, Forsberg Z, Bukhman YV, Vaaje-Kolstad G, Gilbert HJ, Keating DH.

Mol Microbiol. 2014 Oct 8. doi: 10.1111/mmi.12821. [Epub ahead of print]

45.

Editorial overview: Carbohydrate-protein interactions: the future is taking shape.

Brumer H, Gilbert HJ.

Curr Opin Struct Biol. 2014 Oct;28:v-vii. doi: 10.1016/j.sbi.2014.09.001. Epub 2014 Sep 24. No abstract available.

PMID:
25261320
46.

Cloning, purification, crystallization and preliminary X-ray studies of a carbohydrate-binding module (CBM_E1) derived from sugarcane soil metagenome.

Campos BM, Alvarez TM, Liberato MV, Polikarpov I, Gilbert HJ, Zeri AC, Squina FM.

Acta Crystallogr F Struct Biol Commun. 2014 Sep;70(Pt 9):1232-5. doi: 10.1107/S2053230X14015520. Epub 2014 Aug 27.

47.

Structure- and context-based analysis of the GxGYxYP family reveals a new putative class of glycoside hydrolase.

Rigden DJ, Eberhardt RY, Gilbert HJ, Xu Q, Chang Y, Godzik A.

BMC Bioinformatics. 2014 Jun 17;15:196. doi: 10.1186/1471-2105-15-196.

48.

Recovery and fine structure variability of RGII sub-domains in wine (Vitis vinifera Merlot).

Buffetto F, Ropartz D, Zhang XJ, Gilbert HJ, Guillon F, Ralet MC.

Ann Bot. 2014 Oct;114(6):1327-37. doi: 10.1093/aob/mcu097. Epub 2014 Jun 7.

49.

Mechanistic strategies for catalysis adopted by evolutionary distinct family 43 arabinanases.

Santos CR, Polo CC, Costa MC, Nascimento AF, Meza AN, Cota J, Hoffmam ZB, Honorato RV, Oliveira PS, Goldman GH, Gilbert HJ, Prade RA, Ruller R, Squina FM, Wong DW, Murakami MT.

J Biol Chem. 2014 Mar 14;289(11):7362-73. doi: 10.1074/jbc.M113.537167. Epub 2014 Jan 27.

50.

Combined inhibitor free-energy landscape and structural analysis reports on the mannosidase conformational coordinate.

Williams RJ, Iglesias-Fernández J, Stepper J, Jackson A, Thompson AJ, Lowe EC, White JM, Gilbert HJ, Rovira C, Davies GJ, Williams SJ.

Angew Chem Int Ed Engl. 2014 Jan 20;53(4):1087-91. doi: 10.1002/anie.201308334. Epub 2013 Dec 11.

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