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Items: 1 to 50 of 110


Electronic cigarettes disrupt lung lipid homeostasis and innate immunity independent of nicotine.

Madison MC, Landers CT, Gu BH, Chang CY, Tung HY, You R, Hong MJ, Baghaei N, Song LZ, Porter P, Putluri N, Salas R, Gilbert BE, Levental I, Campen MJ, Corry DB, Kheradmand F.

J Clin Invest. 2019 Oct 1;129(10):4290-4304. doi: 10.1172/JCI128531.


Respiratory syncytial virus fusion nanoparticle vaccine immune responses target multiple neutralizing epitopes that contribute to protection against wild-type and palivizumab-resistant mutant virus challenge.

Gilbert BE, Patel N, Lu H, Liu Y, Guebre-Xabier M, Piedra PA, Glenn G, Ellingsworth L, Smith G.

Vaccine. 2018 Dec 18;36(52):8069-8078. doi: 10.1016/j.vaccine.2018.10.073. Epub 2018 Oct 30.


AIMp1 Potentiates TH1 Polarization and Is Critical for Effective Antitumor and Antiviral Immunity.

Liang D, Tian L, You R, Halpert MM, Konduri V, Baig YC, Paust S, Kim D, Kim S, Jia F, Huang S, Zhang X, Kheradmand F, Corry DB, Gilbert BE, Levitt JM, Decker WK.

Front Immunol. 2018 Jan 15;8:1801. doi: 10.3389/fimmu.2017.01801. eCollection 2017.


Correction: Repurposed Transcriptomic Data Reveal Small Viral RNA Produced by Influenza Virus during Infection in Mice.

Koire A, Gilbert BE, Sucgang R, Zechiedrich L.

PLoS One. 2017 Dec 5;12(12):e0189384. doi: 10.1371/journal.pone.0189384. eCollection 2017.


Protective role of γδ T cells in cigarette smoke and influenza infection.

Hong MJ, Gu BH, Madison MC, Landers C, Tung HY, Kim M, Yuan X, You R, Machado AA, Gilbert BE, Soroosh P, Elloso M, Song L, Chen M, Corry DB, Diehl G, Kheradmand F.

Mucosal Immunol. 2018 May;11(3):894-908. doi: 10.1038/mi.2017.93. Epub 2017 Nov 1.


Combined aerosolized Toll-like receptor ligands are an effective therapeutic agent against influenza pneumonia when co-administered with oseltamivir.

Leiva-Juarez MM, Kirkpatrick CT, Gilbert BE, Scott B, Tuvim MJ, Dickey BF, Evans SE, Markesich D.

Eur J Pharmacol. 2018 Jan 5;818:191-197. doi: 10.1016/j.ejphar.2017.10.035. Epub 2017 Oct 21.


A live RSV vaccine with engineered thermostability is immunogenic in cotton rats despite high attenuation.

Stobart CC, Rostad CA, Ke Z, Dillard RS, Hampton CM, Strauss JD, Yi H, Hotard AL, Meng J, Pickles RJ, Sakamoto K, Lee S, Currier MG, Moin SM, Graham BS, Boukhvalova MS, Gilbert BE, Blanco JC, Piedra PA, Wright ER, Moore ML.

Nat Commun. 2016 Dec 21;7:13916. doi: 10.1038/ncomms13916.


Repurposed Transcriptomic Data Reveal Small Viral RNA Produced by Influenza Virus during Infection in Mice.

Koire A, Gilbert BE, Sucgang R, Zechiedrich L.

PLoS One. 2016 Oct 27;11(10):e0165729. doi: 10.1371/journal.pone.0165729. eCollection 2016. Erratum in: PLoS One. 2017 Dec 5;12 (12 ):e0189384.


A Recombinant Respiratory Syncytial Virus Vaccine Candidate Attenuated by a Low-Fusion F Protein Is Immunogenic and Protective against Challenge in Cotton Rats.

Rostad CA, Stobart CC, Gilbert BE, Pickles RJ, Hotard AL, Meng J, Blanco JCG, Moin SM, Graham BS, Piedra PA, Moore ML.

J Virol. 2016 Jul 27;90(16):7508-7518. doi: 10.1128/JVI.00012-16. Print 2016 Aug 15.


GS-5806 Inhibits a Broad Range of Respiratory Syncytial Virus Clinical Isolates by Blocking the Virus-Cell Fusion Process.

Perron M, Stray K, Kinkade A, Theodore D, Lee G, Eisenberg E, Sangi M, Gilbert BE, Jordan R, Piedra PA, Toms GL, Mackman R, Cihlar T.

Antimicrob Agents Chemother. 2015 Dec 14;60(3):1264-73. doi: 10.1128/AAC.01497-15.


Generation and Characterization of ALX-0171, a Potent Novel Therapeutic Nanobody for the Treatment of Respiratory Syncytial Virus Infection.

Detalle L, Stohr T, Palomo C, Piedra PA, Gilbert BE, Mas V, Millar A, Power UF, Stortelers C, Allosery K, Melero JA, Depla E.

Antimicrob Agents Chemother. 2015 Oct 5;60(1):6-13. doi: 10.1128/AAC.01802-15. Print 2016 Jan.


Benzimidazole analogs inhibit respiratory syncytial virus G protein function.

Evans CW, Atkins C, Pathak A, Gilbert BE, Noah JW.

Antiviral Res. 2015 Sep;121:31-8. doi: 10.1016/j.antiviral.2015.06.016. Epub 2015 Jun 24.


Correction for Kim et al., development of an adenovirus-based respiratory syncytial virus vaccine: preclinical evaluation of efficacy, immunogenicity, and enhanced disease in a cotton rat model.

Kim E, Okada K, Beeler JA, Crim RL, Steitz J, Piedra PA, Gilbert BE, Gambotto A.

J Virol. 2015 May;89(9):5193. doi: 10.1128/JVI.03669-14. No abstract available.


Discovery of an oral respiratory syncytial virus (RSV) fusion inhibitor (GS-5806) and clinical proof of concept in a human RSV challenge study.

Mackman RL, Sangi M, Sperandio D, Parrish JP, Eisenberg E, Perron M, Hui H, Zhang L, Siegel D, Yang H, Saunders O, Boojamra C, Lee G, Samuel D, Babaoglu K, Carey A, Gilbert BE, Piedra PA, Strickley R, Iwata Q, Hayes J, Stray K, Kinkade A, Theodore D, Jordan R, Desai M, Cihlar T.

J Med Chem. 2015 Feb 26;58(4):1630-43. doi: 10.1021/jm5017768. Epub 2015 Jan 27.


WFDC1 is a key modulator of inflammatory and wound repair responses.

Ressler SJ, Dang TD, Wu SM, Tse DY, Gilbert BE, Vyakarnam A, Yang F, Schauer IG, Barron DA, Rowley DR.

Am J Pathol. 2014 Nov;184(11):2951-64. doi: 10.1016/j.ajpath.2014.07.013. Epub 2014 Sep 16.


Essential role for autophagy in the maintenance of immunological memory against influenza infection.

Chen M, Hong MJ, Sun H, Wang L, Shi X, Gilbert BE, Corry DB, Kheradmand F, Wang J.

Nat Med. 2014 May;20(5):503-10. doi: 10.1038/nm.3521. Epub 2014 Apr 20.


Glycan variants of a respiratory syncytial virus antibody with enhanced effector function and in vivo efficacy.

Hiatt A, Bohorova N, Bohorov O, Goodman C, Kim D, Pauly MH, Velasco J, Whaley KJ, Piedra PA, Gilbert BE, Zeitlin L.

Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5992-7. doi: 10.1073/pnas.1402458111. Epub 2014 Apr 7.


Development of an adenovirus-based respiratory syncytial virus vaccine: preclinical evaluation of efficacy, immunogenicity, and enhanced disease in a cotton rat model.

Kim E, Okada K, Beeler JA, Crim RL, Piedra PA, Gilbert BE, Gambotto A.

J Virol. 2014 May;88(9):5100-8. doi: 10.1128/JVI.03194-13. Epub 2014 Feb 26. Erratum in: J Virol. 2015 May;89(9):5193.


TRAF3 regulates the effector function of regulatory T cells and humoral immune responses.

Chang JH, Hu H, Jin J, Puebla-Osorio N, Xiao Y, Gilbert BE, Brink R, Ullrich SE, Sun SC.

J Exp Med. 2014 Jan 13;211(1):137-51. doi: 10.1084/jem.20131019. Epub 2013 Dec 30.


Prophylactic and therapeutic testing of Nicotiana-derived RSV-neutralizing human monoclonal antibodies in the cotton rat model.

Zeitlin L, Bohorov O, Bohorova N, Hiatt A, Kim DH, Pauly MH, Velasco J, Whaley KJ, Barnard DL, Bates JT, Crowe JE Jr, Piedra PA, Gilbert BE.

MAbs. 2013 Mar-Apr;5(2):263-9. doi: 10.4161/mabs.23281. Epub 2013 Feb 8.


Synergistic TLR2/6 and TLR9 activation protects mice against lethal influenza pneumonia.

Tuvim MJ, Gilbert BE, Dickey BF, Evans SE.

PLoS One. 2012;7(1):e30596. doi: 10.1371/journal.pone.0030596. Epub 2012 Jan 27.


Supercoiled Minivector DNA resists shear forces associated with gene therapy delivery.

Catanese DJ Jr, Fogg JM, Schrock DE 2nd, Gilbert BE, Zechiedrich L.

Gene Ther. 2012 Jan;19(1):94-100. doi: 10.1038/gt.2011.77. Epub 2011 Jun 2.


Aerosol delivery of liposomal formulated paclitaxel and vitamin E analog reduces murine mammary tumor burden and metastases.

Latimer P, Menchaca M, Snyder RM, Yu W, Gilbert BE, Sanders BG, Kline K.

Exp Biol Med (Maywood). 2009 Oct;234(10):1244-52. doi: 10.3181/0901-RM-8. Epub 2009 Aug 5.


Liposomal encapsulation of deguelin: evidence for enhanced antitumor activity in tobacco carcinogen-induced and oncogenic K-ras-induced lung tumorigenesis.

Woo JK, Choi DS, Tran HT, Gilbert BE, Hong WK, Lee HY.

Cancer Prev Res (Phila). 2009 Apr;2(4):361-9. doi: 10.1158/1940-6207.CAPR-08-0237. Epub 2009 Mar 31.


Augmented lung inflammation protects against influenza A pneumonia.

Tuvim MJ, Evans SE, Clement CG, Dickey BF, Gilbert BE.

PLoS One. 2009;4(1):e4176. doi: 10.1371/journal.pone.0004176. Epub 2009 Jan 12.


MegaRibavirin aerosol for the treatment of influenza A virus infections in mice.

Gilbert BE, McLeay MT.

Antiviral Res. 2008 Jun;78(3):223-9. doi: 10.1016/j.antiviral.2008.01.005. Epub 2008 Feb 4.


Cyclosporin A aerosol improves the anticancer effect of paclitaxel aerosol in mice.

Knight V, Koshkina NV, Golunski E, Roberts LE, Gilbert BE.

Trans Am Clin Climatol Assoc. 2004;115:395-404; discussion 404.


A fullerene-paclitaxel chemotherapeutic: synthesis, characterization, and study of biological activity in tissue culture.

Zakharian TY, Seryshev A, Sitharaman B, Gilbert BE, Knight V, Wilson LJ.

J Am Chem Soc. 2005 Sep 14;127(36):12508-9.


Antiviral efficacy of VP14637 against respiratory syncytial virus in vitro and in cotton rats following delivery by small droplet aerosol.

Wyde PR, Laquerre S, Chetty SN, Gilbert BE, Nitz TJ, Pevear DC.

Antiviral Res. 2005 Oct;68(1):18-26.


Novel vitamin E analogue and 9-nitro-camptothecin administered as liposome aerosols decrease syngeneic mouse mammary tumor burden and inhibit metastasis.

Lawson KA, Anderson K, Snyder RM, Simmons-Menchaca M, Atkinson J, Sun LZ, Bandyopadhyay A, Knight V, Gilbert BE, Sanders BG, Kline K.

Cancer Chemother Pharmacol. 2004 Nov;54(5):421-31.


Cyclosporin A aerosol improves the anticancer effect of paclitaxel aerosol in mice.

Koshkina NV, Golunski E, Roberts LE, Gilbert BE, Knight V.

J Aerosol Med. 2004 Spring;17(1):7-14.


Clinical evaluation of the delivery and safety of aerosolized liposomal 9-nitro-20(s)-camptothecin in patients with advanced pulmonary malignancies.

Verschraegen CF, Gilbert BE, Loyer E, Huaringa A, Walsh G, Newman RA, Knight V.

Clin Cancer Res. 2004 Apr 1;10(7):2319-26.


Novel vitamin E analogue decreases syngeneic mouse mammary tumor burden and reduces lung metastasis.

Lawson KA, Anderson K, Menchaca M, Atkinson J, Sun L, Knight V, Gilbert BE, Conti C, Sanders BG, Kline K.

Mol Cancer Ther. 2003 May;2(5):437-44.


Inhibition of oncogenic K-ras signaling by aerosolized gene delivery in a mouse model of human lung cancer.

Lee HY, Suh YA, Lee JI, Hassan KA, Mao L, Force T, Gilbert BE, Jacks T, Kurie JM.

Clin Cancer Res. 2002 Sep;8(9):2970-5.


9-nitrocamptothecin liposome aerosol: lack of subacute toxicity in dogs.

Gilbert BE, Seryshev A, Knight V, Brayton C.

Inhal Toxicol. 2002 Feb;14(2):185-97.


Improved respiratory delivery of the anticancer drugs, camptothecin and paclitaxel, with 5% CO2-enriched air: pharmacokinetic studies.

Koshkina NV, Knight V, Gilbert BE, Golunski E, Roberts L, Waldrep JC.

Cancer Chemother Pharmacol. 2001 May;47(5):451-6.


Feasibility, phase I, and pharmacological study of aerosolized liposomal 9-nitro-20(S)-camptothecin in patients with advanced malignancies in the lungs.

Verschraegen CF, Gilbert BE, Huaringa AJ, Newman R, Harris N, Leyva FJ, Keus L, Campbell K, Nelson-Taylor T, Knight V.

Ann N Y Acad Sci. 2000;922:352-4. No abstract available.


Alternative administration of camptothecin analogues.

Verschraegen CF, Jaeckle K, Giovanella B, Knight V, Gilbert BE.

Ann N Y Acad Sci. 2000;922:237-46. Review.


9-Nitrocamptothecin liposome aerosol treatment of human cancer subcutaneous xenografts and pulmonary cancer metastases in mice.

Knight V, Kleinerman ES, Waldrep JC, Giovanella BC, Gilbert BE, Koshkina NV.

Ann N Y Acad Sci. 2000;922:151-63.


Use of cotton rats for preclinical evaluation of measles vaccines.

Wyde PR, Stittelaar KJ, Osterhaus AD, Guzman E, Gilbert BE.

Vaccine. 2000 Aug 15;19(1):42-53.


9-Nitrocamptothecin liposome aerosol treatment of melanoma and osteosarcoma lung metastases in mice.

Koshkina NV, Kleinerman ES, Waidrep C, Jia SF, Worth LL, Gilbert BE, Knight V.

Clin Cancer Res. 2000 Jul;6(7):2876-80.


Use of cotton rats to evaluate the efficacy of antivirals in treatment of measles virus infections.

Wyde PR, Moore-Poveda DK, De Clercq E, Neyts J, Matsuda A, Minakawa N, Guzman E, Gilbert BE.

Antimicrob Agents Chemother. 2000 May;44(5):1146-52.


Pharmacokinetics of liposomal aerosolized cyclosporine A for pulmonary immunosuppression.

Letsou GV, Safi HJ, Reardon MJ, Ergenoglu M, Li Z, Klonaris CN, Baldwin JC, Gilbert BE, Waldrep JC.

Ann Thorac Surg. 1999 Dec;68(6):2044-8.


Distribution of camptothecin after delivery as a liposome aerosol or following intramuscular injection in mice.

Koshkina NV, Gilbert BE, Waldrep JC, Seryshev A, Knight V.

Cancer Chemother Pharmacol. 1999;44(3):187-92.


Anticancer effect of 9-nitrocamptothecin liposome aerosol on human cancer xenografts in nude mice.

Knight V, Koshkina NV, Waldrep JC, Giovanella BC, Gilbert BE.

Cancer Chemother Pharmacol. 1999;44(3):177-86.


CL387626 exhibits marked and unusual antiviral activity against respiratory syncytial virus in tissue culture and in cotton rats.

Wyde PR, Moore-Poveda DK, O'Hara B, Ding WD, Mitsner B, Gilbert BE.

Antiviral Res. 1998 Apr;38(1):31-42.


Tolerance of volunteers to cyclosporine A-dilauroylphosphatidylcholine liposome aerosol.

Gilbert BE, Knight C, Alvarez FG, Waldrep C, Rodarte JR, Knight V, Eschenbacher WL.

Am J Respir Crit Care Med. 1997 Dec;156(6):1789-93.


Pulmonary delivery of beclomethasone liposome aerosol in volunteers. Tolerance and safety.

Waldrep JC, Gilbert BE, Knight CM, Black MB, Scherer PW, Knight V, Eschenbacher W.

Chest. 1997 Feb;111(2):316-23.


Liposomal aerosols in the management of pulmonary infections.

Gilbert BE.

J Aerosol Med. 1996 Spring;9(1):111-22. Review.


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