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Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery.

Patel A, Perrin AJ, Flynn HR, Bisson C, Withers-Martinez C, Treeck M, Flueck C, Nicastro G, Martin SR, Ramos A, Gilberger TW, Snijders AP, Blackman MJ, Baker DA.

PLoS Biol. 2019 May 10;17(5):e3000264. doi: 10.1371/journal.pbio.3000264. eCollection 2019 May.


Structure-activity relationships in a series of antiplasmodial thieno[2,3-b]pyridines.

Masch A, Nasereddin A, Alder A, Bird MJ, Schweda SI, Preu L, Doerig C, Dzikowski R, Gilberger TW, Kunick C.

Malar J. 2019 Mar 21;18(1):89. doi: 10.1186/s12936-019-2725-y.


Hierarchical phosphorylation of apical membrane antigen 1 is required for efficient red blood cell invasion by malaria parasites.

Prinz B, Harvey KL, Wilcke L, Ruch U, Engelberg K, Biller L, Lucet I, Erkelenz S, Heincke D, Spielmann T, Doerig C, Kunick C, Crabb BS, Gilson PR, Gilberger TW.

Sci Rep. 2016 Oct 4;6:34479. doi: 10.1038/srep34479.


A MORN1-associated HAD phosphatase in the basal complex is essential for Toxoplasma gondii daughter budding.

Engelberg K, Ivey FD, Lin A, Kono M, Lorestani A, Faugno-Fusci D, Gilberger TW, White M, Gubbels MJ.

Cell Microbiol. 2016 Aug;18(8):1153-71. doi: 10.1111/cmi.12574. Epub 2016 Mar 9.


Pellicle formation in the malaria parasite.

Kono M, Heincke D, Wilcke L, Wong TW, Bruns C, Herrmann S, Spielmann T, Gilberger TW.

J Cell Sci. 2016 Feb 15;129(4):673-80. doi: 10.1242/jcs.181230. Epub 2016 Jan 13.


Critical Steps in Protein Export of Plasmodium falciparum Blood Stages.

Spielmann T, Gilberger TW.

Trends Parasitol. 2015 Oct;31(10):514-525. doi: 10.1016/ Review.


Parasite Calcineurin Regulates Host Cell Recognition and Attachment by Apicomplexans.

Paul AS, Saha S, Engelberg K, Jiang RH, Coleman BI, Kosber AL, Chen CT, Ganter M, Espy N, Gilberger TW, Gubbels MJ, Duraisingh MT.

Cell Host Microbe. 2015 Jul 8;18(1):49-60. doi: 10.1016/j.chom.2015.06.003. Epub 2015 Jun 25.


The role of palmitoylation for protein recruitment to the inner membrane complex of the malaria parasite.

Wetzel J, Herrmann S, Swapna LS, Prusty D, John Peter AT, Kono M, Saini S, Nellimarla S, Wong TW, Wilcke L, Ramsay O, Cabrera A, Biller L, Heincke D, Mossman K, Spielmann T, Ungermann C, Parkinson J, Gilberger TW.

J Biol Chem. 2015 Jan 16;290(3):1712-28. doi: 10.1074/jbc.M114.598094. Epub 2014 Nov 25.


Plasmodium falciparum ATG8 implicated in both autophagy and apicoplast formation.

Tomlins AM, Ben-Rached F, Williams RA, Proto WR, Coppens I, Ruch U, Gilberger TW, Coombs GH, Mottram JC, Müller S, Langsley G.

Autophagy. 2013 Oct;9(10):1540-52. doi: 10.4161/auto.25832. Epub 2013 Aug 29.


Identification of new PNEPs indicates a substantial non-PEXEL exportome and underpins common features in Plasmodium falciparum protein export.

Heiber A, Kruse F, Pick C, Grüring C, Flemming S, Oberli A, Schoeler H, Retzlaff S, Mesén-Ramírez P, Hiss JA, Kadekoppala M, Hecht L, Holder AA, Gilberger TW, Spielmann T.

PLoS Pathog. 2013;9(8):e1003546. doi: 10.1371/journal.ppat.1003546. Epub 2013 Aug 8.


The apicomplexan inner membrane complex.

Kono M, Prusty D, Parkinson J, Gilberger TW.

Front Biosci (Landmark Ed). 2013 Jun 1;18:982-92. Review.


PfSec13 is an unusual chromatin-associated nucleoporin of Plasmodium falciparum that is essential for parasite proliferation in human erythrocytes.

Dahan-Pasternak N, Nasereddin A, Kolevzon N, Pe'er M, Wong W, Shinder V, Turnbull L, Whitchurch CB, Elbaum M, Gilberger TW, Yavin E, Baum J, Dzikowski R.

J Cell Sci. 2013 Jul 15;126(Pt 14):3055-69. doi: 10.1242/jcs.122119. Epub 2013 May 17.


Specific phosphorylation of the PfRh2b invasion ligand of Plasmodium falciparum.

Engelberg K, Paul AS, Prinz B, Kono M, Ching W, Heincke D, Dobner T, Spielmann T, Duraisingh MT, Gilberger TW.

Biochem J. 2013 Jun 15;452(3):457-66. doi: 10.1042/BJ20121694.


The Toxoplasma protein ARO mediates the apical positioning of rhoptry organelles, a prerequisite for host cell invasion.

Mueller C, Klages N, Jacot D, Santos JM, Cabrera A, Gilberger TW, Dubremetz JF, Soldati-Favre D.

Cell Host Microbe. 2013 Mar 13;13(3):289-301. doi: 10.1016/j.chom.2013.02.001.


H2A.Z/H2B.Z double-variant nucleosomes inhabit the AT-rich promoter regions of the Plasmodium falciparum genome.

Hoeijmakers WA, Salcedo-Amaya AM, Smits AH, Françoijs KJ, Treeck M, Gilberger TW, Stunnenberg HG, Bártfai R.

Mol Microbiol. 2013 Mar;87(5):1061-73. doi: 10.1111/mmi.12151. Epub 2013 Jan 28.


Time-lapse imaging of red blood cell invasion by the rodent malaria parasite Plasmodium yoelii.

Yahata K, Treeck M, Culleton R, Gilberger TW, Kaneko O.

PLoS One. 2012;7(12):e50780. doi: 10.1371/journal.pone.0050780. Epub 2012 Dec 5.


Uncovering common principles in protein export of malaria parasites.

Grüring C, Heiber A, Kruse F, Flemming S, Franci G, Colombo SF, Fasana E, Schoeler H, Borgese N, Stunnenberg HG, Przyborski JM, Gilberger TW, Spielmann T.

Cell Host Microbe. 2012 Nov 15;12(5):717-29. doi: 10.1016/j.chom.2012.09.010.


Dissection of minimal sequence requirements for rhoptry membrane targeting in the malaria parasite.

Cabrera A, Herrmann S, Warszta D, Santos JM, John Peter AT, Kono M, Debrouver S, Jacobs T, Spielmann T, Ungermann C, Soldati-Favre D, Gilberger TW.

Traffic. 2012 Oct;13(10):1335-50. doi: 10.1111/j.1600-0854.2012.01394.x. Epub 2012 Aug 1.


Regulation of Plasmodium falciparum glideosome associated protein 45 (PfGAP45) phosphorylation.

Thomas DC, Ahmed A, Gilberger TW, Sharma P.

PLoS One. 2012;7(4):e35855. doi: 10.1371/journal.pone.0035855. Epub 2012 Apr 27.


Evolution and architecture of the inner membrane complex in asexual and sexual stages of the malaria parasite.

Kono M, Herrmann S, Loughran NB, Cabrera A, Engelberg K, Lehmann C, Sinha D, Prinz B, Ruch U, Heussler V, Spielmann T, Parkinson J, Gilberger TW.

Mol Biol Evol. 2012 Sep;29(9):2113-32. doi: 10.1093/molbev/mss081. Epub 2012 Mar 3.


The role of N-terminus of Plasmodium falciparum ORC1 in telomeric localization and var gene silencing.

Deshmukh AS, Srivastava S, Herrmann S, Gupta A, Mitra P, Gilberger TW, Dhar SK.

Nucleic Acids Res. 2012 Jul;40(12):5313-31. doi: 10.1093/nar/gks202. Epub 2012 Feb 29.


Highly co-ordinated var gene expression and switching in clinical Plasmodium falciparum isolates from non-immune malaria patients.

Bachmann A, Predehl S, May J, Harder S, Burchard GD, Gilberger TW, Tannich E, Bruchhaus I.

Cell Microbiol. 2011 Sep;13(9):1397-409. doi: 10.1111/j.1462-5822.2011.01629.x. Epub 2011 Jul 11.


Development and host cell modifications of Plasmodium falciparum blood stages in four dimensions.

Grüring C, Heiber A, Kruse F, Ungefehr J, Gilberger TW, Spielmann T.

Nat Commun. 2011 Jan 25;2:165.


H2A.Z demarcates intergenic regions of the plasmodium falciparum epigenome that are dynamically marked by H3K9ac and H3K4me3.

Bártfai R, Hoeijmakers WA, Salcedo-Amaya AM, Smits AH, Janssen-Megens E, Kaan A, Treeck M, Gilberger TW, Françoijs KJ, Stunnenberg HG.

PLoS Pathog. 2010 Dec 16;6(12):e1001223. doi: 10.1371/journal.ppat.1001223.


Protein kinase a dependent phosphorylation of apical membrane antigen 1 plays an important role in erythrocyte invasion by the malaria parasite.

Leykauf K, Treeck M, Gilson PR, Nebl T, Braulke T, Cowman AF, Gilberger TW, Crabb BS.

PLoS Pathog. 2010 Jun 3;6(6):e1000941. doi: 10.1371/journal.ppat.1000941.


Differential effects of C3d on the immunogenicity of gene gun vaccines encoding Plasmodium falciparum and Plasmodium berghei MSP1(42).

Weiss R, Gabler M, Jacobs T, Gilberger TW, Thalhamer J, Scheiblhofer S.

Vaccine. 2010 Jun 17;28(28):4515-22. doi: 10.1016/j.vaccine.2010.04.054. Epub 2010 May 15.


Transcriptional profiling of growth perturbations of the human malaria parasite Plasmodium falciparum.

Hu G, Cabrera A, Kono M, Mok S, Chaal BK, Haase S, Engelberg K, Cheemadan S, Spielmann T, Preiser PR, Gilberger TW, Bozdech Z.

Nat Biotechnol. 2010 Jan;28(1):91-8. doi: 10.1038/nbt.1597. Epub 2009 Dec 27.


Protein export in malaria parasites: do multiple export motifs add up to multiple export pathways?

Spielmann T, Gilberger TW.

Trends Parasitol. 2010 Jan;26(1):6-10. doi: 10.1016/ Epub 2009 Oct 29. Review.


Caught in action: mechanistic insights into antibody-mediated inhibition of Plasmodium merozoite invasion.

Treeck M, Tamborrini M, Daubenberger CA, Gilberger TW, Voss TS.

Trends Parasitol. 2009 Nov;25(11):494-7. doi: 10.1016/ Epub 2009 Sep 4.


A novel Plasmodium falciparum erythrocyte binding protein associated with the merozoite surface, PfDBLMSP.

Wickramarachchi T, Cabrera AL, Sinha D, Dhawan S, Chandran T, Devi YS, Kono M, Spielmann T, Gilberger TW, Chauhan VS, Mohmmed A.

Int J Parasitol. 2009 Jun;39(7):763-73.


Functional analysis of the leading malaria vaccine candidate AMA-1 reveals an essential role for the cytoplasmic domain in the invasion process.

Treeck M, Zacherl S, Herrmann S, Cabrera A, Kono M, Struck NS, Engelberg K, Haase S, Frischknecht F, Miura K, Spielmann T, Gilberger TW.

PLoS Pathog. 2009 Mar;5(3):e1000322. doi: 10.1371/journal.ppat.1000322. Epub 2009 Mar 6.


Sequence requirements for the export of the Plasmodium falciparum Maurer's clefts protein REX2.

Haase S, Herrmann S, Grüring C, Heiber A, Jansen PW, Langer C, Treeck M, Cabrera A, Bruns C, Struck NS, Kono M, Engelberg K, Ruch U, Stunnenberg HG, Gilberger TW, Spielmann T.

Mol Microbiol. 2009 Feb;71(4):1003-17. doi: 10.1111/j.1365-2958.2008.06582.x. Epub 2008 Dec 18.


Host-cell invasion by malaria parasites: insights from Plasmodium and Toxoplasma.

Baum J, Gilberger TW, Frischknecht F, Meissner M.

Trends Parasitol. 2008 Dec;24(12):557-63. doi: 10.1016/ Epub 2008 Oct 1. Review.


Plasmodium falciparum possesses two GRASP proteins that are differentially targeted to the Golgi complex via a higher- and lower-eukaryote-like mechanism.

Struck NS, Herrmann S, Langer C, Krueger A, Foth BJ, Engelberg K, Cabrera AL, Haase S, Treeck M, Marti M, Cowman AF, Spielmann T, Gilberger TW.

J Cell Sci. 2008 Jul 1;121(Pt 13):2123-9. doi: 10.1242/jcs.021154. Epub 2008 Jun 3.


Spatial dissection of the cis- and trans-Golgi compartments in the malaria parasite Plasmodium falciparum.

Struck NS, Herrmann S, Schmuck-Barkmann I, de Souza Dias S, Haase S, Cabrera AL, Treeck M, Bruns C, Langer C, Cowman AF, Marti M, Spielmann T, Gilberger TW.

Mol Microbiol. 2008 Mar;67(6):1320-30. doi: 10.1111/j.1365-2958.2008.06125.x. Epub 2008 Feb 12.


Characterization of a conserved rhoptry-associated leucine zipper-like protein in the malaria parasite Plasmodium falciparum.

Haase S, Cabrera A, Langer C, Treeck M, Struck N, Herrmann S, Jansen PW, Bruchhaus I, Bachmann A, Dias S, Cowman AF, Stunnenberg HG, Spielmann T, Gilberger TW.

Infect Immun. 2008 Mar;76(3):879-87. doi: 10.1128/IAI.00144-07. Epub 2008 Jan 3.


[New therapeutic approaches for malaria: molecular aspects of erythrocyte invasion].

Spielmann T, Gilberger TW.

Dtsch Med Wochenschr. 2007 Nov;132(45):2383-6. Review. German. No abstract available.


The human malaria parasite Plasmodium falciparum expresses an atypical N-terminally extended pyrophosphokinase with specificity for thiamine.

Eschbach ML, Müller IB, Gilberger TW, Walter RD, Wrenger C.

Biol Chem. 2006 Dec;387(12):1583-91.


Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite.

O'Donnell RA, Hackett F, Howell SA, Treeck M, Struck N, Krnajski Z, Withers-Martinez C, Gilberger TW, Blackman MJ.

J Cell Biol. 2006 Sep 25;174(7):1023-33.


A conserved region in the EBL proteins is implicated in microneme targeting of the malaria parasite Plasmodium falciparum.

Treeck M, Struck NS, Haase S, Langer C, Herrmann S, Healer J, Cowman AF, Gilberger TW.

J Biol Chem. 2006 Oct 20;281(42):31995-2003. Epub 2006 Aug 25.


A conserved molecular motor drives cell invasion and gliding motility across malaria life cycle stages and other apicomplexan parasites.

Baum J, Richard D, Healer J, Rug M, Krnajski Z, Gilberger TW, Green JL, Holder AA, Cowman AF.

J Biol Chem. 2006 Feb 24;281(8):5197-208. Epub 2005 Dec 1.


Re-defining the Golgi complex in Plasmodium falciparum using the novel Golgi marker PfGRASP.

Struck NS, de Souza Dias S, Langer C, Marti M, Pearce JA, Cowman AF, Gilberger TW.

J Cell Sci. 2005 Dec 1;118(Pt 23):5603-13.


The spermidine synthase of the malaria parasite Plasmodium falciparum: molecular and biochemical characterisation of the polyamine synthesis enzyme.

Haider N, Eschbach ML, Dias Sde S, Gilberger TW, Walter RD, Lüersen K.

Mol Biochem Parasitol. 2005 Aug;142(2):224-36.


Transfection of the human malaria parasite Plasmodium falciparum.

Crabb BS, Rug M, Gilberger TW, Thompson JK, Triglia T, Maier AG, Cowman AF.

Methods Mol Biol. 2004;270:263-76.


The cytoplasmic domain of the Plasmodium falciparum ligand EBA-175 is essential for invasion but not protein trafficking.

Gilberger TW, Thompson JK, Reed MB, Good RT, Cowman AF.

J Cell Biol. 2003 Jul 21;162(2):317-27.


A novel erythrocyte binding antigen-175 paralogue from Plasmodium falciparum defines a new trypsin-resistant receptor on human erythrocytes.

Gilberger TW, Thompson JK, Triglia T, Good RT, Duraisingh MT, Cowman AF.

J Biol Chem. 2003 Apr 18;278(16):14480-6. Epub 2003 Jan 29.


Thioredoxin reductase is essential for the survival of Plasmodium falciparum erythrocytic stages.

Krnajski Z, Gilberger TW, Walter RD, Cowman AF, Müller S.

J Biol Chem. 2002 Jul 19;277(29):25970-5. Epub 2002 May 9.


Thioredoxin and glutathione system of malaria parasite Plasmodium falciparum.

Müller S, Gilberger TW, Krnajski Z, Lüersen K, Meierjohann S, Walter RD.

Protoplasma. 2001;217(1-3):43-9. Review.


The malaria parasite Plasmodium falciparum possesses a functional thioredoxin system.

Krnajski Z, Gilberger TW, Walter RD, Müller S.

Mol Biochem Parasitol. 2001 Feb;112(2):219-28.


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