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Items: 26


Plasma exosomes stimulate breast cancer metastasis through surface interactions and activation of FAK signaling.

Shtam T, Naryzhny S, Samsonov R, Karasik D, Mizgirev I, Kopylov A, Petrenko E, Zabrodskaya Y, Kamyshinsky R, Nikitin D, Sorokin M, Buzdin A, Gil-Henn H, Malek A.

Breast Cancer Res Treat. 2018 Nov 27. doi: 10.1007/s10549-018-5043-0. [Epub ahead of print]


L-Norvaline Reverses Cognitive Decline and Synaptic Loss in a Murine Model of Alzheimer's Disease.

Polis B, Srikanth KD, Elliott E, Gil-Henn H, Samson AO.

Neurotherapeutics. 2018 Oct;15(4):1036-1054. doi: 10.1007/s13311-018-0669-5.


FAK family kinases: The Yin and Yang of cancer cell invasiveness.

Genna A, Gil-Henn H.

Mol Cell Oncol. 2018 May 25;5(4):e1449584. doi: 10.1080/23723556.2018.1449584. eCollection 2018.


Tumor cell density regulates matrix metalloproteinases for enhanced migration.

Jayatilaka H, Umanzor FG, Shah V, Meirson T, Russo G, Starich B, Tyle P, Lee JSH, Khatau S, Gil-Henn H, Wirtz D.

Oncotarget. 2018 Aug 24;9(66):32556-32569. doi: 10.18632/oncotarget.25863. eCollection 2018 Aug 24.


Commentary on Giralt et al.: PTK2B/Pyk2 overexpression improves a mouse model of Alzheimer's disease.

Polis B, Gil-Henn H.

Exp Neurol. 2019 Jan;311:313-317. doi: 10.1016/j.expneurol.2018.08.011. Epub 2018 Aug 29.


Targeting invadopodia for blocking breast cancer metastasis.

Meirson T, Gil-Henn H.

Drug Resist Updat. 2018 Jul;39:1-17. doi: 10.1016/j.drup.2018.05.002. Epub 2018 May 17. Review.


Oral inflammation promotes oral squamous cell carcinoma invasion.

Goertzen C, Mahdi H, Laliberte C, Meirson T, Eymael D, Gil-Henn H, Magalhaes M.

Oncotarget. 2018 Jun 26;9(49):29047-29063. doi: 10.18632/oncotarget.25540. eCollection 2018 Jun 26.


Targeting invadopodia-mediated breast cancer metastasis by using ABL kinase inhibitors.

Meirson T, Genna A, Lukic N, Makhnii T, Alter J, Sharma VP, Wang Y, Samson AO, Condeelis JS, Gil-Henn H.

Oncotarget. 2018 Apr 24;9(31):22158-22183. doi: 10.18632/oncotarget.25243. eCollection 2018 Apr 24.


Pyk2 and FAK differentially regulate invadopodia formation and function in breast cancer cells.

Genna A, Lapetina S, Lukic N, Twafra S, Meirson T, Sharma VP, Condeelis JS, Gil-Henn H.

J Cell Biol. 2018 Jan 2;217(1):375-395. doi: 10.1083/jcb.201702184. Epub 2017 Nov 13.


An in silico high-throughput screen identifies potential selective inhibitors for the non-receptor tyrosine kinase Pyk2.

Meirson T, Samson AO, Gil-Henn H.

Drug Des Devel Ther. 2017 May 18;11:1535-1557. doi: 10.2147/DDDT.S136150. eCollection 2017.


Generation of SMURF2 knockout human cells using the CRISPR/Cas9 system.

Manikoth Ayyathan D, Ilić N, Gil-Henn H, Blank M.

Anal Biochem. 2017 Aug 15;531:56-59. doi: 10.1016/j.ab.2017.05.024. Epub 2017 May 26.


Phosphorylated cortactin recruits Vav2 guanine nucleotide exchange factor to activate Rac3 and promote invadopodial function in invasive breast cancer cells.

Rosenberg BJ, Gil-Henn H, Mader CC, Halo T, Yin T, Condeelis J, Machida K, Wu YI, Koleske AJ.

Mol Biol Cell. 2017 May 15;28(10):1347-1360. doi: 10.1091/mbc.E16-12-0885. Epub 2017 Mar 29.


Plasma exosomal miR-21 and miR-181a differentiates follicular from papillary thyroid cancer.

Samsonov R, Burdakov V, Shtam T, Radzhabovа Z, Vasilyev D, Tsyrlina E, Titov S, Ivanov M, Berstein L, Filatov M, Kolesnikov N, Gil-Henn H, Malek A.

Tumour Biol. 2016 Sep;37(9):12011-12021. Epub 2016 May 11.


Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer.

Ben-Chetrit N, Chetrit D, Russell R, Körner C, Mancini M, Abdul-Hai A, Itkin T, Carvalho S, Cohen-Dvashi H, Koestler WJ, Shukla K, Lindzen M, Kedmi M, Lauriola M, Shulman Z, Barr H, Seger D, Ferraro DA, Pareja F, Gil-Henn H, Lapidot T, Alon R, Milanezi F, Symons M, Ben-Hamo R, Efroni S, Schmitt F, Wiemann S, Caldas C, Ehrlich M, Yarden Y.

Sci Signal. 2015 Jan 20;8(360):ra7. doi: 10.1126/scisignal.2005537.


Arg/Abl2 promotes invasion and attenuates proliferation of breast cancer in vivo.

Gil-Henn H, Patsialou A, Wang Y, Warren MS, Condeelis JS, Koleske AJ.

Oncogene. 2013 May 23;32(21):2622-30. doi: 10.1038/onc.2012.284. Epub 2012 Jul 9.


Invadopodia: the leading force.

Sibony-Benyamini H, Gil-Henn H.

Eur J Cell Biol. 2012 Nov-Dec;91(11-12):896-901. doi: 10.1016/j.ejcb.2012.04.001. Epub 2012 May 24. Review.


Cortactin phosphorylation regulates cell invasion through a pH-dependent pathway.

Magalhaes MA, Larson DR, Mader CC, Bravo-Cordero JJ, Gil-Henn H, Oser M, Chen X, Koleske AJ, Condeelis J.

J Cell Biol. 2011 Nov 28;195(5):903-20. doi: 10.1083/jcb.201103045. Epub 2011 Nov 21.


An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion.

Mader CC, Oser M, Magalhaes MA, Bravo-Cordero JJ, Condeelis J, Koleske AJ, Gil-Henn H.

Cancer Res. 2011 Mar 1;71(5):1730-41. doi: 10.1158/0008-5472.CAN-10-1432. Epub 2011 Jan 21.


Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia.

Oser M, Mader CC, Gil-Henn H, Magalhaes M, Bravo-Cordero JJ, Koleske AJ, Condeelis J.

J Cell Sci. 2010 Nov 1;123(Pt 21):3662-73. doi: 10.1242/jcs.068163.


'Tuning' of type I interferon-induced Jak-STAT1 signaling by calcium-dependent kinases in macrophages.

Wang L, Tassiulas I, Park-Min KH, Reid AC, Gil-Henn H, Schlessinger J, Baron R, Zhang JJ, Ivashkiv LB.

Nat Immunol. 2008 Feb;9(2):186-93. Epub 2007 Dec 16.


Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2(-/-) mice.

Gil-Henn H, Destaing O, Sims NA, Aoki K, Alles N, Neff L, Sanjay A, Bruzzaniti A, De Camilli P, Baron R, Schlessinger J.

J Cell Biol. 2007 Sep 10;178(6):1053-64.


Protein tyrosine phosphatase epsilon inhibits signaling by mitogen-activated protein kinases.

Toledano-Katchalski H, Kraut J, Sines T, Granot-Attas S, Shohat G, Gil-Henn H, Yung Y, Elson A.

Mol Cancer Res. 2003 May;1(7):541-50.


Regulation of protein-tyrosine phosphatases alpha and epsilon by calpain-mediated proteolytic cleavage.

Gil-Henn H, Volohonsky G, Elson A.

J Biol Chem. 2001 Aug 24;276(34):31772-9. Epub 2001 Jun 27.


Generation of novel cytoplasmic forms of protein tyrosine phosphatase epsilon by proteolytic processing and translational control.

Gil-Henn H, Volohonsky G, Toledano-Katchalski H, Gandre S, Elson A.

Oncogene. 2000 Sep 7;19(38):4375-84.


Hypomyelination and increased activity of voltage-gated K(+) channels in mice lacking protein tyrosine phosphatase epsilon.

Peretz A, Gil-Henn H, Sobko A, Shinder V, Attali B, Elson A.

EMBO J. 2000 Aug 1;19(15):4036-45.

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