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Analysis of ex vivo HIV-1 infection in a controller-discordant couple.

Madlala P, Van de Velde P, Van Remoortel B, Vets S, Van Wijngaerden E, Van Laethem K, Gijsbers R, Schrijvers R, Debyser Z.

J Virus Erad. 2018 Jul 1;4(3):170-173.


Fate of mesoangioblasts in a vaginal birth injury model: influence of the route of administration.

Mori da Cunha MGMC, Giacomazzi G, Callewaert G, Hympanova L, Russo F, Vande Velde G, Gijsbers R, Albersen M, Sampaolesi M, Deprest J.

Sci Rep. 2018 Jul 13;8(1):10604. doi: 10.1038/s41598-018-28967-w.


Y-box-binding protein 1 supports the early and late steps of HIV replication.

Weydert C, van Heertum B, Dirix L, De Houwer S, De Wit F, Mast J, Husson SJ, Busschots K, König R, Gijsbers R, De Rijck J, Debyser Z.

PLoS One. 2018 Jul 11;13(7):e0200080. doi: 10.1371/journal.pone.0200080. eCollection 2018.


A kindred with mutant IKAROS and autoimmunity.

Van Nieuwenhove E, Garcia-Perez JE, Helsen C, Rodriguez PD, van Schouwenburg PA, Dooley J, Schlenner S, van der Burg M, Verhoeyen E, Gijsbers R, Frietze S, Schjerven H, Meyts I, Claessens F, Humblet-Baron S, Wouters C, Liston A.

J Allergy Clin Immunol. 2018 Aug;142(2):699-702.e12. doi: 10.1016/j.jaci.2018.04.008. Epub 2018 Apr 27. No abstract available.


HOXA9 Cooperates with Activated JAK/STAT Signaling to Drive Leukemia Development.

de Bock CE, Demeyer S, Degryse S, Verbeke D, Sweron B, Gielen O, Vandepoel R, Vicente C, Vanden Bempt M, Dagklis A, Geerdens E, Bornschein S, Gijsbers R, Soulier J, Meijerink JP, Heinäniemi M, Teppo S, Bouvy-Liivrand M, Lohi O, Radaelli E, Cools J.

Cancer Discov. 2018 May;8(5):616-631. doi: 10.1158/2159-8290.CD-17-0583. Epub 2018 Mar 1.


Microgels produced using microfluidic on-chip polymer blending for controlled released of VEGF encoding lentivectors.

Madrigal JL, Sharma SN, Campbell KT, Stilhano RS, Gijsbers R, Silva EA.

Acta Biomater. 2018 Mar 15;69:265-276. doi: 10.1016/j.actbio.2018.01.013. Epub 2018 Feb 2.


Role of the PWWP domain of lens epithelium-derived growth factor (LEDGF)/p75 cofactor in lentiviral integration targeting.

Gijsbers R, Vets S, De Rijck J, Ocwieja KE, Ronen K, Malani N, Bushman FD, Debyser Z.

J Biol Chem. 2018 Jan 5;293(1):114. doi: 10.1074/jbc.W117.001458. No abstract available.


Measles virus envelope pseudotyped lentiviral vectors transduce quiescent human HSCs at an efficiency without precedent.

Lévy C, Amirache F, Girard-Gagnepain A, Frecha C, Roman-Rodríguez FJ, Bernadin O, Costa C, Nègre D, Gutierrez-Guerrero A, Vranckx LS, Clerc I, Taylor N, Thielecke L, Cornils K, Bueren JA, Rio P, Gijsbers R, Cosset FL, Verhoeyen E.

Blood Adv. 2017 Oct 24;1(23):2088-2104. doi: 10.1182/bloodadvances.2017007773. eCollection 2017 Oct 24.


Correction: Substrate-specifying determinants of the nucleotide pyrophosphatases/phosphodiesterases NPP1 and NPP2.

Cimpean A, Stefan C, Gijsbers R, Stalmans W, Bollen M.

Biochem J. 2017 Dec 14;474(24):4273-4274. doi: 10.1042/BCJ-2004-0465_COR. No abstract available.


Functional Evaluation of an IKBKG Variant Suspected to Cause Immunodeficiency Without Ectodermal Dysplasia.

Frans G, van der Werff Ten Bosch J, Moens L, Gijsbers R, Changi-Ashtiani M, Rokni-Zadeh H, Shahrooei M, Wuyts G, Meyts I, Bossuyt X.

J Clin Immunol. 2017 Nov;37(8):801-810. doi: 10.1007/s10875-017-0448-9. Epub 2017 Oct 10.


Engineering Next-Generation BET-Independent MLV Vectors for Safer Gene Therapy.

El Ashkar S, Van Looveren D, Schenk F, Vranckx LS, Demeulemeester J, De Rijck J, Debyser Z, Modlich U, Gijsbers R.

Mol Ther Nucleic Acids. 2017 Jun 16;7:231-245. doi: 10.1016/j.omtn.2017.04.002. Epub 2017 Apr 12.


Inhibition of MicroRNA-146a and Overexpression of Its Target Dihydrolipoyl Succinyltransferase Protect Against Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction.

Heggermont WA, Papageorgiou AP, Quaegebeur A, Deckx S, Carai P, Verhesen W, Eelen G, Schoors S, van Leeuwen R, Alekseev S, Elzenaar I, Vinckier S, Pokreisz P, Walravens AS, Gijsbers R, Van Den Haute C, Nickel A, Schroen B, van Bilsen M, Janssens S, Maack C, Pinto Y, Carmeliet P, Heymans S.

Circulation. 2017 Aug 22;136(8):747-761. doi: 10.1161/CIRCULATIONAHA.116.024171. Epub 2017 Jun 13.


Insight into HIV-2 latency may disclose strategies for a cure for HIV-1 infection.

Saleh S, Vranckx L, Gijsbers R, Christ F, Debyser Z.

J Virus Erad. 2017 Jan 1;3(1):7-14.


A novel kindred with inherited STAT2 deficiency and severe viral illness.

Moens L, Van Eyck L, Jochmans D, Mitera T, Frans G, Bossuyt X, Matthys P, Neyts J, Ciancanelli M, Zhang SY, Gijsbers R, Casanova JL, Boisson-Dupuis S, Meyts I, Liston A.

J Allergy Clin Immunol. 2017 Jun;139(6):1995-1997.e9. doi: 10.1016/j.jaci.2016.10.033. Epub 2017 Jan 10. No abstract available.


Dynamic Oligomerization of Integrase Orchestrates HIV Nuclear Entry.

Borrenberghs D, Dirix L, De Wit F, Rocha S, Blokken J, De Houwer S, Gijsbers R, Christ F, Hofkens J, Hendrix J, Debyser Z.

Sci Rep. 2016 Nov 10;6:36485. doi: 10.1038/srep36485.


Towards a Safer, More Randomized Lentiviral Vector Integration Profile Exploring Artificial LEDGF Chimeras.

Vranckx LS, Demeulemeester J, Debyser Z, Gijsbers R.

PLoS One. 2016 Oct 27;11(10):e0164167. doi: 10.1371/journal.pone.0164167. eCollection 2016.


LEDGIN-mediated Inhibition of Integrase-LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV.

Vranckx LS, Demeulemeester J, Saleh S, Boll A, Vansant G, Schrijvers R, Weydert C, Battivelli E, Verdin E, Cereseto A, Christ F, Gijsbers R, Debyser Z.

EBioMedicine. 2016 Jun;8:248-264. doi: 10.1016/j.ebiom.2016.04.039. Epub 2016 May 13.


Evaluation of WGA-Cre-dependent topological transgene expression in the rodent brain.

Libbrecht S, Van den Haute C, Malinouskaya L, Gijsbers R, Baekelandt V.

Brain Struct Funct. 2017 Mar;222(2):717-733. doi: 10.1007/s00429-016-1241-x. Epub 2016 Jun 3.


Preclinical Evaluation of a P2X7 Receptor-Selective Radiotracer: PET Studies in a Rat Model with Local Overexpression of the Human P2X7 Receptor and in Nonhuman Primates.

Ory D, Celen S, Gijsbers R, Van Den Haute C, Postnov A, Koole M, Vandeputte C, Andrés JI, Alcazar J, De Angelis M, Langlois X, Bhattacharya A, Schmidt M, Letavic MA, Vanduffel W, Van Laere K, Verbruggen A, Debyser Z, Bormans G.

J Nucl Med. 2016 Sep;57(9):1436-41. doi: 10.2967/jnumed.115.169995. Epub 2016 May 19.


Development of an Alpha-synuclein Based Rat Model for Parkinson's Disease via Stereotactic Injection of a Recombinant Adeno-associated Viral Vector.

Van der Perren A, Casteels C, Van Laere K, Gijsbers R, Van den Haute C, Baekelandt V.

J Vis Exp. 2016 Feb 28;(108):53670. doi: 10.3791/53670.


Comparative Analysis of HIV-1 and Murine Leukemia Virus Three-Dimensional Nuclear Distributions.

Quercioli V, Di Primio C, Casini A, Mulder LCF, Vranckx LS, Borrenberghs D, Gijsbers R, Debyser Z, Cereseto A.

J Virol. 2016 Apr 29;90(10):5205-5209. doi: 10.1128/JVI.03188-15. Print 2016 May 15.


Serotype-dependent transduction efficiencies of recombinant adeno-associated viral vectors in monkey neocortex.

Gerits A, Vancraeyenest P, Vreysen S, Laramée ME, Michiels A, Gijsbers R, Van den Haute C, Moons L, Debyser Z, Baekelandt V, Arckens L, Vanduffel W.

Neurophotonics. 2015 Jul;2(3):031209. doi: 10.1117/1.NPh.2.3.031209. Epub 2015 Oct 1.


Cardiac Niche Influences the Direct Reprogramming of Canine Fibroblasts into Cardiomyocyte-Like Cells.

Palazzolo G, Quattrocelli M, Toelen J, Dominici R, Anastasia L, Tettamenti G, Barthelemy I, Blot S, Gijsbers R, Cassano M, Sampaolesi M.

Stem Cells Int. 2016;2016:4969430. doi: 10.1155/2016/4969430. Epub 2015 Nov 23.


The dark side of ID8-Luc2: pitfalls for luciferase tagged murine models for ovarian cancer.

Baert T, Verschuere T, Van Hoylandt A, Gijsbers R, Vergote I, Coosemans A.

J Immunother Cancer. 2015 Dec 15;3:57. doi: 10.1186/s40425-015-0102-0. eCollection 2015.


Sodium Iodide Symporter PET and BLI Noninvasively Reveal Mesoangioblast Survival in Dystrophic Mice.

Holvoet B, Quattrocelli M, Belderbos S, Pollaris L, Wolfs E, Gheysens O, Gijsbers R, Vanoirbeek J, Verfaillie CM, Sampaolesi M, Deroose CM.

Stem Cell Reports. 2015 Dec 8;5(6):1183-1195. doi: 10.1016/j.stemcr.2015.10.018. Epub 2015 Nov 28.


Long-Term Fate Mapping Using Conditional Lentiviral Vectors Reveals a Continuous Contribution of Radial Glia-Like Cells to Adult Hippocampal Neurogenesis in Mice.

Aelvoet SA, Pascual-Brazo J, Libbrecht S, Reumers V, Gijsbers R, Van den Haute C, Baekelandt V.

PLoS One. 2015 Nov 23;10(11):e0143772. doi: 10.1371/journal.pone.0143772. eCollection 2015.


Noninvasive Imaging Reveals Stable Transgene Expression in Mouse Airways After Delivery of a Nonintegrating Recombinant Adeno-Associated Viral Vector.

Vidović D, Gijsbers R, Quiles-Jimenez A, Dooley J, Van den Haute C, Van der Perren A, Liston A, Baekelandt V, Debyser Z, Carlon MS.

Hum Gene Ther. 2016 Jan;27(1):60-71. doi: 10.1089/hum.2015.109. Epub 2015 Dec 21. Erratum in: Hum Gene Ther. 2016 Nov;27(11):946.


Proof-of-concept: neonatal intravenous injection of adeno-associated virus vectors results in successful transduction of myenteric and submucosal neurons in the mouse small and large intestine.

Buckinx R, Van Remoortel S, Gijsbers R, Waddington SN, Timmermans JP.

Neurogastroenterol Motil. 2016 Feb;28(2):299-305. doi: 10.1111/nmo.12724. Epub 2015 Nov 12.


rAAV-CFTRΔR Rescues the Cystic Fibrosis Phenotype in Human Intestinal Organoids and Cystic Fibrosis Mice.

Vidović D, Carlon MS, da Cunha MF, Dekkers JF, Hollenhorst MI, Bijvelds MJ, Ramalho AS, Van den Haute C, Ferrante M, Baekelandt V, Janssens HM, De Boeck K, Sermet-Gaudelus I, de Jonge HR, Gijsbers R, Beekman JM, Edelman A, Debyser Z.

Am J Respir Crit Care Med. 2016 Feb 1;193(3):288-98. doi: 10.1164/rccm.201505-0914OC.


Assessment of bystander killing-mediated therapy of malignant brain tumors using a multimodal imaging approach.

Leten C, Trekker J, Struys T, Dresselaers T, Gijsbers R, Vande Velde G, Lambrichts I, Van Der Linden A, Verfaillie CM, Himmelreich U.

Stem Cell Res Ther. 2015 Sep 7;6:163. doi: 10.1186/s13287-015-0157-3.


Retroviral integration: Site matters: Mechanisms and consequences of retroviral integration site selection.

Demeulemeester J, De Rijck J, Gijsbers R, Debyser Z.

Bioessays. 2015 Nov;37(11):1202-14. doi: 10.1002/bies.201500051. Epub 2015 Aug 21. Review.


Evaluation of the expression pattern of rAAV2/1, 2/5, 2/7, 2/8, and 2/9 serotypes with different promoters in the mouse visual cortex.

Scheyltjens I, Laramée ME, Van den Haute C, Gijsbers R, Debyser Z, Baekelandt V, Vreysen S, Arckens L.

J Comp Neurol. 2015 Oct 1;523(14):2019-42. doi: 10.1002/cne.23819. Epub 2015 Jun 19.


HIV-1 IN/Pol recruits LEDGF/p75 into viral particles.

Desimmie BA, Weydert C, Schrijvers R, Vets S, Demeulemeester J, Proost P, Paron I, De Rijck J, Mast J, Bannert N, Gijsbers R, Christ F, Debyser Z.

Retrovirology. 2015 Feb 12;12:16. doi: 10.1186/s12977-014-0134-4.


FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an α-synuclein-based rat model for Parkinson's disease.

Van der Perren A, Macchi F, Toelen J, Carlon MS, Maris M, de Loor H, Kuypers DR, Gijsbers R, Van den Haute C, Debyser Z, Baekelandt V.

Neurobiol Aging. 2015 Mar;36(3):1559-68. doi: 10.1016/j.neurobiolaging.2015.01.014. Epub 2015 Jan 21.


Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors.

Van der Perren A, Toelen J, Casteels C, Macchi F, Van Rompuy AS, Sarre S, Casadei N, Nuber S, Himmelreich U, Osorio Garcia MI, Michotte Y, D'Hooge R, Bormans G, Van Laere K, Gijsbers R, Van den Haute C, Debyser Z, Baekelandt V.

Neurobiol Aging. 2015 Mar;36(3):1543-58. doi: 10.1016/j.neurobiolaging.2014.11.015. Epub 2014 Dec 17.


Host factors for retroviral integration site selection.

Debyser Z, Christ F, De Rijck J, Gijsbers R.

Trends Biochem Sci. 2015 Feb;40(2):108-16. doi: 10.1016/j.tibs.2014.12.001. Epub 2014 Dec 31. Review.


HIV-1 integrase variants retarget viral integration and are associated with disease progression in a chronic infection cohort.

Demeulemeester J, Vets S, Schrijvers R, Madlala P, De Maeyer M, De Rijck J, Ndung'u T, Debyser Z, Gijsbers R.

Cell Host Microbe. 2014 Nov 12;16(5):651-62. doi: 10.1016/j.chom.2014.09.016. Epub 2014 Nov 12.


Noninvasive bioluminescence imaging of α-synuclein oligomerization in mouse brain using split firefly luciferase reporters.

Aelvoet SA, Ibrahimi A, Macchi F, Gijsbers R, Van den Haute C, Debyser Z, Baekelandt V.

J Neurosci. 2014 Dec 3;34(49):16518-32. doi: 10.1523/JNEUROSCI.4933-13.2014.


Controlling and monitoring stem cell safety in vivo in an experimental rodent model.

Leten C, Roobrouck VD, Struys T, Burns TC, Dresselaers T, Vande Velde G, Santermans J, Lo Nigro A, Ibrahimi A, Gijsbers R, Eggermont K, Lambrichts I, Verfaillie CM, Himmelreich U.

Stem Cells. 2014 Nov;32(11):2833-44. doi: 10.1002/stem.1819.


BET-independent MLV-based Vectors Target Away From Promoters and Regulatory Elements.

El Ashkar S, De Rijck J, Demeulemeester J, Vets S, Madlala P, Cermakova K, Debyser Z, Gijsbers R.

Mol Ther Nucleic Acids. 2014 Jul 29;3:e179. doi: 10.1038/mtna.2014.33.


The HIV-1 integrase mutant R263A/K264A is 2-fold defective for TRN-SR2 binding and viral nuclear import.

De Houwer S, Demeulemeester J, Thys W, Rocha S, Dirix L, Gijsbers R, Christ F, Debyser Z.

J Biol Chem. 2014 Sep 5;289(36):25351-61. doi: 10.1074/jbc.M113.533281. Epub 2014 Jul 25.


Bioluminescence imaging of stroke-induced endogenous neural stem cell response.

Vandeputte C, Reumers V, Aelvoet SA, Thiry I, De Swaef S, Van den Haute C, Pascual-Brazo J, Farr TD, Vande Velde G, Hoehn M, Himmelreich U, Van Laere K, Debyser Z, Gijsbers R, Baekelandt V.

Neurobiol Dis. 2014 Sep;69:144-55. doi: 10.1016/j.nbd.2014.05.014. Epub 2014 May 27.


Optimization of multimodal imaging of mesenchymal stem cells using the human sodium iodide symporter for PET and Cerenkov luminescence imaging.

Wolfs E, Holvoet B, Gijsbers R, Casteels C, Roberts SJ, Struys T, Maris M, Ibrahimi A, Debyser Z, Van Laere K, Verfaillie CM, Deroose CM.

PLoS One. 2014 Apr 18;9(4):e94833. doi: 10.1371/journal.pone.0094833. eCollection 2014.


Immunological ignorance allows long-term gene expression after perinatal recombinant adeno-associated virus-mediated gene transfer to murine airways.

Carlon MS, Vidović D, Dooley J, da Cunha MM, Maris M, Lampi Y, Toelen J, Van den Haute C, Baekelandt V, Deprest J, Verbeken E, Liston A, Gijsbers R, Debyser Z.

Hum Gene Ther. 2014 Jun;25(6):517-28. doi: 10.1089/hum.2013.196. Epub 2014 Mar 26.


Viral vectors expressing a single microRNA-based short-hairpin RNA result in potent gene silencing in vitro and in vivo.

Osório L, Gijsbers R, Oliveras-Salvá M, Michiels A, Debyser Z, Van den Haute C, Baekelandt V.

J Biotechnol. 2014 Jan;169:71-81. doi: 10.1016/j.jbiotec.2013.11.004. Epub 2013 Nov 16.


The BET family of proteins targets moloney murine leukemia virus integration near transcription start sites.

De Rijck J, de Kogel C, Demeulemeester J, Vets S, El Ashkar S, Malani N, Bushman FD, Landuyt B, Husson SJ, Busschots K, Gijsbers R, Debyser Z.

Cell Rep. 2013 Nov 27;5(4):886-94. doi: 10.1016/j.celrep.2013.09.040. Epub 2013 Oct 31.


Recipient leukocyte infusion enhances the local and systemic graft-versus-neuroblastoma effect of allogeneic bone marrow transplantation in mice.

Willems L, Fevery S, Sprangers B, Rutgeerts O, Lenaerts C, Ibrahimi A, Gijsbers R, Van Gool S, Waer M, Billiau AD.

Cancer Immunol Immunother. 2013 Nov;62(11):1733-44. doi: 10.1007/s00262-013-1479-6. Epub 2013 Oct 1.


Long-term miR-669a therapy alleviates chronic dilated cardiomyopathy in dystrophic mice.

Quattrocelli M, Crippa S, Montecchiani C, Camps J, Cornaglia AI, Boldrin L, Morgan J, Calligaro A, Casasco A, Orlacchio A, Gijsbers R, D'Hooge J, Toelen J, Janssens S, Sampaolesi M.

J Am Heart Assoc. 2013 Aug 20;2(4):e000284. doi: 10.1161/JAHA.113.000284.


LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions.

Desimmie BA, Schrijvers R, Demeulemeester J, Borrenberghs D, Weydert C, Thys W, Vets S, Van Remoortel B, Hofkens J, De Rijck J, Hendrix J, Bannert N, Gijsbers R, Christ F, Debyser Z.

Retrovirology. 2013 May 30;10:57. doi: 10.1186/1742-4690-10-57.


PEAR1 attenuates megakaryopoiesis via control of the PI3K/PTEN pathway.

Kauskot A, Vandenbriele C, Louwette S, Gijsbers R, Tousseyn T, Freson K, Verhamme P, Hoylaerts MF.

Blood. 2013 Jun 27;121(26):5208-17. doi: 10.1182/blood-2012-10-462887. Epub 2013 May 10.

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