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An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis.

Smith HW, Hirukawa A, Sanguin-Gendreau V, Nandi I, Dufour CR, Zuo D, Tandoc K, Leibovitch M, Singh S, Rennhack JP, Swiatnicki M, Lavoie C, Papavasiliou V, Temps C, Carragher NO, Unciti-Broceta A, Savage P, Basik M, van Hoef V, Larsson O, Cooper CL, Vargas Calderon AC, Beith J, Millar E, Selinger C, Giguère V, Park M, Harris LN, Varadan V, Andrechek ER, O'Toole SA, Topisirovic I, Muller WJ.

Nat Commun. 2019 Jul 1;10(1):2901. doi: 10.1038/s41467-019-10681-4.


ERRα as a Bridge Between Transcription and Function: Role in Liver Metabolism and Disease.

Xia H, Dufour CR, Giguère V.

Front Endocrinol (Lausanne). 2019 Apr 5;10:206. doi: 10.3389/fendo.2019.00206. eCollection 2019. Review.


Isolation and functional characterization of a novel endogenous inverse agonist of estrogen related receptors (ERRs) from human pregnancy urine.

Ghanbari F, Hebert-Losier A, Barry J, Poirier D, Giguere V, Mader S, Philip A.

J Steroid Biochem Mol Biol. 2019 Jul;191:105352. doi: 10.1016/j.jsbmb.2019.04.001. Epub 2019 Apr 5.


Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis.

Morita M, Siddiqui N, Katsumura S, Rouya C, Larsson O, Nagashima T, Hekmatnejad B, Takahashi A, Kiyonari H, Zang M, St-Arnaud R, Oike Y, Giguère V, Topisirovic I, Okada-Hatakeyama M, Yamamoto T, Sonenberg N.

Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7973-7981. doi: 10.1073/pnas.1816023116. Epub 2019 Mar 29.


Loss of Estrogen-Related Receptor Alpha Facilitates Angiogenesis in Endothelial Cells.

Likhite N, Yadav V, Milliman EJ, Sopariwala DH, Lorca S, Narayana NP, Sheth M, Reineke EL, Giguère V, Narkar V.

Mol Cell Biol. 2019 Feb 15;39(5). pii: e00411-18. doi: 10.1128/MCB.00411-18. Print 2019 Mar 1.


Targeting EZH2 reactivates a breast cancer subtype-specific anti-metastatic transcriptional program.

Hirukawa A, Smith HW, Zuo D, Dufour CR, Savage P, Bertos N, Johnson RM, Bui T, Bourque G, Basik M, Giguère V, Park M, Muller WJ.

Nat Commun. 2018 Jun 29;9(1):2547. doi: 10.1038/s41467-018-04864-8.


Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function.

Singh BK, Sinha RA, Tripathi M, Mendoza A, Ohba K, Sy JAC, Xie SY, Zhou J, Ho JP, Chang CY, Wu Y, Giguère V, Bay BH, Vanacker JM, Ghosh S, Gauthier K, Hollenberg AN, McDonnell DP, Yen PM.

Sci Signal. 2018 Jun 26;11(536). pii: eaam5855. doi: 10.1126/scisignal.aam5855.


SREBF1 Activity Is Regulated by an AR/mTOR Nuclear Axis in Prostate Cancer.

Audet-Walsh É, Vernier M, Yee T, Laflamme C, Li S, Chen Y, Giguère V.

Mol Cancer Res. 2018 Sep;16(9):1396-1405. doi: 10.1158/1541-7786.MCR-17-0410. Epub 2018 May 21.


Divergent Role of Estrogen-Related Receptor α in Lipid- and Fasting-Induced Hepatic Steatosis in Mice.

B'chir W, Dufour CR, Ouellet C, Yan M, Tam IS, Andrzejewski S, Xia H, Nabata K, St-Pierre J, Giguère V.

Endocrinology. 2018 May 1;159(5):2153-2164. doi: 10.1210/en.2018-00115.


Canonical signaling and nuclear activity of mTOR-a teamwork effort to regulate metabolism and cell growth.

Giguère V.

FEBS J. 2018 May;285(9):1572-1588. doi: 10.1111/febs.14384. Epub 2018 Jan 31. Review.


ESRRA (estrogen-related receptor α) is a key coordinator of transcriptional and post-translational activation of autophagy to promote innate host defense.

Kim SY, Yang CS, Lee HM, Kim JK, Kim YS, Kim YR, Kim JS, Kim TS, Yuk JM, Dufour CR, Lee SH, Kim JM, Choi HS, Giguère V, Jo EK.

Autophagy. 2018;14(1):152-168. doi: 10.1080/15548627.2017.1339001. Epub 2017 Sep 1.


Nuclear mTOR acts as a transcriptional integrator of the androgen signaling pathway in prostate cancer.

Audet-Walsh É, Dufour CR, Yee T, Zouanat FZ, Yan M, Kalloghlian G, Vernier M, Caron M, Bourque G, Scarlata E, Hamel L, Brimo F, Aprikian AG, Lapointe J, Chevalier S, Giguère V.

Genes Dev. 2017 Jun 15;31(12):1228-1242. doi: 10.1101/gad.299958.117. Epub 2017 Jul 19.


MYC-dependent oxidative metabolism regulates osteoclastogenesis via nuclear receptor ERRα.

Bae S, Lee MJ, Mun SH, Giannopoulou EG, Yong-Gonzalez V, Cross JR, Murata K, Giguère V, van der Meulen M, Park-Min KH.

J Clin Invest. 2017 Jun 30;127(7):2555-2568. doi: 10.1172/JCI89935. Epub 2017 May 22.


Inverse Regulation of DHT Synthesis Enzymes 5α-Reductase Types 1 and 2 by the Androgen Receptor in Prostate Cancer.

Audet-Walsh É, Yee T, Tam IS, Giguère V.

Endocrinology. 2017 Apr 1;158(4):1015-1021. doi: 10.1210/en.2016-1926.


Androgen-Dependent Repression of ERRγ Reprograms Metabolism in Prostate Cancer.

Audet-Walsh É, Yee T, McGuirk S, Vernier M, Ouellet C, St-Pierre J, Giguère V.

Cancer Res. 2017 Jan 15;77(2):378-389. doi: 10.1158/0008-5472.CAN-16-1204. Epub 2016 Nov 7.


Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2.

Tahmasebi S, Jafarnejad SM, Tam IS, Gonatopoulos-Pournatzis T, Matta-Camacho E, Tsukumo Y, Yanagiya A, Li W, Atlasi Y, Caron M, Braunschweig U, Pearl D, Khoutorsky A, Gkogkas CG, Nadon R, Bourque G, Yang XJ, Tian B, Stunnenberg HG, Yamanaka Y, Blencowe BJ, Giguère V, Sonenberg N.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12360-12367. Epub 2016 Oct 24.


ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer.

Deblois G, Smith HW, Tam IS, Gravel SP, Caron M, Savage P, Labbé DP, Bégin LR, Tremblay ML, Park M, Bourque G, St-Pierre J, Muller WJ, Giguère V.

Nat Commun. 2016 Jul 12;7:12156. doi: 10.1038/ncomms12156.


Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRα.

Yan M, Audet-Walsh É, Manteghi S, Dufour CR, Walker B, Baba M, St-Pierre J, Giguère V, Pause A.

Genes Dev. 2016 May 1;30(9):1034-46. doi: 10.1101/gad.281410.116.


The PGC-1α/ERRα Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast Cancer.

Audet-Walsh É, Papadopoli DJ, Gravel SP, Yee T, Bridon G, Caron M, Bourque G, Giguère V, St-Pierre J.

Cell Rep. 2016 Feb 2;14(4):920-931. doi: 10.1016/j.celrep.2015.12.086. Epub 2016 Jan 21.


Orphan Nuclear Receptor ERRα Controls Macrophage Metabolic Signaling and A20 Expression to Negatively Regulate TLR-Induced Inflammation.

Yuk JM, Kim TS, Kim SY, Lee HM, Han J, Dufour CR, Kim JK, Jin HS, Yang CS, Park KS, Lee CH, Kim JM, Kweon GR, Choi HS, Vanacker JM, Moore DD, Giguère V, Jo EK.

Immunity. 2015 Jul 21;43(1):80-91. doi: 10.1016/j.immuni.2015.07.003.


There and back again: The journey of the estrogen-related receptors in the cancer realm.

Tam IS, Giguère V.

J Steroid Biochem Mol Biol. 2016 Mar;157:13-9. doi: 10.1016/j.jsbmb.2015.06.009. Epub 2015 Jul 4. Review.


Editorial: What's in a Name, or the Impact of Misnomers in Endocrine Research.

Giguère V.

Mol Endocrinol. 2015 Jun;29(6):789-90. doi: 10.1210/me.2015-1119. No abstract available.


Estrogen-related receptor α (ERRα) and ERRγ are essential coordinators of cardiac metabolism and function.

Wang T, McDonald C, Petrenko NB, Leblanc M, Wang T, Giguere V, Evans RM, Patel VV, Pei L.

Mol Cell Biol. 2015 Apr;35(7):1281-98. doi: 10.1128/MCB.01156-14. Epub 2015 Jan 26.


The multiple universes of estrogen-related receptor α and γ in metabolic control and related diseases.

Audet-Walsh É, Giguére V.

Acta Pharmacol Sin. 2015 Jan;36(1):51-61. doi: 10.1038/aps.2014.121. Epub 2014 Dec 15. Review.


Inactivation of RARβ inhibits Wnt1-induced mammary tumorigenesis by suppressing epithelial-mesenchymal transitions.

Liu X, Giguère V.

Nucl Recept Signal. 2014 Nov 4;12:e004. doi: 10.1621/nrs.12004. eCollection 2014.


Estrogen-related receptor-α coordinates transcriptional programs essential for exercise tolerance and muscle fitness.

Perry MC, Dufour CR, Tam IS, B'chir W, Giguère V.

Mol Endocrinol. 2014 Dec;28(12):2060-71. doi: 10.1210/me.2014-1281.


Estrogen-related receptor α decreases RHOA stability to induce orientated cell migration.

Sailland J, Tribollet V, Forcet C, Billon C, Barenton B, Carnesecchi J, Bachmann A, Gauthier KC, Yu S, Giguère V, Chan FL, Vanacker JM.

Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15108-13. doi: 10.1073/pnas.1402094111. Epub 2014 Oct 6.


ERBB2 deficiency alters an E2F-1-dependent adaptive stress response and leads to cardiac dysfunction.

Perry MC, Dufour CR, Eichner LJ, Tsang DW, Deblois G, Muller WJ, Giguère V.

Mol Cell Biol. 2014 Dec 1;34(23):4232-43. doi: 10.1128/MCB.00895-14. Epub 2014 Sep 22.


Estrogen receptor mutations in breast cancer-an anticipated "rediscovery?".

Giguère V.

Mol Endocrinol. 2014 Apr;28(4):427-8. doi: 10.1210/me.2014-1071. No abstract available.


Prostate cancer genetic-susceptibility locus on chromosome 20q13 is amplified and coupled to androgen receptor-regulation in metastatic tumors.

Labbé DP, Nowak DG, Deblois G, Lessard L, Giguère V, Trotman LC, Tremblay ML.

Mol Cancer Res. 2014 Feb;12(2):184-9. doi: 10.1158/1541-7786.MCR-13-0477. Epub 2013 Dec 30.


PGC-1α supports glutamine metabolism in breast cancer.

McGuirk S, Gravel SP, Deblois G, Papadopoli DJ, Faubert B, Wegner A, Hiller K, Avizonis D, Akavia UD, Jones RG, Giguère V, St-Pierre J.

Cancer Metab. 2013 Dec 5;1(1):22. doi: 10.1186/2049-3002-1-22.


Loss of estrogen-related receptor α promotes hepatocarcinogenesis development via metabolic and inflammatory disturbances.

Hong EJ, Levasseur MP, Dufour CR, Perry MC, Giguère V.

Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17975-80. doi: 10.1073/pnas.1315319110. Epub 2013 Oct 14.


β-Catenin signaling is a critical event in ErbB2-mediated mammary tumor progression.

Schade B, Lesurf R, Sanguin-Gendreau V, Bui T, Deblois G, O'Toole SA, Millar EK, Zardawi SJ, Lopez-Knowles E, Sutherland RL, Giguère V, Kahn M, Hallett M, Muller WJ.

Cancer Res. 2013 Jul 15;73(14):4474-87. doi: 10.1158/0008-5472.CAN-12-3925. Epub 2013 May 29.


Molecular and genetic crosstalks between mTOR and ERRα are key determinants of rapamycin-induced nonalcoholic fatty liver.

Chaveroux C, Eichner LJ, Dufour CR, Shatnawi A, Khoutorsky A, Bourque G, Sonenberg N, Giguère V.

Cell Metab. 2013 Apr 2;17(4):586-98. doi: 10.1016/j.cmet.2013.03.003.


ELF3 is a repressor of androgen receptor action in prostate cancer cells.

Shatnawi A, Norris JD, Chaveroux C, Jasper JS, Sherk AB, McDonnell DP, Giguère V.

Oncogene. 2014 Feb 13;33(7):862-71. doi: 10.1038/onc.2013.15. Epub 2013 Feb 25.


The PGC-1/ERR signaling axis in cancer.

Deblois G, St-Pierre J, Giguère V.

Oncogene. 2013 Jul 25;32(30):3483-90. doi: 10.1038/onc.2012.529. Epub 2012 Dec 3. Review.


Oestrogen-related receptors in breast cancer: control of cellular metabolism and beyond.

Deblois G, Giguère V.

Nat Rev Cancer. 2013 Jan;13(1):27-36. doi: 10.1038/nrc3396. Epub 2012 Nov 29. Review.


PTP1B is an androgen receptor-regulated phosphatase that promotes the progression of prostate cancer.

Lessard L, Labbé DP, Deblois G, Bégin LR, Hardy S, Mes-Masson AM, Saad F, Trotman LC, Giguère V, Tremblay ML.

Cancer Res. 2012 Mar 15;72(6):1529-37. doi: 10.1158/0008-5472.CAN-11-2602. Epub 2012 Jan 26.


Cancer: Reprogramming clinical outcome.

Deblois G, Giguère V.

Nature. 2012 Jan 18;481(7381):275-6. doi: 10.1038/481275a. No abstract available.


Estrogen-related receptor α, the molecular clock, and transcriptional control of metabolic outputs.

Giguère V, Dufour CR, Eichner LJ, Deblois G, Cermakian N.

Cold Spring Harb Symp Quant Biol. 2011;76:57-61. doi: 10.1101/sqb.2011.76.011031. Epub 2011 Dec 16. Review.


Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation.

Michalek RD, Gerriets VA, Nichols AG, Inoue M, Kazmin D, Chang CY, Dwyer MA, Nelson ER, Pollizzi KN, Ilkayeva O, Giguere V, Zuercher WJ, Powell JD, Shinohara ML, McDonnell DP, Rathmell JC.

Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18348-53. doi: 10.1073/pnas.1108856108. Epub 2011 Oct 31.


Genomic convergence among ERRα, PROX1, and BMAL1 in the control of metabolic clock outputs.

Dufour CR, Levasseur MP, Pham NH, Eichner LJ, Wilson BJ, Charest-Marcotte A, Duguay D, Poirier-Héon JF, Cermakian N, Giguère V.

PLoS Genet. 2011 Jun;7(6):e1002143. doi: 10.1371/journal.pgen.1002143. Epub 2011 Jun 23.


Interferon regulatory factor 8 regulates pathways for antigen presentation in myeloid cells and during tuberculosis.

Marquis JF, Kapoustina O, Langlais D, Ruddy R, Dufour CR, Kim BH, MacMicking JD, Giguère V, Gros P.

PLoS Genet. 2011 Jun;7(6):e1002097. doi: 10.1371/journal.pgen.1002097. Epub 2011 Jun 23.


Nuclear localization of maspin is essential for its inhibition of tumor growth and metastasis.

Goulet B, Kennette W, Ablack A, Postenka CO, Hague MN, Mymryk JS, Tuck AB, Giguère V, Chambers AF, Lewis JD.

Lab Invest. 2011 Aug;91(8):1181-7. doi: 10.1038/labinvest.2011.66. Epub 2011 Apr 18.


Estrogen related receptors (ERRs): a new dawn in transcriptional control of mitochondrial gene networks.

Eichner LJ, Giguère V.

Mitochondrion. 2011 Jul;11(4):544-52. doi: 10.1016/j.mito.2011.03.121. Epub 2011 Apr 7. Review.


Stromal retinoic acid receptor beta promotes mammary gland tumorigenesis.

Liu X, Nugoli M, Laferrière J, Saleh SM, Rodrigue-Gervais IG, Saleh M, Park M, Hallett MT, Muller WJ, Giguère V.

Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):774-9. doi: 10.1073/pnas.1011845108. Epub 2010 Dec 27.


Functional and physiological genomics of estrogen-related receptors (ERRs) in health and disease.

Deblois G, Giguère V.

Biochim Biophys Acta. 2011 Aug;1812(8):1032-40. doi: 10.1016/j.bbadis.2010.12.009. Epub 2010 Dec 21. Review.


Transcriptional control of the ERBB2 amplicon by ERRalpha and PGC-1beta promotes mammary gland tumorigenesis.

Deblois G, Chahrour G, Perry MC, Sylvain-Drolet G, Muller WJ, Giguère V.

Cancer Res. 2010 Dec 15;70(24):10277-87. doi: 10.1158/0008-5472.CAN-10-2840. Epub 2010 Oct 20. Erratum in: Cancer Res. 2011 Feb 15;71(4):1508.


miR-378(∗) mediates metabolic shift in breast cancer cells via the PGC-1β/ERRγ transcriptional pathway.

Eichner LJ, Perry MC, Dufour CR, Bertos N, Park M, St-Pierre J, Giguère V.

Cell Metab. 2010 Oct 6;12(4):352-361. doi: 10.1016/j.cmet.2010.09.002.


An acetylation switch modulates the transcriptional activity of estrogen-related receptor alpha.

Wilson BJ, Tremblay AM, Deblois G, Sylvain-Drolet G, Giguère V.

Mol Endocrinol. 2010 Jul;24(7):1349-58. doi: 10.1210/me.2009-0441. Epub 2010 May 19.

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