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Items: 1 to 50 of 72

1.

Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition.

Kalinski AL, Kar AN, Craver J, Tosolini AP, Sleigh JN, Lee SJ, Hawthorne A, Brito-Vargas P, Miller-Randolph S, Passino R, Shi L, Wong VSC, Picci C, Smith DS, Willis DE, Havton LA, Schiavo G, Giger RJ, Langley B, Twiss JL.

J Cell Biol. 2019 Jun 3;218(6):1871-1890. doi: 10.1083/jcb.201702187. Epub 2019 May 8.

PMID:
31068376
2.

Protective role of the lipid phosphatase Fig4 in the adult nervous system.

Mironova YA, Lin JP, Kalinski AL, Huffman LD, Lenk GM, Havton LA, Meisler MH, Giger RJ.

Hum Mol Genet. 2018 Jul 15;27(14):2443-2453. doi: 10.1093/hmg/ddy145.

PMID:
29688489
3.

PlexinA2 Forward Signaling through Rap1 GTPases Regulates Dentate Gyrus Development and Schizophrenia-like Behaviors.

Zhao XF, Kohen R, Parent R, Duan Y, Fisher GL, Korn MJ, Ji L, Wan G, Jin J, Püschel AW, Dolan DF, Parent JM, Corfas G, Murphy GG, Giger RJ.

Cell Rep. 2018 Jan 9;22(2):456-470. doi: 10.1016/j.celrep.2017.12.044.

4.
5.

Neuropilin-1 promotes Hedgehog signaling through a novel cytoplasmic motif.

Pinskey JM, Franks NE, McMellen AN, Giger RJ, Allen BL.

J Biol Chem. 2017 Sep 15;292(37):15192-15204. doi: 10.1074/jbc.M117.783845. Epub 2017 Jun 30.

6.

Nogo receptor blockade overcomes remyelination failure after white matter stroke and stimulates functional recovery in aged mice.

Sozmen EG, Rosenzweig S, Llorente IL, DiTullio DJ, Machnicki M, Vinters HV, Havton LA, Giger RJ, Hinman JD, Carmichael ST.

Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):E8453-E8462. doi: 10.1073/pnas.1615322113. Epub 2016 Dec 12.

7.

Reassembly of Excitable Domains after CNS Axon Regeneration.

Marin MA, de Lima S, Gilbert HY, Giger RJ, Benowitz L, Rasband MN.

J Neurosci. 2016 Aug 31;36(35):9148-60. doi: 10.1523/JNEUROSCI.1747-16.2016.

8.

An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK.

Hao Y, Frey E, Yoon C, Wong H, Nestorovski D, Holzman LB, Giger RJ, DiAntonio A, Collins C.

Elife. 2016 Jun 7;5. pii: e14048. doi: 10.7554/eLife.14048.

9.

Semaphorin 3A is a retrograde cell death signal in developing sympathetic neurons.

Wehner AB, Abdesselem H, Dickendesher TL, Imai F, Yoshida Y, Giger RJ, Pierchala BA.

Development. 2016 May 1;143(9):1560-70. doi: 10.1242/dev.134627.

10.

PI(3,5)P2 biosynthesis regulates oligodendrocyte differentiation by intrinsic and extrinsic mechanisms.

Mironova YA, Lenk GM, Lin JP, Lee SJ, Twiss JL, Vaccari I, Bolino A, Havton LA, Min SH, Abrams CS, Shrager P, Meisler MH, Giger RJ.

Elife. 2016 Mar 23;5. pii: e13023. doi: 10.7554/eLife.13023.

11.

Stable biomarker for plastic microglia.

Segal BM, Giger RJ.

Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3130-2. doi: 10.1073/pnas.1601669113. Epub 2016 Mar 10. No abstract available.

12.

Inside Out: Core Network of Transcription Factors Drives Axon Regeneration.

Yoon C, Giger RJ.

Neuron. 2016 Mar 2;89(5):881-4. doi: 10.1016/j.neuron.2016.02.022.

13.

Rescue of neurodegeneration in the Fig4 null mouse by a catalytically inactive FIG4 transgene.

Lenk GM, Frei CM, Miller AC, Wallen RC, Mironova YA, Giger RJ, Meisler MH.

Hum Mol Genet. 2016 Jan 15;25(2):340-7. doi: 10.1093/hmg/ddv480. Epub 2015 Nov 24.

14.

Th Cell Diversity in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis.

Carbajal KS, Mironova Y, Ulrich-Lewis JT, Kulkarni D, Grifka-Walk HM, Huber AK, Shrager P, Giger RJ, Segal BM.

J Immunol. 2015 Sep 15;195(6):2552-9. doi: 10.4049/jimmunol.1501097. Epub 2015 Aug 3.

15.

Insights into the physiological role of CNS regeneration inhibitors.

Baldwin KT, Giger RJ.

Front Mol Neurosci. 2015 Jun 11;8:23. doi: 10.3389/fnmol.2015.00023. eCollection 2015. Review.

16.

Neuroinflammation triggered by β-glucan/dectin-1 signaling enables CNS axon regeneration.

Baldwin KT, Carbajal KS, Segal BM, Giger RJ.

Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2581-6. doi: 10.1073/pnas.1423221112. Epub 2015 Feb 9.

17.

Semaphorin 5A inhibits synaptogenesis in early postnatal- and adult-born hippocampal dentate granule cells.

Duan Y, Wang SH, Song J, Mironova Y, Ming GL, Kolodkin AL, Giger RJ.

Elife. 2014 Oct 14;3. doi: 10.7554/eLife.04390.

18.

Loss of Fig4 in both Schwann cells and motor neurons contributes to CMT4J neuropathy.

Vaccari I, Carbone A, Previtali SC, Mironova YA, Alberizzi V, Noseda R, Rivellini C, Bianchi F, Del Carro U, D'Antonio M, Lenk GM, Wrabetz L, Giger RJ, Meisler MH, Bolino A.

Hum Mol Genet. 2015 Jan 15;24(2):383-96. doi: 10.1093/hmg/ddu451. Epub 2014 Sep 3.

19.

Post-transcriptional regulation of GABAB receptor and GIRK1 channels by Nogo receptor 1.

Murthy R, Kim J, Sun X, Giger RJ, Fink DJ, Mata M.

Mol Brain. 2013 Jul 6;6:30. doi: 10.1186/1756-6606-6-30.

20.

Where no synapses go: gatekeepers of circuit remodeling and synaptic strength.

Mironova YA, Giger RJ.

Trends Neurosci. 2013 Jun;36(6):363-73. doi: 10.1016/j.tins.2013.04.003. Epub 2013 May 2. Review.

21.

LDL receptor-related protein-1 is a sialic-acid-independent receptor for myelin-associated glycoprotein that functions in neurite outgrowth inhibition by MAG and CNS myelin.

Stiles TL, Dickendesher TL, Gaultier A, Fernandez-Castaneda A, Mantuano E, Giger RJ, Gonias SL.

J Cell Sci. 2013 Jan 1;126(Pt 1):209-20. doi: 10.1242/jcs.113191. Epub 2012 Nov 6.

22.

Neuronal expression of Fig4 is both necessary and sufficient to prevent spongiform neurodegeneration.

Ferguson CJ, Lenk GM, Jones JM, Grant AE, Winters JJ, Dowling JJ, Giger RJ, Meisler MH.

Hum Mol Genet. 2012 Aug 15;21(16):3525-34. doi: 10.1093/hmg/dds179. Epub 2012 May 11.

23.

NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans.

Dickendesher TL, Baldwin KT, Mironova YA, Koriyama Y, Raiker SJ, Askew KL, Wood A, Geoffroy CG, Zheng B, Liepmann CD, Katagiri Y, Benowitz LI, Geller HM, Giger RJ.

Nat Neurosci. 2012 Mar 11;15(5):703-12. doi: 10.1038/nn.3070.

24.

The nogo receptor family restricts synapse number in the developing hippocampus.

Wills ZP, Mandel-Brehm C, Mardinly AR, McCord AE, Giger RJ, Greenberg ME.

Neuron. 2012 Feb 9;73(3):466-81. doi: 10.1016/j.neuron.2011.11.029.

25.

Congenital CNS hypomyelination in the Fig4 null mouse is rescued by neuronal expression of the PI(3,5)P(2) phosphatase Fig4.

Winters JJ, Ferguson CJ, Lenk GM, Giger-Mateeva VI, Shrager P, Meisler MH, Giger RJ.

J Neurosci. 2011 Nov 30;31(48):17736-51. doi: 10.1523/JNEUROSCI.1482-11.2011.

26.

Class 5 transmembrane semaphorins control selective Mammalian retinal lamination and function.

Matsuoka RL, Chivatakarn O, Badea TC, Samuels IS, Cahill H, Katayama K, Kumar SR, Suto F, Chédotal A, Peachey NS, Nathans J, Yoshida Y, Giger RJ, Kolodkin AL.

Neuron. 2011 Aug 11;71(3):460-73. doi: 10.1016/j.neuron.2011.06.009.

27.

VEGF shows its attractive side at the midline.

Dickendesher TL, Giger RJ.

Neuron. 2011 Jun 9;70(5):808-12. doi: 10.1016/j.neuron.2011.05.020.

28.

Pathogenic mechanism of the FIG4 mutation responsible for Charcot-Marie-Tooth disease CMT4J.

Lenk GM, Ferguson CJ, Chow CY, Jin N, Jones JM, Grant AE, Zolov SN, Winters JJ, Giger RJ, Dowling JJ, Weisman LS, Meisler MH.

PLoS Genet. 2011 Jun;7(6):e1002104. doi: 10.1371/journal.pgen.1002104. Epub 2011 Jun 2.

29.

Crystal structure of the Nogo-receptor-2.

Semavina M, Saha N, Kolev MV, Goldgur Y, Giger RJ, Himanen JP, Nikolov DB.

Protein Sci. 2011 Apr;20(4):684-9. doi: 10.1002/pro.597.

30.

Decorin, erythroblastic leukaemia viral oncogene homologue B4 and signal transducer and activator of transcription 3 regulation of semaphorin 3A in central nervous system scar tissue.

Minor KH, Bournat JC, Toscano N, Giger RJ, Davies SJ.

Brain. 2011 Apr;134(Pt 4):1140-55. doi: 10.1093/brain/awq304. Epub 2010 Nov 28.

31.

An age-related sprouting transcriptome provides molecular control of axonal sprouting after stroke.

Li S, Overman JJ, Katsman D, Kozlov SV, Donnelly CJ, Twiss JL, Giger RJ, Coppola G, Geschwind DH, Carmichael ST.

Nat Neurosci. 2010 Dec;13(12):1496-504. doi: 10.1038/nn.2674. Epub 2010 Nov 7.

32.

Oligodendrocyte-myelin glycoprotein and Nogo negatively regulate activity-dependent synaptic plasticity.

Raiker SJ, Lee H, Baldwin KT, Duan Y, Shrager P, Giger RJ.

J Neurosci. 2010 Sep 15;30(37):12432-45. doi: 10.1523/JNEUROSCI.0895-10.2010.

33.

Guidance molecules in axon regeneration.

Giger RJ, Hollis ER 2nd, Tuszynski MH.

Cold Spring Harb Perspect Biol. 2010 Jul;2(7):a001867. doi: 10.1101/cshperspect.a001867. Epub 2010 Jun 2. Review.

34.

A new role for RPTPsigma in spinal cord injury: signaling chondroitin sulfate proteoglycan inhibition.

Duan Y, Giger RJ.

Sci Signal. 2010 Feb 23;3(110):pe6. doi: 10.1126/scisignal.3110pe6.

PMID:
20179269
35.

A large-scale chemical screen for regulators of the arginase 1 promoter identifies the soy isoflavone daidzeinas a clinically approved small molecule that can promote neuronal protection or regeneration via a cAMP-independent pathway.

Ma TC, Campana A, Lange PS, Lee HH, Banerjee K, Bryson JB, Mahishi L, Alam S, Giger RJ, Barnes S, Morris SM Jr, Willis DE, Twiss JL, Filbin MT, Ratan RR.

J Neurosci. 2010 Jan 13;30(2):739-48. doi: 10.1523/JNEUROSCI.5266-09.2010.

36.

Semaphorin function in neural plasticity and disease.

Pasterkamp RJ, Giger RJ.

Curr Opin Neurobiol. 2009 Jun;19(3):263-74. doi: 10.1016/j.conb.2009.06.001. Epub 2009 Jun 21. Review.

37.

Molecular basis of the interactions of the Nogo-66 receptor and its homolog NgR2 with myelin-associated glycoprotein: development of NgROMNI-Fc, a novel antagonist of CNS myelin inhibition.

Robak LA, Venkatesh K, Lee H, Raiker SJ, Duan Y, Lee-Osbourne J, Hofer T, Mage RG, Rader C, Giger RJ.

J Neurosci. 2009 May 6;29(18):5768-83. doi: 10.1523/JNEUROSCI.4935-08.2009.

38.

Mechanisms of CNS myelin inhibition: evidence for distinct and neuronal cell type specific receptor systems.

Giger RJ, Venkatesh K, Chivatakarn O, Raiker SJ, Robak L, Hofer T, Lee H, Rader C.

Restor Neurol Neurosci. 2008;26(2-3):97-115. Review.

PMID:
18820405
39.

Synaptic function for the Nogo-66 receptor NgR1: regulation of dendritic spine morphology and activity-dependent synaptic strength.

Lee H, Raiker SJ, Venkatesh K, Geary R, Robak LA, Zhang Y, Yeh HH, Shrager P, Giger RJ.

J Neurosci. 2008 Mar 12;28(11):2753-65. doi: 10.1523/JNEUROSCI.5586-07.2008.

40.
41.
42.

Chimeric rabbit/human Fab and IgG specific for members of the Nogo-66 receptor family selected for species cross-reactivity with an improved phage display vector.

Hofer T, Tangkeangsirisin W, Kennedy MG, Mage RG, Raiker SJ, Venkatesh K, Lee H, Giger RJ, Rader C.

J Immunol Methods. 2007 Jan 10;318(1-2):75-87. Epub 2006 Nov 7.

43.

Probing microtubule +TIPs: regulation of axon branching.

Kornack DR, Giger RJ.

Curr Opin Neurobiol. 2005 Feb;15(1):58-66. Review.

PMID:
15721745
44.

The Nogo-66 receptor homolog NgR2 is a sialic acid-dependent receptor selective for myelin-associated glycoprotein.

Venkatesh K, Chivatakarn O, Lee H, Joshi PS, Kantor DB, Newman BA, Mage R, Rader C, Giger RJ.

J Neurosci. 2005 Jan 26;25(4):808-22.

45.

Semaphorin 5A is a bifunctional axon guidance cue regulated by heparan and chondroitin sulfate proteoglycans.

Kantor DB, Chivatakarn O, Peer KL, Oster SF, Inatani M, Hansen MJ, Flanagan JG, Yamaguchi Y, Sretavan DW, Giger RJ, Kolodkin AL.

Neuron. 2004 Dec 16;44(6):961-75.

46.

Transient downregulation of Sema3A mRNA in a rat model for temporal lobe epilepsy. A novel molecular event potentially contributing to mossy fiber sprouting.

Holtmaat AJ, Gorter JA, De Wit J, Tolner EA, Spijker S, Giger RJ, Lopes da Silva FH, Verhaagen J.

Exp Neurol. 2003 Jul;182(1):142-50.

PMID:
12821384
47.

Neuropilin-2 mediates axonal fasciculation, zonal segregation, but not axonal convergence, of primary accessory olfactory neurons.

Cloutier JF, Giger RJ, Koentges G, Dulac C, Kolodkin AL, Ginty DD.

Neuron. 2002 Mar 14;33(6):877-92.

48.

Silencing the siren: guidance cue hierarchies at the CNS midline.

Giger RJ, Kolodkin AL.

Cell. 2001 Apr 6;105(1):1-4. Review. No abstract available.

49.

Ectopic adenoviral vector-directed expression of Sema3A in organotypic spinal cord explants inhibits growth of primary sensory afferents.

Pasterkamp RJ, Giger RJ, Baker RE, Hermens WT, Verhaagen J.

Dev Biol. 2000 Apr 15;220(2):129-41.

50.

Frazzled precision guides axons.

Giger RJ, Kolodkin AL.

Nature. 2000 Aug 24;406(6798):841, 843. No abstract available.

PMID:
10972274

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