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Items: 15

1.

The force-dependent mechanism of DnaK-mediated mechanical folding.

Perales-Calvo J, Giganti D, Stirnemann G, Garcia-Manyes S.

Sci Adv. 2018 Feb 9;4(2):eaaq0243. doi: 10.1126/sciadv.aaq0243. eCollection 2018 Feb.

2.

Disulfide isomerization reactions in titin immunoglobulin domains enable a mode of protein elasticity.

Giganti D, Yan K, Badilla CL, Fernandez JM, Alegre-Cebollada J.

Nat Commun. 2018 Jan 12;9(1):185. doi: 10.1038/s41467-017-02528-7.

3.

Single-molecule Force Spectroscopy Predicts a Misfolded, Domain-swapped Conformation in human γD-Crystallin Protein.

Garcia-Manyes S, Giganti D, Badilla CL, Lezamiz A, Perales-Calvo J, Beedle AE, Fernández JM.

J Biol Chem. 2016 Feb 19;291(8):4226-35. doi: 10.1074/jbc.M115.673871. Epub 2015 Dec 24.

4.

Secondary structure reshuffling modulates glycosyltransferase function at the membrane.

Giganti D, Albesa-Jové D, Urresti S, Rodrigo-Unzueta A, Martínez MA, Comino N, Barilone N, Bellinzoni M, Chenal A, Guerin ME, Alzari PM.

Nat Chem Biol. 2015 Jan;11(1):16-8. doi: 10.1038/nchembio.1694. Epub 2014 Nov 17.

PMID:
25402770
5.

A novel Plasmodium-specific prodomain fold regulates the malaria drug target SUB1 subtilase.

Giganti D, Bouillon A, Tawk L, Robert F, Martinez M, Crublet E, Weber P, Girard-Blanc C, Petres S, Haouz A, Hernandez JF, Mercereau-Puijalon O, Alzari PM, Barale JC.

Nat Commun. 2014 Sep 10;5:4833. doi: 10.1038/ncomms5833.

PMID:
25204226
6.

S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding.

Alegre-Cebollada J, Kosuri P, Giganti D, Eckels E, Rivas-Pardo JA, Hamdani N, Warren CM, Solaro RJ, Linke WA, Fernández JM.

Cell. 2014 Mar 13;156(6):1235-1246. doi: 10.1016/j.cell.2014.01.056.

7.

Structure-function relationships of membrane-associated GT-B glycosyltransferases.

Albesa-Jové D, Giganti D, Jackson M, Alzari PM, Guerin ME.

Glycobiology. 2014 Feb;24(2):108-24. doi: 10.1093/glycob/cwt101. Epub 2013 Nov 18. Review.

8.

Conformational plasticity of the essential membrane-associated mannosyltransferase PimA from mycobacteria.

Giganti D, Alegre-Cebollada J, Urresti S, Albesa-Jové D, Rodrigo-Unzueta A, Comino N, Kachala M, López-Fernández S, Svergun DI, Fernández JM, Guerin ME.

J Biol Chem. 2013 Oct 11;288(41):29797-808. doi: 10.1074/jbc.M113.462705. Epub 2013 Aug 20.

9.

In Silico screening on the three-dimensional model of the Plasmodium vivax SUB1 protease leads to the validation of a novel anti-parasite compound.

Bouillon A, Giganti D, Benedet C, Gorgette O, Pêtres S, Crublet E, Girard-Blanc C, Witkowski B, Ménard D, Nilges M, Mercereau-Puijalon O, Stoven V, Barale JC.

J Biol Chem. 2013 Jun 21;288(25):18561-73. doi: 10.1074/jbc.M113.456764. Epub 2013 May 7.

10.

Elasticity, structure, and relaxation of extended proteins under force.

Stirnemann G, Giganti D, Fernandez JM, Berne BJ.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3847-52. doi: 10.1073/pnas.1300596110. Epub 2013 Feb 13.

11.

Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance.

Manina G, Bellinzoni M, Pasca MR, Neres J, Milano A, Ribeiro AL, Buroni S, Skovierová H, Dianišková P, Mikušová K, Marák J, Makarov V, Giganti D, Haouz A, Lucarelli AP, Degiacomi G, Piazza A, Chiarelli LR, De Rossi E, Salina E, Cole ST, Alzari PM, Riccardi G.

Mol Microbiol. 2010 Sep;77(5):1172-85. doi: 10.1111/j.1365-2958.2010.07277.x.

12.

Comparative evaluation of 3D virtual ligand screening methods: impact of the molecular alignment on enrichment.

Giganti D, Guillemain H, Spadoni JL, Nilges M, Zagury JF, Montes M.

J Chem Inf Model. 2010 Jun 28;50(6):992-1004. doi: 10.1021/ci900507g.

PMID:
20527883
13.

Substrate-induced conformational changes in the essential peripheral membrane-associated mannosyltransferase PimA from mycobacteria: implications for catalysis.

Guerin ME, Schaeffer F, Chaffotte A, Gest P, Giganti D, Korduláková J, van der Woerd M, Jackson M, Alzari PM.

J Biol Chem. 2009 Aug 7;284(32):21613-25. doi: 10.1074/jbc.M109.003947. Epub 2009 Jun 11.

14.

Molecular recognition and interfacial catalysis by the essential phosphatidylinositol mannosyltransferase PimA from mycobacteria.

Guerin ME, Kordulakova J, Schaeffer F, Svetlikova Z, Buschiazzo A, Giganti D, Gicquel B, Mikusova K, Jackson M, Alzari PM.

J Biol Chem. 2007 Jul 13;282(28):20705-14. Epub 2007 May 16.

15.

Three dimensional structure and implications for the catalytic mechanism of 6-phosphogluconolactonase from Trypanosoma brucei.

Delarue M, Duclert-Savatier N, Miclet E, Haouz A, Giganti D, Ouazzani J, Lopez P, Nilges M, Stoven V.

J Mol Biol. 2007 Feb 23;366(3):868-81. Epub 2006 Nov 22.

PMID:
17196981

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