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Stem Cell-Derived Exosomes Protect Astrocyte Cultures From in vitro Ischemia and Decrease Injury as Post-stroke Intravenous Therapy.

Sun X, Jung JH, Arvola O, Santoso MR, Giffard RG, Yang PC, Stary CM.

Front Cell Neurosci. 2019 Sep 3;13:394. doi: 10.3389/fncel.2019.00394. eCollection 2019.


Postinjury Inhibition of miR-181a Promotes Restoration of Hippocampal CA1 Neurons after Transient Forebrain Ischemia in Rats.

Griffiths BB, Ouyang YB, Xu L, Sun X, Giffard RG, Stary CM.

eNeuro. 2019 Aug 29;6(4). pii: ENEURO.0002-19.2019. doi: 10.1523/ENEURO.0002-19.2019. Print 2019 Jul/Aug.


Nursing Markedly Protects Postpartum Mice From Stroke: Associated Central and Peripheral Neuroimmune Changes and a Role for Oxytocin.

Stary CM, Xu L, Voloboueva LA, Alcántara-Hernández M, Arvola OJ, Idoyaga J, Giffard RG.

Front Neurosci. 2019 Jul 8;13:609. doi: 10.3389/fnins.2019.00609. eCollection 2019.


Pre-treatment with microRNA-181a Antagomir Prevents Loss of Parvalbumin Expression and Preserves Novel Object Recognition Following Mild Traumatic Brain Injury.

Griffiths BB, Sahbaie P, Rao A, Arvola O, Xu L, Liang D, Ouyang Y, Clark DJ, Giffard RG, Stary CM.

Neuromolecular Med. 2019 Jun;21(2):170-181. doi: 10.1007/s12017-019-08532-y. Epub 2019 Mar 21.


Role of Myeloid Lineage Cell Autophagy in Ischemic Brain Injury.

Kotoda M, Furukawa H, Miyamoto T, Korai M, Shikata F, Kuwabara A, Xiong X, Rutledge C, Giffard RG, Hashimoto T.

Stroke. 2018 Jun;49(6):1488-1495. doi: 10.1161/STROKEAHA.117.018637. Epub 2018 May 10.


MicroRNA Changes in Preconditioning-Induced Neuroprotection.

Bell JD, Cho JE, Giffard RG.

Transl Stroke Res. 2017 Dec;8(6):585-596. doi: 10.1007/s12975-017-0547-1. Epub 2017 Jun 23. Review.


Inhibition of miR-181a protects female mice from transient focal cerebral ischemia by targeting astrocyte estrogen receptor-α.

Stary CM, Xu L, Li L, Sun X, Ouyang YB, Xiong X, Zhao J, Giffard RG.

Mol Cell Neurosci. 2017 Jul;82:118-125. doi: 10.1016/j.mcn.2017.05.004. Epub 2017 May 15.


High Dose Gamma Radiation Selectively Reduces GABAA-slow Inhibition.

Dagne BA, Sunay MK, Cayla NS, Ouyang YB, Knox SJ, Giffard RG, Adler JR, Maciver B.

Cureus. 2017 Mar 4;9(3):e1076. doi: 10.7759/cureus.1076.


Gpr124 is essential for blood-brain barrier integrity in central nervous system disease.

Chang J, Mancuso MR, Maier C, Liang X, Yuki K, Yang L, Kwong JW, Wang J, Rao V, Vallon M, Kosinski C, Zhang JJ, Mah AT, Xu L, Li L, Gholamin S, Reyes TF, Li R, Kuhnert F, Han X, Yuan J, Chiou SH, Brettman AD, Daly L, Corney DC, Cheshier SH, Shortliffe LD, Wu X, Snyder M, Chan P, Giffard RG, Chang HY, Andreasson K, Kuo CJ.

Nat Med. 2017 Apr;23(4):450-460. doi: 10.1038/nm.4309. Epub 2017 Mar 13.


Distinct Effects of miR-210 Reduction on Neurogenesis: Increased Neuronal Survival of Inflammation But Reduced Proliferation Associated with Mitochondrial Enhancement.

Voloboueva LA, Sun X, Xu L, Ouyang YB, Giffard RG.

J Neurosci. 2017 Mar 15;37(11):3072-3084. doi: 10.1523/JNEUROSCI.1777-16.2017. Epub 2017 Feb 10.


miR-29a differentially regulates cell survival in astrocytes from cornu ammonis 1 and dentate gyrus by targeting VDAC1.

Stary CM, Sun X, Ouyang Y, Li L, Giffard RG.

Mitochondrion. 2016 Sep;30:248-54. doi: 10.1016/j.mito.2016.08.013. Epub 2016 Aug 21.


Astrocytes Protect against Isoflurane Neurotoxicity by Buffering pro-brain-derived Neurotrophic Factor.

Stary CM, Sun X, Giffard RG.

Anesthesiology. 2015 Oct;123(4):810-9. doi: 10.1097/ALN.0000000000000824.


Physiologically normal 5% O2 supports neuronal differentiation and resistance to inflammatory injury in neural stem cell cultures.

Sun X, Voloboueva LA, Stary CM, Giffard RG.

J Neurosci Res. 2015 Nov;93(11):1703-12. doi: 10.1002/jnr.23615. Epub 2015 Jul 3.


IL-4 Is Required for Sex Differences in Vulnerability to Focal Ischemia in Mice.

Xiong X, Xu L, Wei L, White RE, Ouyang YB, Giffard RG.

Stroke. 2015 Aug;46(8):2271-6. doi: 10.1161/STROKEAHA.115.008897. Epub 2015 Jun 30.


MicroRNA-200c contributes to injury from transient focal cerebral ischemia by targeting Reelin.

Stary CM, Xu L, Sun X, Ouyang YB, White RE, Leong J, Li J, Xiong X, Giffard RG.

Stroke. 2015 Feb;46(2):551-6. doi: 10.1161/STROKEAHA.114.007041. Epub 2015 Jan 20.


Post-stroke treatment with miR-181 antagomir reduces injury and improves long-term behavioral recovery in mice after focal cerebral ischemia.

Xu LJ, Ouyang YB, Xiong X, Stary CM, Giffard RG.

Exp Neurol. 2015 Feb;264:1-7. doi: 10.1016/j.expneurol.2014.11.007. Epub 2014 Nov 26.


Role of Astrocytes in Delayed Neuronal Death: GLT-1 and its Novel Regulation by MicroRNAs.

Ouyang YB, Xu L, Liu S, Giffard RG.

Adv Neurobiol. 2014;11:171-88. doi: 10.1007/978-3-319-08894-5_9.


Advances in astrocyte-targeted approaches for stroke therapy: an emerging role for mitochondria and microRNAS.

Stary CM, Giffard RG.

Neurochem Res. 2015 Feb;40(2):301-7. doi: 10.1007/s11064-014-1373-4. Epub 2014 Jul 4. Review.


Overexpression of heat shock protein 72 attenuates NF-κB activation using a combination of regulatory mechanisms in microglia.

Sheppard PW, Sun X, Khammash M, Giffard RG.

PLoS Comput Biol. 2014 Feb 6;10(2):e1003471. doi: 10.1371/journal.pcbi.1003471. eCollection 2014 Feb.


MicroRNAs affect BCL-2 family proteins in the setting of cerebral ischemia.

Ouyang YB, Giffard RG.

Neurochem Int. 2014 Nov;77:2-8. doi: 10.1016/j.neuint.2013.12.006. Epub 2013 Dec 25. Review.


The use of microRNAs to modulate redox and immune response to stroke.

Ouyang YB, Stary CM, White RE, Giffard RG.

Antioxid Redox Signal. 2015 Jan 10;22(2):187-202. doi: 10.1089/ars.2013.5757. Review.


MicroRNAs regulate the chaperone network in cerebral ischemia.

Ouyang YB, Giffard RG.

Transl Stroke Res. 2013 Dec;4(6):693-703. doi: 10.1007/s12975-013-0280-3. Epub 2013 Aug 17. Review.


Neuroprotection by astrocytes in brain ischemia: importance of microRNAs.

Ouyang YB, Xu L, Yue S, Liu S, Giffard RG.

Neurosci Lett. 2014 Apr 17;565:53-8. doi: 10.1016/j.neulet.2013.11.015. Epub 2013 Nov 19. Review.


The future of molecular chaperones and beyond.

Giffard RG, Macario AJ, de Macario EC.

J Clin Invest. 2013 Aug;123(8):3206-8.


Astrocyte-enriched miR-29a targets PUMA and reduces neuronal vulnerability to forebrain ischemia.

Ouyang YB, Xu L, Lu Y, Sun X, Yue S, Xiong XX, Giffard RG.

Glia. 2013 Nov;61(11):1784-94. doi: 10.1002/glia.22556. Epub 2013 Aug 30.


Inhibition of microRNA-181 reduces forebrain ischemia-induced neuronal loss.

Moon JM, Xu L, Giffard RG.

J Cereb Blood Flow Metab. 2013 Dec;33(12):1976-82. doi: 10.1038/jcbfm.2013.157. Epub 2013 Sep 4.


Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar.

Jevtovic-Todorovic V, Absalom AR, Blomgren K, Brambrink A, Crosby G, Culley DJ, Fiskum G, Giffard RG, Herold KF, Loepke AW, Ma D, Orser BA, Planel E, Slikker W Jr, Soriano SG, Stratmann G, Vutskits L, Xie Z, Hemmings HC Jr.

Br J Anaesth. 2013 Aug;111(2):143-51. doi: 10.1093/bja/aet177. Epub 2013 May 30.


Selective activation of protein kinase C∊ in mitochondria is neuroprotective in vitro and reduces focal ischemic brain injury in mice.

Sun X, Budas GR, Xu L, Barreto GE, Mochly-Rosen D, Giffard RG.

J Neurosci Res. 2013 Jun;91(6):799-807. doi: 10.1002/jnr.23186. Epub 2013 Feb 21.


Inflammatory response of microglial BV-2 cells includes a glycolytic shift and is modulated by mitochondrial glucose-regulated protein 75/mortalin.

Voloboueva LA, Emery JF, Sun X, Giffard RG.

FEBS Lett. 2013 Mar 18;587(6):756-62. doi: 10.1016/j.febslet.2013.01.067. Epub 2013 Feb 8.


Mitigation of murine focal cerebral ischemia by the hypocretin/orexin system is associated with reduced inflammation.

Xiong X, White RE, Xu L, Yang L, Sun X, Zou B, Pascual C, Sakurai T, Giffard RG, Xie XS.

Stroke. 2013 Mar;44(3):764-70. doi: 10.1161/STROKEAHA.112.681700. Epub 2013 Jan 24.


Effects of heat shock protein 72 (Hsp72) on evolution of astrocyte activation following stroke in the mouse.

Barreto GE, White RE, Xu L, Palm CJ, Giffard RG.

Exp Neurol. 2012 Dec;238(2):284-96. doi: 10.1016/j.expneurol.2012.08.015. Epub 2012 Aug 20.


Mice lacking the β2 adrenergic receptor have a unique genetic profile before and after focal brain ischaemia.

White RE, Palm C, Xu L, Ling E, Ginsburg M, Daigle BJ, Han R, Patterson A, Altman RB, Giffard RG.

ASN Neuro. 2012 Sep 7;4(5). pii: e00096. doi: 10.1042/AN20110020.


MicroRNA-320 induces neurite outgrowth by targeting ARPP-19.

White RE, Giffard RG.

Neuroreport. 2012 Jul 11;23(10):590-5. doi: 10.1097/WNR.0b013e3283540394.


ER-Mitochondria Crosstalk during Cerebral Ischemia: Molecular Chaperones and ER-Mitochondrial Calcium Transfer.

Ouyang YB, Giffard RG.

Int J Cell Biol. 2012;2012:493934. doi: 10.1155/2012/493934. Epub 2012 Apr 2.


Genomic analysis of reactive astrogliosis.

Zamanian JL, Xu L, Foo LC, Nouri N, Zhou L, Giffard RG, Barres BA.

J Neurosci. 2012 May 2;32(18):6391-410. doi: 10.1523/JNEUROSCI.6221-11.2012.


Neuroprotection from stroke in the absence of MHCI or PirB.

Adelson JD, Barreto GE, Xu L, Kim T, Brott BK, Ouyang YB, Naserke T, Djurisic M, Xiong X, Shatz CJ, Giffard RG.

Neuron. 2012 Mar 22;73(6):1100-7. doi: 10.1016/j.neuron.2012.01.020. Epub 2012 Mar 21.


Astrocyte proliferation following stroke in the mouse depends on distance from the infarct.

Barreto GE, Sun X, Xu L, Giffard RG.

PLoS One. 2011;6(11):e27881. doi: 10.1371/journal.pone.0027881. Epub 2011 Nov 21.


Significance of marrow-derived nicotinamide adenine dinucleotide phosphate oxidase in experimental ischemic stroke.

Tang XN, Zheng Z, Giffard RG, Yenari MA.

Ann Neurol. 2011 Oct;70(4):606-15. doi: 10.1002/ana.22476.


miR-181 regulates GRP78 and influences outcome from cerebral ischemia in vitro and in vivo.

Ouyang YB, Lu Y, Yue S, Xu LJ, Xiong XX, White RE, Sun X, Giffard RG.

Neurobiol Dis. 2012 Jan;45(1):555-63. doi: 10.1016/j.nbd.2011.09.012. Epub 2011 Sep 24.


miR-181 targets multiple Bcl-2 family members and influences apoptosis and mitochondrial function in astrocytes.

Ouyang YB, Lu Y, Yue S, Giffard RG.

Mitochondrion. 2012 Mar;12(2):213-9. doi: 10.1016/j.mito.2011.09.001. Epub 2011 Sep 17.


Inflammation, mitochondria, and the inhibition of adult neurogenesis.

Voloboueva LA, Giffard RG.

J Neurosci Res. 2011 Dec;89(12):1989-96. doi: 10.1002/jnr.22768. Epub 2011 Sep 9. Review.


Quantitative characterization and analysis of the dynamic NF-κB response in microglia.

Sheppard PW, Sun X, Emery JF, Giffard RG, Khammash M.

BMC Bioinformatics. 2011 Jul 5;12:276. doi: 10.1186/1471-2105-12-276.


Increased brain injury and worsened neurological outcome in interleukin-4 knockout mice after transient focal cerebral ischemia.

Xiong X, Barreto GE, Xu L, Ouyang YB, Xie X, Giffard RG.

Stroke. 2011 Jul;42(7):2026-32. doi: 10.1161/STROKEAHA.110.593772. Epub 2011 May 19.


Astrocytes: targets for neuroprotection in stroke.

Barreto G, White RE, Ouyang Y, Xu L, Giffard RG.

Cent Nerv Syst Agents Med Chem. 2011 Jun 1;11(2):164-73. Review.


Endotoxin-activated microglia injure brain derived endothelial cells via NF-κB, JAK-STAT and JNK stress kinase pathways.

Kacimi R, Giffard RG, Yenari MA.

J Inflamm (Lond). 2011 Mar 7;8:7. doi: 10.1186/1476-9255-8-7.


Heat shock protein 72 overexpression prevents early postoperative memory decline after orthopedic surgery under general anesthesia in mice.

Vizcaychipi MP, Xu L, Barreto GE, Ma D, Maze M, Giffard RG.

Anesthesiology. 2011 Apr;114(4):891-900. doi: 10.1097/ALN.0b013e31820ad3ce.


Direct protection of cultured neurons from ischemia-like injury by minocycline.

Huang WC, Qiao Y, Xu L, Kacimi R, Sun X, Giffard RG, Yenari MA.

Anat Cell Biol. 2010 Dec;43(4):325-31. doi: 10.5115/acb.2010.43.4.325. Epub 2010 Dec 31.


Overexpressing GRP78 influences Ca2+ handling and function of mitochondria in astrocytes after ischemia-like stress.

Ouyang YB, Xu LJ, Emery JF, Lee AS, Giffard RG.

Mitochondrion. 2011 Mar;11(2):279-86. doi: 10.1016/j.mito.2010.10.007. Epub 2010 Nov 1.


Mitochondrial protection attenuates inflammation-induced impairment of neurogenesis in vitro and in vivo.

Voloboueva LA, Lee SW, Emery JF, Palmer TD, Giffard RG.

J Neurosci. 2010 Sep 15;30(37):12242-51. doi: 10.1523/JNEUROSCI.1752-10.2010.


Age-related defects in sensorimotor activity, spatial learning, and memory in C57BL/6 mice.

Barreto G, Huang TT, Giffard RG.

J Neurosurg Anesthesiol. 2010 Jul;22(3):214-9. doi: 10.1097/ANA.0b013e3181d56c98.

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