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Items: 1 to 50 of 275

1.

Interleukin 21 Receptor/Ligand Interaction Is Linked to Disease Progression in Pancreatic Cancer.

Linnebacher A, Mayer P, Marnet N, Bergmann F, Herpel E, Revia S, Yin L, Liu L, Hackert T, Giese T, Herr I, Gaida MM.

Cells. 2019 Sep 18;8(9). pii: E1104. doi: 10.3390/cells8091104.

2.

The effect of gender-specific invitation letters on utilization of colorectal cancer screening.

Zhan T, Hielscher T, Eckardt M, Giese T, Schäfer C, Riemann JF, Ebert MP, Belle S.

Z Gastroenterol. 2019 Sep;57(9):1051-1058. doi: 10.1055/a-0958-2874. Epub 2019 Sep 16.

PMID:
31525797
3.
4.

Cleaning Up Mechanistic Debris Generated by Twister Ribozymes Using Computational RNA Enzymology.

Gaines CS, Giese TJ, York DM.

ACS Catal. 2019 Jul 5;9(7):5803-5815. doi: 10.1021/acscatal.9b01155. Epub 2019 May 22.

PMID:
31328021
5.

A study of 51 subtypes of peripheral blood immune cells in newly diagnosed young type 1 diabetes patients.

Oras A, Peet A, Giese T, Tillmann V, Uibo R.

Clin Exp Immunol. 2019 Oct;198(1):57-70. doi: 10.1111/cei.13332. Epub 2019 Jun 21.

PMID:
31116879
6.

Disseminated Mycosis by Arthrocladium fulminans Jeopardizing a Patient with GATA2 Deficiency.

Egenlauf B, Schuhmann M, Giese T, Junghanss T, Stojkovic M, Tintelnot K, de Hoog S, Greil J, Richter E, Vehresschild M, Heussel CP, Herth FJF, Kreuter M.

Respiration. 2019;97(5):472-475. doi: 10.1159/000493429. Epub 2019 Mar 29.

PMID:
30928982
7.

Blood immune cell biomarkers in lung cancer.

Riemann D, Cwikowski M, Turzer S, Giese T, Grallert M, Schütte W, Seliger B.

Clin Exp Immunol. 2019 Feb;195(2):179-189. doi: 10.1111/cei.13219. Epub 2018 Nov 9.

PMID:
30246868
8.

GPU-Accelerated Molecular Dynamics and Free Energy Methods in Amber18: Performance Enhancements and New Features.

Lee TS, Cerutti DS, Mermelstein D, Lin C, LeGrand S, Giese TJ, Roitberg A, Case DA, Walker RC, York DM.

J Chem Inf Model. 2018 Oct 22;58(10):2043-2050. doi: 10.1021/acs.jcim.8b00462. Epub 2018 Sep 25.

9.

Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects.

Schwab C, Gabrysch A, Olbrich P, Patiño V, Warnatz K, Wolff D, Hoshino A, Kobayashi M, Imai K, Takagi M, Dybedal I, Haddock JA, Sansom DM, Lucena JM, Seidl M, Schmitt-Graeff A, Reiser V, Emmerich F, Frede N, Bulashevska A, Salzer U, Schubert D, Hayakawa S, Okada S, Kanariou M, Kucuk ZY, Chapdelaine H, Petruzelkova L, Sumnik Z, Sediva A, Slatter M, Arkwright PD, Cant A, Lorenz HM, Giese T, Lougaris V, Plebani A, Price C, Sullivan KE, Moutschen M, Litzman J, Freiberger T, van de Veerdonk FL, Recher M, Albert MH, Hauck F, Seneviratne S, Pachlopnik Schmid J, Kolios A, Unglik G, Klemann C, Speckmann C, Ehl S, Leichtner A, Blumberg R, Franke A, Snapper S, Zeissig S, Cunningham-Rundles C, Giulino-Roth L, Elemento O, Dückers G, Niehues T, Fronkova E, Kanderová V, Platt CD, Chou J, Chatila TA, Geha R, McDermott E, Bunn S, Kurzai M, Schulz A, Alsina L, Casals F, Deyà-Martinez A, Hambleton S, Kanegane H, Taskén K, Neth O, Grimbacher B.

J Allergy Clin Immunol. 2018 Dec;142(6):1932-1946. doi: 10.1016/j.jaci.2018.02.055. Epub 2018 May 4.

10.

Endogenous CHRNA7-ligand SLURP1 as a potential tumor suppressor and anti-nicotinic factor in pancreatic cancer.

Throm VM, Männle D, Giese T, Bauer AS, Gaida MM, Kopitz J, Bruckner T, Plaschke K, Grekova SP, Felix K, Hackert T, Giese NA, Strobel O.

Oncotarget. 2018 Jan 24;9(14):11734-11751. doi: 10.18632/oncotarget.24312. eCollection 2018 Feb 20.

11.

Blood tolerogenic monocytes and low proportions of dendritic cell subpopulations are hallmarks of human tuberculosis.

Dirix V, Corbière V, Wyndham-Thomas C, Selis E, Allard S, Hites M, Aerts L, Giese T, Mascart F.

J Leukoc Biol. 2018 May;103(5):945-954. doi: 10.1002/JLB.4A1117-448R. Epub 2018 Feb 28.

PMID:
29489031
12.

A GPU-Accelerated Parameter Interpolation Thermodynamic Integration Free Energy Method.

Giese TJ, York DM.

J Chem Theory Comput. 2018 Mar 13;14(3):1564-1582. doi: 10.1021/acs.jctc.7b01175. Epub 2018 Feb 7.

13.

Invitation letters increase participation in colorectal cancer screening - results from an observational study.

Zhan T, Hielscher T, Bilge A, Giese T, Schäfer C, Riemann JF, Ebert MP, Belle S.

Z Gastroenterol. 2017 Dec;55(12):1307-1312. doi: 10.1055/s-0043-121347. Epub 2017 Dec 6.

PMID:
29212101
14.

Improved Pulse Wave Velocity and Renal Function in Individualized Calcineurin Inhibitor Treatment by Immunomonitoring: The Randomized Controlled Calcineurin Inhibitor-Sparing Trial.

Sommerer C, Brocke J, Bruckner T, Schaier M, Morath C, Meuer S, Zeier M, Giese T.

Transplantation. 2018 Mar;102(3):510-520. doi: 10.1097/TP.0000000000001973.

PMID:
29077654
15.

Quantum mechanical force fields for condensed phase molecular simulations.

Giese TJ, York DM.

J Phys Condens Matter. 2017 Sep 27;29(38):383002. doi: 10.1088/1361-648X/aa7c5c. Epub 2017 Aug 17.

16.

A Multidimensional B-Spline Correction for Accurate Modeling Sugar Puckering in QM/MM Simulations.

Huang M, Dissanayake T, Kuechler E, Radak BK, Lee TS, Giese TJ, York DM.

J Chem Theory Comput. 2017 Sep 12;13(9):3975-3984. doi: 10.1021/acs.jctc.7b00161. Epub 2017 Aug 17.

17.

Human monocytes downregulate innate response receptors following exposure to the microbial metabolite n-butyrate.

Lasitschka F, Giese T, Paparella M, Kurzhals SR, Wabnitz G, Jacob K, Gras J, Bode KA, Heninger AK, Sziskzai T, Samstag Y, Leszinski C, Jocher B, Al-Saeedi M, Meuer SC, Schröder-Braunstein J.

Immun Inflamm Dis. 2017 Dec;5(4):480-492. doi: 10.1002/iid3.184. Epub 2017 Jul 6.

18.

PZT-Actuated and -Sensed Resonant Micromirrors with Large Scan Angles Applying Mechanical Leverage Amplification for Biaxial Scanning.

Gu-Stoppel S, Giese T, Quenzer HJ, Hofmann U, Benecke W.

Micromachines (Basel). 2017 Jul 6;8(7). pii: E215. doi: 10.3390/mi8070215.

19.

Divalent Metal Ion Activation of a Guanine General Base in the Hammerhead Ribozyme: Insights from Molecular Simulations.

Chen H, Giese TJ, Golden BL, York DM.

Biochemistry. 2017 Jun 20;56(24):2985-2994. doi: 10.1021/acs.biochem.6b01192. Epub 2017 Jun 12.

20.

Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency.

Lovric S, Goncalves S, Gee HY, Oskouian B, Srinivas H, Choi WI, Shril S, Ashraf S, Tan W, Rao J, Airik M, Schapiro D, Braun DA, Sadowski CE, Widmeier E, Jobst-Schwan T, Schmidt JM, Girik V, Capitani G, Suh JH, Lachaussée N, Arrondel C, Patat J, Gribouval O, Furlano M, Boyer O, Schmitt A, Vuiblet V, Hashmi S, Wilcken R, Bernier FP, Innes AM, Parboosingh JS, Lamont RE, Midgley JP, Wright N, Majewski J, Zenker M, Schaefer F, Kuss N, Greil J, Giese T, Schwarz K, Catheline V, Schanze D, Franke I, Sznajer Y, Truant AS, Adams B, Désir J, Biemann R, Pei Y, Ars E, Lloberas N, Madrid A, Dharnidharka VR, Connolly AM, Willing MC, Cooper MA, Lifton RP, Simons M, Riezman H, Antignac C, Saba JD, Hildebrandt F.

J Clin Invest. 2017 Mar 1;127(3):912-928. doi: 10.1172/JCI89626. Epub 2017 Feb 6.

21.

Correlation between pharmacokinetics of tacrolimus and pharmacodynamics on NFAT-regulated gene expression in stable kidney transplant recipients
.

Keller F, Sommerer C, Giese T, Zeier M, Schröppel B.

Clin Nephrol. 2017 Feb;87 (2017)(2):93-99. doi: 10.5414/CN108893.

PMID:
28025957
22.

Establishment and Characterization of a Novel Cell Line, ASAN-PaCa, Derived From Human Adenocarcinoma Arising in Intraductal Papillary Mucinous Neoplasm of the Pancreas.

Heller A, Angelova AL, Bauer S, Grekova SP, Aprahamian M, Rommelaere J, Volkmar M, Janssen JW, Bauer N, Herr I, Giese T, Gaida MM, Bergmann F, Hackert T, Fritz S, Giese NA.

Pancreas. 2016 Nov;45(10):1452-1460.

PMID:
27518460
23.

Analytical Validation and Cross-Validation of an NFAT-Regulated Gene Expression Assay for Pharmacodynamic Monitoring of Therapy With Calcineurin Inhibitors.

Abdel-Kahaar E, Giese T, Sommerer C, Rieger H, Shipkova M, Wieland E.

Ther Drug Monit. 2016 Dec;38(6):711-716.

PMID:
27661400
24.

EDA-Fibronectin Originating from Osteoblasts Inhibits the Immune Response against Cancer.

Rossnagl S, Altrock E, Sens C, Kraft S, Rau K, Milsom MD, Giese T, Samstag Y, Nakchbandi IA.

PLoS Biol. 2016 Sep 21;14(9):e1002562. doi: 10.1371/journal.pbio.1002562. eCollection 2016 Sep.

25.

The osteoblast as an inflammatory cell: production of cytokines in response to bacteria and components of bacterial biofilms.

Dapunt U, Giese T, Stegmaier S, Moghaddam A, Hänsch GM.

BMC Musculoskelet Disord. 2016 Jun 2;17:243. doi: 10.1186/s12891-016-1091-y.

26.

Role of TFEB-driven autophagy regulation in pancreatic cancer treatment.

Klein K, Werner K, Teske C, Schenk M, Giese T, Weitz J, Welsch T.

Int J Oncol. 2016 Jul;49(1):164-72. doi: 10.3892/ijo.2016.3505. Epub 2016 May 5.

PMID:
27175909
27.

Ambient-Potential Composite Ewald Method for ab Initio Quantum Mechanical/Molecular Mechanical Molecular Dynamics Simulation.

Giese TJ, York DM.

J Chem Theory Comput. 2016 Jun 14;12(6):2611-32. doi: 10.1021/acs.jctc.6b00198. Epub 2016 May 26.

28.

Expression of CDKN1C in the bone marrow of patients with myelodysplastic syndrome and secondary acute myeloid leukemia is associated with poor survival after conventional chemotherapy.

Radujkovic A, Dietrich S, Andrulis M, Benner A, Longerich T, Pellagatti A, Nanda K, Giese T, Germing U, Baldus S, Boultwood J, Ho AD, Dreger P, Luft T.

Int J Cancer. 2016 Sep 15;139(6):1402-13. doi: 10.1002/ijc.30181. Epub 2016 Jun 3.

29.

VR-SCOSMO: A smooth conductor-like screening model with charge-dependent radii for modeling chemical reactions.

Kuechler ER, Giese TJ, York DM.

J Chem Phys. 2016 Apr 28;144(16):164115. doi: 10.1063/1.4946779.

30.

CD14 is associated with biliary stricture formation.

Friedrich K, Smit M, Brune M, Giese T, Rupp C, Wannhoff A, Kloeters P, Leopold Y, Denk GU, Weiss KH, Stremmel W, Sauer P, Hohenester S, Schirmacher P, Schemmer P, Gotthardt DN.

Hepatology. 2016 Sep;64(3):843-52. doi: 10.1002/hep.28543. Epub 2016 Apr 20.

PMID:
26970220
31.

Charge-dependent many-body exchange and dispersion interactions in combined QM/MM simulations.

Kuechler ER, Giese TJ, York DM.

J Chem Phys. 2015 Dec 21;143(23):234111. doi: 10.1063/1.4937166.

32.

Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits pancreatic cancer progression.

Alam MS, Gaida MM, Bergmann F, Lasitschka F, Giese T, Giese NA, Hackert T, Hinz U, Hussain SP, Kozlov SV, Ashwell JD.

Nat Med. 2015 Nov;21(11):1337-43. doi: 10.1038/nm.3957. Epub 2015 Oct 19.

33.

Nuclear Factor of Activated T Cells-Regulated Gene Expression as Predictive Biomarker of Personal Response to Calcineurin Inhibitors.

Sommerer C, Giese T.

Ther Drug Monit. 2016 Apr;38 Suppl 1:S50-6. doi: 10.1097/FTD.0000000000000234. Review.

PMID:
26418701
34.

Tasting Pseudomonas aeruginosa Biofilms: Human Neutrophils Express the Bitter Receptor T2R38 as Sensor for the Quorum Sensing Molecule N-(3-Oxododecanoyl)-l-Homoserine Lactone.

Maurer S, Wabnitz GH, Kahle NA, Stegmaier S, Prior B, Giese T, Gaida MM, Samstag Y, Hänsch GM.

Front Immunol. 2015 Jul 24;6:369. doi: 10.3389/fimmu.2015.00369. eCollection 2015.

35.

Monitoring of calcineurin inhibitors by NFAT-regulated gene expression in de novo renal allograft recipients on cyclosporine A.

Sommerer C, Zeier M, Meuer S, Giese T.

Clin Nephrol. 2015 Sep;84(3):165-72. doi: 10.5414/CN108623.

PMID:
26226950
36.

Stratification of pancreatic tissue samples for molecular studies: RNA-based cellular annotation procedure.

Heller A, Gaida MM, Männle D, Giese T, Scarpa A, Neoptolemos JP, Hackert T, Strobel O, Hoheisel JD, Giese NA, Bauer AS.

Pancreatology. 2015 Jul-Aug;15(4):423-31. doi: 10.1016/j.pan.2015.05.480. Epub 2015 Jun 15.

37.

Nucleic acid reactivity: challenges for next-generation semiempirical quantum models.

Huang M, Giese TJ, York DM.

J Comput Chem. 2015 Jul 5;36(18):1370-89. doi: 10.1002/jcc.23933. Epub 2015 May 6.

38.

JAK1/STAT3 activation directly inhibits IL-12 production in dendritic cells by preventing CDK9/P-TEFb recruitment to the p35 promoter.

Wagner AH, Conzelmann M, Fitzer F, Giese T, Gülow K, Falk CS, Krämer OH, Dietrich S, Hecker M, Luft T.

Biochem Pharmacol. 2015 Jul 1;96(1):52-64. doi: 10.1016/j.bcp.2015.04.019. Epub 2015 Apr 28.

PMID:
25931145
39.

Neutrophil-derived MRP-14 is up-regulated in infectious osteomyelitis and stimulates osteoclast generation.

Dapunt U, Giese T, Maurer S, Stegmaier S, Prior B, Hänsch GM, Gaida MM.

J Leukoc Biol. 2015 Oct;98(4):575-82. doi: 10.1189/jlb.3VMA1014-482R. Epub 2015 Mar 12.

PMID:
25765681
40.

Multipolar Ewald methods, 2: applications using a quantum mechanical force field.

Giese TJ, Panteva MT, Chen H, York DM.

J Chem Theory Comput. 2015 Feb 10;11(2):451-61. doi: 10.1021/ct500799g.

41.

Multipolar Ewald methods, 1: theory, accuracy, and performance.

Giese TJ, Panteva MT, Chen H, York DM.

J Chem Theory Comput. 2015 Feb 10;11(2):436-50. doi: 10.1021/ct5007983.

42.

Standardization of a human organ culture model of intestinal inflammation and its application for drug testing.

Szikszai T, Lasitschka F, Giese T, Greulich M, Lee YS, Ilse J, Schiessling S, Leowardi C, Al-Saeedi M, Winter J, Meuer S, Schröder-Braunstein J.

J Immunol Methods. 2015 Jun;421:96-103. doi: 10.1016/j.jim.2014.12.014. Epub 2014 Dec 31.

PMID:
25556347
43.

Immunomodulation of human intestinal T cells by the synthetic CD80 antagonist RhuDex®.

Heninger AK, Wentrup S, Al-Saeedi M, Schiessling S, Giese T, Wartha F, Meuer S, Schröder-Braunstein J.

Immun Inflamm Dis. 2014 Nov;2(3):166-80. doi: 10.1002/iid3.34. Epub 2014 Nov 3.

44.
45.

Predicting therapeutic efficacy of intravenous immunoglobulin (IVIG) in individual patients with relapsing remitting multiple sclerosis (RRMS) by functional genomics.

Berger T, Jacobi C, Haas J, Ransmayr G, Guger M, Zettl UK, Di Pauli F, Taumberger B, Wietek S, Meuer S, Reindl M, Giese T.

J Neuroimmunol. 2014 Dec 15;277(1-2):145-52. doi: 10.1016/j.jneuroim.2014.10.001. Epub 2014 Oct 12.

PMID:
25454729
46.

IL-17A influences essential functions of the monocyte/macrophage lineage and is involved in advanced murine and human atherosclerosis.

Erbel C, Akhavanpoor M, Okuyucu D, Wangler S, Dietz A, Zhao L, Stellos K, Little KM, Lasitschka F, Doesch A, Hakimi M, Dengler TJ, Giese T, Blessing E, Katus HA, Gleissner CA.

J Immunol. 2014 Nov 1;193(9):4344-55. doi: 10.4049/jimmunol.1400181. Epub 2014 Sep 26.

47.

Mechanistic insights into RNA transphosphorylation from kinetic isotope effects and linear free energy relationships of model reactions.

Chen H, Giese TJ, Huang M, Wong KY, Harris ME, York DM.

Chemistry. 2014 Oct 27;20(44):14336-43. doi: 10.1002/chem.201403862. Epub 2014 Sep 15.

48.

Effect of delayed CNI-based immunosuppression with Advagraf® on liver function after MELD-based liver transplantation [IMUTECT].

Richter S, Polychronidis G, Gotthardt DN, Houben P, Giese T, Sander A, Dörr-Harim C, Diener MK, Schemmer P.

BMC Surg. 2014 Sep 1;14:64. doi: 10.1186/1471-2482-14-64.

49.

Granulocyte functions are independent of arginine availability.

Kapp K, Prüfer S, Michel CS, Habermeier A, Luckner-Minden C, Giese T, Bomalaski J, Langhans CD, Kropf P, Müller I, Closs EI, Radsak MP, Munder M.

J Leukoc Biol. 2014 Dec;96(6):1047-53. doi: 10.1189/jlb.3AB0214-082R. Epub 2014 Aug 7.

PMID:
25104794
50.

The CARD11-BCL10-MALT1 (CBM) signalosome complex: Stepping into the limelight of human primary immunodeficiency.

Turvey SE, Durandy A, Fischer A, Fung SY, Geha RS, Gewies A, Giese T, Greil J, Keller B, McKinnon ML, Neven B, Rozmus J, Ruland J, Snow AL, Stepensky P, Warnatz K.

J Allergy Clin Immunol. 2014 Aug;134(2):276-84. doi: 10.1016/j.jaci.2014.06.015. Review.

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