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Items: 14

1.

Tissue-Specific Oncogenic Activity of KRASA146T.

Poulin EJ, Bera AK, Lu J, Lin YJ, Strasser SD, Paulo JA, Huang TQ, Morales C, Yan W, Cook J, Nowak JA, Brubaker DK, Joughin BA, Johnson CW, DeStefanis RA, Ghazi PC, Gondi S, Wales TE, Iacob RE, Bogdanova L, Gierut JJ, Li Y, Engen JR, Perez-Mancera PA, Braun BS, Gygi SP, Lauffenburger DA, Westover KD, Haigis KM.

Cancer Discov. 2019 Jun;9(6):738-755. doi: 10.1158/2159-8290.CD-18-1220. Epub 2019 Apr 5.

PMID:
30952657
2.

The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile.

Lyons J, Ghazi PC, Starchenko A, Tovaglieri A, Baldwin KR, Poulin EJ, Gierut JJ, Genetti C, Yajnik V, Breault DT, Lauffenburger DA, Haigis KM.

PLoS Biol. 2018 Mar 29;16(3):e2002417. doi: 10.1371/journal.pbio.2002417. eCollection 2018 Mar.

3.

Kinase-Dependent and -Independent Roles for PTK6 in Colon Cancer.

Mathur PS, Gierut JJ, Guzman G, Xie H, Xicola RM, Llor X, Chastkofsky MI, Perekatt AO, Tyner AL.

Mol Cancer Res. 2016 Jun;14(6):563-73. doi: 10.1158/1541-7786.MCR-15-0450. Epub 2016 Mar 16.

4.

Network-level effects of kinase inhibitors modulate TNF-α-induced apoptosis in the intestinal epithelium.

Gierut JJ, Wood LB, Lau KS, Lin YJ, Genetti C, Samatar AA, Lauffenburger DA, Haigis KM.

Sci Signal. 2015 Dec 15;8(407):ra129. doi: 10.1126/scisignal.aac7235.

5.

Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation.

Nicolay BN, Danielian PS, Kottakis F, Lapek JD Jr, Sanidas I, Miles WO, Dehnad M, Tschöp K, Gierut JJ, Manning AL, Morris R, Haigis K, Bardeesy N, Lees JA, Haas W, Dyson NJ.

Genes Dev. 2015 Sep 1;29(17):1875-89. doi: 10.1101/gad.264127.115. Epub 2015 Aug 27.

6.

Oncogenic K-Ras promotes proliferation in quiescent intestinal stem cells.

Gierut JJ, Lyons J, Shah MS, Genetti C, Breault DT, Haigis KM.

Stem Cell Res. 2015 Jul;15(1):165-71. doi: 10.1016/j.scr.2015.06.003. Epub 2015 Jun 10.

7.

K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif.

Tsai FD, Lopes MS, Zhou M, Court H, Ponce O, Fiordalisi JJ, Gierut JJ, Cox AD, Haigis KM, Philips MR.

Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):779-84. doi: 10.1073/pnas.1412811112. Epub 2015 Jan 5.

8.

Whole-mount X-Gal staining of mouse tissues.

Gierut JJ, Jacks TE, Haigis KM.

Cold Spring Harb Protoc. 2014 Apr 1;2014(4):417-9. doi: 10.1101/pdb.prot073452.

9.

Strategies to achieve conditional gene mutation in mice.

Gierut JJ, Jacks TE, Haigis KM.

Cold Spring Harb Protoc. 2014 Apr 1;2014(4):339-49. doi: 10.1101/pdb.top069807. Review.

10.

In vivo delivery of lenti-Cre or adeno-Cre into mice using intranasal instillation.

Gierut JJ, Jacks TE, Haigis KM.

Cold Spring Harb Protoc. 2014 Mar 1;2014(3):307-9. doi: 10.1101/pdb.prot073445.

11.

Producing and concentrating lenti-Cre for mouse infections.

Gierut JJ, Jacks TE, Haigis KM.

Cold Spring Harb Protoc. 2014 Mar 1;2014(3):304-6. doi: 10.1101/pdb.prot073437.

12.

Targeting protein tyrosine kinase 6 enhances apoptosis of colon cancer cells following DNA damage.

Gierut JJ, Mathur PS, Bie W, Han J, Tyner AL.

Mol Cancer Ther. 2012 Nov;11(11):2311-20. doi: 10.1158/1535-7163.MCT-12-0009. Epub 2012 Sep 18.

13.

Identification of beta-catenin as a target of the intracellular tyrosine kinase PTK6.

Palka-Hamblin HL, Gierut JJ, Bie W, Brauer PM, Zheng Y, Asara JM, Tyner AL.

J Cell Sci. 2010 Jan 15;123(Pt 2):236-45. doi: 10.1242/jcs.053264. Epub 2009 Dec 21.

14.

Induction of protein tyrosine kinase 6 in mouse intestinal crypt epithelial cells promotes DNA damage-induced apoptosis.

Haegebarth A, Perekatt AO, Bie W, Gierut JJ, Tyner AL.

Gastroenterology. 2009 Sep;137(3):945-54. doi: 10.1053/j.gastro.2009.05.054. Epub 2009 Jun 6.

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