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Items: 36

1.

Quantification of peptide m/z distributions from 13C-labeled cultures with high-resolution mass spectrometry.

Allen DK, Goldford J, Gierse JK, Mandy D, Diepenbrock C, Libourel IG.

Anal Chem. 2014 Feb 4;86(3):1894-901. doi: 10.1021/ac403985w. Epub 2014 Jan 21.

2.

Structure-based parallel medicinal chemistry approach to improve metabolic stability of benzopyran COX-2 inhibitors.

Xing L, Hamper BC, Fletcher TR, Wendling JM, Carter J, Gierse JK, Liao S.

Bioorg Med Chem Lett. 2011 Feb 1;21(3):993-6. doi: 10.1016/j.bmcl.2010.12.023. Epub 2010 Dec 10.

PMID:
21215625
3.

In vitro assays for cyclooxygenase activity and inhibitor characterization.

Walker MC, Gierse JK.

Methods Mol Biol. 2010;644:131-44. doi: 10.1007/978-1-59745-364-6_11.

PMID:
20645170
4.

Purification of recombinant human COX-1 and COX-2.

Gierse JK.

Methods Mol Biol. 2010;644:21-9. doi: 10.1007/978-1-59745-364-6_3.

PMID:
20645162
5.

Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor.

Mbalaviele G, Pauley AM, Shaffer AF, Zweifel BS, Mathialagan S, Mnich SJ, Nemirovskiy OV, Carter J, Gierse JK, Wang JL, Vazquez ML, Moore WM, Masferrer JL.

Biochem Pharmacol. 2010 May 15;79(10):1445-54. doi: 10.1016/j.bcp.2010.01.003. Epub 2010 Jan 11.

PMID:
20067770
6.

Homo-timeric structural model of human microsomal prostaglandin E synthase-1 and characterization of its substrate/inhibitor binding interactions.

Xing L, Kurumbail RG, Frazier RB, Davies MS, Fujiwara H, Weinberg RA, Gierse JK, Caspers N, Carter JS, McDonald JJ, Moore WM, Vazquez ML.

J Comput Aided Mol Des. 2009 Jan;23(1):13-24. doi: 10.1007/s10822-008-9233-4. Epub 2008 Sep 6.

PMID:
18777160
7.

Development of a fluorescence-based enzyme assay of human 5-lipoxygenase.

Pufahl RA, Kasten TP, Hills R, Gierse JK, Reitz BA, Weinberg RA, Masferrer JL.

Anal Biochem. 2007 May 15;364(2):204-12. Epub 2007 Feb 14.

PMID:
17376394
8.

Enzymologic and pharmacologic profile of loxoprofen sodium and its metabolites.

Noguchi M, Kimoto A, Gierse JK, Walker MC, Zweifel BS, Nozaki K, Sasamata M.

Biol Pharm Bull. 2005 Nov;28(11):2075-9.

9.

Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity.

Gierse JK, Zhang Y, Hood WF, Walker MC, Trigg JS, Maziasz TJ, Koboldt CM, Muhammad JL, Zweifel BS, Masferrer JL, Isakson PC, Seibert K.

J Pharmacol Exp Ther. 2005 Mar;312(3):1206-12. Epub 2004 Oct 19.

PMID:
15494548
10.

Characterization of celecoxib and valdecoxib binding to cyclooxygenase.

Hood WF, Gierse JK, Isakson PC, Kiefer JR, Kurumbail RG, Seibert K, Monahan JB.

Mol Pharmacol. 2003 Apr;63(4):870-7.

PMID:
12644588
11.

Synthesis of imidazopyridines and purines as potent inhibitors of leukotriene A4 hydrolase.

Penning TD, Chandrakumar NS, Desai BN, Djuric SW, Gasiecki AF, Malecha JW, Miyashiro JM, Russell MA, Askonas LJ, Gierse JK, Harding EI, Highkin MK, Kachur JF, Kim SH, Villani-Price D, Pyla EY, Ghoreishi-Haack NS, Smith WG.

Bioorg Med Chem Lett. 2003 Mar 24;13(6):1137-9.

PMID:
12643929
12.

Cloning, expression, and selective inhibition of canine cyclooxygenase-1 and cyclooxygenase-2.

Gierse JK, Staten NR, Casperson GF, Koboldt CM, Trigg JS, Reitz BA, Pierce JL, Seibert K.

Vet Ther. 2002 Fall;3(3):270-80.

PMID:
12447834
13.

Pyrrolidine and piperidine analogues of SC-57461A as potent, orally active inhibitors of leukotriene A(4) hydrolase.

Penning TD, Chandrakumar NS, Desai BN, Djuric SW, Gasiecki AF, Liang CD, Miyashiro JM, Russell MA, Askonas LJ, Gierse JK, Harding EI, Highkin MK, Kachur JF, Kim SH, Villani-Price D, Pyla EY, Ghoreishi-Haack NS, Smith WG.

Bioorg Med Chem Lett. 2002 Dec 2;12(23):3383-6.

PMID:
12419366
14.

Synthesis of potent leukotriene A(4) hydrolase inhibitors. Identification of 3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid.

Penning TD, Russell MA, Chen BB, Chen HY, Liang CD, Mahoney MW, Malecha JW, Miyashiro JM, Yu SS, Askonas LJ, Gierse JK, Harding EI, Highkin MK, Kachur JF, Kim SH, Villani-Price D, Pyla EY, Ghoreishi-Haack NS, Smith WG.

J Med Chem. 2002 Aug 1;45(16):3482-90.

PMID:
12139459
15.

A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors.

Walker MC, Kurumbail RG, Kiefer JR, Moreland KT, Koboldt CM, Isakson PC, Seibert K, Gierse JK.

Biochem J. 2001 Aug 1;357(Pt 3):709-18.

16.

Cyclooxygenase assays.

Gierse JK, Koboldt CM.

Curr Protoc Pharmacol. 2001 May;Chapter 3:Unit3.1. doi: 10.1002/0471141755.ph0301s00. No abstract available.

PMID:
21971797
17.

Structural insights into the stereochemistry of the cyclooxygenase reaction.

Kiefer JR, Pawlitz JL, Moreland KT, Stegeman RA, Hood WF, Gierse JK, Stevens AM, Goodwin DC, Rowlinson SW, Marnett LJ, Stallings WC, Kurumbail RG.

Nature. 2000 May 4;405(6782):97-101.

PMID:
10811226
18.
19.

Structure-activity relationship studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A(4) (LTA(4)) hydrolase.

Penning TD, Chandrakumar NS, Chen BB, Chen HY, Desai BN, Djuric SW, Docter SH, Gasiecki AF, Haack RA, Miyashiro JM, Russell MA, Yu SS, Corley DG, Durley RC, Kilpatrick BF, Parnas BL, Askonas LJ, Gierse JK, Harding EI, Highkin MK, Kachur JF, Kim SH, Krivi GG, Villani-Price D, Pyla EY, Smith WG.

J Med Chem. 2000 Feb 24;43(4):721-35.

PMID:
10691697
20.

Kinetic basis for selective inhibition of cyclo-oxygenases.

Gierse JK, Koboldt CM, Walker MC, Seibert K, Isakson PC.

Biochem J. 1999 May 1;339 ( Pt 3):607-14.

22.

Nitric oxide trapping of the tyrosyl radical of prostaglandin H synthase-2 leads to tyrosine iminoxyl radical and nitrotyrosine formation.

Gunther MR, Hsi LC, Curtis JF, Gierse JK, Marnett LJ, Eling TE, Mason RP.

J Biol Chem. 1997 Jul 4;272(27):17086-90.

23.

Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents.

Kurumbail RG, Stevens AM, Gierse JK, McDonald JJ, Stegeman RA, Pak JY, Gildehaus D, Miyashiro JM, Penning TD, Seibert K, Isakson PC, Stallings WC.

Nature. 1996 Dec 19-26;384(6610):644-8. Erratum in: Nature 1997 Feb 6;385(6616):555.

PMID:
8967954
24.

A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors.

Gierse JK, McDonald JJ, Hauser SD, Rangwala SH, Koboldt CM, Seibert K.

J Biol Chem. 1996 Jun 28;271(26):15810-4.

25.

Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase.

Gierse JK, Hauser SD, Creely DP, Koboldt C, Rangwala SH, Isakson PC, Seibert K.

Biochem J. 1995 Jan 15;305 ( Pt 2):479-84.

26.
27.

High-level expression and purification of human leukotriene A4 hydrolase from insect cells infected with a baculovirus vector.

Gierse JK, Luckow VA, Askonas LJ, Duffin KL, Aykent S, Bild GS, Rodi CP, Sullivan PM, Bourner MJ, Kimack NM, et al.

Protein Expr Purif. 1993 Oct;4(5):358-66.

PMID:
8251746
28.
29.

Production of bovine insulin-like growth factor 2 (bIGF2) in Escherichia coli.

Easton AM, Gierse JK, Seetharam R, Klein BK, Kotts CE.

Gene. 1991 May 30;101(2):291-5.

PMID:
2055493
30.

Alternative mechanisms for atriopeptin prohormone processing by isolated perfused rat hearts.

Toki Y, Ito T, Shiono S, Siegel NR, Gierse JK, Wilkins MR, Needleman P.

J Pharmacol Exp Ther. 1990 Jul;254(1):228-35.

PMID:
2142220
31.

Substrate specificity of recombinant human renal renin: effect of histidine in the P2 subsite on pH dependence.

Green DW, Aykent S, Gierse JK, Zupec ME.

Biochemistry. 1990 Mar 27;29(12):3126-33.

PMID:
2186807
32.

Preliminary crystallographic study of glycosylated recombinant human renin.

Lim LW, Stegeman RA, Leimgruber NK, Gierse JK, Abdel-Meguid SS.

J Mol Biol. 1989 Nov 5;210(1):239-40.

PMID:
2685330
33.

Expression, purification, and in vivo activity of atrial natriuretic factor prohormone produced in Escherichia coli.

Gierse JK, Olins PO, Devine CS, Marlay JD, Obukowicz MG, Mortensen LH, McMahon EG, Blaine EH, Seetharam R.

Arch Biochem Biophys. 1989 Jun;271(2):441-6.

PMID:
2525000
34.

Manipulation of stretch-induced atriopeptin prohormone release and processing in the perfused rat heart.

Ito T, Toki Y, Siegel N, Gierse JK, Needleman P.

Proc Natl Acad Sci U S A. 1988 Nov;85(21):8365-9.

35.

Phosphorylation of high- and low-molecular-mass atrial natriuretic peptide analogs by cyclic AMP-dependent protein kinase.

Olins GM, Mehta PP, Blehm DJ, Patton DR, Zupec ME, Whipple DE, Tjoeng FS, Adams SP, Olins PO, Gierse JK.

FEBS Lett. 1987 Nov 30;224(2):325-30.

36.

Proteolytic processing of atriopeptin prohormone.

Michener ML, Gierse JK, Seetharam R, Fok KF, Olins PO, Mai MS, Needleman P.

Mol Pharmacol. 1986 Dec;30(6):552-7.

PMID:
2946928

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