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ColorEM: analytical electron microscopy for element-guided identification and imaging of the building blocks of life.

Pirozzi NM, Hoogenboom JP, Giepmans BNG.

Histochem Cell Biol. 2018 Nov;150(5):509-520. doi: 10.1007/s00418-018-1707-4. Epub 2018 Aug 17. Review.


Iron deficiency impairs contractility of human cardiomyocytes through decreased mitochondrial function.

Hoes MF, Grote Beverborg N, Kijlstra JD, Kuipers J, Swinkels DW, Giepmans BNG, Rodenburg RJ, van Veldhuisen DJ, de Boer RA, van der Meer P.

Eur J Heart Fail. 2018 May;20(5):910-919. doi: 10.1002/ejhf.1154. Epub 2018 Feb 27.


A novel flatworm-specific gene implicated in reproduction in Macrostomum lignano.

Grudniewska M, Mouton S, Grelling M, Wolters AHG, Kuipers J, Giepmans BNG, Berezikov E.

Sci Rep. 2018 Feb 16;8(1):3192. doi: 10.1038/s41598-018-21107-4.


A small protein probe for correlated microscopy of endogenous proteins.

de Beer MA, Kuipers J, van Bergen En Henegouwen PMP, Giepmans BNG.

Histochem Cell Biol. 2018 Mar;149(3):261-268. doi: 10.1007/s00418-018-1632-6. Epub 2018 Jan 11.


Guanine quadruplex structures localize to heterochromatin.

Hoffmann RF, Moshkin YM, Mouton S, Grzeschik NA, Kalicharan RD, Kuipers J, Wolters AHG, Nishida K, Romashchenko AV, Postberg J, Lipps H, Berezikov E, Sibon OCM, Giepmans BNG, Lansdorp PM.

Nucleic Acids Res. 2017 Jun 2;45(10):6253. doi: 10.1093/nar/gkx301. No abstract available.


Nanodiamonds as multi-purpose labels for microscopy.

Hemelaar SR, de Boer P, Chipaux M, Zuidema W, Hamoh T, Martinez FP, Nagl A, Hoogenboom JP, Giepmans BNG, Schirhagl R.

Sci Rep. 2017 Apr 7;7(1):720. doi: 10.1038/s41598-017-00797-2.


Multi-color electron microscopy by element-guided identification of cells, organelles and molecules.

Scotuzzi M, Kuipers J, Wensveen DI, de Boer P, Hagen KC, Hoogenboom JP, Giepmans BN.

Sci Rep. 2017 Apr 7;7:45970. doi: 10.1038/srep45970.


Transient von Willebrand factor-mediated platelet influx stimulates liver regeneration after partial hepatectomy in mice.

Kirschbaum M, Jenne CN, Veldhuis ZJ, Sjollema KA, Lenting PJ, Giepmans BNG, Porte RJ, Kubes P, Denis CV, Lisman T.

Liver Int. 2017 Nov;37(11):1731-1737. doi: 10.1111/liv.13386. Epub 2017 Mar 5.


Re-addressing the 2013 consensus guidelines for the diagnosis of insulitis in human type 1 diabetes: is change necessary?

Campbell-Thompson ML, Atkinson MA, Butler AE, Giepmans BN, von Herrath MG, Hyöty H, Kay TW, Morgan NG, Powers AC, Pugliese A, Richardson SJ, In't Veld PA.

Diabetologia. 2017 Apr;60(4):753-755. doi: 10.1007/s00125-016-4195-x. Epub 2017 Jan 9. No abstract available.


Particle Bombardment of Ex Vivo Skin to Deliver DNA and Express Proteins.

Sokol E, Nijenhuis M, Sjollema KA, Jonkman MF, Pas HH, Giepmans BNG.

Methods Mol Biol. 2017;1559:107-118. doi: 10.1007/978-1-4939-6786-5_9.


Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome.

Matas-Rico E, van Veen M, Leyton-Puig D, van den Berg J, Koster J, Kedziora KM, Molenaar B, Weerts MJA, de Rink I, Medema RH, Giepmans BNG, Perrakis A, Jalink K, Versteeg R, Moolenaar WH.

Cancer Cell. 2016 Dec 12;30(6):986. doi: 10.1016/j.ccell.2016.11.008. No abstract available.


Multicolor Electron Microscopy for Simultaneous Visualization of Multiple Molecular Species.

Adams SR, Mackey MR, Ramachandra R, Palida Lemieux SF, Steinbach P, Bushong EA, Butko MT, Giepmans BNG, Ellisman MH, Tsien RY.

Cell Chem Biol. 2016 Nov 17;23(11):1417-1427. doi: 10.1016/j.chembiol.2016.10.006. Epub 2016 Nov 3.


Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome.

Matas-Rico E, van Veen M, Leyton-Puig D, van den Berg J, Koster J, Kedziora KM, Molenaar B, Weerts MJ, de Rink I, Medema RH, Giepmans BN, Perrakis A, Jalink K, Versteeg R, Moolenaar WH.

Cancer Cell. 2016 Oct 10;30(4):548-562. doi: 10.1016/j.ccell.2016.08.016. Epub 2016 Sep 29. Erratum in: Cancer Cell. 2016 Dec 12;30(6):986.


Enterovirus infection of human islets of Langerhans affects β-cell function resulting in disintegrated islets, decreased glucose stimulated insulin secretion and loss of Golgi structure.

Hodik M, Skog O, Lukinius A, Isaza-Correa JM, Kuipers J, Giepmans BN, Frisk G.

BMJ Open Diabetes Res Care. 2016 Aug 10;4(1):e000179. doi: 10.1136/bmjdrc-2015-000179. eCollection 2016.


Large-scale Scanning Transmission Electron Microscopy (Nanotomy) of Healthy and Injured Zebrafish Brain.

Kuipers J, Kalicharan RD, Wolters AH, van Ham TJ, Giepmans BN.

J Vis Exp. 2016 May 25;(111). doi: 10.3791/53635.


Selection of polymers for application in scaffolds applicable for human pancreatic islet transplantation.

Smink AM, de Haan BJ, Paredes-Juarez GA, Wolters AH, Kuipers J, Giepmans BN, Schwab L, Engelse MA, van Apeldoorn AA, de Koning E, Faas MM, de Vos P.

Biomed Mater. 2016 May 13;11(3):035006. doi: 10.1088/1748-6041/11/3/035006.


Normothermic machine perfusion reduces bile duct injury and improves biliary epithelial function in rat donor livers.

Op den Dries S, Karimian N, Westerkamp AC, Sutton ME, Kuipers M, Wiersema-Buist J, Ottens PJ, Kuipers J, Giepmans BN, Leuvenink HG, Lisman T, Porte RJ.

Liver Transpl. 2016 Jul;22(7):994-1005. doi: 10.1002/lt.24436.


Enzymes for Pancreatic Islet Isolation Impact Chemokine-Production and Polarization of Insulin-Producing β-Cells with Reduced Functional Survival of Immunoisolated Rat Islet-Allografts as a Consequence.

de Vos P, Smink AM, Paredes G, Lakey JR, Kuipers J, Giepmans BN, de Haan BJ, Faas MM.

PLoS One. 2016 Jan 29;11(1):e0147992. doi: 10.1371/journal.pone.0147992. eCollection 2016.


The role of enterocyte defects in the pathogenesis of congenital diarrheal disorders.

Overeem AW, Posovszky C, Rings EH, Giepmans BN, van IJzendoorn SC.

Dis Model Mech. 2016 Jan;9(1):1-12. doi: 10.1242/dmm.022269. Review.


Long-Term In Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals.

Maimets M, Rocchi C, Bron R, Pringle S, Kuipers J, Giepmans BN, Vries RG, Clevers H, de Haan G, van Os R, Coppes RP.

Stem Cell Reports. 2016 Jan 12;6(1):150-62. doi: 10.1016/j.stemcr.2015.11.009. Epub 2015 Dec 24.


Overexpression of Cystathionine γ-Lyase Suppresses Detrimental Effects of Spinocerebellar Ataxia Type 3.

Snijder PM, Baratashvili M, Grzeschik NA, Leuvenink HGD, Kuijpers L, Huitema S, Schaap O, Giepmans BNG, Kuipers J, Miljkovic JL, Mitrovic A, Bos EM, Szabó C, Kampinga HH, Dijkers PF, Bos EM, Szabó C, Kampinga HH, Dijkers PF, Dunnen WFAD, Filipovic MR, Goor HV, Sibon OCM.

Mol Med. 2016 Jan;21(1):758-768. doi: 10.2119/molmed.2015.00221. Epub 2015 Oct 13.


Guanine quadruplex structures localize to heterochromatin.

Hoffmann RF, Moshkin YM, Mouton S, Grzeschik NA, Kalicharan RD, Kuipers J, Wolters AH, Nishida K, Romashchenko AV, Postberg J, Lipps H, Berezikov E, Sibon OC, Giepmans BN, Lansdorp PM.

Nucleic Acids Res. 2016 Jan 8;44(1):152-63. doi: 10.1093/nar/gkv900. Epub 2015 Sep 17.


Scanning EM of non-heavy metal stained biosamples: Large-field of view, high contrast and highly efficient immunolabeling.

Kuipers J, de Boer P, Giepmans BN.

Exp Cell Res. 2015 Oct 1;337(2):202-7. doi: 10.1016/j.yexcr.2015.07.012. Epub 2015 Aug 10. Review.


Horizontal RNA transfer mediates platelet-induced hepatocyte proliferation.

Kirschbaum M, Karimian G, Adelmeijer J, Giepmans BN, Porte RJ, Lisman T.

Blood. 2015 Aug 6;126(6):798-806. doi: 10.1182/blood-2014-09-600312. Epub 2015 Jun 8.


Correlated light and electron microscopy: ultrastructure lights up!

de Boer P, Hoogenboom JP, Giepmans BN.

Nat Methods. 2015 Jun;12(6):503-13. doi: 10.1038/nmeth.3400. Review.


Mitochondrial Dysfunction in Human Leukemic Stem/Progenitor Cells upon Loss of RAC2.

Capala ME, Maat H, Bonardi F, van den Boom V, Kuipers J, Vellenga E, Giepmans BN, Schuringa JJ.

PLoS One. 2015 May 27;10(5):e0128585. doi: 10.1371/journal.pone.0128585. eCollection 2015.


Large-Scale Electron Microscopy Maps of Patient Skin and Mucosa Provide Insight into Pathogenesis of Blistering Diseases.

Sokol E, Kramer D, Diercks GFH, Kuipers J, Jonkman MF, Pas HH, Giepmans BNG.

J Invest Dermatol. 2015 Jul;135(7):1763-1770. doi: 10.1038/jid.2015.109. Epub 2015 Mar 19.


FLIPPER, a combinatorial probe for correlated live imaging and electron microscopy, allows identification and quantitative analysis of various cells and organelles.

Kuipers J, van Ham TJ, Kalicharan RD, Veenstra-Algra A, Sjollema KA, Dijk F, Schnell U, Giepmans BN.

Cell Tissue Res. 2015 Apr;360(1):61-70. doi: 10.1007/s00441-015-2142-7. Epub 2015 Mar 19.


Intravital correlated microscopy reveals differential macrophage and microglial dynamics during resolution of neuroinflammation.

van Ham TJ, Brady CA, Kalicharan RD, Oosterhof N, Kuipers J, Veenstra-Algra A, Sjollema KA, Peterson RT, Kampinga HH, Giepmans BN.

Dis Model Mech. 2014 Jul;7(7):857-69. doi: 10.1242/dmm.014886.


The diagnosis of insulitis in human type 1 diabetes.

Campbell-Thompson ML, Atkinson MA, Butler AE, Chapman NM, Frisk G, Gianani R, Giepmans BN, von Herrath MG, Hyöty H, Kay TW, Korsgren O, Morgan NG, Powers AC, Pugliese A, Richardson SJ, Rowe PA, Tracy S, In't Veld PA.

Diabetologia. 2013 Nov;56(11):2541-3. doi: 10.1007/s00125-013-3043-5. Epub 2013 Sep 5. No abstract available.


Lack of claudin-7 is a strong predictor of regional recurrence in oral and oropharyngeal squamous cell carcinoma.

Melchers LJ, Bruine de Bruin L, Schnell U, Slagter-Menkema L, Mastik MF, de Bock GH, van Dijk BA, Giepmans BN, van der Laan BF, van der Wal JE, Roodenburg JL, Schuuring E.

Oral Oncol. 2013 Oct;49(10):998-1005. doi: 10.1016/j.oraloncology.2013.07.008. Epub 2013 Aug 13.


Destruction of tissue, cells and organelles in type 1 diabetic rats presented at macromolecular resolution.

Ravelli RB, Kalicharan RD, Avramut MC, Sjollema KA, Pronk JW, Dijk F, Koster AJ, Visser JT, Faas FG, Giepmans BN.

Sci Rep. 2013;3:1804. doi: 10.1038/srep01804.


EpCAM: structure and function in health and disease.

Schnell U, Cirulli V, Giepmans BN.

Biochim Biophys Acta. 2013 Aug;1828(8):1989-2001. doi: 10.1016/j.bbamem.2013.04.018. Epub 2013 Apr 23. Review.


Absence of cell-surface EpCAM in congenital tufting enteropathy.

Schnell U, Kuipers J, Mueller JL, Veenstra-Algra A, Sivagnanam M, Giepmans BN.

Hum Mol Genet. 2013 Jul 1;22(13):2566-71. doi: 10.1093/hmg/ddt105. Epub 2013 Mar 5.


EpCAM proteolysis: new fragments with distinct functions?

Schnell U, Kuipers J, Giepmans BN.

Biosci Rep. 2013 Mar 19;33(2):e00030. doi: 10.1042/BSR20120128.


Correlated light microscopy and electron microscopy.

Sjollema KA, Schnell U, Kuipers J, Kalicharan R, Giepmans BN.

Methods Cell Biol. 2012;111:157-73. doi: 10.1016/B978-0-12-416026-2.00009-1. Review.


Immunolabeling artifacts and the need for live-cell imaging.

Schnell U, Dijk F, Sjollema KA, Giepmans BN.

Nat Methods. 2012 Jan 30;9(2):152-8. doi: 10.1038/nmeth.1855.


Gap junctional channels are parts of multiprotein complexes.

Hervé JC, Derangeon M, Sarrouilhe D, Giepmans BN, Bourmeyster N.

Biochim Biophys Acta. 2012 Aug;1818(8):1844-65. doi: 10.1016/j.bbamem.2011.12.009. Epub 2011 Dec 14. Review.


Cx36 makes channels coupling human pancreatic beta-cells, and correlates with insulin expression.

Serre-Beinier V, Bosco D, Zulianello L, Charollais A, Caille D, Charpantier E, Gauthier BR, Diaferia GR, Giepmans BN, Lupi R, Marchetti P, Deng S, Buhler L, Berney T, Cirulli V, Meda P.

Hum Mol Genet. 2009 Feb 1;18(3):428-39. doi: 10.1093/hmg/ddn370. Epub 2008 Nov 10.


Epithelial cell-cell junctions and plasma membrane domains.

Giepmans BN, van Ijzendoorn SC.

Biochim Biophys Acta. 2009 Apr;1788(4):820-31. doi: 10.1016/j.bbamem.2008.07.015. Epub 2008 Jul 28. Review.


Bridging fluorescence microscopy and electron microscopy.

Giepmans BN.

Histochem Cell Biol. 2008 Aug;130(2):211-7. doi: 10.1007/s00418-008-0460-5. Epub 2008 Jun 25. Review.


Visualization of polarized membrane type 1 matrix metalloproteinase activity in live cells by fluorescence resonance energy transfer imaging.

Ouyang M, Lu S, Li XY, Xu J, Seong J, Giepmans BN, Shyy JY, Weiss SJ, Wang Y.

J Biol Chem. 2008 Jun 20;283(25):17740-8. doi: 10.1074/jbc.M709872200. Epub 2008 Apr 25.


Regulation of connexin43 gap junctional communication by phosphatidylinositol 4,5-bisphosphate.

van Zeijl L, Ponsioen B, Giepmans BN, Ariaens A, Postma FR, Várnai P, Balla T, Divecha N, Jalink K, Moolenaar WH.

J Cell Biol. 2007 Jun 4;177(5):881-91. Epub 2007 May 29.


Markers for correlated light and electron microscopy.

Sosinsky GE, Giepmans BN, Deerinck TJ, Gaietta GM, Ellisman MH.

Methods Cell Biol. 2007;79:575-91. Review. No abstract available.


Light and electron microscopic localization of multiple proteins using quantum dots.

Deerinck TJ, Giepmans BN, Smarr BL, Martone ME, Ellisman MH.

Methods Mol Biol. 2007;374:43-53.


Golgi twins in late mitosis revealed by genetically encoded tags for live cell imaging and correlated electron microscopy.

Gaietta GM, Giepmans BN, Deerinck TJ, Smith WB, Ngan L, Llopis J, Adams SR, Tsien RY, Ellisman MH.

Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17777-82. Epub 2006 Nov 13.


Role of connexin43-interacting proteins at gap junctions.

Giepmans BN.

Adv Cardiol. 2006;42:41-56.


The fluorescent toolbox for assessing protein location and function.

Giepmans BN, Adams SR, Ellisman MH, Tsien RY.

Science. 2006 Apr 14;312(5771):217-24. Review.


Correlated light and electron microscopic imaging of multiple endogenous proteins using Quantum dots.

Giepmans BN, Deerinck TJ, Smarr BL, Jones YZ, Ellisman MH.

Nat Methods. 2005 Oct;2(10):743-9.


Mammalian cell-based optimization of the biarsenical-binding tetracysteine motif for improved fluorescence and affinity.

Martin BR, Giepmans BN, Adams SR, Tsien RY.

Nat Biotechnol. 2005 Oct;23(10):1308-14. Epub 2005 Sep 11.


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