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Items: 29


Concepts for agonistic targeting of CD40 in immuno-oncology.

Richards DM, Sefrin JP, Gieffers C, Hill O, Merz C.

Hum Vaccin Immunother. 2019 Sep 5:1-11. doi: 10.1080/21645515.2019.1653744. [Epub ahead of print]


HERA-GITRL activates T cells and promotes anti-tumor efficacy independent of FcγR-binding functionality.

Richards DM, Marschall V, Billian-Frey K, Heinonen K, Merz C, Redondo Müller M, Sefrin JP, Schröder M, Sykora J, Fricke H, Hill O, Gieffers C, Thiemann M.

J Immunother Cancer. 2019 Jul 19;7(1):191. doi: 10.1186/s40425-019-0671-4.


A Single-Chain-Based Hexavalent CD27 Agonist Enhances T Cell Activation and Induces Anti-Tumor Immunity.

Thiemann M, Richards DM, Heinonen K, Kluge M, Marschall V, Merz C, Redondo Müller M, Schnyder T, Sefrin JP, Sykora J, Fricke H, Gieffers C, Hill O.

Front Oncol. 2018 Sep 19;8:387. doi: 10.3389/fonc.2018.00387. eCollection 2018.


The Hexavalent CD40 Agonist HERA-CD40L Induces T-Cell-mediated Antitumor Immune Response Through Activation of Antigen-presenting Cells.

Merz C, Sykora J, Marschall V, Richards DM, Heinonen K, Redondo Müller M, Thiemann M, Schnyder T, Fricke H, Hill O, Gieffers C.

J Immunother. 2018 Nov/Dec;41(9):385-398. doi: 10.1097/CJI.0000000000000246.


The novel TRAIL-receptor agonist APG350 exerts superior therapeutic activity in pancreatic cancer cells.

Legler K, Hauser C, Egberts JH, Willms A, Heneweer C, Boretius S, Röcken C, Glüer CC, Becker T, Kluge M, Hill O, Gieffers C, Fricke H, Kalthoff H, Lemke J, Trauzold A.

Cell Death Dis. 2018 May 1;9(5):445. doi: 10.1038/s41419-018-0478-0.


Inhibition of CD95/CD95L (FAS/FASLG) Signaling with APG101 Prevents Invasion and Enhances Radiation Therapy for Glioblastoma.

Blaes J, Thomé CM, Pfenning PN, Rübmann P, Sahm F, Wick A, Bunse T, Schmenger T, Sykora J, von Deimling A, Wiestler B, Merz C, Jugold M, Haberkorn U, Abdollahi A, Debus J, Gieffers C, Kunz C, Bendszus M, Kluge M, Platten M, Fricke H, Wick W, Lemke D.

Mol Cancer Res. 2018 May;16(5):767-776. doi: 10.1158/1541-7786.MCR-17-0563. Epub 2018 Feb 16.


CD95 maintains stem cell-like and non-classical EMT programs in primary human glioblastoma cells.

Drachsler M, Kleber S, Mateos A, Volk K, Mohr N, Chen S, Cirovic B, Tüttenberg J, Gieffers C, Sykora J, Wirtz CR, Mueller W, Synowitz M, Martin-Villalba A.

Cell Death Dis. 2016 Apr 28;7:e2209. doi: 10.1038/cddis.2016.102.


Neutralization of the CD95 ligand by APG101 inhibits invasion of glioma cells in vitro.

Merz C, Strecker A, Sykora J, Hill O, Fricke H, Angel P, Gieffers C, Peterziel H.

Anticancer Drugs. 2015 Aug;26(7):716-27. doi: 10.1097/CAD.0000000000000237.


CD95 promotes metastatic spread via Sck in pancreatic ductal adenocarcinoma.

Teodorczyk M, Kleber S, Wollny D, Sefrin JP, Aykut B, Mateos A, Herhaus P, Sancho-Martinez I, Hill O, Gieffers C, Sykora J, Weichert W, Eisen C, Trumpp A, Sprick MR, Bergmann F, Welsch T, Martin-Villalba A.

Cell Death Differ. 2015 Jul;22(7):1192-202. doi: 10.1038/cdd.2014.217. Epub 2015 Jan 23.


APG350 induces superior clustering of TRAIL receptors and shows therapeutic antitumor efficacy independent of cross-linking via Fcγ receptors.

Gieffers C, Kluge M, Merz C, Sykora J, Thiemann M, Schaal R, Fischer C, Branschädel M, Abhari BA, Hohenberger P, Fulda S, Fricke H, Hill O.

Mol Cancer Ther. 2013 Dec;12(12):2735-47. doi: 10.1158/1535-7163.MCT-13-0323. Epub 2013 Oct 7.


The death receptor CD95 activates adult neural stem cells for working memory formation and brain repair.

Corsini NS, Sancho-Martinez I, Laudenklos S, Glagow D, Kumar S, Letellier E, Koch P, Teodorczyk M, Kleber S, Klussmann S, Wiestler B, Brüstle O, Mueller W, Gieffers C, Hill O, Thiemann M, Seedorf M, Gretz N, Sprengel R, Celikel T, Martin-Villalba A.

Cell Stem Cell. 2009 Aug 7;5(2):178-90. doi: 10.1016/j.stem.2009.05.004.


Yes and PI3K bind CD95 to signal invasion of glioblastoma.

Kleber S, Sancho-Martinez I, Wiestler B, Beisel A, Gieffers C, Hill O, Thiemann M, Mueller W, Sykora J, Kuhn A, Schreglmann N, Letellier E, Zuliani C, Klussmann S, Teodorczyk M, Gröne HJ, Ganten TM, Sültmann H, Tüttenberg J, von Deimling A, Regnier-Vigouroux A, Herold-Mende C, Martin-Villalba A.

Cancer Cell. 2008 Mar;13(3):235-48. doi: 10.1016/j.ccr.2008.02.003.


Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C.

Dube P, Herzog F, Gieffers C, Sander B, Riedel D, Müller SA, Engel A, Peters JM, Stark H.

Mol Cell. 2005 Dec 22;20(6):867-79.


Mitotic regulation of the human anaphase-promoting complex by phosphorylation.

Kraft C, Herzog F, Gieffers C, Mechtler K, Hagting A, Pines J, Peters JM.

EMBO J. 2003 Dec 15;22(24):6598-609.


TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1.

Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM.

Curr Biol. 2003 Sep 2;13(17):1459-68.


Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex.

Wendt KS, Vodermaier HC, Jacob U, Gieffers C, Gmachl M, Peters JM, Huber R, Sondermann P.

Nat Struct Biol. 2001 Sep;8(9):784-8.


Three-dimensional structure of the anaphase-promoting complex.

Gieffers C, Dube P, Harris JR, Stark H, Peters JM.

Mol Cell. 2001 Apr;7(4):907-13.


Characterization of vertebrate cohesin complexes and their regulation in prophase.

Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM.

J Cell Biol. 2000 Nov 13;151(4):749-62.


Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1.

Petersen BO, Wagener C, Marinoni F, Kramer ER, Melixetian M, Lazzerini Denchi E, Gieffers C, Matteucci C, Peters JM, Helin K.

Genes Dev. 2000 Sep 15;14(18):2330-43.


The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex.

Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM.

Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8973-8.


Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons.

Gieffers C, Peters BH, Kramer ER, Dotti CG, Peters JM.

Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11317-22.


Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex.

Grossberger R, Gieffers C, Zachariae W, Podtelejnikov AV, Schleiffer A, Nasmyth K, Mann M, Peters JM.

J Biol Chem. 1999 May 14;274(20):14500-7.


Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family.

Kramer ER, Gieffers C, Hölzl G, Hengstschläger M, Peters JM.

Curr Biol. 1998 Nov 5;8(22):1207-10.


Mitofilin is a transmembrane protein of the inner mitochondrial membrane expressed as two isoforms.

Gieffers C, Korioth F, Heimann P, Ungermann C, Frey J.

Exp Cell Res. 1997 May 1;232(2):395-9.


Cloning and characterization of the human gene encoding aspartyl beta-hydroxylase.

Korioth F, Gieffers C, Frey J.

Gene. 1994 Dec 15;150(2):395-9.


Receptor binding of osteoblast-specific factor 1 (OSF-1/HB-GAM) to human osteosarcoma cells promotes cell attachment.

Gieffers C, Engelhardt W, Brenzel G, Matsuishi T, Frey J.

Eur J Cell Biol. 1993 Dec;62(2):352-61.


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