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Items: 48

1.

A role for picomolar concentrations of pregnenolone sulfate in synaptic activity-dependent Ca2+ signaling and CREB activation.

Smith CC, Martin SC, Sugunan K, Russek SJ, Gibbs TT, Farb DH.

Mol Pharmacol. 2014 Oct;86(4):390-8. doi: 10.1124/mol.114.094128. Epub 2014 Jul 23.

2.

Pregnenolone sulfate as a modulator of synaptic plasticity.

Smith CC, Gibbs TT, Farb DH.

Psychopharmacology (Berl). 2014 Sep;231(17):3537-56. doi: 10.1007/s00213-014-3643-x. Epub 2014 Jul 6. Review.

3.

Reduced serotonin receptor subtypes in a limbic and a neocortical region in autism.

Oblak A, Gibbs TT, Blatt GJ.

Autism Res. 2013 Dec;6(6):571-83. doi: 10.1002/aur.1317. Epub 2013 Jul 24.

4.

The neuroactive steroid pregnenolone sulfate stimulates trafficking of functional N-methyl D-aspartate receptors to the cell surface via a noncanonical, G protein, and Ca2+-dependent mechanism.

Kostakis E, Smith C, Jang MK, Martin SC, Richards KG, Russek SJ, Gibbs TT, Farb DH.

Mol Pharmacol. 2013 Aug;84(2):261-74. doi: 10.1124/mol.113.085696. Epub 2013 May 28.

5.

A steroid modulatory domain in NR2A collaborates with NR1 exon-5 to control NMDAR modulation by pregnenolone sulfate and protons.

Kostakis E, Jang MK, Russek SJ, Gibbs TT, Farb DH.

J Neurochem. 2011 Nov;119(3):486-96. doi: 10.1111/j.1471-4159.2011.07442.x. Epub 2011 Sep 28.

6.

Reduced GABAA receptors and benzodiazepine binding sites in the posterior cingulate cortex and fusiform gyrus in autism.

Oblak AL, Gibbs TT, Blatt GJ.

Brain Res. 2011 Mar 22;1380:218-28. doi: 10.1016/j.brainres.2010.09.021. Epub 2010 Sep 19.

7.

Decreased GABA(B) receptors in the cingulate cortex and fusiform gyrus in autism.

Oblak AL, Gibbs TT, Blatt GJ.

J Neurochem. 2010 Sep 1;114(5):1414-23. doi: 10.1111/j.1471-4159.2010.06858.x. Epub 2010 Jun 12.

8.

Decreased GABAA receptors and benzodiazepine binding sites in the anterior cingulate cortex in autism.

Oblak A, Gibbs TT, Blatt GJ.

Autism Res. 2009 Aug;2(4):205-19. doi: 10.1002/aur.88. Erratum in: Autism Res. 2009 Aug;2(4):237.

9.

Docking of 1,4-benzodiazepines in the alpha1/gamma2 GABA(A) receptor modulator site.

Berezhnoy D, Gibbs TT, Farb DH.

Mol Pharmacol. 2009 Aug;76(2):440-50. doi: 10.1124/mol.109.054650. Epub 2009 May 29.

10.

Nanomolar concentrations of pregnenolone sulfate enhance striatal dopamine overflow in vivo.

Sadri-Vakili G, Janis GC, Pierce RC, Gibbs TT, Farb DH.

J Pharmacol Exp Ther. 2008 Dec;327(3):840-5. doi: 10.1124/jpet.108.143958. Epub 2008 Sep 4.

11.

Pregnenolone sulfate induces NMDA receptor dependent release of dopamine from synaptic terminals in the striatum.

Whittaker MT, Gibbs TT, Farb DH.

J Neurochem. 2008 Oct;107(2):510-21. doi: 10.1111/j.1471-4159.2008.05627.x. Epub 2008 Aug 14.

12.

Pharmacological Properties of DOV 315,090, an ocinaplon metabolite.

Berezhnoy D, Gravielle MC, Downing S, Kostakis E, Basile AS, Skolnick P, Gibbs TT, Farb DH.

BMC Pharmacol. 2008 Jun 13;8:11. doi: 10.1186/1471-2210-8-11.

13.

Sulfated steroids as endogenous neuromodulators.

Gibbs TT, Russek SJ, Farb DH.

Pharmacol Biochem Behav. 2006 Aug;84(4):555-67. Epub 2006 Oct 4. Review.

PMID:
17023038
14.

[3H]-flunitrazepam-labeled benzodiazepine binding sites in the hippocampal formation in autism: a multiple concentration autoradiographic study.

Guptill JT, Booker AB, Gibbs TT, Kemper TL, Bauman ML, Blatt GJ.

J Autism Dev Disord. 2007 May;37(5):911-20.

PMID:
17019626
15.

The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors.

Popik P, Kostakis E, Krawczyk M, Nowak G, Szewczyk B, Krieter P, Chen Z, Russek SJ, Gibbs TT, Farb DH, Skolnick P, Lippa AS, Basile AS.

J Pharmacol Exp Ther. 2006 Dec;319(3):1244-52. Epub 2006 Sep 13.

PMID:
16971504
16.
17.

Selective anxiolysis produced by ocinaplon, a GABA(A) receptor modulator.

Lippa A, Czobor P, Stark J, Beer B, Kostakis E, Gravielle M, Bandyopadhyay S, Russek SJ, Gibbs TT, Farb DH, Skolnick P.

Proc Natl Acad Sci U S A. 2005 May 17;102(20):7380-5. Epub 2005 May 3.

18.
20.

Dueling enigmas: neurosteroids and sigma receptors in the limelight.

Gibbs TT, Farb DH.

Sci STKE. 2000 Nov 28;2000(60):pe1. Review.

PMID:
11752623
22.

Geometry and charge determine pharmacological effects of steroids on N-methyl-D-aspartate receptor-induced Ca(2+) accumulation and cell death.

Weaver CE, Land MB, Purdy RH, Richards KG, Gibbs TT, Farb DH.

J Pharmacol Exp Ther. 2000 Jun;293(3):747-54.

PMID:
10869372
23.
24.

Sulfated and unsulfated steroids modulate gamma-aminobutyric acidA receptor function through distinct sites.

Park-Chung M, Malayev A, Purdy RH, Gibbs TT, Farb DH.

Brain Res. 1999 May 29;830(1):72-87.

PMID:
10350561
25.

Pregnenolone sulfate exacerbates NMDA-induced death of hippocampal neurons.

Weaver CE Jr, Wu FS, Gibbs TT, Farb DH.

Brain Res. 1998 Aug 24;803(1-2):129-36.

PMID:
9729331
26.

Neurosteroid modulation of recombinant ionotropic glutamate receptors.

Yaghoubi N, Malayev A, Russek SJ, Gibbs TT, Farb DH.

Brain Res. 1998 Aug 24;803(1-2):153-60.

PMID:
9729352
27.

Distinct sites for inverse modulation of N-methyl-D-aspartate receptors by sulfated steroids.

Park-Chung M, Wu FS, Purdy RH, Malayev AA, Gibbs TT, Farb DH.

Mol Pharmacol. 1997 Dec;52(6):1113-23.

PMID:
9396781
28.

17beta-Estradiol protects against NMDA-induced excitotoxicity by direct inhibition of NMDA receptors.

Weaver CE Jr, Park-Chung M, Gibbs TT, Farb DH.

Brain Res. 1997 Jul 4;761(2):338-41.

PMID:
9252035
30.
31.
33.

Steroid modulation of amino acid neurotransmitter receptors.

Farb DH, Gibbs TT, Wu FS, Gyenes M, Friedman L, Russek SJ.

Adv Biochem Psychopharmacol. 1992;47:119-31. No abstract available.

PMID:
1324566
34.

Negative modulation of the gamma-aminobutyric acid response by extracellular zinc.

Celentano JJ, Gyenes M, Gibbs TT, Farb DH.

Mol Pharmacol. 1991 Nov;40(5):766-73.

PMID:
1658609
35.

Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor.

Wu FS, Gibbs TT, Farb DH.

Mol Pharmacol. 1991 Sep;40(3):333-6.

PMID:
1654510
36.
37.

Inverse modulation of gamma-aminobutyric acid- and glycine-induced currents by progesterone.

Wu FS, Gibbs TT, Farb DH.

Mol Pharmacol. 1990 May;37(5):597-602.

PMID:
2338942
38.
39.

Molecular and cellular mechanisms of GABA/benzodiazepine-receptor regulation: electrophysiological and biochemical studies.

Farrant M, Gibbs TT, Farb DH.

Neurochem Res. 1990 Feb;15(2):175-91. Review. No abstract available.

PMID:
2159123
41.

Ethanol potentiates GABA- and glycine-induced chloride currents in chick spinal cord neurons.

Celentano JJ, Gibbs TT, Farb DH.

Brain Res. 1988 Jul 12;455(2):377-80.

PMID:
2900060
42.

Functional and structural correlates of GABA receptor modulation.

Gibbs TT, Mierlak D, Gyenes M, Celentano JJ, Farb DH.

Adv Biochem Psychopharmacol. 1988;45:95-107. No abstract available.

PMID:
2845741
43.
44.

Turnover of the benzodiazepine/gamma-aminobutyric acid receptor complex determined in situ.

Farb DH, Czajkowski CM, Borden LA, Schiller GD, Gibbs TT.

Adv Biochem Psychopharmacol. 1986;41:51-66. No abstract available.

PMID:
3017074
45.

Benzodiazepine receptor photoaffinity labeling: correlation of function with binding.

Gibbs TT, Chan CY, Czajkowski CM, Farb DH.

Eur J Pharmacol. 1985 Apr 2;110(2):171-80.

PMID:
2985408
46.

Modulation of neuronal function through benzodiazepine receptors: biochemical and electrophysiological studies of neurons in primary monolayer cell culture.

Farb DH, Borden LA, Chan CY, Czajkowski CM, Gibbs TT, Schiller GD.

Ann N Y Acad Sci. 1984;435:1-31. No abstract available.

PMID:
6099704
47.

Multiple embryonic benzodiazepine binding sites: evidence for functionality.

Chan CY, Gibbs TT, Borden LA, Farb DH.

Life Sci. 1983 Nov 21;33(21):2061-9.

PMID:
6316055
48.

Mispair correction in nucleic acids with alternate forms.

Zipser D, Gibbs TT.

J Theor Biol. 1975 Sep;53(2):395-402. No abstract available.

PMID:
1195770

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