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Items: 1 to 50 of 114

1.

The formyl peptide fMLF primes platelet activation and augments thrombus formation.

Salamah MF, Ravishankar D, Vaiyapuri R, Moraes LA, Patel K, Perretti M, Gibbins JM, Vaiyapuri S.

J Thromb Haemost. 2019 Jul;17(7):1120-1133. doi: 10.1111/jth.14466. Epub 2019 May 24.

2.

Flow cytometry for near-patient testing in premature neonates reveals variation in platelet function: a novel approach to guide platelet transfusion.

Waller AK, Lantos L, Sammut A, Salgin B, McKinney H, Foster HR, Kriek N, Gibbins JM, Stanworth SJ, Garner SF, Venkatesh V, Curley A, Belteki G, Ghevaert C.

Pediatr Res. 2019 May;85(6):874-884. doi: 10.1038/s41390-019-0316-9. Epub 2019 Jan 29.

PMID:
30742030
3.

Gradient-dependent inhibition of stimulatory signaling from platelet G protein-coupled receptors.

Macwan AS, Boknäs N, Ntzouni MP, Ramström S, Gibbins JM, Faxälv L, Lindahl TL.

Haematologica. 2019 Jul;104(7):1482-1492. doi: 10.3324/haematol.2018.205815. Epub 2019 Jan 10.

4.

The endogenous antimicrobial cathelicidin LL37 induces platelet activation and augments thrombus formation.

Salamah MF, Ravishankar D, Kodji X, Moraes LA, Williams HF, Vallance TM, Albadawi DA, Vaiyapuri R, Watson K, Gibbins JM, Brain SD, Perretti M, Vaiyapuri S.

Blood Adv. 2018 Nov 13;2(21):2973-2985. doi: 10.1182/bloodadvances.2018021758.

5.

Advancing research on blood coagulation and thrombosis: Reply to the comments on "Modeling thrombosis in silico: Frontiers, challenges, unresolved problems and milestones".

Belyaev AV, Dunster JL, Gibbins JM, Panteleev MA, Volpert V.

Phys Life Rev. 2018 Nov;26-27:116-119. doi: 10.1016/j.plrev.2018.09.006. Epub 2018 Oct 3. No abstract available.

PMID:
30297158
6.

Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction.

Unsworth AJ, Bye AP, Kriek N, Sage T, Osborne AA, Donaghy D, Gibbins JM.

Platelets. 2019;30(6):762-772. doi: 10.1080/09537104.2018.1514107. Epub 2018 Sep 25.

7.

Mathematical Techniques for Understanding Platelet Regulation and the Development of New Pharmacological Approaches.

Dunster JL, Panteleev MA, Gibbins JM, Sveshnikova AN.

Methods Mol Biol. 2018;1812:255-279. doi: 10.1007/978-1-4939-8585-2_15.

PMID:
30171583
8.

Screening and High-Throughput Platelet Assays.

Bye AP, Unsworth AJ, Gibbins JM.

Methods Mol Biol. 2018;1812:81-94. doi: 10.1007/978-1-4939-8585-2_5.

PMID:
30171573
9.

Functional redundancy between RAP1 isoforms in murine platelet production and function.

Stefanini L, Lee RH, Paul DS, O'Shaughnessy EC, Ghalloussi D, Jones CI, Boulaftali Y, Poe KO, Piatt R, Kechele DO, Caron KM, Hahn KM, Gibbins JM, Bergmeier W.

Blood. 2018 Nov 1;132(18):1951-1962. doi: 10.1182/blood-2018-03-838714. Epub 2018 Aug 21.

PMID:
30131434
10.

Move along, nothing to see here: Btk inhibitors stop platelets sticking to plaques.

Bye AP, Gibbins JM.

J Thromb Haemost. 2018 Jul 20. doi: 10.1111/jth.14201. [Epub ahead of print] No abstract available.

PMID:
30030898
11.

Talin is a substrate for SUMOylation in migrating cancer cells.

Huang Z, Barker D, Gibbins JM, Dash PR.

Exp Cell Res. 2018 Sep 15;370(2):417-425. doi: 10.1016/j.yexcr.2018.07.005. Epub 2018 Jul 9.

12.

Connexins and Pannexins in Vascular Function and Disease.

Molica F, Figueroa XF, Kwak BR, Isakson BE, Gibbins JM.

Int J Mol Sci. 2018 Jun 5;19(6). pii: E1663. doi: 10.3390/ijms19061663. Review.

13.

NADPH oxidase 2 (NOX2): A key target of oxidative stress-mediated platelet activation and thrombosis.

Fuentes E, Gibbins JM, Holbrook LM, Palomo I.

Trends Cardiovasc Med. 2018 Oct;28(7):429-434. doi: 10.1016/j.tcm.2018.03.001. Epub 2018 Mar 26. Review.

PMID:
29661712
14.

Modeling thrombosis in silico: Frontiers, challenges, unresolved problems and milestones.

Belyaev AV, Dunster JL, Gibbins JM, Panteleev MA, Volpert V.

Phys Life Rev. 2018 Nov;26-27:57-95. doi: 10.1016/j.plrev.2018.02.005. Epub 2018 Mar 5. Review.

PMID:
29550179
15.

The chaperone protein HSP47: a platelet collagen binding protein that contributes to thrombosis and hemostasis.

Sasikumar P, AlOuda KS, Kaiser WJ, Holbrook LM, Kriek N, Unsworth AJ, Bye AP, Sage T, Ushioda R, Nagata K, Farndale RW, Gibbins JM.

J Thromb Haemost. 2018 May;16(5):946-959. doi: 10.1111/jth.13998. Epub 2018 Apr 15.

16.

Non-genomic effects of nuclear receptors: insights from the anucleate platelet.

Unsworth AJ, Flora GD, Gibbins JM.

Cardiovasc Res. 2018 Apr 1;114(5):645-655. doi: 10.1093/cvr/cvy044.

17.

Severe platelet dysfunction in NHL patients receiving ibrutinib is absent in patients receiving acalabrutinib.

Bye AP, Unsworth AJ, Desborough MJ, Hildyard CAT, Appleby N, Bruce D, Kriek N, Nock SH, Sage T, Hughes CE, Gibbins JM.

Blood Adv. 2017 Dec 12;1(26):2610-2623. doi: 10.1182/bloodadvances.2017011999. eCollection 2017 Dec 12. Erratum in: Blood Adv. 2018 Dec 11;2(23):3515.

18.

Lipopolysaccharide potentiates platelet responses via toll-like receptor 4-stimulated Akt-Erk-PLA2 signalling.

Lopes Pires ME, Clarke SR, Marcondes S, Gibbins JM.

PLoS One. 2017 Nov 14;12(11):e0186981. doi: 10.1371/journal.pone.0186981. eCollection 2017.

19.

A humanized monoclonal antibody that inhibits platelet-surface ERp72 reveals a role for ERp72 in thrombosis.

Holbrook LM, Sandhar GK, Sasikumar P, Schenk MP, Stainer AR, Sahli KA, Flora GD, Bicknell AB, Gibbins JM.

J Thromb Haemost. 2018 Feb;16(2):367-377. doi: 10.1111/jth.13878. Epub 2018 Jan 15.

20.

Farnesoid X Receptor and Liver X Receptor Ligands Initiate Formation of Coated Platelets.

Unsworth AJ, Bye AP, Tannetta DS, Desborough MJR, Kriek N, Sage T, Allan HE, Crescente M, Yaqoob P, Warner TD, Jones CI, Gibbins JM.

Arterioscler Thromb Vasc Biol. 2017 Aug;37(8):1482-1493. doi: 10.1161/ATVBAHA.117.309135. Epub 2017 Jun 15.

21.

Evidence for shear-mediated Ca2+ entry through mechanosensitive cation channels in human platelets and a megakaryocytic cell line.

Ilkan Z, Wright JR, Goodall AH, Gibbins JM, Jones CI, Mahaut-Smith MP.

J Biol Chem. 2017 Jun 2;292(22):9204-9217. doi: 10.1074/jbc.M116.766196. Epub 2017 Apr 17.

22.

RXR Ligands Negatively Regulate Thrombosis and Hemostasis.

Unsworth AJ, Flora GD, Sasikumar P, Bye AP, Sage T, Kriek N, Crescente M, Gibbins JM.

Arterioscler Thromb Vasc Biol. 2017 May;37(5):812-822. doi: 10.1161/ATVBAHA.117.309207. Epub 2017 Mar 2.

23.

Challenges in diagnosing and treating snakebites in a rural population of Tamil Nadu, India: The views of clinicians.

Williams HF, Vaiyapuri R, Gajjeraman P, Hutchinson G, Gibbins JM, Bicknell AB, Vaiyapuri S.

Toxicon. 2017 May;130:44-46. doi: 10.1016/j.toxicon.2017.02.025. Epub 2017 Feb 24.

PMID:
28238804
24.

PPARγ agonists negatively regulate αIIbβ3 integrin outside-in signaling and platelet function through up-regulation of protein kinase A activity.

Unsworth AJ, Kriek N, Bye AP, Naran K, Sage T, Flora GD, Gibbins JM.

J Thromb Haemost. 2017 Feb;15(2):356-369. doi: 10.1111/jth.13578. Epub 2017 Feb 7.

25.

Farnesoid X Receptor and Its Ligands Inhibit the Function of Platelets.

Moraes LA, Unsworth AJ, Vaiyapuri S, Ali MS, Sasikumar P, Sage T, Flora GD, Bye AP, Kriek N, Dorchies E, Molendi-Coste O, Dombrowicz D, Staels B, Bishop-Bailey D, Gibbins JM.

Arterioscler Thromb Vasc Biol. 2016 Dec;36(12):2324-2333. doi: 10.1161/ATVBAHA.116.308093. Epub 2016 Oct 6.

26.

Intracellular Trafficking, Localization, and Mobilization of Platelet-Borne Thiol Isomerases.

Crescente M, Pluthero FG, Li L, Lo RW, Walsh TG, Schenk MP, Holbrook LM, Louriero S, Ali MS, Vaiyapuri S, Falet H, Jones IM, Poole AW, Kahr WH, Gibbins JM.

Arterioscler Thromb Vasc Biol. 2016 Jun;36(6):1164-73. doi: 10.1161/ATVBAHA.116.307461. Epub 2016 Apr 14.

27.

Platelets stop us leaking.

Gibbins JM.

Blood. 2016 Mar 24;127(12):1528-9. doi: 10.1182/blood-2016-01-692186.

28.

Platelet signaling: a complex interplay between inhibitory and activatory networks.

Bye AP, Unsworth AJ, Gibbins JM.

J Thromb Haemost. 2016 May;14(5):918-30. doi: 10.1111/jth.13302. Epub 2016 Apr 9. Review.

29.

A high-density immunoblotting methodology for quantification of total protein levels and phosphorylation modifications.

Mazet F, Dunster JL, Jones CI, Vaiyapuri S, Tindall MJ, Fry MJ, Gibbins JM.

Sci Rep. 2015 Nov 23;5:16995. doi: 10.1038/srep16995.

30.

Regulation of Early Steps of GPVI Signal Transduction by Phosphatases: A Systems Biology Approach.

Dunster JL, Mazet F, Fry MJ, Gibbins JM, Tindall MJ.

PLoS Comput Biol. 2015 Nov 19;11(11):e1004589. doi: 10.1371/journal.pcbi.1004589. eCollection 2015 Nov.

31.

Syncytiotrophoblast Extracellular Vesicles from Pre-Eclampsia Placentas Differentially Affect Platelet Function.

Tannetta DS, Hunt K, Jones CI, Davidson N, Coxon CH, Ferguson D, Redman CW, Gibbins JM, Sargent IL, Tucker KL.

PLoS One. 2015 Nov 9;10(11):e0142538. doi: 10.1371/journal.pone.0142538. eCollection 2015.

32.

Ibrutinib Inhibits Platelet Integrin αIIbβ3 Outside-In Signaling and Thrombus Stability But Not Adhesion to Collagen.

Bye AP, Unsworth AJ, Vaiyapuri S, Stainer AR, Fry MJ, Gibbins JM.

Arterioscler Thromb Vasc Biol. 2015 Nov;35(11):2326-35. doi: 10.1161/ATVBAHA.115.306130. Epub 2015 Sep 10.

PMID:
26359510
33.

GRID and docking analyses reveal a molecular basis for flavonoid inhibition of Src family kinase activity.

Wright B, Watson KA, McGuffin LJ, Lovegrove JA, Gibbins JM.

J Nutr Biochem. 2015 Nov;26(11):1156-65. doi: 10.1016/j.jnutbio.2015.05.004. Epub 2015 Jun 9.

PMID:
26140983
34.

Gap junctions and connexin hemichannels in the regulation of haemostasis and thrombosis.

Vaiyapuri S, Flora GD, Gibbins JM.

Biochem Soc Trans. 2015 Jun;43(3):489-94. doi: 10.1042/BST20150055. Review.

PMID:
26009196
35.

Pharmacological actions of nobiletin in the modulation of platelet function.

Vaiyapuri S, Roweth H, Ali MS, Unsworth AJ, Stainer AR, Flora GD, Crescente M, Jones CI, Moraes LA, Gibbins JM.

Br J Pharmacol. 2015 Aug;172(16):4133-45. doi: 10.1111/bph.13191. Epub 2015 Jun 26.

36.

EphB2 regulates contact-dependent and contact-independent signaling to control platelet function.

Vaiyapuri S, Sage T, Rana RH, Schenk MP, Ali MS, Unsworth AJ, Jones CI, Stainer AR, Kriek N, Moraes LA, Gibbins JM.

Blood. 2015 Jan 22;125(4):720-30. doi: 10.1182/blood-2014-06-585083. Epub 2014 Nov 4.

37.

Discovery of novel GPVI receptor antagonists by structure-based repurposing.

Taylor L, Vasudevan SR, Jones CI, Gibbins JM, Churchill GC, Campbell RD, Coxon CH.

PLoS One. 2014 Jun 27;9(6):e101209. doi: 10.1371/journal.pone.0101209. eCollection 2014.

38.

Platelet endothelial cell adhesion molecule-1 inhibits platelet response to thrombin and von Willebrand factor by regulating the internalization of glycoprotein Ib via AKT/glycogen synthase kinase-3/dynamin and integrin αIIbβ3.

Jones CI, Sage T, Moraes LA, Vaiyapuri S, Hussain U, Tucker KL, Barrett NE, Gibbins JM.

Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):1968-76. doi: 10.1161/ATVBAHA.114.304097. Epub 2014 Jun 26.

PMID:
24969778
39.

Integrin-linked kinase regulates the rate of platelet activation and is essential for the formation of stable thrombi.

Jones CI, Tucker KL, Sasikumar P, Sage T, Kaiser WJ, Moore C, Emerson M, Gibbins JM.

J Thromb Haemost. 2014 Aug;12(8):1342-52. doi: 10.1111/jth.12620. Epub 2014 Jul 31.

40.

Ibuprofen inhibits migration and proliferation of human coronary artery smooth muscle cells by inducing a differentiated phenotype: role of peroxisome proliferator-activated receptor γ.

Dannoura A, Giraldo A, Pereira I, Gibbins JM, Dash PR, Bicknell KA, Brooks G.

J Pharm Pharmacol. 2014 Jun;66(6):779-92. doi: 10.1111/jphp.12203. Epub 2014 Jan 20.

PMID:
24438071
41.

Investigating flavonoids as molecular templates for the design of small-molecule inhibitors of cell signaling.

Wright B, Tindall MJ, Lovegrove JA, Gibbins JM.

J Food Sci. 2013 Dec;78(12):N1921-8. doi: 10.1111/1750-3841.12293.

PMID:
24329957
42.

The role of plasma membrane STIM1 and Ca(2+)entry in platelet aggregation. STIM1 binds to novel proteins in human platelets.

Ambily A, Kaiser WJ, Pierro C, Chamberlain EV, Li Z, Jones CI, Kassouf N, Gibbins JM, Authi KS.

Cell Signal. 2014 Mar;26(3):502-11. doi: 10.1016/j.cellsig.2013.11.025. Epub 2013 Dec 2.

43.

Snakebite and its socio-economic impact on the rural population of Tamil Nadu, India.

Vaiyapuri S, Vaiyapuri R, Ashokan R, Ramasamy K, Nattamaisundar K, Jeyaraj A, Chandran V, Gajjeraman P, Baksh MF, Gibbins JM, Hutchinson EG.

PLoS One. 2013 Nov 21;8(11):e80090. doi: 10.1371/journal.pone.0080090. eCollection 2013.

44.

Platelets using proteins creatively.

Gibbins JM.

Blood. 2013 Nov 21;122(22):3553-4. doi: 10.1182/blood-2013-09-527663.

45.

Tangeretin regulates platelet function through inhibition of phosphoinositide 3-kinase and cyclic nucleotide signaling.

Vaiyapuri S, Ali MS, Moraes LA, Sage T, Lewis KR, Jones CI, Gibbins JM.

Arterioscler Thromb Vasc Biol. 2013 Dec;33(12):2740-9. doi: 10.1161/ATVBAHA.113.301988. Epub 2013 Oct 17.

PMID:
24135020
46.

Flavonoid inhibitory pharmacodynamics on platelet function in physiological environments.

Wright B, Spencer JP, Lovegrove JA, Gibbins JM.

Food Funct. 2013 Dec;4(12):1803-10. doi: 10.1039/c3fo60272a. Epub 2013 Oct 14.

PMID:
24121953
47.

Connexin40 regulates platelet function.

Vaiyapuri S, Moraes LA, Sage T, Ali MS, Lewis KR, Mahaut-Smith MP, Oviedo-Orta E, Simon AM, Gibbins JM.

Nat Commun. 2013;4:2564. doi: 10.1038/ncomms3564.

48.

Antithrombotic actions of statins involve PECAM-1 signaling.

Moraes LA, Vaiyapuri S, Sasikumar P, Ali MS, Kriek N, Sage T, Gibbins JM.

Blood. 2013 Oct 31;122(18):3188-96. doi: 10.1182/blood-2013-04-491845. Epub 2013 Sep 12.

49.

Staphylococcus aureus lipoteichoic acid inhibits platelet activation and thrombus formation via the Paf receptor.

Waller AK, Sage T, Kumar C, Carr T, Gibbins JM, Clarke SR.

J Infect Dis. 2013 Dec 15;208(12):2046-57. doi: 10.1093/infdis/jit398. Epub 2013 Aug 2.

50.

Platelet protein disulfide isomerase is required for thrombus formation but not for hemostasis in mice.

Kim K, Hahm E, Li J, Holbrook LM, Sasikumar P, Stanley RG, Ushio-Fukai M, Gibbins JM, Cho J.

Blood. 2013 Aug 8;122(6):1052-61. doi: 10.1182/blood-2013-03-492504. Epub 2013 Jun 20.

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